KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DHX33
Full Name:
Putative ATP-dependent RNA helicase DHX33
Alias:
DDX33; DEAH (Asp-Glu-Ala-His) box polypeptide 33; DKFZp762F2011; EC 3.6.1.-; FLJ21972
Type:
Helicase; EC 3.6.1.-
Mass (Da):
78741
Number AA:
707
UniProt ID:
Q9H6R0
International Prot ID:
IPI00655950
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
A
K
R
F
R
P
G
S
G
P
P
S
R
A
G
Site 2
S21
R
P
G
S
G
P
P
S
R
A
G
S
F
P
P
Site 3
S25
G
P
P
S
R
A
G
S
F
P
P
G
R
Q
V
Site 4
S59
Q
P
P
L
A
Q
P
S
A
S
P
Y
P
E
A
Site 5
S61
P
L
A
Q
P
S
A
S
P
Y
P
E
A
V
E
Site 6
Y63
A
Q
P
S
A
S
P
Y
P
E
A
V
E
L
Q
Site 7
S73
A
V
E
L
Q
R
R
S
L
P
I
L
Q
A
R
Site 8
T105
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
L
Y
Site 9
Y110
K
T
T
Q
I
P
Q
Y
L
Y
E
G
G
I
S
Site 10
Y112
T
Q
I
P
Q
Y
L
Y
E
G
G
I
S
R
Q
Site 11
T125
R
Q
G
I
I
A
V
T
Q
P
R
R
V
A
A
Site 12
S134
P
R
R
V
A
A
I
S
L
A
T
R
V
S
D
Site 13
S140
I
S
L
A
T
R
V
S
D
E
K
R
T
E
L
Site 14
T161
T
V
R
F
D
D
V
T
S
E
D
T
G
I
K
Site 15
S162
V
R
F
D
D
V
T
S
E
D
T
G
I
K
F
Site 16
T171
D
T
G
I
K
F
L
T
D
G
M
L
L
R
E
Site 17
S181
M
L
L
R
E
A
I
S
D
S
L
L
R
K
Y
Site 18
S183
L
R
E
A
I
S
D
S
L
L
R
K
Y
S
C
Site 19
Y188
S
D
S
L
L
R
K
Y
S
C
V
I
L
D
E
Site 20
Y250
F
N
G
A
P
V
L
Y
L
E
G
R
Q
H
P
Site 21
Y270
T
K
Q
P
Q
N
D
Y
L
H
A
A
L
V
S
Site 22
T307
E
I
E
A
M
S
K
T
C
R
D
I
A
K
H
Site 23
S353
G
Y
R
K
V
I
I
S
T
N
I
A
E
T
S
Site 24
Y380
G
M
V
K
A
K
K
Y
N
P
D
S
G
L
E
Site 25
S384
A
K
K
Y
N
P
D
S
G
L
E
V
L
A
V
Site 26
S395
V
L
A
V
Q
R
V
S
K
T
Q
A
W
Q
R
Site 27
T397
A
V
Q
R
V
S
K
T
Q
A
W
Q
R
T
G
Site 28
S411
G
R
A
G
R
E
D
S
G
I
C
Y
R
L
Y
Site 29
Y415
R
E
D
S
G
I
C
Y
R
L
Y
T
E
D
E
Site 30
Y418
S
G
I
C
Y
R
L
Y
T
E
D
E
F
E
K
Site 31
T419
G
I
C
Y
R
L
Y
T
E
D
E
F
E
K
F
Site 32
T430
F
E
K
F
D
K
M
T
V
P
E
I
Q
R
C
Site 33
S441
I
Q
R
C
N
L
A
S
V
M
L
Q
L
L
A
Site 34
S461
V
L
T
F
D
F
M
S
K
P
S
P
D
H
I
Site 35
S464
F
D
F
M
S
K
P
S
P
D
H
I
Q
A
A
Site 36
T489
E
H
K
D
D
Q
L
T
L
T
P
M
G
R
K
Site 37
T491
K
D
D
Q
L
T
L
T
P
M
G
R
K
M
A
Site 38
S540
S
V
L
H
N
P
P
S
R
R
E
E
V
Q
G
Site 39
S554
G
V
R
K
K
F
I
S
S
E
G
D
H
M
T
Site 40
T561
S
S
E
G
D
H
M
T
L
L
N
I
Y
R
T
Site 41
T568
T
L
L
N
I
Y
R
T
F
K
N
L
G
G
N
Site 42
S607
R
D
I
C
L
K
M
S
M
P
I
A
S
S
R
Site 43
S612
K
M
S
M
P
I
A
S
S
R
G
D
V
E
S
Site 44
S613
M
S
M
P
I
A
S
S
R
G
D
V
E
S
V
Site 45
S619
S
S
R
G
D
V
E
S
V
R
R
C
L
A
H
Site 46
S631
L
A
H
S
L
F
M
S
T
A
E
L
Q
P
D
Site 47
Y641
E
L
Q
P
D
G
T
Y
A
T
T
D
T
H
Q
Site 48
T646
G
T
Y
A
T
T
D
T
H
Q
P
V
A
I
H
Site 49
Y673
V
V
Y
T
E
L
L
Y
T
N
K
C
Y
M
R
Site 50
Y697
L
Y
E
A
A
P
E
Y
F
R
R
K
L
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation