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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF644
Full Name:
Zinc finger protein 644
Alias:
BM-005; DJ924G13.1; KIAA1221; MGC60165; MGC70410; Zep-2; Zinc finger motif enhancer binding protein 2; Zinc finger motif enhancer-binding protein 2; ZN644
Type:
Uncharacterized protein
Mass (Da):
149565
Number AA:
1327
UniProt ID:
Q9H582
International Prot ID:
IPI00398725
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
L
Q
Q
D
V
N
K
T
K
S
R
L
N
V
L
Site 2
S14
Q
D
V
N
K
T
K
S
R
L
N
V
L
N
G
Site 3
T36
L
K
I
N
T
D
I
T
G
A
K
E
E
L
L
Site 4
S50
L
D
D
N
N
F
I
S
D
K
E
S
G
V
H
Site 5
S54
N
F
I
S
D
K
E
S
G
V
H
K
P
K
D
Site 6
S65
K
P
K
D
C
Q
T
S
F
Q
K
N
N
T
L
Site 7
T73
F
Q
K
N
N
T
L
T
L
P
E
E
L
S
K
Site 8
S79
L
T
L
P
E
E
L
S
K
D
K
S
E
N
A
Site 9
S83
E
E
L
S
K
D
K
S
E
N
A
L
S
G
G
Site 10
S88
D
K
S
E
N
A
L
S
G
G
Q
S
S
L
F
Site 11
S104
H
A
G
A
P
T
V
S
S
E
N
F
I
L
P
Site 12
S105
A
G
A
P
T
V
S
S
E
N
F
I
L
P
K
Site 13
S121
A
A
V
N
G
P
V
S
H
S
S
L
T
K
T
Site 14
S124
N
G
P
V
S
H
S
S
L
T
K
T
S
N
M
Site 15
T128
S
H
S
S
L
T
K
T
S
N
M
N
K
G
S
Site 16
S129
H
S
S
L
T
K
T
S
N
M
N
K
G
S
V
Site 17
S135
T
S
N
M
N
K
G
S
V
S
L
T
T
G
Q
Site 18
S137
N
M
N
K
G
S
V
S
L
T
T
G
Q
P
V
Site 19
T139
N
K
G
S
V
S
L
T
T
G
Q
P
V
D
Q
Site 20
T148
G
Q
P
V
D
Q
P
T
T
E
S
C
S
T
L
Site 21
T149
Q
P
V
D
Q
P
T
T
E
S
C
S
T
L
K
Site 22
S164
V
A
A
D
L
Q
L
S
T
P
Q
K
A
S
Q
Site 23
T165
A
A
D
L
Q
L
S
T
P
Q
K
A
S
Q
H
Site 24
S170
L
S
T
P
Q
K
A
S
Q
H
Q
V
L
F
L
Site 25
S190
H
A
K
N
P
T
H
S
N
K
K
L
P
T
S
Site 26
S197
S
N
K
K
L
P
T
S
A
S
V
G
C
D
I
Site 27
S199
K
K
L
P
T
S
A
S
V
G
C
D
I
Q
N
Site 28
S207
V
G
C
D
I
Q
N
S
V
G
S
N
I
K
S
Site 29
S210
D
I
Q
N
S
V
G
S
N
I
K
S
D
G
T
Site 30
S214
S
V
G
S
N
I
K
S
D
G
T
L
I
N
Q
Site 31
T217
S
N
I
K
S
D
G
T
L
I
N
Q
V
E
V
Site 32
T240
V
K
D
D
C
V
N
T
V
T
G
I
S
S
G
Site 33
T242
D
D
C
V
N
T
V
T
G
I
S
S
G
T
D
Site 34
S253
S
G
T
D
G
F
R
S
E
N
D
T
N
W
D
Site 35
T257
G
F
R
S
E
N
D
T
N
W
D
P
Q
K
E
Site 36
T275
F
L
M
T
N
E
E
T
V
D
K
A
P
P
H
Site 37
S283
V
D
K
A
P
P
H
S
K
I
G
L
E
K
K
Site 38
S298
R
K
R
K
M
D
V
S
K
I
T
R
Y
T
E
Site 39
Y303
D
V
S
K
I
T
R
Y
T
E
D
C
F
S
D
Site 40
T304
V
S
K
I
T
R
Y
T
E
D
C
F
S
D
S
Site 41
S309
R
Y
T
E
D
C
F
S
D
S
N
C
V
P
N
Site 42
S311
T
E
D
C
F
S
D
S
N
C
V
P
N
K
S
Site 43
S337
E
E
L
Q
A
V
D
S
Q
K
Y
A
L
S
K
Site 44
S343
D
S
Q
K
Y
A
L
S
K
V
K
P
E
S
T
Site 45
S349
L
S
K
V
K
P
E
S
T
D
E
D
L
E
S
Site 46
S356
S
T
D
E
D
L
E
S
V
D
A
F
Q
H
L
Site 47
Y365
D
A
F
Q
H
L
I
Y
N
P
D
K
C
G
E
Site 48
S375
D
K
C
G
E
E
S
S
P
V
H
T
S
T
F
Site 49
T379
E
E
S
S
P
V
H
T
S
T
F
L
S
N
T
Site 50
S380
E
S
S
P
V
H
T
S
T
F
L
S
N
T
L
Site 51
T381
S
S
P
V
H
T
S
T
F
L
S
N
T
L
K
Site 52
S384
V
H
T
S
T
F
L
S
N
T
L
K
K
K
C
Site 53
S394
L
K
K
K
C
E
E
S
D
S
E
S
P
A
T
Site 54
S396
K
K
C
E
E
S
D
S
E
S
P
A
T
F
S
Site 55
S398
C
E
E
S
D
S
E
S
P
A
T
F
S
T
E
Site 56
T401
S
D
S
E
S
P
A
T
F
S
T
E
E
P
S
Site 57
S403
S
E
S
P
A
T
F
S
T
E
E
P
S
F
Y
Site 58
T404
E
S
P
A
T
F
S
T
E
E
P
S
F
Y
P
Site 59
Y410
S
T
E
E
P
S
F
Y
P
C
T
K
C
N
V
Site 60
Y448
H
L
N
V
P
R
P
Y
A
C
R
E
C
G
R
Site 61
T456
A
C
R
E
C
G
R
T
F
R
D
R
N
S
L
Site 62
S462
R
T
F
R
D
R
N
S
L
L
K
H
M
I
I
Site 63
T510
F
G
T
N
C
P
K
T
F
V
Q
H
A
K
T
Site 64
Y524
T
H
E
K
D
K
R
Y
Y
C
C
E
E
C
N
Site 65
T566
S
D
I
A
Q
R
K
T
Q
K
K
T
F
M
K
Site 66
T570
Q
R
K
T
Q
K
K
T
F
M
K
D
S
V
V
Site 67
S575
K
K
T
F
M
K
D
S
V
V
G
S
S
K
K
Site 68
S579
M
K
D
S
V
V
G
S
S
K
K
S
A
T
Y
Site 69
S580
K
D
S
V
V
G
S
S
K
K
S
A
T
Y
I
Site 70
S583
V
V
G
S
S
K
K
S
A
T
Y
I
C
K
M
Site 71
Y586
S
S
K
K
S
A
T
Y
I
C
K
M
C
P
F
Site 72
S599
P
F
T
T
S
A
K
S
V
L
K
K
H
T
E
Site 73
Y607
V
L
K
K
H
T
E
Y
L
H
S
S
S
C
V
Site 74
S610
K
H
T
E
Y
L
H
S
S
S
C
V
D
S
F
Site 75
S611
H
T
E
Y
L
H
S
S
S
C
V
D
S
F
G
Site 76
S612
T
E
Y
L
H
S
S
S
C
V
D
S
F
G
S
Site 77
S616
H
S
S
S
C
V
D
S
F
G
S
P
L
G
L
Site 78
S619
S
C
V
D
S
F
G
S
P
L
G
L
D
K
R
Site 79
S637
I
L
E
E
P
V
D
S
D
S
T
K
T
L
T
Site 80
S639
E
E
P
V
D
S
D
S
T
K
T
L
T
K
Q
Site 81
T642
V
D
S
D
S
T
K
T
L
T
K
Q
Q
S
T
Site 82
T644
S
D
S
T
K
T
L
T
K
Q
Q
S
T
T
F
Site 83
S648
K
T
L
T
K
Q
Q
S
T
T
F
P
K
N
S
Site 84
T650
L
T
K
Q
Q
S
T
T
F
P
K
N
S
A
L
Site 85
T664
L
K
Q
D
V
K
R
T
F
G
S
T
S
Q
S
Site 86
S667
D
V
K
R
T
F
G
S
T
S
Q
S
S
S
F
Site 87
T668
V
K
R
T
F
G
S
T
S
Q
S
S
S
F
S
Site 88
S669
K
R
T
F
G
S
T
S
Q
S
S
S
F
S
K
Site 89
S671
T
F
G
S
T
S
Q
S
S
S
F
S
K
I
H
Site 90
S672
F
G
S
T
S
Q
S
S
S
F
S
K
I
H
K
Site 91
S673
G
S
T
S
Q
S
S
S
F
S
K
I
H
K
R
Site 92
S675
T
S
Q
S
S
S
F
S
K
I
H
K
R
P
H
Site 93
S690
R
I
Q
K
A
R
K
S
I
A
Q
S
G
V
N
Site 94
S694
A
R
K
S
I
A
Q
S
G
V
N
M
C
N
Q
Site 95
T710
S
S
P
H
K
N
V
T
I
K
S
S
V
D
Q
Site 96
S713
H
K
N
V
T
I
K
S
S
V
D
Q
K
P
K
Site 97
S714
K
N
V
T
I
K
S
S
V
D
Q
K
P
K
Y
Site 98
Y721
S
V
D
Q
K
P
K
Y
F
H
Q
A
A
K
E
Site 99
S730
H
Q
A
A
K
E
K
S
N
A
K
A
N
S
H
Site 100
Y738
N
A
K
A
N
S
H
Y
L
Y
R
H
K
Y
E
Site 101
Y740
K
A
N
S
H
Y
L
Y
R
H
K
Y
E
N
Y
Site 102
Y744
H
Y
L
Y
R
H
K
Y
E
N
Y
R
M
I
K
Site 103
S753
N
Y
R
M
I
K
K
S
G
E
S
Y
P
V
H
Site 104
Y757
I
K
K
S
G
E
S
Y
P
V
H
F
K
K
E
Site 105
S767
H
F
K
K
E
E
A
S
S
L
N
S
L
H
L
Site 106
S768
F
K
K
E
E
A
S
S
L
N
S
L
H
L
F
Site 107
S771
E
E
A
S
S
L
N
S
L
H
L
F
S
S
S
Site 108
S776
L
N
S
L
H
L
F
S
S
S
S
N
S
H
N
Site 109
S777
N
S
L
H
L
F
S
S
S
S
N
S
H
N
N
Site 110
S778
S
L
H
L
F
S
S
S
S
N
S
H
N
N
F
Site 111
S779
L
H
L
F
S
S
S
S
N
S
H
N
N
F
I
Site 112
S781
L
F
S
S
S
S
N
S
H
N
N
F
I
S
D
Site 113
S787
N
S
H
N
N
F
I
S
D
P
H
K
P
D
A
Site 114
S799
P
D
A
K
R
P
E
S
F
K
D
H
R
R
V
Site 115
S815
V
K
R
V
I
K
E
S
K
K
E
S
S
V
G
Site 116
S819
I
K
E
S
K
K
E
S
S
V
G
G
E
D
L
Site 117
S820
K
E
S
K
K
E
S
S
V
G
G
E
D
L
D
Site 118
S828
V
G
G
E
D
L
D
S
Y
P
D
F
L
H
K
Site 119
Y829
G
G
E
D
L
D
S
Y
P
D
F
L
H
K
M
Site 120
S846
V
V
L
Q
K
L
N
S
A
E
K
K
D
S
Y
Site 121
S852
N
S
A
E
K
K
D
S
Y
E
T
E
D
E
S
Site 122
Y853
S
A
E
K
K
D
S
Y
E
T
E
D
E
S
S
Site 123
T855
E
K
K
D
S
Y
E
T
E
D
E
S
S
W
D
Site 124
S860
Y
E
T
E
D
E
S
S
W
D
N
V
E
L
G
Site 125
Y869
D
N
V
E
L
G
D
Y
T
T
Q
A
I
E
D
Site 126
T871
V
E
L
G
D
Y
T
T
Q
A
I
E
D
E
T
Site 127
T878
T
Q
A
I
E
D
E
T
Y
S
D
I
N
Q
E
Site 128
Y879
Q
A
I
E
D
E
T
Y
S
D
I
N
Q
E
H
Site 129
S880
A
I
E
D
E
T
Y
S
D
I
N
Q
E
H
V
Site 130
S909
P
G
E
N
A
T
L
S
Y
D
Q
N
D
G
F
Site 131
Y910
G
E
N
A
T
L
S
Y
D
Q
N
D
G
F
Y
Site 132
Y917
Y
D
Q
N
D
G
F
Y
F
E
Y
Y
E
D
T
Site 133
Y920
N
D
G
F
Y
F
E
Y
Y
E
D
T
G
S
N
Site 134
Y921
D
G
F
Y
F
E
Y
Y
E
D
T
G
S
N
N
Site 135
T941
H
D
P
Q
H
L
E
T
A
D
A
S
L
S
K
Site 136
S945
H
L
E
T
A
D
A
S
L
S
K
H
S
S
V
Site 137
S947
E
T
A
D
A
S
L
S
K
H
S
S
V
F
H
Site 138
S951
A
S
L
S
K
H
S
S
V
F
H
W
T
D
L
Site 139
S959
V
F
H
W
T
D
L
S
L
E
K
K
S
C
P
Site 140
S964
D
L
S
L
E
K
K
S
C
P
Y
C
P
A
T
Site 141
S979
F
E
T
G
V
G
L
S
N
H
V
R
G
H
L
Site 142
S992
H
L
H
R
A
G
L
S
Y
E
A
R
H
V
V
Site 143
Y993
L
H
R
A
G
L
S
Y
E
A
R
H
V
V
S
Site 144
S1000
Y
E
A
R
H
V
V
S
P
E
Q
I
A
T
S
Site 145
T1006
V
S
P
E
Q
I
A
T
S
D
K
M
Q
H
F
Site 146
S1007
S
P
E
Q
I
A
T
S
D
K
M
Q
H
F
K
Site 147
T1018
Q
H
F
K
R
T
G
T
G
T
P
V
K
R
V
Site 148
T1020
F
K
R
T
G
T
G
T
P
V
K
R
V
R
K
Site 149
S1032
V
R
K
A
I
E
K
S
E
T
T
S
E
H
T
Site 150
T1034
K
A
I
E
K
S
E
T
T
S
E
H
T
C
Q
Site 151
S1036
I
E
K
S
E
T
T
S
E
H
T
C
Q
L
C
Site 152
S1054
F
D
T
K
I
G
L
S
N
H
V
R
G
H
L
Site 153
S1098
K
I
L
K
A
L
N
S
R
R
I
I
P
R
P
Site 154
S1113
F
V
A
Q
K
L
A
S
S
D
D
F
I
S
Q
Site 155
S1114
V
A
Q
K
L
A
S
S
D
D
F
I
S
Q
N
Site 156
S1119
A
S
S
D
D
F
I
S
Q
N
V
I
P
L
E
Site 157
T1134
A
Y
R
N
G
L
K
T
E
A
L
S
V
S
A
Site 158
S1138
G
L
K
T
E
A
L
S
V
S
A
S
E
E
E
Site 159
S1140
K
T
E
A
L
S
V
S
A
S
E
E
E
G
L
Site 160
S1142
E
A
L
S
V
S
A
S
E
E
E
G
L
N
F
Site 161
Y1153
G
L
N
F
L
N
E
Y
D
E
T
K
P
E
L
Site 162
T1156
F
L
N
E
Y
D
E
T
K
P
E
L
P
S
G
Site 163
S1168
P
S
G
K
K
N
Q
S
L
T
L
I
E
L
L
Site 164
S1186
R
M
G
E
E
R
N
S
A
I
S
P
Q
K
I
Site 165
S1189
E
E
R
N
S
A
I
S
P
Q
K
I
H
N
Q
Site 166
T1197
P
Q
K
I
H
N
Q
T
A
R
K
R
F
V
Q
Site 167
S1214
V
L
P
L
N
E
D
S
P
L
M
Y
Q
P
Q
Site 168
Y1218
N
E
D
S
P
L
M
Y
Q
P
Q
K
M
D
L
Site 169
T1226
Q
P
Q
K
M
D
L
T
M
H
S
A
L
D
C
Site 170
S1238
L
D
C
K
Q
K
K
S
R
S
R
S
G
S
K
Site 171
S1240
C
K
Q
K
K
S
R
S
R
S
G
S
K
K
K
Site 172
S1242
Q
K
K
S
R
S
R
S
G
S
K
K
K
M
L
Site 173
S1244
K
S
R
S
R
S
G
S
K
K
K
M
L
T
L
Site 174
Y1259
P
H
G
A
D
E
V
Y
I
L
R
C
R
F
C
Site 175
S1275
L
V
F
R
G
P
L
S
V
Q
E
D
W
I
K
Site 176
T1296
V
N
A
N
L
P
R
T
G
A
G
M
V
E
V
Site 177
S1312
S
L
L
K
K
P
A
S
I
T
E
T
S
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation