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Updated November 2019
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Protein Info
Short Name:
PCNXL3
Full Name:
Pecanex-like protein 3
Alias:
DKFZp686M14190; ENSP00000381731; PCX3
Type:
Uncharacterized
Mass (Da):
222039
Number AA:
2034
UniProt ID:
Q9H6A9
International Prot ID:
IPI00869136
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
G
S
Q
V
L
Q
I
L
R
Site 2
Y50
L
I
F
P
F
L
L
Y
M
V
L
P
P
S
L
Site 3
Y63
S
L
M
V
A
G
V
Y
C
L
V
V
A
V
I
Site 4
S96
E
I
V
E
K
R
S
S
T
M
G
E
L
E
E
Site 5
T97
I
V
E
K
R
S
S
T
M
G
E
L
E
E
E
Site 6
S110
E
E
P
A
Q
G
D
S
N
P
P
R
D
P
G
Site 7
T121
R
D
P
G
V
E
M
T
V
F
R
K
V
S
S
Site 8
S127
M
T
V
F
R
K
V
S
S
T
P
P
V
R
C
Site 9
S128
T
V
F
R
K
V
S
S
T
P
P
V
R
C
S
Site 10
T129
V
F
R
K
V
S
S
T
P
P
V
R
C
S
S
Site 11
S135
S
T
P
P
V
R
C
S
S
Q
H
S
V
F
G
Site 12
S136
T
P
P
V
R
C
S
S
Q
H
S
V
F
G
F
Site 13
S139
V
R
C
S
S
Q
H
S
V
F
G
F
N
Q
V
Site 14
S156
L
L
P
R
M
E
D
S
G
P
L
R
D
I
K
Site 15
S178
S
N
N
V
I
V
T
S
A
D
R
E
M
L
K
Site 16
S187
D
R
E
M
L
K
L
S
S
Q
E
K
L
I
G
Site 17
S188
R
E
M
L
K
L
S
S
Q
E
K
L
I
G
D
Site 18
T199
L
I
G
D
L
P
Q
T
P
P
G
A
V
P
D
Site 19
S208
P
G
A
V
P
D
P
S
L
A
S
T
D
S
S
Site 20
S211
V
P
D
P
S
L
A
S
T
D
S
S
E
P
S
Site 21
T212
P
D
P
S
L
A
S
T
D
S
S
E
P
S
P
Site 22
S214
P
S
L
A
S
T
D
S
S
E
P
S
P
L
A
Site 23
S215
S
L
A
S
T
D
S
S
E
P
S
P
L
A
G
Site 24
S218
S
T
D
S
S
E
P
S
P
L
A
G
D
G
A
Site 25
S228
A
G
D
G
A
P
W
S
G
S
S
M
A
D
T
Site 26
S230
D
G
A
P
W
S
G
S
S
M
A
D
T
P
M
Site 27
S231
G
A
P
W
S
G
S
S
M
A
D
T
P
M
S
Site 28
T235
S
G
S
S
M
A
D
T
P
M
S
P
L
L
K
Site 29
S238
S
M
A
D
T
P
M
S
P
L
L
K
G
S
L
Site 30
S244
M
S
P
L
L
K
G
S
L
S
Q
E
L
S
K
Site 31
S246
P
L
L
K
G
S
L
S
Q
E
L
S
K
S
F
Site 32
S250
G
S
L
S
Q
E
L
S
K
S
F
L
T
L
T
Site 33
S252
L
S
Q
E
L
S
K
S
F
L
T
L
T
Q
P
Site 34
T257
S
K
S
F
L
T
L
T
Q
P
D
R
A
L
V
Site 35
T266
P
D
R
A
L
V
R
T
S
S
R
R
E
Q
R
Site 36
S267
D
R
A
L
V
R
T
S
S
R
R
E
Q
R
R
Site 37
S268
R
A
L
V
R
T
S
S
R
R
E
Q
R
R
G
Site 38
Y279
Q
R
R
G
A
G
G
Y
Q
P
L
D
R
R
G
Site 39
S287
Q
P
L
D
R
R
G
S
G
E
P
T
P
Q
K
Site 40
T291
R
R
G
S
G
E
P
T
P
Q
K
A
G
S
S
Site 41
S297
P
T
P
Q
K
A
G
S
S
D
S
C
F
S
G
Site 42
S298
T
P
Q
K
A
G
S
S
D
S
C
F
S
G
T
Site 43
S300
Q
K
A
G
S
S
D
S
C
F
S
G
T
D
R
Site 44
T305
S
D
S
C
F
S
G
T
D
R
E
T
L
S
S
Site 45
T309
F
S
G
T
D
R
E
T
L
S
S
F
K
S
E
Site 46
S311
G
T
D
R
E
T
L
S
S
F
K
S
E
K
T
Site 47
S312
T
D
R
E
T
L
S
S
F
K
S
E
K
T
N
Site 48
S315
E
T
L
S
S
F
K
S
E
K
T
N
S
T
H
Site 49
T318
S
S
F
K
S
E
K
T
N
S
T
H
L
D
S
Site 50
S320
F
K
S
E
K
T
N
S
T
H
L
D
S
P
P
Site 51
T321
K
S
E
K
T
N
S
T
H
L
D
S
P
P
G
Site 52
S325
T
N
S
T
H
L
D
S
P
P
G
G
P
A
P
Site 53
S335
G
G
P
A
P
E
G
S
D
T
D
P
P
S
E
Site 54
T337
P
A
P
E
G
S
D
T
D
P
P
S
E
A
E
Site 55
S341
G
S
D
T
D
P
P
S
E
A
E
L
P
A
S
Site 56
S348
S
E
A
E
L
P
A
S
P
D
A
G
V
P
S
Site 57
S355
S
P
D
A
G
V
P
S
D
D
T
L
R
S
F
Site 58
T358
A
G
V
P
S
D
D
T
L
R
S
F
D
T
V
Site 59
S361
P
S
D
D
T
L
R
S
F
D
T
V
I
G
A
Site 60
T364
D
T
L
R
S
F
D
T
V
I
G
A
G
T
P
Site 61
T370
D
T
V
I
G
A
G
T
P
P
G
L
A
E
P
Site 62
S392
D
L
A
L
L
R
P
S
K
R
Q
P
P
L
R
Site 63
S402
Q
P
P
L
R
R
H
S
P
P
G
R
A
P
R
Site 64
T424
G
F
F
E
D
E
D
T
S
E
G
S
E
L
S
Site 65
S425
F
F
E
D
E
D
T
S
E
G
S
E
L
S
P
Site 66
S431
T
S
E
G
S
E
L
S
P
A
S
S
L
R
S
Site 67
S434
G
S
E
L
S
P
A
S
S
L
R
S
Q
R
R
Site 68
S435
S
E
L
S
P
A
S
S
L
R
S
Q
R
R
Y
Site 69
S438
S
P
A
S
S
L
R
S
Q
R
R
Y
S
T
D
Site 70
Y442
S
L
R
S
Q
R
R
Y
S
T
D
S
S
S
S
Site 71
S443
L
R
S
Q
R
R
Y
S
T
D
S
S
S
S
T
Site 72
T444
R
S
Q
R
R
Y
S
T
D
S
S
S
S
T
S
Site 73
S446
Q
R
R
Y
S
T
D
S
S
S
S
T
S
C
Y
Site 74
S447
R
R
Y
S
T
D
S
S
S
S
T
S
C
Y
S
Site 75
S448
R
Y
S
T
D
S
S
S
S
T
S
C
Y
S
P
Site 76
S449
Y
S
T
D
S
S
S
S
T
S
C
Y
S
P
E
Site 77
T450
S
T
D
S
S
S
S
T
S
C
Y
S
P
E
S
Site 78
S451
T
D
S
S
S
S
T
S
C
Y
S
P
E
S
S
Site 79
Y453
S
S
S
S
T
S
C
Y
S
P
E
S
S
R
G
Site 80
S454
S
S
S
T
S
C
Y
S
P
E
S
S
R
G
A
Site 81
S457
T
S
C
Y
S
P
E
S
S
R
G
A
A
G
G
Site 82
S458
S
C
Y
S
P
E
S
S
R
G
A
A
G
G
P
Site 83
T478
P
H
G
A
E
E
G
T
A
V
P
P
K
R
P
Site 84
Y486
A
V
P
P
K
R
P
Y
G
T
Q
R
T
P
S
Site 85
T488
P
P
K
R
P
Y
G
T
Q
R
T
P
S
T
A
Site 86
T491
R
P
Y
G
T
Q
R
T
P
S
T
A
S
A
K
Site 87
S493
Y
G
T
Q
R
T
P
S
T
A
S
A
K
T
H
Site 88
T494
G
T
Q
R
T
P
S
T
A
S
A
K
T
H
A
Site 89
S496
Q
R
T
P
S
T
A
S
A
K
T
H
A
R
V
Site 90
T499
P
S
T
A
S
A
K
T
H
A
R
V
L
S
M
Site 91
S505
K
T
H
A
R
V
L
S
M
D
G
A
G
G
D
Site 92
T573
V
G
G
A
A
E
E
T
G
R
R
D
R
S
S
Site 93
S579
E
T
G
R
R
D
R
S
S
S
V
R
R
T
Q
Site 94
S580
T
G
R
R
D
R
S
S
S
V
R
R
T
Q
A
Site 95
S581
G
R
R
D
R
S
S
S
V
R
R
T
Q
A
I
Site 96
T585
R
S
S
S
V
R
R
T
Q
A
I
R
R
R
H
Site 97
S596
R
R
R
H
N
A
G
S
N
P
T
P
P
A
S
Site 98
T599
H
N
A
G
S
N
P
T
P
P
A
S
V
M
G
Site 99
S603
S
N
P
T
P
P
A
S
V
M
G
S
P
P
S
Site 100
S607
P
P
A
S
V
M
G
S
P
P
S
S
L
Q
E
Site 101
S610
S
V
M
G
S
P
P
S
S
L
Q
E
A
Q
R
Site 102
S611
V
M
G
S
P
P
S
S
L
Q
E
A
Q
R
G
Site 103
S622
A
Q
R
G
R
A
A
S
H
S
R
A
L
T
L
Site 104
S624
R
G
R
A
A
S
H
S
R
A
L
T
L
P
S
Site 105
T653
A
N
V
H
E
A
C
T
F
D
D
T
S
E
G
Site 106
T657
E
A
C
T
F
D
D
T
S
E
G
A
V
H
Y
Site 107
Y664
T
S
E
G
A
V
H
Y
F
Y
D
E
S
G
V
Site 108
Y666
E
G
A
V
H
Y
F
Y
D
E
S
G
V
R
R
Site 109
S674
D
E
S
G
V
R
R
S
Y
T
F
G
L
A
G
Site 110
Y675
E
S
G
V
R
R
S
Y
T
F
G
L
A
G
G
Site 111
T676
S
G
V
R
R
S
Y
T
F
G
L
A
G
G
G
Site 112
Y684
F
G
L
A
G
G
G
Y
E
N
P
V
G
Q
Q
Site 113
S704
N
G
A
W
D
R
H
S
H
S
S
S
F
H
S
Site 114
S706
A
W
D
R
H
S
H
S
S
S
F
H
S
A
D
Site 115
S707
W
D
R
H
S
H
S
S
S
F
H
S
A
D
V
Site 116
S708
D
R
H
S
H
S
S
S
F
H
S
A
D
V
P
Site 117
S711
S
H
S
S
S
F
H
S
A
D
V
P
E
A
T
Site 118
S760
A
P
P
R
A
Q
H
S
Y
K
Y
W
L
L
P
Site 119
Y761
P
P
R
A
Q
H
S
Y
K
Y
W
L
L
P
G
Site 120
Y763
R
A
Q
H
S
Y
K
Y
W
L
L
P
G
R
W
Site 121
T771
W
L
L
P
G
R
W
T
S
V
R
Y
E
R
L
Site 122
S772
L
L
P
G
R
W
T
S
V
R
Y
E
R
L
A
Site 123
Y775
G
R
W
T
S
V
R
Y
E
R
L
A
L
L
A
Site 124
S838
C
Q
Y
S
L
L
K
S
V
Q
P
D
A
A
S
Site 125
S845
S
V
Q
P
D
A
A
S
P
M
H
G
H
N
W
Site 126
T974
F
C
L
G
A
I
K
T
P
W
P
E
Q
H
V
Site 127
S1000
V
A
L
S
Y
H
L
S
R
Q
S
S
D
P
T
Site 128
S1003
S
Y
H
L
S
R
Q
S
S
D
P
T
V
L
W
Site 129
S1004
Y
H
L
S
R
Q
S
S
D
P
T
V
L
W
S
Site 130
T1007
S
R
Q
S
S
D
P
T
V
L
W
S
L
I
R
Site 131
S1011
S
D
P
T
V
L
W
S
L
I
R
S
K
L
F
Site 132
S1044
L
P
D
K
M
R
Q
S
V
R
E
V
L
H
S
Site 133
S1121
V
L
K
P
L
E
Y
S
Q
Y
E
V
R
G
A
Site 134
Y1123
K
P
L
E
Y
S
Q
Y
E
V
R
G
A
A
Q
Site 135
T1164
A
L
T
V
D
A
H
T
V
V
S
H
P
D
K
Site 136
S1218
H
F
D
Y
P
R
L
S
Q
G
F
L
L
D
Y
Site 137
S1233
F
L
M
S
L
L
C
S
K
L
W
D
L
L
Y
Site 138
Y1313
L
K
F
W
E
R
D
Y
N
T
K
R
V
D
H
Site 139
S1321
N
T
K
R
V
D
H
S
N
T
R
L
V
T
Q
Site 140
T1327
H
S
N
T
R
L
V
T
Q
L
D
R
N
P
G
Site 141
T1349
S
I
F
Y
E
H
L
T
R
S
L
Q
H
T
L
Site 142
T1407
R
G
L
E
F
R
G
T
Y
C
Q
Q
R
E
V
Site 143
Y1408
G
L
E
F
R
G
T
Y
C
Q
Q
R
E
V
E
Site 144
Y1459
W
E
V
T
A
S
K
Y
V
L
E
G
Y
S
I
Site 145
S1467
V
L
E
G
Y
S
I
S
D
N
N
A
A
S
M
Site 146
Y1494
Y
Y
V
K
S
I
I
Y
Y
V
S
R
S
P
K
Site 147
Y1495
Y
V
K
S
I
I
Y
Y
V
S
R
S
P
K
L
Site 148
S1497
K
S
I
I
Y
Y
V
S
R
S
P
K
L
E
V
Site 149
S1499
I
I
Y
Y
V
S
R
S
P
K
L
E
V
W
L
Site 150
Y1523
R
P
V
R
V
P
G
Y
A
D
S
D
P
T
F
Site 151
S1526
R
V
P
G
Y
A
D
S
D
P
T
F
S
L
S
Site 152
T1529
G
Y
A
D
S
D
P
T
F
S
L
S
V
D
E
Site 153
S1531
A
D
S
D
P
T
F
S
L
S
V
D
E
D
Y
Site 154
S1533
S
D
P
T
F
S
L
S
V
D
E
D
Y
D
L
Site 155
Y1538
S
L
S
V
D
E
D
Y
D
L
R
L
S
G
L
Site 156
S1543
E
D
Y
D
L
R
L
S
G
L
S
L
P
S
F
Site 157
Y1560
V
H
L
E
W
I
Q
Y
C
A
S
R
R
S
Q
Site 158
S1566
Q
Y
C
A
S
R
R
S
Q
P
V
D
Q
D
W
Site 159
T1594
L
G
R
R
A
L
G
T
A
S
H
S
M
S
A
Site 160
S1596
R
R
A
L
G
T
A
S
H
S
M
S
A
S
L
Site 161
S1598
A
L
G
T
A
S
H
S
M
S
A
S
L
E
P
Site 162
S1600
G
T
A
S
H
S
M
S
A
S
L
E
P
F
L
Site 163
S1602
A
S
H
S
M
S
A
S
L
E
P
F
L
Y
G
Site 164
T1621
F
K
G
D
F
R
I
T
S
P
R
D
E
W
V
Site 165
S1622
K
G
D
F
R
I
T
S
P
R
D
E
W
V
F
Site 166
S1656
L
H
Q
D
H
F
T
S
P
D
E
Y
E
E
P
Site 167
Y1660
H
F
T
S
P
D
E
Y
E
E
P
A
A
L
Y
Site 168
S1689
E
G
D
P
A
W
R
S
A
I
L
S
N
T
P
Site 169
T1695
R
S
A
I
L
S
N
T
P
S
L
L
A
L
R
Site 170
S1697
A
I
L
S
N
T
P
S
L
L
A
L
R
H
V
Site 171
S1709
R
H
V
L
D
D
A
S
D
E
Y
K
I
I
M
Site 172
Y1712
L
D
D
A
S
D
E
Y
K
I
I
M
L
N
R
Site 173
S1723
M
L
N
R
R
H
L
S
F
R
V
I
K
V
N
Site 174
S1757
N
R
N
P
E
R
G
S
I
Q
N
A
K
Q
A
Site 175
S1771
A
L
R
N
M
I
N
S
S
C
D
Q
P
L
G
Site 176
Y1782
Q
P
L
G
Y
P
I
Y
V
S
P
L
T
T
S
Site 177
S1789
Y
V
S
P
L
T
T
S
L
A
G
S
H
P
Q
Site 178
S1838
S
G
G
N
V
D
D
S
D
C
S
G
G
G
G
Site 179
S1841
N
V
D
D
S
D
C
S
G
G
G
G
L
T
S
Site 180
S1848
S
G
G
G
G
L
T
S
L
S
N
N
P
P
V
Site 181
S1850
G
G
G
L
T
S
L
S
N
N
P
P
V
A
H
Site 182
T1859
N
P
P
V
A
H
P
T
P
E
N
T
A
G
N
Site 183
S1881
G
P
G
W
G
P
R
S
S
L
S
G
S
G
D
Site 184
S1882
P
G
W
G
P
R
S
S
L
S
G
S
G
D
G
Site 185
S1884
W
G
P
R
S
S
L
S
G
S
G
D
G
R
P
Site 186
S1886
P
R
S
S
L
S
G
S
G
D
G
R
P
P
P
Site 187
S1909
L
P
G
P
P
P
A
S
P
I
P
T
E
G
P
Site 188
T1913
P
P
A
S
P
I
P
T
E
G
P
R
T
S
R
Site 189
T1918
I
P
T
E
G
P
R
T
S
R
P
P
G
P
G
Site 190
S1919
P
T
E
G
P
R
T
S
R
P
P
G
P
G
L
Site 191
S1928
P
P
G
P
G
L
L
S
S
E
G
P
S
G
K
Site 192
S1929
P
G
P
G
L
L
S
S
E
G
P
S
G
K
W
Site 193
S1933
L
L
S
S
E
G
P
S
G
K
W
S
L
G
G
Site 194
S1937
E
G
P
S
G
K
W
S
L
G
G
R
K
G
L
Site 195
S1947
G
R
K
G
L
G
G
S
D
G
E
P
A
S
G
Site 196
S1953
G
S
D
G
E
P
A
S
G
S
P
K
G
G
T
Site 197
S1955
D
G
E
P
A
S
G
S
P
K
G
G
T
P
K
Site 198
T1960
S
G
S
P
K
G
G
T
P
K
S
Q
A
P
L
Site 199
S1963
P
K
G
G
T
P
K
S
Q
A
P
L
D
L
S
Site 200
S1982
L
S
L
S
P
D
V
S
T
E
A
S
P
P
R
Site 201
T1983
S
L
S
P
D
V
S
T
E
A
S
P
P
R
A
Site 202
S1986
P
D
V
S
T
E
A
S
P
P
R
A
S
Q
D
Site 203
S1991
E
A
S
P
P
R
A
S
Q
D
I
P
C
L
D
Site 204
S1999
Q
D
I
P
C
L
D
S
S
A
P
E
S
G
T
Site 205
S2000
D
I
P
C
L
D
S
S
A
P
E
S
G
T
P
Site 206
S2004
L
D
S
S
A
P
E
S
G
T
P
M
G
A
L
Site 207
T2006
S
S
A
P
E
S
G
T
P
M
G
A
L
G
D
Site 208
S2023
A
P
I
E
E
R
E
S
P
A
A
Q
P
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation