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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ESF1
Full Name:
ESF1 homolog
Alias:
ABT1-associated protein; BA526K24.1; C20orf6; CT006; CT06; ESF1, nucleolar pre-rRNA processing protein,; Hypothetical protein C20orf6
Type:
Transcription, coactivator/corepressor
Mass (Da):
98796
Number AA:
851
UniProt ID:
Q9H501
International Prot ID:
IPI00024167
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
S
K
Q
E
I
M
S
D
Q
R
F
R
R
V
Site 2
Y51
D
K
K
F
K
L
N
Y
A
V
D
K
R
G
R
Site 3
S61
D
K
R
G
R
P
I
S
H
S
T
T
E
D
L
Site 4
S63
R
G
R
P
I
S
H
S
T
T
E
D
L
K
R
Site 5
T65
R
P
I
S
H
S
T
T
E
D
L
K
R
F
Y
Site 6
Y72
T
E
D
L
K
R
F
Y
D
L
S
D
S
D
S
Site 7
S75
L
K
R
F
Y
D
L
S
D
S
D
S
N
L
S
Site 8
S77
R
F
Y
D
L
S
D
S
D
S
N
L
S
G
E
Site 9
S79
Y
D
L
S
D
S
D
S
N
L
S
G
E
D
S
Site 10
S82
S
D
S
D
S
N
L
S
G
E
D
S
K
A
L
Site 11
S86
S
N
L
S
G
E
D
S
K
A
L
S
Q
K
K
Site 12
S90
G
E
D
S
K
A
L
S
Q
K
K
I
K
K
K
Site 13
T99
K
K
I
K
K
K
K
T
Q
T
K
K
E
I
D
Site 14
T129
H
K
G
S
E
N
K
T
D
L
D
N
S
I
G
Site 15
S134
N
K
T
D
L
D
N
S
I
G
I
K
K
M
K
Site 16
T142
I
G
I
K
K
M
K
T
S
C
K
F
K
I
D
Site 17
S143
G
I
K
K
M
K
T
S
C
K
F
K
I
D
S
Site 18
S150
S
C
K
F
K
I
D
S
N
I
S
P
K
K
D
Site 19
S153
F
K
I
D
S
N
I
S
P
K
K
D
S
K
E
Site 20
T162
K
K
D
S
K
E
F
T
Q
K
N
K
K
E
K
Site 21
S179
I
V
Q
H
T
T
D
S
S
L
E
E
K
Q
R
Site 22
S180
V
Q
H
T
T
D
S
S
L
E
E
K
Q
R
T
Site 23
T187
S
L
E
E
K
Q
R
T
L
D
S
G
T
S
E
Site 24
S190
E
K
Q
R
T
L
D
S
G
T
S
E
I
V
K
Site 25
T192
Q
R
T
L
D
S
G
T
S
E
I
V
K
S
P
Site 26
S193
R
T
L
D
S
G
T
S
E
I
V
K
S
P
R
Site 27
S198
G
T
S
E
I
V
K
S
P
R
I
E
C
S
K
Site 28
S204
K
S
P
R
I
E
C
S
K
T
R
R
E
M
Q
Site 29
T206
P
R
I
E
C
S
K
T
R
R
E
M
Q
S
V
Site 30
S212
K
T
R
R
E
M
Q
S
V
V
Q
L
I
M
T
Site 31
T219
S
V
V
Q
L
I
M
T
R
D
S
D
G
Y
E
Site 32
S222
Q
L
I
M
T
R
D
S
D
G
Y
E
N
S
T
Site 33
Y225
M
T
R
D
S
D
G
Y
E
N
S
T
D
G
E
Site 34
S228
D
S
D
G
Y
E
N
S
T
D
G
E
M
C
D
Site 35
T229
S
D
G
Y
E
N
S
T
D
G
E
M
C
D
K
Site 36
S243
K
D
A
L
E
E
D
S
E
S
V
S
E
I
G
Site 37
S245
A
L
E
E
D
S
E
S
V
S
E
I
G
S
D
Site 38
S247
E
E
D
S
E
S
V
S
E
I
G
S
D
E
E
Site 39
S251
E
S
V
S
E
I
G
S
D
E
E
S
E
N
E
Site 40
S255
E
I
G
S
D
E
E
S
E
N
E
I
T
S
V
Site 41
T260
E
E
S
E
N
E
I
T
S
V
G
R
A
S
G
Site 42
S261
E
S
E
N
E
I
T
S
V
G
R
A
S
G
D
Site 43
S266
I
T
S
V
G
R
A
S
G
D
D
D
G
S
E
Site 44
S272
A
S
G
D
D
D
G
S
E
D
D
E
E
E
D
Site 45
S290
E
E
D
E
D
E
D
S
E
D
D
D
K
S
D
Site 46
S296
D
S
E
D
D
D
K
S
D
S
G
P
D
L
A
Site 47
S298
E
D
D
D
K
S
D
S
G
P
D
L
A
R
G
Site 48
T311
R
G
K
G
N
I
E
T
S
S
E
D
E
D
D
Site 49
S312
G
K
G
N
I
E
T
S
S
E
D
E
D
D
T
Site 50
S313
K
G
N
I
E
T
S
S
E
D
E
D
D
T
A
Site 51
T319
S
S
E
D
E
D
D
T
A
D
L
F
P
E
E
Site 52
T347
A
P
R
A
D
E
I
T
R
R
L
A
V
C
N
Site 53
S381
P
K
G
G
V
I
F
S
V
K
I
Y
P
S
E
Site 54
S407
Q
G
P
V
E
L
L
S
I
P
E
D
A
P
E
Site 55
T418
D
A
P
E
K
D
W
T
S
R
E
K
L
R
D
Site 56
S419
A
P
E
K
D
W
T
S
R
E
K
L
R
D
Y
Site 57
Y426
S
R
E
K
L
R
D
Y
Q
F
K
R
L
K
Y
Site 58
Y433
Y
Q
F
K
R
L
K
Y
Y
Y
A
V
V
D
C
Site 59
Y434
Q
F
K
R
L
K
Y
Y
Y
A
V
V
D
C
D
Site 60
Y435
F
K
R
L
K
Y
Y
Y
A
V
V
D
C
D
S
Site 61
S442
Y
A
V
V
D
C
D
S
P
E
T
A
S
K
I
Site 62
S461
D
G
L
E
F
E
S
S
C
S
F
I
D
L
R
Site 63
T475
R
F
I
P
D
D
I
T
F
D
D
E
P
K
D
Site 64
S485
D
E
P
K
D
V
A
S
E
V
N
L
T
A
Y
Site 65
T490
V
A
S
E
V
N
L
T
A
Y
K
P
K
Y
F
Site 66
Y492
S
E
V
N
L
T
A
Y
K
P
K
Y
F
T
S
Site 67
Y496
L
T
A
Y
K
P
K
Y
F
T
S
A
A
M
G
Site 68
S499
Y
K
P
K
Y
F
T
S
A
A
M
G
T
S
T
Site 69
T506
S
A
A
M
G
T
S
T
V
E
I
T
W
D
E
Site 70
T520
E
T
D
H
E
R
I
T
M
L
N
R
K
F
K
Site 71
Y539
L
D
M
D
F
Q
A
Y
L
A
S
S
S
E
D
Site 72
T568
N
V
E
E
D
G
K
T
K
K
S
Q
K
D
D
Site 73
S571
E
D
G
K
T
K
K
S
Q
K
D
D
E
E
Q
Site 74
T630
L
E
G
K
D
K
L
T
P
W
E
Q
F
L
E
Site 75
S657
K
A
L
A
E
E
A
S
E
E
E
L
P
S
D
Site 76
S663
A
S
E
E
E
L
P
S
D
V
D
L
N
D
P
Site 77
Y671
D
V
D
L
N
D
P
Y
F
A
E
E
V
K
Q
Site 78
S685
Q
I
G
I
N
K
K
S
V
K
S
A
K
D
G
Site 79
S688
I
N
K
K
S
V
K
S
A
K
D
G
T
S
P
Site 80
T693
V
K
S
A
K
D
G
T
S
P
E
E
E
I
E
Site 81
S694
K
S
A
K
D
G
T
S
P
E
E
E
I
E
I
Site 82
Y725
D
S
K
K
H
F
N
Y
N
K
I
V
E
H
Q
Site 83
S735
I
V
E
H
Q
N
L
S
K
K
K
K
K
Q
L
Site 84
Y766
D
A
R
F
Q
A
M
Y
T
S
H
L
F
N
L
Site 85
S776
H
L
F
N
L
D
P
S
D
P
N
F
K
K
T
Site 86
T783
S
D
P
N
F
K
K
T
K
A
M
E
K
I
L
Site 87
T805
E
R
K
E
Q
E
L
T
Q
A
I
K
K
K
E
Site 88
S813
Q
A
I
K
K
K
E
S
E
I
E
K
E
S
Q
Site 89
S819
E
S
E
I
E
K
E
S
Q
R
K
S
I
D
P
Site 90
S823
E
K
E
S
Q
R
K
S
I
D
P
A
L
S
M
Site 91
S829
K
S
I
D
P
A
L
S
M
L
I
K
S
I
K
Site 92
S834
A
L
S
M
L
I
K
S
I
K
T
K
T
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation