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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BICC1
Full Name:
Protein bicaudal C homolog 1
Alias:
Bicaudal C 1; Bicaudal C homolog 1; Protein bicaudal C homolog 1
Type:
RNA binding protein
Mass (Da):
104844
Number AA:
974
UniProt ID:
Q9H694
International Prot ID:
IPI00645643
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0032501
GO:0032502
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
A
Q
G
E
P
G
Y
L
A
A
Q
S
D
P
Site 2
S14
P
G
Y
L
A
A
Q
S
D
P
G
S
N
S
E
Site 3
S18
A
A
Q
S
D
P
G
S
N
S
E
R
S
T
D
Site 4
S20
Q
S
D
P
G
S
N
S
E
R
S
T
D
S
P
Site 5
S23
P
G
S
N
S
E
R
S
T
D
S
P
V
P
G
Site 6
T24
G
S
N
S
E
R
S
T
D
S
P
V
P
G
S
Site 7
S26
N
S
E
R
S
T
D
S
P
V
P
G
S
E
D
Site 8
S31
T
D
S
P
V
P
G
S
E
D
D
L
V
A
G
Site 9
S43
V
A
G
A
T
L
H
S
P
E
W
S
E
E
R
Site 10
S47
T
L
H
S
P
E
W
S
E
E
R
F
R
V
D
Site 11
S72
A
A
E
G
K
G
R
S
G
E
D
F
F
Q
K
Site 12
T86
K
I
M
E
E
T
N
T
Q
I
A
W
P
S
K
Site 13
S124
E
A
K
E
M
I
M
S
V
L
D
T
K
S
N
Site 14
S130
M
S
V
L
D
T
K
S
N
R
V
T
L
K
M
Site 15
T134
D
T
K
S
N
R
V
T
L
K
M
D
V
S
H
Site 16
S140
V
T
L
K
M
D
V
S
H
T
E
H
S
H
V
Site 17
S145
D
V
S
H
T
E
H
S
H
V
I
G
K
G
G
Site 18
S180
R
N
N
Q
A
E
K
S
N
Q
V
S
I
A
G
Site 19
S184
A
E
K
S
N
Q
V
S
I
A
G
Q
P
A
G
Site 20
S194
G
Q
P
A
G
V
E
S
A
R
V
R
I
R
E
Site 21
S225
Q
P
V
P
D
P
N
S
P
S
I
Q
H
I
S
Site 22
S232
S
P
S
I
Q
H
I
S
Q
T
Y
N
I
S
V
Site 23
T234
S
I
Q
H
I
S
Q
T
Y
N
I
S
V
S
F
Site 24
S238
I
S
Q
T
Y
N
I
S
V
S
F
K
Q
R
S
Site 25
S240
Q
T
Y
N
I
S
V
S
F
K
Q
R
S
R
M
Site 26
Y248
F
K
Q
R
S
R
M
Y
G
A
T
V
I
V
R
Site 27
T251
R
S
R
M
Y
G
A
T
V
I
V
R
G
S
Q
Site 28
T261
V
R
G
S
Q
N
N
T
S
A
V
K
E
G
T
Site 29
S262
R
G
S
Q
N
N
T
S
A
V
K
E
G
T
A
Site 30
S324
Q
I
H
F
P
D
P
S
N
P
Q
K
K
S
T
Site 31
S330
P
S
N
P
Q
K
K
S
T
V
Y
L
Q
G
T
Site 32
Y333
P
Q
K
K
S
T
V
Y
L
Q
G
T
I
E
S
Site 33
S383
E
Q
L
D
V
F
I
S
I
K
P
K
P
K
Q
Site 34
S392
K
P
K
P
K
Q
P
S
K
S
V
I
V
K
S
Site 35
S394
K
P
K
Q
P
S
K
S
V
I
V
K
S
V
E
Site 36
S399
S
K
S
V
I
V
K
S
V
E
R
N
A
L
N
Site 37
Y408
E
R
N
A
L
N
M
Y
E
A
R
K
C
L
L
Site 38
T423
G
L
E
S
S
G
V
T
I
A
T
S
P
S
P
Site 39
S468
T
T
L
S
L
N
T
S
T
T
P
N
S
L
L
Site 40
T469
T
L
S
L
N
T
S
T
T
P
N
S
L
L
N
Site 41
T470
L
S
L
N
T
S
T
T
P
N
S
L
L
N
A
Site 42
S473
N
T
S
T
T
P
N
S
L
L
N
A
L
N
S
Site 43
S483
N
A
L
N
S
S
V
S
P
L
Q
S
P
S
S
Site 44
S487
S
S
V
S
P
L
Q
S
P
S
S
G
T
P
S
Site 45
S489
V
S
P
L
Q
S
P
S
S
G
T
P
S
P
T
Site 46
S490
S
P
L
Q
S
P
S
S
G
T
P
S
P
T
L
Site 47
T492
L
Q
S
P
S
S
G
T
P
S
P
T
L
W
A
Site 48
S494
S
P
S
S
G
T
P
S
P
T
L
W
A
P
P
Site 49
T496
S
S
G
T
P
S
P
T
L
W
A
P
P
L
A
Site 50
T522
P
H
L
M
I
P
S
T
A
Q
A
T
L
T
N
Site 51
Y538
L
L
S
G
V
P
T
Y
G
H
T
A
P
S
P
Site 52
S544
T
Y
G
H
T
A
P
S
P
P
P
G
L
T
P
Site 53
T550
P
S
P
P
P
G
L
T
P
V
D
V
H
I
N
Site 54
S567
Q
T
E
G
K
K
I
S
A
A
L
N
G
H
A
Site 55
S576
A
L
N
G
H
A
Q
S
P
D
I
K
Y
G
A
Site 56
Y581
A
Q
S
P
D
I
K
Y
G
A
I
S
T
S
S
Site 57
S585
D
I
K
Y
G
A
I
S
T
S
S
L
G
E
K
Site 58
S595
S
L
G
E
K
V
L
S
A
N
H
G
D
P
S
Site 59
S602
S
A
N
H
G
D
P
S
I
Q
T
S
G
S
E
Site 60
S606
G
D
P
S
I
Q
T
S
G
S
E
Q
T
S
P
Site 61
S608
P
S
I
Q
T
S
G
S
E
Q
T
S
P
K
S
Site 62
S612
T
S
G
S
E
Q
T
S
P
K
S
S
P
T
E
Site 63
S615
S
E
Q
T
S
P
K
S
S
P
T
E
G
C
N
Site 64
S616
E
Q
T
S
P
K
S
S
P
T
E
G
C
N
D
Site 65
S633
V
E
V
G
M
P
R
S
P
S
H
S
G
N
A
Site 66
S635
V
G
M
P
R
S
P
S
H
S
G
N
A
G
D
Site 67
S637
M
P
R
S
P
S
H
S
G
N
A
G
D
L
K
Site 68
T659
V
S
C
A
K
R
Q
T
V
E
L
L
Q
G
T
Site 69
S669
L
L
Q
G
T
K
N
S
H
L
H
S
T
D
R
Site 70
S673
T
K
N
S
H
L
H
S
T
D
R
L
L
S
D
Site 71
T674
K
N
S
H
L
H
S
T
D
R
L
L
S
D
P
Site 72
S679
H
S
T
D
R
L
L
S
D
P
E
L
S
A
T
Site 73
S684
L
L
S
D
P
E
L
S
A
T
E
S
P
L
A
Site 74
T686
S
D
P
E
L
S
A
T
E
S
P
L
A
D
K
Site 75
S688
P
E
L
S
A
T
E
S
P
L
A
D
K
K
A
Site 76
S698
A
D
K
K
A
P
G
S
E
R
A
A
E
R
A
Site 77
S712
A
A
A
A
Q
Q
N
S
E
R
A
H
L
A
P
Site 78
S721
R
A
H
L
A
P
R
S
S
Y
V
N
M
Q
A
Site 79
S722
A
H
L
A
P
R
S
S
Y
V
N
M
Q
A
F
Site 80
Y723
H
L
A
P
R
S
S
Y
V
N
M
Q
A
F
D
Site 81
Y731
V
N
M
Q
A
F
D
Y
E
Q
K
K
L
L
A
Site 82
T753
P
V
V
T
E
V
R
T
P
T
N
T
W
S
G
Site 83
T755
V
T
E
V
R
T
P
T
N
T
W
S
G
L
G
Site 84
T757
E
V
R
T
P
T
N
T
W
S
G
L
G
F
S
Site 85
S759
R
T
P
T
N
T
W
S
G
L
G
F
S
K
S
Site 86
S766
S
G
L
G
F
S
K
S
M
P
A
E
T
I
K
Site 87
S782
L
R
R
A
N
H
V
S
Y
K
P
T
M
T
T
Site 88
T786
N
H
V
S
Y
K
P
T
M
T
T
T
Y
E
G
Site 89
T790
Y
K
P
T
M
T
T
T
Y
E
G
S
S
M
S
Site 90
Y791
K
P
T
M
T
T
T
Y
E
G
S
S
M
S
L
Site 91
S794
M
T
T
T
Y
E
G
S
S
M
S
L
S
R
S
Site 92
S795
T
T
T
Y
E
G
S
S
M
S
L
S
R
S
N
Site 93
S797
T
Y
E
G
S
S
M
S
L
S
R
S
N
S
R
Site 94
S799
E
G
S
S
M
S
L
S
R
S
N
S
R
E
H
Site 95
S801
S
S
M
S
L
S
R
S
N
S
R
E
H
L
G
Site 96
S803
M
S
L
S
R
S
N
S
R
E
H
L
G
G
G
Site 97
S811
R
E
H
L
G
G
G
S
E
S
D
N
W
R
D
Site 98
S813
H
L
G
G
G
S
E
S
D
N
W
R
D
R
N
Site 99
S826
R
N
G
I
G
P
G
S
H
S
E
F
A
A
S
Site 100
S833
S
H
S
E
F
A
A
S
I
G
S
P
K
R
K
Site 101
S836
E
F
A
A
S
I
G
S
P
K
R
K
Q
N
K
Site 102
S844
P
K
R
K
Q
N
K
S
T
E
H
Y
L
S
S
Site 103
T845
K
R
K
Q
N
K
S
T
E
H
Y
L
S
S
S
Site 104
Y848
Q
N
K
S
T
E
H
Y
L
S
S
S
N
Y
M
Site 105
S850
K
S
T
E
H
Y
L
S
S
S
N
Y
M
D
C
Site 106
Y854
H
Y
L
S
S
S
N
Y
M
D
C
I
S
S
L
Site 107
S859
S
N
Y
M
D
C
I
S
S
L
T
G
S
N
G
Site 108
S864
C
I
S
S
L
T
G
S
N
G
C
N
L
N
S
Site 109
S871
S
N
G
C
N
L
N
S
S
F
K
G
S
D
L
Site 110
S872
N
G
C
N
L
N
S
S
F
K
G
S
D
L
P
Site 111
S876
L
N
S
S
F
K
G
S
D
L
P
E
L
F
S
Site 112
S883
S
D
L
P
E
L
F
S
K
L
G
L
G
K
Y
Site 113
Y890
S
K
L
G
L
G
K
Y
T
D
V
F
Q
Q
Q
Site 114
T903
Q
Q
E
I
D
L
Q
T
F
L
T
L
T
D
Q
Site 115
T906
I
D
L
Q
T
F
L
T
L
T
D
Q
D
L
K
Site 116
T918
D
L
K
E
L
G
I
T
T
F
G
A
R
R
K
Site 117
T919
L
K
E
L
G
I
T
T
F
G
A
R
R
K
M
Site 118
S931
R
K
M
L
L
A
I
S
E
L
N
K
N
R
R
Site 119
S943
N
R
R
K
L
F
E
S
P
N
A
R
T
S
F
Site 120
S949
E
S
P
N
A
R
T
S
F
L
E
G
G
A
S
Site 121
S956
S
F
L
E
G
G
A
S
G
R
L
P
R
Q
Y
Site 122
Y963
S
G
R
L
P
R
Q
Y
H
S
D
I
A
S
V
Site 123
S965
R
L
P
R
Q
Y
H
S
D
I
A
S
V
S
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation