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Updated November 2019
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Protein Info
Short Name:
DENND2D
Full Name:
DENN domain-containing protein 2D
Alias:
Type:
Mass (Da):
53672
Number AA:
471
UniProt ID:
Q9H6A0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
A
G
P
P
Q
D
N
S
G
E
A
L
K
E
P
Site 2
S43
P
E
R
A
Q
E
H
S
L
P
N
F
A
G
G
Site 3
S61
F
E
Y
L
L
V
V
S
L
K
K
K
R
S
E
Site 4
S67
V
S
L
K
K
K
R
S
E
D
D
Y
E
P
I
Site 5
Y71
K
K
R
S
E
D
D
Y
E
P
I
I
T
Y
Q
Site 6
T76
D
D
Y
E
P
I
I
T
Y
Q
F
P
K
R
E
Site 7
Y77
D
Y
E
P
I
I
T
Y
Q
F
P
K
R
E
N
Site 8
S113
P
D
G
N
E
W
A
S
L
T
E
Y
P
R
E
Site 9
T115
G
N
E
W
A
S
L
T
E
Y
P
R
E
T
F
Site 10
Y117
E
W
A
S
L
T
E
Y
P
R
E
T
F
S
F
Site 11
T121
L
T
E
Y
P
R
E
T
F
S
F
V
L
T
N
Site 12
S123
E
Y
P
R
E
T
F
S
F
V
L
T
N
V
D
Site 13
T127
E
T
F
S
F
V
L
T
N
V
D
G
S
R
K
Site 14
Y137
D
G
S
R
K
I
G
Y
C
R
R
L
L
P
A
Site 15
Y185
Q
I
S
M
A
V
I
Y
P
F
M
Q
G
L
R
Site 16
S207
G
K
T
V
T
L
K
S
F
I
P
D
S
G
T
Site 17
T214
S
F
I
P
D
S
G
T
E
F
I
S
L
T
R
Site 18
S218
D
S
G
T
E
F
I
S
L
T
R
P
L
D
S
Site 19
T220
G
T
E
F
I
S
L
T
R
P
L
D
S
H
L
Site 20
S225
S
L
T
R
P
L
D
S
H
L
E
H
V
D
F
Site 21
T286
Y
P
F
S
W
A
H
T
Y
I
P
V
V
P
E
Site 22
Y287
P
F
S
W
A
H
T
Y
I
P
V
V
P
E
S
Site 23
S320
F
Q
Q
E
V
M
D
S
P
M
E
E
V
L
L
Site 24
S357
L
Q
D
D
I
L
D
S
L
G
Q
G
I
N
E
Site 25
S392
K
I
V
G
H
Y
A
S
Y
I
K
R
E
A
N
Site 26
S408
Q
G
H
F
Q
E
R
S
F
C
K
A
L
T
S
Site 27
S415
S
F
C
K
A
L
T
S
K
T
N
R
R
F
V
Site 28
T417
C
K
A
L
T
S
K
T
N
R
R
F
V
K
K
Site 29
S441
F
I
Q
E
A
E
K
S
K
N
P
P
A
G
Y
Site 30
Y448
S
K
N
P
P
A
G
Y
F
Q
Q
K
I
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation