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Updated November 2019
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Protein Info
Short Name:
SCAF1
Full Name:
Splicing factor, arginine/serine-rich 19
Alias:
FLJ00034; SCAF; Serine arginine-rich pre-mRNA splicing factor SR-A1; SFR19; Splicing factor, arginine/serine-rich 19; Splicing factor, arginine/serine-rich 19: Serine arginine-rich pre-mRNA splicing factor SR-A1: SR-related-CTD-associated factor; SR-A1; SR-related CTD-associated factor 1; SR-related-CTD-associated factor
Type:
Unknown function
Mass (Da):
139266
Number AA:
1312
UniProt ID:
Q9H7N4
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
E
E
D
E
S
R
G
K
T
E
E
S
Site 2
T11
E
D
E
S
R
G
K
T
E
E
S
G
E
D
R
Site 3
S14
S
R
G
K
T
E
E
S
G
E
D
R
G
D
G
Site 4
T28
G
P
P
D
R
D
P
T
L
S
P
S
A
F
I
Site 5
S30
P
D
R
D
P
T
L
S
P
S
A
F
I
L
R
Site 6
S58
L
P
N
D
K
D
G
S
R
C
H
G
L
R
W
Site 7
S70
L
R
W
R
R
C
R
S
P
R
S
E
P
R
S
Site 8
S73
R
R
C
R
S
P
R
S
E
P
R
S
Q
E
S
Site 9
S77
S
P
R
S
E
P
R
S
Q
E
S
G
G
T
D
Site 10
T83
R
S
Q
E
S
G
G
T
D
T
A
T
V
L
D
Site 11
T87
S
G
G
T
D
T
A
T
V
L
D
M
A
T
D
Site 12
T109
S
V
L
D
P
P
D
T
W
V
P
S
R
L
D
Site 13
S113
P
P
D
T
W
V
P
S
R
L
D
L
R
P
G
Site 14
S122
L
D
L
R
P
G
E
S
E
D
M
L
E
L
V
Site 15
S146
P
I
P
L
P
V
P
S
L
L
P
R
L
R
A
Site 16
T156
P
R
L
R
A
W
R
T
G
K
T
V
S
P
Q
Site 17
T159
R
A
W
R
T
G
K
T
V
S
P
Q
S
N
S
Site 18
S161
W
R
T
G
K
T
V
S
P
Q
S
N
S
S
R
Site 19
S164
G
K
T
V
S
P
Q
S
N
S
S
R
P
T
C
Site 20
S166
T
V
S
P
Q
S
N
S
S
R
P
T
C
A
R
Site 21
T170
Q
S
N
S
S
R
P
T
C
A
R
H
L
T
L
Site 22
T176
P
T
C
A
R
H
L
T
L
G
T
G
D
G
G
Site 23
S191
P
A
P
P
P
A
P
S
S
A
S
S
S
P
S
Site 24
S192
A
P
P
P
A
P
S
S
A
S
S
S
P
S
P
Site 25
S194
P
P
A
P
S
S
A
S
S
S
P
S
P
S
P
Site 26
S195
P
A
P
S
S
A
S
S
S
P
S
P
S
P
S
Site 27
S196
A
P
S
S
A
S
S
S
P
S
P
S
P
S
S
Site 28
S198
S
S
A
S
S
S
P
S
P
S
P
S
S
S
S
Site 29
S200
A
S
S
S
P
S
P
S
P
S
S
S
S
P
S
Site 30
S202
S
S
P
S
P
S
P
S
S
S
S
P
S
P
P
Site 31
S203
S
P
S
P
S
P
S
S
S
S
P
S
P
P
P
Site 32
S204
P
S
P
S
P
S
S
S
S
P
S
P
P
P
P
Site 33
S205
S
P
S
P
S
S
S
S
P
S
P
P
P
P
P
Site 34
S207
S
P
S
S
S
S
P
S
P
P
P
P
P
P
P
Site 35
Y228
P
A
P
R
F
D
I
Y
D
P
F
H
P
T
D
Site 36
T234
I
Y
D
P
F
H
P
T
D
E
A
Y
S
P
P
Site 37
Y238
F
H
P
T
D
E
A
Y
S
P
P
P
A
P
E
Site 38
S239
H
P
T
D
E
A
Y
S
P
P
P
A
P
E
Q
Site 39
Y248
P
P
A
P
E
Q
K
Y
D
P
F
E
P
T
G
Site 40
T254
K
Y
D
P
F
E
P
T
G
S
N
P
S
S
S
Site 41
S256
D
P
F
E
P
T
G
S
N
P
S
S
S
A
G
Site 42
S260
P
T
G
S
N
P
S
S
S
A
G
T
P
S
P
Site 43
S261
T
G
S
N
P
S
S
S
A
G
T
P
S
P
E
Site 44
T264
N
P
S
S
S
A
G
T
P
S
P
E
E
E
E
Site 45
S266
S
S
S
A
G
T
P
S
P
E
E
E
E
E
E
Site 46
S291
E
E
E
E
E
G
L
S
Q
S
I
S
R
I
S
Site 47
S293
E
E
E
G
L
S
Q
S
I
S
R
I
S
E
T
Site 48
S295
E
G
L
S
Q
S
I
S
R
I
S
E
T
L
A
Site 49
S298
S
Q
S
I
S
R
I
S
E
T
L
A
G
I
Y
Site 50
Y305
S
E
T
L
A
G
I
Y
D
D
N
S
L
S
Q
Site 51
S309
A
G
I
Y
D
D
N
S
L
S
Q
D
F
P
G
Site 52
S311
I
Y
D
D
N
S
L
S
Q
D
F
P
G
D
E
Site 53
S319
Q
D
F
P
G
D
E
S
P
R
P
D
A
Q
P
Site 54
T327
P
R
P
D
A
Q
P
T
Q
P
T
P
A
P
G
Site 55
T330
D
A
Q
P
T
Q
P
T
P
A
P
G
T
P
P
Site 56
T335
Q
P
T
P
A
P
G
T
P
P
Q
V
D
S
T
Site 57
S341
G
T
P
P
Q
V
D
S
T
R
A
D
G
A
M
Site 58
T342
T
P
P
Q
V
D
S
T
R
A
D
G
A
M
R
Site 59
S389
P
L
L
P
P
G
D
S
E
I
E
E
G
E
I
Site 60
S408
E
E
P
R
L
A
L
S
L
F
R
P
G
G
R
Site 61
S424
A
R
P
P
P
A
A
S
A
T
P
T
A
Q
P
Site 62
T426
P
P
P
A
A
S
A
T
P
T
A
Q
P
L
P
Site 63
T428
P
A
A
S
A
T
P
T
A
Q
P
L
P
Q
P
Site 64
S448
P
E
G
D
D
F
L
S
L
H
A
E
S
D
G
Site 65
S453
F
L
S
L
H
A
E
S
D
G
E
G
A
L
Q
Site 66
S475
P
A
P
P
A
A
D
S
R
W
G
G
L
D
L
Site 67
T488
D
L
R
R
K
I
L
T
Q
R
R
E
R
Y
R
Site 68
Y494
L
T
Q
R
R
E
R
Y
R
Q
R
S
P
S
P
Site 69
S498
R
E
R
Y
R
Q
R
S
P
S
P
A
P
A
P
Site 70
S500
R
Y
R
Q
R
S
P
S
P
A
P
A
P
A
P
Site 71
T515
A
A
A
A
G
P
P
T
R
K
K
S
R
R
E
Site 72
S519
G
P
P
T
R
K
K
S
R
R
E
R
K
R
S
Site 73
S526
S
R
R
E
R
K
R
S
G
E
A
K
E
A
A
Site 74
S534
G
E
A
K
E
A
A
S
S
S
S
G
T
Q
P
Site 75
S535
E
A
K
E
A
A
S
S
S
S
G
T
Q
P
A
Site 76
S536
A
K
E
A
A
S
S
S
S
G
T
Q
P
A
P
Site 77
T539
A
A
S
S
S
S
G
T
Q
P
A
P
P
A
P
Site 78
S548
P
A
P
P
A
P
A
S
P
W
D
S
K
K
H
Site 79
S552
A
P
A
S
P
W
D
S
K
K
H
R
S
R
D
Site 80
S557
W
D
S
K
K
H
R
S
R
D
R
K
P
G
S
Site 81
S564
S
R
D
R
K
P
G
S
H
A
S
S
S
A
R
Site 82
S567
R
K
P
G
S
H
A
S
S
S
A
R
R
R
S
Site 83
S568
K
P
G
S
H
A
S
S
S
A
R
R
R
S
R
Site 84
S569
P
G
S
H
A
S
S
S
A
R
R
R
S
R
S
Site 85
S574
S
S
S
A
R
R
R
S
R
S
R
S
R
S
R
Site 86
S576
S
A
R
R
R
S
R
S
R
S
R
S
R
S
T
Site 87
S578
R
R
R
S
R
S
R
S
R
S
R
S
T
R
R
Site 88
S580
R
S
R
S
R
S
R
S
R
S
T
R
R
R
S
Site 89
S582
R
S
R
S
R
S
R
S
T
R
R
R
S
R
S
Site 90
T583
S
R
S
R
S
R
S
T
R
R
R
S
R
S
T
Site 91
S587
S
R
S
T
R
R
R
S
R
S
T
D
R
R
R
Site 92
S589
S
T
R
R
R
S
R
S
T
D
R
R
R
G
G
Site 93
T590
T
R
R
R
S
R
S
T
D
R
R
R
G
G
S
Site 94
S597
T
D
R
R
R
G
G
S
R
R
S
R
S
R
E
Site 95
S600
R
R
G
G
S
R
R
S
R
S
R
E
K
R
R
Site 96
S602
G
G
S
R
R
S
R
S
R
E
K
R
R
R
R
Site 97
S612
K
R
R
R
R
R
R
S
A
S
P
P
P
A
T
Site 98
S614
R
R
R
R
R
S
A
S
P
P
P
A
T
S
S
Site 99
T619
S
A
S
P
P
P
A
T
S
S
S
S
S
S
R
Site 100
S620
A
S
P
P
P
A
T
S
S
S
S
S
S
R
R
Site 101
S621
S
P
P
P
A
T
S
S
S
S
S
S
R
R
E
Site 102
S622
P
P
P
A
T
S
S
S
S
S
S
R
R
E
R
Site 103
S623
P
P
A
T
S
S
S
S
S
S
R
R
E
R
H
Site 104
S624
P
A
T
S
S
S
S
S
S
R
R
E
R
H
R
Site 105
S625
A
T
S
S
S
S
S
S
R
R
E
R
H
R
G
Site 106
S640
K
H
R
D
G
G
G
S
K
K
K
K
K
R
S
Site 107
S647
S
K
K
K
K
K
R
S
R
S
R
G
E
K
R
Site 108
S649
K
K
K
K
R
S
R
S
R
G
E
K
R
S
G
Site 109
S655
R
S
R
G
E
K
R
S
G
D
G
S
E
K
A
Site 110
S659
E
K
R
S
G
D
G
S
E
K
A
P
A
P
A
Site 111
S670
P
A
P
A
P
P
P
S
G
S
T
S
C
G
D
Site 112
S672
P
A
P
P
P
S
G
S
T
S
C
G
D
R
D
Site 113
S674
P
P
P
S
G
S
T
S
C
G
D
R
D
S
R
Site 114
S680
T
S
C
G
D
R
D
S
R
R
R
G
A
V
P
Site 115
S689
R
R
G
A
V
P
P
S
I
Q
D
L
T
D
H
Site 116
T694
P
P
S
I
Q
D
L
T
D
H
D
L
F
A
I
Site 117
T706
F
A
I
K
R
T
I
T
V
G
R
L
D
K
S
Site 118
S713
T
V
G
R
L
D
K
S
D
P
R
G
P
S
P
Site 119
S719
K
S
D
P
R
G
P
S
P
A
P
A
S
S
P
Site 120
S724
G
P
S
P
A
P
A
S
S
P
K
R
E
V
L
Site 121
S725
P
S
P
A
P
A
S
S
P
K
R
E
V
L
Y
Site 122
Y732
S
P
K
R
E
V
L
Y
D
S
E
G
L
S
G
Site 123
S734
K
R
E
V
L
Y
D
S
E
G
L
S
G
E
E
Site 124
S738
L
Y
D
S
E
G
L
S
G
E
E
R
G
G
K
Site 125
S747
E
E
R
G
G
K
S
S
Q
K
D
R
R
R
S
Site 126
S754
S
Q
K
D
R
R
R
S
G
A
A
S
S
S
S
Site 127
S758
R
R
R
S
G
A
A
S
S
S
S
S
S
R
E
Site 128
S759
R
R
S
G
A
A
S
S
S
S
S
S
R
E
K
Site 129
S760
R
S
G
A
A
S
S
S
S
S
S
R
E
K
G
Site 130
S761
S
G
A
A
S
S
S
S
S
S
R
E
K
G
S
Site 131
S762
G
A
A
S
S
S
S
S
S
R
E
K
G
S
R
Site 132
S763
A
A
S
S
S
S
S
S
R
E
K
G
S
R
R
Site 133
S768
S
S
S
R
E
K
G
S
R
R
K
A
L
D
G
Site 134
S791
R
D
R
D
R
D
R
S
S
K
K
A
R
P
P
Site 135
S792
D
R
D
R
D
R
S
S
K
K
A
R
P
P
K
Site 136
S801
K
A
R
P
P
K
E
S
A
P
S
S
G
P
P
Site 137
S804
P
P
K
E
S
A
P
S
S
G
P
P
P
K
P
Site 138
S805
P
K
E
S
A
P
S
S
G
P
P
P
K
P
P
Site 139
S814
P
P
P
K
P
P
V
S
S
G
S
G
S
S
S
Site 140
S815
P
P
K
P
P
V
S
S
G
S
G
S
S
S
S
Site 141
S817
K
P
P
V
S
S
G
S
G
S
S
S
S
S
S
Site 142
S819
P
V
S
S
G
S
G
S
S
S
S
S
S
S
C
Site 143
S820
V
S
S
G
S
G
S
S
S
S
S
S
S
C
S
Site 144
S821
S
S
G
S
G
S
S
S
S
S
S
S
C
S
S
Site 145
S822
S
G
S
G
S
S
S
S
S
S
S
C
S
S
R
Site 146
S823
G
S
G
S
S
S
S
S
S
S
C
S
S
R
K
Site 147
S824
S
G
S
S
S
S
S
S
S
C
S
S
R
K
V
Site 148
S825
G
S
S
S
S
S
S
S
C
S
S
R
K
V
K
Site 149
S827
S
S
S
S
S
S
C
S
S
R
K
V
K
L
Q
Site 150
S828
S
S
S
S
S
C
S
S
R
K
V
K
L
Q
S
Site 151
S846
V
L
I
R
E
G
V
S
S
T
T
P
A
K
D
Site 152
S847
L
I
R
E
G
V
S
S
T
T
P
A
K
D
A
Site 153
T849
R
E
G
V
S
S
T
T
P
A
K
D
A
A
S
Site 154
S856
T
P
A
K
D
A
A
S
A
G
L
G
S
I
G
Site 155
S867
G
S
I
G
V
K
F
S
R
D
R
E
S
R
S
Site 156
S872
K
F
S
R
D
R
E
S
R
S
P
F
L
K
P
Site 157
S874
S
R
D
R
E
S
R
S
P
F
L
K
P
D
E
Site 158
T885
K
P
D
E
R
A
P
T
E
M
A
K
A
A
P
Site 159
S894
M
A
K
A
A
P
G
S
T
K
P
K
K
T
K
Site 160
T911
A
K
A
G
A
K
K
T
K
G
T
K
G
K
T
Site 161
T918
T
K
G
T
K
G
K
T
K
P
S
K
T
R
K
Site 162
S921
T
K
G
K
T
K
P
S
K
T
R
K
K
V
R
Site 163
T923
G
K
T
K
P
S
K
T
R
K
K
V
R
S
G
Site 164
S929
K
T
R
K
K
V
R
S
G
G
G
S
G
G
S
Site 165
S933
K
V
R
S
G
G
G
S
G
G
S
G
G
Q
V
Site 166
S936
S
G
G
G
S
G
G
S
G
G
Q
V
S
L
K
Site 167
S941
G
G
S
G
G
Q
V
S
L
K
K
S
K
A
D
Site 168
S945
G
Q
V
S
L
K
K
S
K
A
D
S
C
S
Q
Site 169
S949
L
K
K
S
K
A
D
S
C
S
Q
A
A
G
T
Site 170
S951
K
S
K
A
D
S
C
S
Q
A
A
G
T
K
G
Site 171
T962
G
T
K
G
A
E
E
T
S
W
S
G
E
E
R
Site 172
S963
T
K
G
A
E
E
T
S
W
S
G
E
E
R
A
Site 173
S965
G
A
E
E
T
S
W
S
G
E
E
R
A
A
K
Site 174
S975
E
R
A
A
K
V
P
S
T
P
P
P
K
A
A
Site 175
T976
R
A
A
K
V
P
S
T
P
P
P
K
A
A
P
Site 176
T989
A
P
P
P
P
A
L
T
P
D
S
Q
T
V
D
Site 177
S992
P
P
A
L
T
P
D
S
Q
T
V
D
S
S
C
Site 178
T994
A
L
T
P
D
S
Q
T
V
D
S
S
C
K
T
Site 179
S997
P
D
S
Q
T
V
D
S
S
C
K
T
P
E
V
Site 180
S998
D
S
Q
T
V
D
S
S
C
K
T
P
E
V
S
Site 181
T1001
T
V
D
S
S
C
K
T
P
E
V
S
F
L
P
Site 182
S1005
S
C
K
T
P
E
V
S
F
L
P
E
E
A
T
Site 183
S1056
S
T
A
A
A
A
P
S
T
A
P
S
A
G
S
Site 184
S1060
A
A
P
S
T
A
P
S
A
G
S
T
A
G
D
Site 185
S1063
S
T
A
P
S
A
G
S
T
A
G
D
S
G
A
Site 186
T1064
T
A
P
S
A
G
S
T
A
G
D
S
G
A
E
Site 187
S1068
A
G
S
T
A
G
D
S
G
A
E
D
G
P
A
Site 188
S1076
G
A
E
D
G
P
A
S
R
V
S
Q
L
P
T
Site 189
S1079
D
G
P
A
S
R
V
S
Q
L
P
T
L
P
P
Site 190
T1083
S
R
V
S
Q
L
P
T
L
P
P
P
M
P
W
Site 191
S1136
Q
A
T
N
Q
I
L
S
H
R
K
P
P
S
S
Site 192
S1142
L
S
H
R
K
P
P
S
S
L
G
M
T
P
A
Site 193
S1143
S
H
R
K
P
P
S
S
L
G
M
T
P
A
P
Site 194
T1147
P
P
S
S
L
G
M
T
P
A
P
V
P
T
S
Site 195
S1154
T
P
A
P
V
P
T
S
L
G
L
P
P
G
P
Site 196
Y1164
L
P
P
G
P
S
S
Y
L
L
P
G
S
L
P
Site 197
S1177
L
P
L
G
G
C
G
S
T
P
P
T
P
T
G
Site 198
T1178
P
L
G
G
C
G
S
T
P
P
T
P
T
G
L
Site 199
T1181
G
C
G
S
T
P
P
T
P
T
G
L
A
A
T
Site 200
S1189
P
T
G
L
A
A
T
S
D
K
R
E
G
S
S
Site 201
S1195
T
S
D
K
R
E
G
S
S
S
S
E
G
R
G
Site 202
S1197
D
K
R
E
G
S
S
S
S
E
G
R
G
D
T
Site 203
S1198
K
R
E
G
S
S
S
S
E
G
R
G
D
T
D
Site 204
T1204
S
S
E
G
R
G
D
T
D
K
Y
L
K
K
L
Site 205
Y1207
G
R
G
D
T
D
K
Y
L
K
K
L
H
T
Q
Site 206
T1213
K
Y
L
K
K
L
H
T
Q
E
R
A
V
E
E
Site 207
Y1229
K
L
A
I
K
P
Y
Y
Q
K
K
D
I
T
K
Site 208
S1255
H
K
I
C
H
S
K
S
G
E
I
N
P
V
K
Site 209
S1264
E
I
N
P
V
K
V
S
N
L
V
R
A
Y
V
Site 210
Y1270
V
S
N
L
V
R
A
Y
V
Q
R
Y
R
Y
F
Site 211
Y1276
A
Y
V
Q
R
Y
R
Y
F
R
K
H
G
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation