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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM59A
Full Name:
Protein FAM59A
Alias:
C18orf11; FA59A; Family with sequence similarity 59, member A; FLJ21610; GAREM; Grb2-associated and regulator of Erk/MAPK
Type:
Adaptor/scaffold
Mass (Da):
97186
Number AA:
876
UniProt ID:
Q9H706
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
P
A
P
S
L
G
C
S
L
K
D
Site 2
S10
P
A
P
S
L
G
C
S
L
K
D
V
K
W
S
Site 3
Y52
E
G
L
R
E
N
D
Y
L
L
I
H
S
C
R
Site 4
Y74
H
S
L
E
E
G
H
Y
V
I
G
P
K
I
E
Site 5
Y105
D
I
K
E
P
V
Q
Y
F
N
S
V
E
E
V
Site 6
S108
E
P
V
Q
Y
F
N
S
V
E
E
V
A
K
A
Site 7
Y121
K
A
F
P
E
R
V
Y
V
M
E
D
I
T
F
Site 8
T141
S
G
E
C
N
E
D
T
E
V
Y
N
I
T
L
Site 9
Y164
M
G
Q
A
E
I
L
Y
A
K
T
F
K
E
K
Site 10
T167
A
E
I
L
Y
A
K
T
F
K
E
K
S
R
L
Site 11
S172
A
K
T
F
K
E
K
S
R
L
N
T
I
F
K
Site 12
T176
K
E
K
S
R
L
N
T
I
F
K
K
I
G
K
Site 13
S186
K
K
I
G
K
L
N
S
I
S
K
L
G
K
G
Site 14
S188
I
G
K
L
N
S
I
S
K
L
G
K
G
K
M
Site 15
S210
H
R
T
N
E
S
I
S
L
P
F
Q
C
K
G
Site 16
S220
F
Q
C
K
G
R
F
S
T
R
S
P
L
E
L
Site 17
T221
Q
C
K
G
R
F
S
T
R
S
P
L
E
L
Q
Site 18
S223
K
G
R
F
S
T
R
S
P
L
E
L
Q
M
Q
Site 19
T235
Q
M
Q
E
G
E
H
T
I
R
N
I
V
E
K
Site 20
T250
T
R
L
P
V
N
V
T
V
P
S
P
P
P
R
Site 21
S253
P
V
N
V
T
V
P
S
P
P
P
R
N
P
Y
Site 22
Y260
S
P
P
P
R
N
P
Y
D
L
H
F
I
R
E
Site 23
Y271
F
I
R
E
G
H
R
Y
K
F
V
N
I
Q
T
Site 24
S317
E
H
L
V
K
G
E
S
W
P
E
T
L
V
H
Site 25
Y339
E
Q
F
D
I
D
E
Y
S
R
A
V
R
D
V
Site 26
T348
R
A
V
R
D
V
K
T
D
W
N
E
E
C
K
Site 27
S356
D
W
N
E
E
C
K
S
P
K
K
G
R
C
S
Site 28
S363
S
P
K
K
G
R
C
S
G
H
N
H
V
P
N
Site 29
S371
G
H
N
H
V
P
N
S
L
S
Y
A
R
D
E
Site 30
S373
N
H
V
P
N
S
L
S
Y
A
R
D
E
L
T
Site 31
Y374
H
V
P
N
S
L
S
Y
A
R
D
E
L
T
Q
Site 32
T380
S
Y
A
R
D
E
L
T
Q
S
F
H
R
L
S
Site 33
S382
A
R
D
E
L
T
Q
S
F
H
R
L
S
V
C
Site 34
Y391
H
R
L
S
V
C
V
Y
G
N
N
L
H
G
N
Site 35
S399
G
N
N
L
H
G
N
S
E
V
N
L
H
G
C
Site 36
Y423
F
P
H
D
I
L
P
Y
Q
D
S
G
D
S
G
Site 37
S426
D
I
L
P
Y
Q
D
S
G
D
S
G
S
D
Y
Site 38
S429
P
Y
Q
D
S
G
D
S
G
S
D
Y
L
F
P
Site 39
S431
Q
D
S
G
D
S
G
S
D
Y
L
F
P
E
A
Site 40
Y433
S
G
D
S
G
S
D
Y
L
F
P
E
A
S
E
Site 41
S439
D
Y
L
F
P
E
A
S
E
E
S
A
G
I
P
Site 42
S449
S
A
G
I
P
G
K
S
E
L
P
Y
E
E
L
Site 43
Y453
P
G
K
S
E
L
P
Y
E
E
L
W
L
E
E
Site 44
S464
W
L
E
E
G
K
P
S
H
Q
P
L
T
R
S
Site 45
T469
K
P
S
H
Q
P
L
T
R
S
L
S
E
K
N
Site 46
S471
S
H
Q
P
L
T
R
S
L
S
E
K
N
R
C
Site 47
S473
Q
P
L
T
R
S
L
S
E
K
N
R
C
D
Q
Site 48
S484
R
C
D
Q
F
R
G
S
V
R
S
K
C
A
T
Site 49
S487
Q
F
R
G
S
V
R
S
K
C
A
T
S
P
L
Site 50
T491
S
V
R
S
K
C
A
T
S
P
L
P
I
P
G
Site 51
S492
V
R
S
K
C
A
T
S
P
L
P
I
P
G
T
Site 52
T509
A
A
V
K
S
S
D
T
A
L
P
P
P
P
V
Site 53
S520
P
P
P
V
P
P
K
S
E
A
V
R
E
E
C
Site 54
S539
A
P
P
V
P
P
R
S
A
K
P
L
S
T
S
Site 55
S544
P
R
S
A
K
P
L
S
T
S
P
S
I
P
P
Site 56
T545
R
S
A
K
P
L
S
T
S
P
S
I
P
P
R
Site 57
S546
S
A
K
P
L
S
T
S
P
S
I
P
P
R
T
Site 58
S548
K
P
L
S
T
S
P
S
I
P
P
R
T
V
K
Site 59
T553
S
P
S
I
P
P
R
T
V
K
P
A
R
Q
Q
Site 60
T561
V
K
P
A
R
Q
Q
T
R
S
P
S
P
T
L
Site 61
S563
P
A
R
Q
Q
T
R
S
P
S
P
T
L
S
Y
Site 62
S565
R
Q
Q
T
R
S
P
S
P
T
L
S
Y
Y
S
Site 63
T567
Q
T
R
S
P
S
P
T
L
S
Y
Y
S
S
G
Site 64
S569
R
S
P
S
P
T
L
S
Y
Y
S
S
G
L
H
Site 65
Y570
S
P
S
P
T
L
S
Y
Y
S
S
G
L
H
N
Site 66
Y571
P
S
P
T
L
S
Y
Y
S
S
G
L
H
N
I
Site 67
S573
P
T
L
S
Y
Y
S
S
G
L
H
N
I
S
V
Site 68
S579
S
S
G
L
H
N
I
S
V
T
K
T
D
T
N
Site 69
T583
H
N
I
S
V
T
K
T
D
T
N
P
S
E
S
Site 70
T585
I
S
V
T
K
T
D
T
N
P
S
E
S
T
P
Site 71
S588
T
K
T
D
T
N
P
S
E
S
T
P
V
S
C
Site 72
S590
T
D
T
N
P
S
E
S
T
P
V
S
C
Y
P
Site 73
T591
D
T
N
P
S
E
S
T
P
V
S
C
Y
P
C
Site 74
S594
P
S
E
S
T
P
V
S
C
Y
P
C
N
R
V
Site 75
Y596
E
S
T
P
V
S
C
Y
P
C
N
R
V
K
T
Site 76
T603
Y
P
C
N
R
V
K
T
D
S
V
D
L
K
S
Site 77
S605
C
N
R
V
K
T
D
S
V
D
L
K
S
P
F
Site 78
S610
T
D
S
V
D
L
K
S
P
F
G
S
P
S
A
Site 79
S614
D
L
K
S
P
F
G
S
P
S
A
E
A
V
S
Site 80
S616
K
S
P
F
G
S
P
S
A
E
A
V
S
S
R
Site 81
S621
S
P
S
A
E
A
V
S
S
R
L
S
W
P
N
Site 82
S622
P
S
A
E
A
V
S
S
R
L
S
W
P
N
H
Site 83
S625
E
A
V
S
S
R
L
S
W
P
N
H
Y
S
G
Site 84
Y630
R
L
S
W
P
N
H
Y
S
G
A
S
E
S
Q
Site 85
S631
L
S
W
P
N
H
Y
S
G
A
S
E
S
Q
T
Site 86
S634
P
N
H
Y
S
G
A
S
E
S
Q
T
R
S
D
Site 87
S636
H
Y
S
G
A
S
E
S
Q
T
R
S
D
F
L
Site 88
T638
S
G
A
S
E
S
Q
T
R
S
D
F
L
L
D
Site 89
S640
A
S
E
S
Q
T
R
S
D
F
L
L
D
P
S
Site 90
S647
S
D
F
L
L
D
P
S
R
S
Y
S
Y
P
R
Site 91
S649
F
L
L
D
P
S
R
S
Y
S
Y
P
R
Q
K
Site 92
Y650
L
L
D
P
S
R
S
Y
S
Y
P
R
Q
K
T
Site 93
S651
L
D
P
S
R
S
Y
S
Y
P
R
Q
K
T
P
Site 94
Y652
D
P
S
R
S
Y
S
Y
P
R
Q
K
T
P
G
Site 95
T657
Y
S
Y
P
R
Q
K
T
P
G
T
P
K
R
N
Site 96
T660
P
R
Q
K
T
P
G
T
P
K
R
N
C
P
A
Site 97
T685
A
S
P
T
S
P
V
T
A
E
F
S
S
S
V
Site 98
S689
S
P
V
T
A
E
F
S
S
S
V
S
G
C
P
Site 99
S691
V
T
A
E
F
S
S
S
V
S
G
C
P
K
S
Site 100
S693
A
E
F
S
S
S
V
S
G
C
P
K
S
A
S
Site 101
S698
S
V
S
G
C
P
K
S
A
S
Y
S
L
E
S
Site 102
S700
S
G
C
P
K
S
A
S
Y
S
L
E
S
T
D
Site 103
Y701
G
C
P
K
S
A
S
Y
S
L
E
S
T
D
V
Site 104
S702
C
P
K
S
A
S
Y
S
L
E
S
T
D
V
K
Site 105
S705
S
A
S
Y
S
L
E
S
T
D
V
K
S
L
A
Site 106
T706
A
S
Y
S
L
E
S
T
D
V
K
S
L
A
A
Site 107
S710
L
E
S
T
D
V
K
S
L
A
A
G
V
T
K
Site 108
T716
K
S
L
A
A
G
V
T
K
Q
S
T
S
C
P
Site 109
S719
A
A
G
V
T
K
Q
S
T
S
C
P
A
L
P
Site 110
T720
A
G
V
T
K
Q
S
T
S
C
P
A
L
P
P
Site 111
S721
G
V
T
K
Q
S
T
S
C
P
A
L
P
P
R
Site 112
S739
L
V
E
E
K
V
A
S
E
T
S
P
L
P
L
Site 113
S742
E
K
V
A
S
E
T
S
P
L
P
L
K
I
D
Site 114
S757
G
A
E
E
D
P
K
S
G
S
P
D
L
S
E
Site 115
S759
E
E
D
P
K
S
G
S
P
D
L
S
E
D
Q
Site 116
S763
K
S
G
S
P
D
L
S
E
D
Q
Y
F
V
K
Site 117
Y767
P
D
L
S
E
D
Q
Y
F
V
K
K
G
M
Q
Site 118
S778
K
G
M
Q
D
I
F
S
A
S
Y
P
F
S
S
Site 119
S780
M
Q
D
I
F
S
A
S
Y
P
F
S
S
P
L
Site 120
Y781
Q
D
I
F
S
A
S
Y
P
F
S
S
P
L
H
Site 121
S785
S
A
S
Y
P
F
S
S
P
L
H
L
Q
L
A
Site 122
S795
H
L
Q
L
A
P
R
S
C
G
D
G
S
P
W
Site 123
S800
P
R
S
C
G
D
G
S
P
W
Q
P
P
A
D
Site 124
S809
W
Q
P
P
A
D
L
S
G
L
S
I
E
E
V
Site 125
S812
P
A
D
L
S
G
L
S
I
E
E
V
S
K
S
Site 126
T847
G
N
L
L
V
Q
L
T
E
E
I
L
S
E
D
Site 127
S852
Q
L
T
E
E
I
L
S
E
D
F
K
L
S
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation