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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLJ21940
Full Name:
Probable ATP-dependent RNA helicase YTHDC2
Alias:
DKFZp564A186; FLJ10053; FLJ2194; YTDC2; YTH domain containing 2
Type:
Mass (Da):
160248
Number AA:
1430
UniProt ID:
Q9H6S0
International Prot ID:
IPI00010200
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004386
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
R
P
S
S
V
S
P
R
Q
P
Site 2
S6
_
_
M
S
R
P
S
S
V
S
P
R
Q
P
A
Site 3
S8
M
S
R
P
S
S
V
S
P
R
Q
P
A
P
G
Site 4
S23
G
G
G
G
G
G
P
S
P
C
G
P
G
G
G
Site 5
Y58
I
A
L
E
R
F
R
Y
G
D
Q
R
E
M
E
Site 6
S69
R
E
M
E
F
P
S
S
L
T
S
T
E
R
A
Site 7
S72
E
F
P
S
S
L
T
S
T
E
R
A
F
I
H
Site 8
T73
F
P
S
S
L
T
S
T
E
R
A
F
I
H
R
Site 9
S89
S
Q
S
L
G
L
V
S
K
S
K
G
K
G
A
Site 10
S91
S
L
G
L
V
S
K
S
K
G
K
G
A
N
R
Site 11
Y99
K
G
K
G
A
N
R
Y
L
T
V
K
K
K
D
Site 12
T101
K
G
A
N
R
Y
L
T
V
K
K
K
D
G
S
Site 13
S108
T
V
K
K
K
D
G
S
E
T
A
H
A
M
M
Site 14
T120
A
M
M
T
C
N
L
T
H
N
T
K
H
A
V
Site 15
T123
T
C
N
L
T
H
N
T
K
H
A
V
R
S
L
Site 16
T148
R
T
E
L
L
P
K
T
E
R
G
N
V
F
A
Site 17
S164
E
A
E
N
R
E
M
S
K
T
S
G
R
L
N
Site 18
T166
E
N
R
E
M
S
K
T
S
G
R
L
N
N
G
Site 19
S167
N
R
E
M
S
K
T
S
G
R
L
N
N
G
I
Site 20
S184
I
P
V
K
R
G
E
S
E
F
D
S
F
R
Q
Site 21
S188
R
G
E
S
E
F
D
S
F
R
Q
S
L
P
V
Site 22
S192
E
F
D
S
F
R
Q
S
L
P
V
F
E
K
Q
Site 23
T224
E
T
G
S
G
K
T
T
Q
I
P
Q
F
L
L
Site 24
Y274
R
I
G
Q
T
I
G
Y
Q
I
R
L
E
S
R
Site 25
S280
G
Y
Q
I
R
L
E
S
R
V
S
P
K
T
L
Site 26
S283
I
R
L
E
S
R
V
S
P
K
T
L
L
T
F
Site 27
T286
E
S
R
V
S
P
K
T
L
L
T
F
C
T
N
Site 28
S305
R
T
L
M
A
G
D
S
T
L
S
T
V
T
H
Site 29
S325
V
H
E
R
D
R
F
S
D
F
L
L
T
K
L
Site 30
T341
D
L
L
Q
K
H
P
T
L
K
L
I
L
S
S
Site 31
T387
L
E
D
I
L
R
T
T
G
Y
T
N
K
E
M
Site 32
Y389
D
I
L
R
T
T
G
Y
T
N
K
E
M
L
K
Site 33
T390
I
L
R
T
T
G
Y
T
N
K
E
M
L
K
Y
Site 34
Y397
T
N
K
E
M
L
K
Y
K
K
E
K
Q
Q
E
Site 35
T409
Q
Q
E
E
K
Q
Q
T
T
L
T
E
W
Y
S
Site 36
T412
E
K
Q
Q
T
T
L
T
E
W
Y
S
A
Q
E
Site 37
S416
T
T
L
T
E
W
Y
S
A
Q
E
N
S
F
K
Site 38
S421
W
Y
S
A
Q
E
N
S
F
K
P
E
S
Q
R
Site 39
S426
E
N
S
F
K
P
E
S
Q
R
Q
R
T
V
L
Site 40
T431
P
E
S
Q
R
Q
R
T
V
L
N
V
T
D
E
Site 41
Y439
V
L
N
V
T
D
E
Y
D
L
L
D
D
G
G
Site 42
S451
D
G
G
D
A
V
F
S
Q
L
T
E
K
D
V
Site 43
S498
L
I
L
T
E
N
V
S
V
D
Y
R
H
S
E
Site 44
Y501
T
E
N
V
S
V
D
Y
R
H
S
E
T
S
A
Site 45
S504
V
S
V
D
Y
R
H
S
E
T
S
A
T
A
L
Site 46
S507
D
Y
R
H
S
E
T
S
A
T
A
L
M
V
A
Site 47
S528
S
Q
V
E
Q
L
I
S
M
G
A
N
V
H
S
Site 48
T565
L
L
E
S
Y
S
A
T
L
E
F
G
N
L
D
Site 49
S574
E
F
G
N
L
D
E
S
S
L
V
Q
T
N
G
Site 50
S575
F
G
N
L
D
E
S
S
L
V
Q
T
N
G
S
Site 51
T579
D
E
S
S
L
V
Q
T
N
G
S
D
L
S
A
Site 52
S582
S
L
V
Q
T
N
G
S
D
L
S
A
E
D
R
Site 53
S598
L
L
K
A
Y
H
H
S
F
D
D
E
K
V
D
Site 54
S652
D
D
K
R
F
A
D
S
T
H
R
Y
Q
V
F
Site 55
Y656
F
A
D
S
T
H
R
Y
Q
V
F
M
L
H
S
Site 56
S668
L
H
S
N
M
Q
T
S
D
Q
K
K
V
L
K
Site 57
S706
D
V
V
F
V
I
D
S
G
K
V
K
E
K
S
Site 58
S713
S
G
K
V
K
E
K
S
F
D
A
L
N
F
V
Site 59
T765
Q
N
M
L
E
F
Q
T
P
E
L
L
R
M
P
Site 60
T821
K
T
I
D
A
M
D
T
W
E
D
L
T
E
L
Site 61
T890
M
L
C
R
K
R
F
T
A
G
A
F
S
D
H
Site 62
S912
Q
A
W
Q
K
A
R
S
D
G
W
E
R
A
F
Site 63
S947
L
L
G
Q
L
R
A
S
G
F
V
R
A
R
G
Site 64
T963
G
D
I
R
D
V
N
T
N
S
E
N
W
A
V
Site 65
T994
D
R
E
N
L
V
L
T
G
P
K
E
K
K
V
Site 66
S1007
K
V
R
F
H
P
A
S
V
L
S
Q
P
Q
Y
Site 67
S1010
F
H
P
A
S
V
L
S
Q
P
Q
Y
K
K
I
Site 68
Y1014
S
V
L
S
Q
P
Q
Y
K
K
I
P
P
A
N
Site 69
Y1037
L
P
T
D
W
L
I
Y
D
E
M
T
R
A
H
Site 70
T1056
I
R
C
C
S
A
V
T
P
V
T
I
L
V
F
Site 71
S1071
C
G
P
A
R
L
A
S
N
A
L
Q
E
P
S
Site 72
S1078
S
N
A
L
Q
E
P
S
S
F
R
V
D
G
I
Site 73
S1079
N
A
L
Q
E
P
S
S
F
R
V
D
G
I
P
Site 74
S1089
V
D
G
I
P
N
D
S
S
D
S
E
M
E
D
Site 75
S1090
D
G
I
P
N
D
S
S
D
S
E
M
E
D
K
Site 76
S1092
I
P
N
D
S
S
D
S
E
M
E
D
K
T
T
Site 77
T1098
D
S
E
M
E
D
K
T
T
A
N
L
A
A
L
Site 78
T1099
S
E
M
E
D
K
T
T
A
N
L
A
A
L
K
Site 79
T1114
L
D
E
W
L
H
F
T
L
E
P
E
A
A
S
Site 80
S1132
Q
L
R
Q
K
W
H
S
L
F
L
R
R
M
R
Site 81
S1142
L
R
R
M
R
A
P
S
K
P
W
S
Q
V
D
Site 82
S1146
R
A
P
S
K
P
W
S
Q
V
D
E
A
T
I
Site 83
S1183
G
Q
R
P
R
P
M
S
S
E
E
L
P
L
A
Site 84
S1184
Q
R
P
R
P
M
S
S
E
E
L
P
L
A
S
Site 85
S1191
S
E
E
L
P
L
A
S
S
W
R
S
N
N
S
Site 86
S1192
E
E
L
P
L
A
S
S
W
R
S
N
N
S
R
Site 87
S1195
P
L
A
S
S
W
R
S
N
N
S
R
K
S
S
Site 88
S1198
S
S
W
R
S
N
N
S
R
K
S
S
A
D
T
Site 89
S1201
R
S
N
N
S
R
K
S
S
A
D
T
E
F
S
Site 90
S1202
S
N
N
S
R
K
S
S
A
D
T
E
F
S
D
Site 91
T1205
S
R
K
S
S
A
D
T
E
F
S
D
E
C
T
Site 92
S1208
S
S
A
D
T
E
F
S
D
E
C
T
T
A
E
Site 93
T1212
T
E
F
S
D
E
C
T
T
A
E
R
V
L
M
Site 94
T1213
E
F
S
D
E
C
T
T
A
E
R
V
L
M
K
Site 95
S1221
A
E
R
V
L
M
K
S
P
S
P
A
L
H
P
Site 96
S1223
R
V
L
M
K
S
P
S
P
A
L
H
P
P
Q
Site 97
Y1232
A
L
H
P
P
Q
K
Y
K
D
R
G
I
L
H
Site 98
T1244
I
L
H
P
K
R
G
T
E
D
R
S
D
Q
S
Site 99
S1248
K
R
G
T
E
D
R
S
D
Q
S
S
L
K
S
Site 100
S1251
T
E
D
R
S
D
Q
S
S
L
K
S
T
D
S
Site 101
S1252
E
D
R
S
D
Q
S
S
L
K
S
T
D
S
S
Site 102
S1255
S
D
Q
S
S
L
K
S
T
D
S
S
S
Y
P
Site 103
T1256
D
Q
S
S
L
K
S
T
D
S
S
S
Y
P
S
Site 104
S1258
S
S
L
K
S
T
D
S
S
S
Y
P
S
P
C
Site 105
S1259
S
L
K
S
T
D
S
S
S
Y
P
S
P
C
A
Site 106
S1260
L
K
S
T
D
S
S
S
Y
P
S
P
C
A
S
Site 107
Y1261
K
S
T
D
S
S
S
Y
P
S
P
C
A
S
P
Site 108
S1263
T
D
S
S
S
Y
P
S
P
C
A
S
P
S
P
Site 109
S1267
S
Y
P
S
P
C
A
S
P
S
P
P
S
S
G
Site 110
S1269
P
S
P
C
A
S
P
S
P
P
S
S
G
K
G
Site 111
S1272
C
A
S
P
S
P
P
S
S
G
K
G
S
K
S
Site 112
S1273
A
S
P
S
P
P
S
S
G
K
G
S
K
S
P
Site 113
S1277
P
P
S
S
G
K
G
S
K
S
P
S
P
R
P
Site 114
S1279
S
S
G
K
G
S
K
S
P
S
P
R
P
N
M
Site 115
S1281
G
K
G
S
K
S
P
S
P
R
P
N
M
P
V
Site 116
Y1290
R
P
N
M
P
V
R
Y
F
I
M
K
S
S
N
Site 117
S1295
V
R
Y
F
I
M
K
S
S
N
L
R
N
L
E
Site 118
S1296
R
Y
F
I
M
K
S
S
N
L
R
N
L
E
I
Site 119
S1304
N
L
R
N
L
E
I
S
Q
Q
K
G
I
W
S
Site 120
S1311
S
Q
Q
K
G
I
W
S
T
T
P
S
N
E
R
Site 121
T1313
Q
K
G
I
W
S
T
T
P
S
N
E
R
K
L
Site 122
S1315
G
I
W
S
T
T
P
S
N
E
R
K
L
N
R
Site 123
S1346
S
G
H
F
Q
G
F
S
R
M
S
S
E
I
G
Site 124
S1349
F
Q
G
F
S
R
M
S
S
E
I
G
R
E
K
Site 125
S1350
Q
G
F
S
R
M
S
S
E
I
G
R
E
K
S
Site 126
S1357
S
E
I
G
R
E
K
S
Q
D
W
G
S
A
G
Site 127
S1362
E
K
S
Q
D
W
G
S
A
G
L
G
G
V
F
Site 128
S1378
V
E
W
I
R
K
E
S
L
P
F
Q
F
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation