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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM125B
Full Name:
Multivesicular body subunit 12B
Alias:
C9orf28; ESCRT-I complex subunit MVB12B; F125B; Family with sequence similarity 125, member B; FLJ00001; Protein FAM125B
Type:
Unknown function
Mass (Da):
35601
Number AA:
319
UniProt ID:
Q9H7P6
International Prot ID:
IPI00022918
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
C
F
C
V
R
R
S
R
D
P
P
P
P
Q
Site 2
T27
P
P
P
P
Q
R
G
T
D
Q
S
T
M
P
E
Site 3
S30
P
Q
R
G
T
D
Q
S
T
M
P
E
V
K
D
Site 4
S39
M
P
E
V
K
D
L
S
E
A
L
P
E
T
S
Site 5
S46
S
E
A
L
P
E
T
S
M
D
P
I
T
G
V
Site 6
S58
T
G
V
G
V
V
A
S
R
N
R
A
P
T
G
Site 7
T64
A
S
R
N
R
A
P
T
G
Y
D
V
V
A
Q
Site 8
Y66
R
N
R
A
P
T
G
Y
D
V
V
A
Q
T
A
Site 9
Y93
F
K
S
K
V
T
R
Y
L
C
F
T
R
S
F
Site 10
T97
V
T
R
Y
L
C
F
T
R
S
F
S
K
E
N
Site 11
S99
R
Y
L
C
F
T
R
S
F
S
K
E
N
S
H
Site 12
S101
L
C
F
T
R
S
F
S
K
E
N
S
H
L
G
Site 13
S105
R
S
F
S
K
E
N
S
H
L
G
N
V
L
V
Site 14
T122
K
L
I
D
I
K
D
T
L
P
V
G
F
I
P
Site 15
T136
P
I
Q
E
T
V
D
T
Q
E
V
A
F
R
K
Site 16
S155
I
K
F
I
P
R
D
S
T
E
A
A
I
C
D
Site 17
T156
K
F
I
P
R
D
S
T
E
A
A
I
C
D
I
Site 18
T169
D
I
R
I
M
G
R
T
K
Q
A
P
P
Q
Y
Site 19
Y176
T
K
Q
A
P
P
Q
Y
T
F
I
G
E
L
N
Site 20
T177
K
Q
A
P
P
Q
Y
T
F
I
G
E
L
N
S
Site 21
Y189
L
N
S
M
G
I
W
Y
R
M
G
R
V
P
R
Site 22
S200
R
V
P
R
N
H
D
S
S
Q
P
T
T
P
S
Site 23
S201
V
P
R
N
H
D
S
S
Q
P
T
T
P
S
Q
Site 24
T204
N
H
D
S
S
Q
P
T
T
P
S
Q
S
S
A
Site 25
T205
H
D
S
S
Q
P
T
T
P
S
Q
S
S
A
A
Site 26
S207
S
S
Q
P
T
T
P
S
Q
S
S
A
A
S
T
Site 27
S209
Q
P
T
T
P
S
Q
S
S
A
A
S
T
P
A
Site 28
S210
P
T
T
P
S
Q
S
S
A
A
S
T
P
A
P
Site 29
S213
P
S
Q
S
S
A
A
S
T
P
A
P
N
L
P
Site 30
T214
S
Q
S
S
A
A
S
T
P
A
P
N
L
P
R
Site 31
S224
P
N
L
P
R
H
I
S
L
T
L
P
A
T
F
Site 32
T226
L
P
R
H
I
S
L
T
L
P
A
T
F
R
G
Site 33
T230
I
S
L
T
L
P
A
T
F
R
G
R
N
S
T
Site 34
S236
A
T
F
R
G
R
N
S
T
R
T
D
Y
E
Y
Site 35
T237
T
F
R
G
R
N
S
T
R
T
D
Y
E
Y
Q
Site 36
T239
R
G
R
N
S
T
R
T
D
Y
E
Y
Q
H
S
Site 37
Y241
R
N
S
T
R
T
D
Y
E
Y
Q
H
S
N
L
Site 38
Y243
S
T
R
T
D
Y
E
Y
Q
H
S
N
L
Y
A
Site 39
Y249
E
Y
Q
H
S
N
L
Y
A
I
S
A
M
D
G
Site 40
S295
I
E
K
E
Y
E
Y
S
F
R
T
E
Q
S
A
Site 41
S301
Y
S
F
R
T
E
Q
S
A
A
A
R
L
P
P
Site 42
S309
A
A
A
R
L
P
P
S
P
T
R
C
Q
Q
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation