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Updated November 2019
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Protein Info
Short Name:
DOCK5
Full Name:
Dedicator of cytokinesis protein 5
Alias:
Dedicator of cytokinesis 5
Type:
Guanine nucleotide exchange factor (GEF) for Rho and Rac
Mass (Da):
215309
Number AA:
1870
UniProt ID:
Q9H7D0
International Prot ID:
IPI00792788
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005085
GO:0030234
GO:0030695
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
I
P
T
K
R
Q
K
Y
G
V
A
I
Y
N
Y
Site 2
Y17
Q
K
Y
G
V
A
I
Y
N
Y
N
A
S
Q
D
Site 3
Y19
Y
G
V
A
I
Y
N
Y
N
A
S
Q
D
V
E
Site 4
S22
A
I
Y
N
Y
N
A
S
Q
D
V
E
L
S
L
Site 5
S28
A
S
Q
D
V
E
L
S
L
Q
I
G
D
T
V
Site 6
Y41
T
V
H
I
L
E
M
Y
E
G
W
Y
R
G
Y
Site 7
Y48
Y
E
G
W
Y
R
G
Y
T
L
Q
N
K
S
K
Site 8
T49
E
G
W
Y
R
G
Y
T
L
Q
N
K
S
K
K
Site 9
S54
G
Y
T
L
Q
N
K
S
K
K
G
I
F
P
E
Site 10
Y63
K
G
I
F
P
E
T
Y
I
H
L
K
E
A
T
Site 11
T70
Y
I
H
L
K
E
A
T
V
E
D
L
G
Q
H
Site 12
T79
E
D
L
G
Q
H
E
T
V
I
P
G
E
L
P
Site 13
Y106
A
V
I
W
R
K
L
Y
V
N
N
K
L
T
L
Site 14
Y122
R
Q
L
Q
Q
M
T
Y
S
L
I
E
W
R
S
Site 15
S123
Q
L
Q
Q
M
T
Y
S
L
I
E
W
R
S
Q
Site 16
S133
E
W
R
S
Q
I
L
S
G
T
L
P
K
D
E
Site 17
T135
R
S
Q
I
L
S
G
T
L
P
K
D
E
L
A
Site 18
T178
N
I
L
D
P
D
E
T
S
T
I
A
L
F
K
Site 19
S191
F
K
A
H
E
V
A
S
K
R
I
E
E
K
I
Site 20
S203
E
K
I
Q
E
E
K
S
I
L
Q
N
L
D
L
Site 21
S214
N
L
D
L
R
G
Q
S
I
F
S
T
I
H
T
Site 22
T218
R
G
Q
S
I
F
S
T
I
H
T
Y
G
L
Y
Site 23
Y246
A
E
L
F
M
A
L
Y
D
P
D
Q
S
T
F
Site 24
S251
A
L
Y
D
P
D
Q
S
T
F
I
S
E
N
Y
Site 25
T252
L
Y
D
P
D
Q
S
T
F
I
S
E
N
Y
L
Site 26
Y258
S
T
F
I
S
E
N
Y
L
I
R
W
G
S
N
Site 27
Y356
Q
Q
I
A
M
E
T
Y
I
R
Q
R
Q
L
I
Site 28
S365
R
Q
R
Q
L
I
M
S
P
L
I
T
S
H
V
Site 29
S381
G
E
N
E
P
L
T
S
V
L
N
K
V
I
A
Site 30
S402
K
G
Q
G
L
W
V
S
L
K
L
L
P
G
D
Site 31
T411
K
L
L
P
G
D
L
T
Q
V
Q
K
N
F
S
Site 32
T425
S
H
L
V
D
R
S
T
A
I
A
R
K
M
G
Site 33
Y447
G
D
V
R
N
D
I
Y
V
T
L
I
H
G
E
Site 34
T462
F
D
K
G
K
K
K
T
P
K
N
V
E
V
T
Site 35
S471
K
N
V
E
V
T
M
S
V
H
D
E
E
G
K
Site 36
Y490
A
I
H
P
G
A
G
Y
E
G
I
S
E
Y
K
Site 37
S494
G
A
G
Y
E
G
I
S
E
Y
K
S
V
V
Y
Site 38
Y496
G
Y
E
G
I
S
E
Y
K
S
V
V
Y
Y
Q
Site 39
S498
E
G
I
S
E
Y
K
S
V
V
Y
Y
Q
V
K
Site 40
Y501
S
E
Y
K
S
V
V
Y
Y
Q
V
K
Q
P
C
Site 41
Y502
E
Y
K
S
V
V
Y
Y
Q
V
K
Q
P
C
W
Site 42
Y510
Q
V
K
Q
P
C
W
Y
E
T
V
K
V
S
I
Site 43
S535
R
F
T
F
R
H
R
S
S
Q
E
T
R
D
K
Site 44
S536
F
T
F
R
H
R
S
S
Q
E
T
R
D
K
S
Site 45
T539
R
H
R
S
S
Q
E
T
R
D
K
S
E
R
A
Site 46
S543
S
Q
E
T
R
D
K
S
E
R
A
F
G
V
A
Site 47
T560
K
L
M
N
P
D
G
T
T
L
Q
D
G
R
H
Site 48
T561
L
M
N
P
D
G
T
T
L
Q
D
G
R
H
D
Site 49
Y585
K
M
E
D
A
K
F
Y
L
T
L
P
G
T
K
Site 50
T587
E
D
A
K
F
Y
L
T
L
P
G
T
K
M
E
Site 51
S603
E
E
K
E
L
Q
A
S
K
N
L
V
T
F
T
Site 52
T608
Q
A
S
K
N
L
V
T
F
T
P
S
K
D
S
Site 53
T610
S
K
N
L
V
T
F
T
P
S
K
D
S
T
K
Site 54
S615
T
F
T
P
S
K
D
S
T
K
D
S
F
Q
I
Site 55
T616
F
T
P
S
K
D
S
T
K
D
S
F
Q
I
A
Site 56
S619
S
K
D
S
T
K
D
S
F
Q
I
A
T
L
I
Site 57
T624
K
D
S
F
Q
I
A
T
L
I
C
S
T
K
L
Site 58
S645
L
G
L
L
N
W
R
S
N
S
Q
N
I
K
H
Site 59
S647
L
L
N
W
R
S
N
S
Q
N
I
K
H
N
L
Site 60
T688
M
E
M
S
D
S
E
T
Y
D
F
L
V
F
D
Site 61
Y740
L
S
K
V
L
N
F
Y
V
A
N
A
D
D
S
Site 62
S747
Y
V
A
N
A
D
D
S
S
K
T
E
L
L
F
Site 63
S748
V
A
N
A
D
D
S
S
K
T
E
L
L
F
A
Site 64
Y778
R
V
L
Y
L
R
F
Y
G
Q
S
K
D
G
D
Site 65
S781
Y
L
R
F
Y
G
Q
S
K
D
G
D
E
F
N
Site 66
S790
D
G
D
E
F
N
N
S
I
R
Q
L
F
L
A
Site 67
T867
M
T
K
I
V
E
S
T
L
F
R
Q
S
E
C
Site 68
S872
E
S
T
L
F
R
Q
S
E
C
R
E
V
L
L
Site 69
S887
P
L
L
T
D
Q
L
S
G
Q
L
D
D
N
S
Site 70
S894
S
G
Q
L
D
D
N
S
N
K
P
D
H
E
A
Site 71
S902
N
K
P
D
H
E
A
S
S
Q
L
L
S
N
I
Site 72
S903
K
P
D
H
E
A
S
S
Q
L
L
S
N
I
L
Site 73
T939
L
L
R
R
I
N
R
T
V
I
G
M
N
R
Q
Site 74
Y969
Q
Q
M
D
D
S
H
Y
S
H
Y
I
S
T
F
Site 75
Y972
D
D
S
H
Y
S
H
Y
I
S
T
F
K
T
R
Site 76
S1065
S
L
Q
L
E
T
F
S
Q
A
K
R
N
K
I
Site 77
Y1076
R
N
K
I
V
K
K
Y
G
D
M
R
K
E
I
Site 78
Y1168
G
G
R
G
D
E
Q
Y
K
V
L
L
E
K
L
Site 79
Y1185
E
H
C
R
K
H
K
Y
L
S
S
S
G
E
V
Site 80
S1187
C
R
K
H
K
Y
L
S
S
S
G
E
V
F
A
Site 81
S1189
K
H
K
Y
L
S
S
S
G
E
V
F
A
L
L
Site 82
T1209
E
N
L
L
D
Y
R
T
I
I
M
Q
D
E
S
Site 83
S1222
E
S
K
E
N
R
M
S
C
T
V
N
V
L
N
Site 84
Y1240
E
K
K
R
E
D
I
Y
I
R
Y
L
Y
K
L
Site 85
Y1243
R
E
D
I
Y
I
R
Y
L
Y
K
L
R
D
L
Site 86
Y1245
D
I
Y
I
R
Y
L
Y
K
L
R
D
L
H
R
Site 87
Y1257
L
H
R
D
C
E
N
Y
T
E
A
A
Y
T
L
Site 88
Y1288
H
L
L
Q
K
D
S
Y
Y
V
Y
T
Q
Q
E
Site 89
Y1289
L
L
Q
K
D
S
Y
Y
V
Y
T
Q
Q
E
L
Site 90
Y1291
Q
K
D
S
Y
Y
V
Y
T
Q
Q
E
L
K
E
Site 91
Y1301
Q
E
L
K
E
K
L
Y
Q
E
I
I
S
Y
F
Site 92
Y1307
L
Y
Q
E
I
I
S
Y
F
D
K
G
K
M
W
Site 93
T1327
L
S
K
E
L
A
E
T
Y
E
S
K
V
F
D
Site 94
Y1328
S
K
E
L
A
E
T
Y
E
S
K
V
F
D
Y
Site 95
S1330
E
L
A
E
T
Y
E
S
K
V
F
D
Y
E
G
Site 96
Y1335
Y
E
S
K
V
F
D
Y
E
G
L
G
N
L
L
Site 97
S1347
N
L
L
K
K
R
A
S
F
Y
E
N
I
I
K
Site 98
Y1349
L
K
K
R
A
S
F
Y
E
N
I
I
K
A
M
Site 99
Y1362
A
M
R
P
Q
P
E
Y
F
A
V
G
Y
Y
G
Site 100
Y1367
P
E
Y
F
A
V
G
Y
Y
G
Q
G
F
P
S
Site 101
Y1368
E
Y
F
A
V
G
Y
Y
G
Q
G
F
P
S
F
Site 102
Y1388
F
I
Y
R
G
K
E
Y
E
R
R
E
D
F
S
Site 103
S1395
Y
E
R
R
E
D
F
S
L
R
L
L
T
Q
F
Site 104
T1400
D
F
S
L
R
L
L
T
Q
F
P
N
A
E
K
Site 105
S1410
P
N
A
E
K
M
T
S
T
T
P
P
G
E
D
Site 106
T1412
A
E
K
M
T
S
T
T
P
P
G
E
D
I
K
Site 107
S1420
P
P
G
E
D
I
K
S
S
P
K
Q
Y
M
Q
Site 108
S1421
P
G
E
D
I
K
S
S
P
K
Q
Y
M
Q
C
Site 109
Y1425
I
K
S
S
P
K
Q
Y
M
Q
C
F
T
V
K
Site 110
S1436
F
T
V
K
P
V
M
S
L
P
P
S
Y
K
D
Site 111
S1440
P
V
M
S
L
P
P
S
Y
K
D
K
P
V
P
Site 112
Y1453
V
P
E
Q
I
L
N
Y
Y
R
A
N
E
V
Q
Site 113
Y1454
P
E
Q
I
L
N
Y
Y
R
A
N
E
V
Q
Q
Site 114
Y1464
N
E
V
Q
Q
F
R
Y
S
R
P
F
R
K
G
Site 115
S1465
E
V
Q
Q
F
R
Y
S
R
P
F
R
K
G
E
Site 116
Y1489
M
W
I
E
R
T
T
Y
T
T
A
Y
T
F
P
Site 117
T1491
I
E
R
T
T
Y
T
T
A
Y
T
F
P
G
I
Site 118
Y1493
R
T
T
Y
T
T
A
Y
T
F
P
G
I
L
K
Site 119
T1494
T
T
Y
T
T
A
Y
T
F
P
G
I
L
K
W
Site 120
S1508
W
F
E
V
K
Q
I
S
T
E
E
I
S
P
L
Site 121
S1513
Q
I
S
T
E
E
I
S
P
L
E
N
A
I
E
Site 122
T1525
A
I
E
T
M
E
L
T
N
E
R
I
S
N
C
Site 123
S1541
Q
Q
H
A
W
D
R
S
L
S
V
H
P
L
S
Site 124
S1543
H
A
W
D
R
S
L
S
V
H
P
L
S
M
L
Site 125
Y1566
V
M
G
G
F
S
N
Y
E
K
A
F
F
T
E
Site 126
Y1575
K
A
F
F
T
E
K
Y
L
Q
E
H
P
E
D
Site 127
T1601
A
L
Q
M
P
L
L
T
E
G
I
R
I
H
G
Site 128
T1612
R
I
H
G
E
K
L
T
E
Q
L
K
P
L
H
Site 129
S1623
K
P
L
H
E
R
L
S
S
C
F
R
E
L
K
Site 130
S1624
P
L
H
E
R
L
S
S
C
F
R
E
L
K
E
Site 131
T1641
E
K
H
Y
G
V
I
T
L
P
P
N
L
T
E
Site 132
T1647
I
T
L
P
P
N
L
T
E
R
K
Q
S
R
T
Site 133
S1652
N
L
T
E
R
K
Q
S
R
T
G
S
I
V
L
Site 134
T1654
T
E
R
K
Q
S
R
T
G
S
I
V
L
P
Y
Site 135
S1656
R
K
Q
S
R
T
G
S
I
V
L
P
Y
I
M
Site 136
Y1661
T
G
S
I
V
L
P
Y
I
M
S
S
T
L
R
Site 137
S1671
S
S
T
L
R
R
L
S
I
T
S
V
T
S
S
Site 138
S1678
S
I
T
S
V
T
S
S
V
V
S
T
S
S
N
Site 139
S1681
S
V
T
S
S
V
V
S
T
S
S
N
S
S
D
Site 140
T1682
V
T
S
S
V
V
S
T
S
S
N
S
S
D
N
Site 141
S1683
T
S
S
V
V
S
T
S
S
N
S
S
D
N
A
Site 142
S1684
S
S
V
V
S
T
S
S
N
S
S
D
N
A
P
Site 143
S1686
V
V
S
T
S
S
N
S
S
D
N
A
P
S
R
Site 144
S1687
V
S
T
S
S
N
S
S
D
N
A
P
S
R
P
Site 145
S1692
N
S
S
D
N
A
P
S
R
P
G
S
D
G
S
Site 146
S1696
N
A
P
S
R
P
G
S
D
G
S
I
L
E
P
Site 147
S1699
S
R
P
G
S
D
G
S
I
L
E
P
L
L
E
Site 148
S1710
P
L
L
E
R
R
A
S
S
G
A
R
V
E
D
Site 149
S1711
L
L
E
R
R
A
S
S
G
A
R
V
E
D
L
Site 150
S1719
G
A
R
V
E
D
L
S
L
R
E
E
N
S
E
Site 151
S1725
L
S
L
R
E
E
N
S
E
N
R
I
S
K
F
Site 152
S1730
E
N
S
E
N
R
I
S
K
F
K
R
K
D
W
Site 153
S1738
K
F
K
R
K
D
W
S
L
S
K
S
Q
V
I
Site 154
S1740
K
R
K
D
W
S
L
S
K
S
Q
V
I
A
E
Site 155
S1742
K
D
W
S
L
S
K
S
Q
V
I
A
E
K
A
Site 156
S1756
A
P
E
P
D
L
M
S
P
T
R
K
A
Q
R
Site 157
S1766
R
K
A
Q
R
P
K
S
L
Q
L
M
D
N
R
Site 158
S1775
Q
L
M
D
N
R
L
S
P
F
H
G
S
S
P
Site 159
S1780
R
L
S
P
F
H
G
S
S
P
P
Q
S
T
P
Site 160
S1781
L
S
P
F
H
G
S
S
P
P
Q
S
T
P
L
Site 161
S1785
H
G
S
S
P
P
Q
S
T
P
L
S
P
P
P
Site 162
T1786
G
S
S
P
P
Q
S
T
P
L
S
P
P
P
L
Site 163
S1789
P
P
Q
S
T
P
L
S
P
P
P
L
T
P
K
Site 164
T1794
P
L
S
P
P
P
L
T
P
K
A
T
R
T
L
Site 165
T1798
P
P
L
T
P
K
A
T
R
T
L
S
S
P
S
Site 166
T1800
L
T
P
K
A
T
R
T
L
S
S
P
S
L
Q
Site 167
S1802
P
K
A
T
R
T
L
S
S
P
S
L
Q
T
D
Site 168
S1803
K
A
T
R
T
L
S
S
P
S
L
Q
T
D
G
Site 169
S1805
T
R
T
L
S
S
P
S
L
Q
T
D
G
I
A
Site 170
T1808
L
S
S
P
S
L
Q
T
D
G
I
A
A
T
P
Site 171
T1814
Q
T
D
G
I
A
A
T
P
V
P
P
P
P
P
Site 172
S1824
P
P
P
P
P
P
K
S
K
P
Y
E
G
S
Q
Site 173
S1830
K
S
K
P
Y
E
G
S
Q
R
N
S
T
E
L
Site 174
S1834
Y
E
G
S
Q
R
N
S
T
E
L
A
P
P
L
Site 175
T1835
E
G
S
Q
R
N
S
T
E
L
A
P
P
L
P
Site 176
S1860
P
P
P
K
A
R
K
S
G
I
P
T
S
E
P
Site 177
T1864
A
R
K
S
G
I
P
T
S
E
P
G
S
Q
_
Site 178
S1865
R
K
S
G
I
P
T
S
E
P
G
S
Q
_
_
Site 179
S1869
I
P
T
S
E
P
G
S
Q
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation