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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH2D4A
Full Name:
SH2 domain-containing protein 4A
Alias:
FLJ20967; SH2 domain containing 4A; SH24A; SH2A
Type:
Unknown function
Mass (Da):
52727
Number AA:
454
UniProt ID:
Q9H788
International Prot ID:
IPI00100731
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
K
Q
I
L
S
E
M
Y
I
D
P
D
L
L
A
Site 2
S20
P
D
L
L
A
E
L
S
E
E
Q
K
Q
I
L
Site 3
S51
A
A
M
E
R
K
E
S
L
P
V
K
P
R
P
Site 4
S65
P
K
K
E
N
G
K
S
V
H
W
K
L
G
A
Site 5
Y90
E
H
H
L
D
K
P
Y
D
V
L
C
N
E
I
Site 6
T116
E
A
E
E
P
R
K
T
H
S
E
E
F
T
N
Site 7
T122
K
T
H
S
E
E
F
T
N
S
L
K
T
K
S
Site 8
S124
H
S
E
E
F
T
N
S
L
K
T
K
S
Q
Y
Site 9
S129
T
N
S
L
K
T
K
S
Q
Y
H
D
L
Q
A
Site 10
Y131
S
L
K
T
K
S
Q
Y
H
D
L
Q
A
P
D
Site 11
S172
L
E
E
E
K
I
R
S
L
S
S
S
S
R
N
Site 12
S174
E
E
K
I
R
S
L
S
S
S
S
R
N
I
Q
Site 13
S175
E
K
I
R
S
L
S
S
S
S
R
N
I
Q
Q
Site 14
S176
K
I
R
S
L
S
S
S
S
R
N
I
Q
Q
M
Site 15
S202
A
F
H
Q
K
K
E
S
M
K
K
K
Q
D
E
Site 16
S230
C
K
S
W
K
E
D
S
E
W
Q
A
S
L
R
Site 17
S235
E
D
S
E
W
Q
A
S
L
R
K
S
K
A
A
Site 18
S239
W
Q
A
S
L
R
K
S
K
A
A
D
E
K
R
Site 19
S248
A
A
D
E
K
R
R
S
L
A
K
Q
A
R
E
Site 20
Y257
A
K
Q
A
R
E
D
Y
K
R
L
S
L
G
A
Site 21
S261
R
E
D
Y
K
R
L
S
L
G
A
Q
K
G
R
Site 22
S275
R
G
G
E
R
L
Q
S
P
L
R
V
P
Q
K
Site 23
S297
P
K
P
Q
F
L
N
S
G
A
Y
P
Q
K
P
Site 24
Y300
Q
F
L
N
S
G
A
Y
P
Q
K
P
L
R
N
Site 25
T313
R
N
Q
G
V
V
R
T
L
S
S
S
A
Q
E
Site 26
S315
Q
G
V
V
R
T
L
S
S
S
A
Q
E
D
I
Site 27
S316
G
V
V
R
T
L
S
S
S
A
Q
E
D
I
I
Site 28
S317
V
V
R
T
L
S
S
S
A
Q
E
D
I
I
R
Site 29
Y337
Q
L
P
L
R
A
G
Y
Q
K
T
S
D
T
I
Site 30
S341
R
A
G
Y
Q
K
T
S
D
T
I
A
P
W
F
Site 31
T353
P
W
F
H
G
I
L
T
L
K
K
A
N
E
L
Site 32
S375
G
S
F
L
I
R
V
S
E
R
I
K
G
Y
A
Site 33
S384
R
I
K
G
Y
A
L
S
Y
L
S
E
D
G
C
Site 34
Y385
I
K
G
Y
A
L
S
Y
L
S
E
D
G
C
K
Site 35
T429
Y
H
K
E
E
P
I
T
S
L
G
K
E
L
L
Site 36
S430
H
K
E
E
P
I
T
S
L
G
K
E
L
L
L
Site 37
Y438
L
G
K
E
L
L
L
Y
P
C
G
Q
Q
D
Q
Site 38
Y449
Q
Q
D
Q
L
P
D
Y
L
E
L
F
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation