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Updated November 2019
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Protein Info
Short Name:
PLEKHG2
Full Name:
Pleckstrin homology domain-containing family G member 2
Alias:
CLG; PKHG2; Pleckstrin homology domain-containing family G member 2: Pleckstrin homology domain-containing family G member 2
Type:
Guanine nucleotide exchange factor, misc.
Mass (Da):
147915
Number AA:
1386
UniProt ID:
Q9H7P9
International Prot ID:
IPI00303373
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
E
G
A
Q
G
L
S
L
S
K
P
S
P
S
Site 2
S11
G
A
Q
G
L
S
L
S
K
P
S
P
S
L
G
Site 3
S14
G
L
S
L
S
K
P
S
P
S
L
G
C
G
R
Site 4
S16
S
L
S
K
P
S
P
S
L
G
C
G
R
R
G
Site 5
T30
G
E
V
C
D
C
G
T
V
C
E
T
R
T
A
Site 6
S45
P
A
A
P
T
M
A
S
P
R
G
S
G
S
S
Site 7
S49
T
M
A
S
P
R
G
S
G
S
S
T
S
L
S
Site 8
S51
A
S
P
R
G
S
G
S
S
T
S
L
S
T
V
Site 9
S52
S
P
R
G
S
G
S
S
T
S
L
S
T
V
G
Site 10
T53
P
R
G
S
G
S
S
T
S
L
S
T
V
G
S
Site 11
S54
R
G
S
G
S
S
T
S
L
S
T
V
G
S
E
Site 12
S56
S
G
S
S
T
S
L
S
T
V
G
S
E
G
D
Site 13
T57
G
S
S
T
S
L
S
T
V
G
S
E
G
D
P
Site 14
S60
T
S
L
S
T
V
G
S
E
G
D
P
A
P
G
Site 15
T69
G
D
P
A
P
G
P
T
P
A
C
S
A
S
R
Site 16
S73
P
G
P
T
P
A
C
S
A
S
R
P
E
P
L
Site 17
S75
P
T
P
A
C
S
A
S
R
P
E
P
L
P
G
Site 18
S97
S
P
V
G
I
P
G
S
A
R
P
S
R
L
E
Site 19
S101
I
P
G
S
A
R
P
S
R
L
E
R
V
A
R
Site 20
T113
V
A
R
E
I
V
E
T
E
R
A
Y
V
R
D
Site 21
Y117
I
V
E
T
E
R
A
Y
V
R
D
L
R
S
I
Site 22
S169
L
L
E
D
L
E
N
S
S
S
A
G
G
I
A
Site 23
S171
E
D
L
E
N
S
S
S
A
G
G
I
A
E
C
Site 24
Y189
R
S
E
D
F
D
I
Y
T
L
Y
C
M
N
Y
Site 25
Y192
D
F
D
I
Y
T
L
Y
C
M
N
Y
P
S
S
Site 26
S226
R
Q
A
Q
L
R
H
S
L
P
L
Q
S
F
L
Site 27
S231
R
H
S
L
P
L
Q
S
F
L
L
K
P
V
Q
Site 28
T260
H
W
A
E
G
P
G
T
G
G
R
E
M
V
E
Site 29
T304
Q
R
R
L
G
G
W
T
G
P
E
L
S
A
F
Site 30
Y354
A
K
R
R
G
L
E
Y
T
Y
K
G
H
I
F
Site 31
T355
K
R
R
G
L
E
Y
T
Y
K
G
H
I
F
C
Site 32
Y356
R
R
G
L
E
Y
T
Y
K
G
H
I
F
C
C
Site 33
S366
H
I
F
C
C
N
L
S
V
S
E
S
P
R
D
Site 34
S368
F
C
C
N
L
S
V
S
E
S
P
R
D
P
L
Site 35
S370
C
N
L
S
V
S
E
S
P
R
D
P
L
G
F
Site 36
S380
D
P
L
G
F
K
V
S
D
L
T
I
P
K
H
Site 37
T383
G
F
K
V
S
D
L
T
I
P
K
H
R
H
L
Site 38
S417
F
F
E
N
H
P
A
S
I
P
A
K
A
K
Q
Site 39
S430
K
Q
V
L
L
E
N
S
L
H
C
A
P
K
S
Site 40
S437
S
L
H
C
A
P
K
S
K
P
V
L
E
P
L
Site 41
T445
K
P
V
L
E
P
L
T
P
P
L
G
S
P
R
Site 42
S450
P
L
T
P
P
L
G
S
P
R
P
R
D
A
R
Site 43
S458
P
R
P
R
D
A
R
S
F
T
P
G
R
R
N
Site 44
T460
P
R
D
A
R
S
F
T
P
G
R
R
N
T
A
Site 45
T466
F
T
P
G
R
R
N
T
A
P
S
P
G
P
S
Site 46
S469
G
R
R
N
T
A
P
S
P
G
P
S
V
I
R
Site 47
S473
T
A
P
S
P
G
P
S
V
I
R
R
G
R
R
Site 48
S482
I
R
R
G
R
R
Q
S
E
P
V
K
D
P
Y
Site 49
Y489
S
E
P
V
K
D
P
Y
V
M
F
P
Q
N
A
Site 50
S505
P
G
F
K
H
A
G
S
E
G
E
L
Y
P
P
Site 51
Y510
A
G
S
E
G
E
L
Y
P
P
E
S
Q
P
P
Site 52
S514
G
E
L
Y
P
P
E
S
Q
P
P
V
S
G
S
Site 53
S519
P
E
S
Q
P
P
V
S
G
S
A
P
P
E
D
Site 54
S521
S
Q
P
P
V
S
G
S
A
P
P
E
D
L
E
Site 55
T534
L
E
D
A
G
P
P
T
L
D
P
S
G
T
S
Site 56
S538
G
P
P
T
L
D
P
S
G
T
S
I
T
E
E
Site 57
S561
G
L
R
D
P
G
P
S
T
H
D
I
P
K
F
Site 58
T562
L
R
D
P
G
P
S
T
H
D
I
P
K
F
P
Site 59
S572
I
P
K
F
P
G
D
S
Q
V
P
G
D
S
E
Site 60
T582
P
G
D
S
E
T
L
T
F
Q
A
L
P
S
R
Site 61
S588
L
T
F
Q
A
L
P
S
R
D
S
S
E
E
E
Site 62
S591
Q
A
L
P
S
R
D
S
S
E
E
E
E
E
E
Site 63
S592
A
L
P
S
R
D
S
S
E
E
E
E
E
E
E
Site 64
S610
E
M
D
E
R
G
P
S
P
L
H
V
L
E
G
Site 65
S620
H
V
L
E
G
L
E
S
S
I
A
A
E
M
P
Site 66
S621
V
L
E
G
L
E
S
S
I
A
A
E
M
P
S
Site 67
S646
P
N
L
P
E
I
P
S
R
C
E
I
P
E
G
Site 68
S654
R
C
E
I
P
E
G
S
R
L
P
S
L
S
D
Site 69
S658
P
E
G
S
R
L
P
S
L
S
D
I
S
D
V
Site 70
S660
G
S
R
L
P
S
L
S
D
I
S
D
V
F
E
Site 71
S663
L
P
S
L
S
D
I
S
D
V
F
E
M
P
C
Site 72
T680
A
I
P
S
V
P
N
T
P
S
L
S
S
T
P
Site 73
S682
P
S
V
P
N
T
P
S
L
S
S
T
P
T
L
Site 74
S684
V
P
N
T
P
S
L
S
S
T
P
T
L
S
C
Site 75
T686
N
T
P
S
L
S
S
T
P
T
L
S
C
D
S
Site 76
T688
P
S
L
S
S
T
P
T
L
S
C
D
S
W
L
Site 77
S690
L
S
S
T
P
T
L
S
C
D
S
W
L
Q
G
Site 78
S693
T
P
T
L
S
C
D
S
W
L
Q
G
P
L
Q
Site 79
T708
E
P
A
E
A
P
A
T
R
R
E
L
F
S
G
Site 80
S714
A
T
R
R
E
L
F
S
G
S
N
P
G
K
L
Site 81
S716
R
R
E
L
F
S
G
S
N
P
G
K
L
G
E
Site 82
S726
G
K
L
G
E
P
P
S
G
G
K
A
G
P
E
Site 83
S740
E
E
D
E
E
G
V
S
F
T
D
F
Q
P
Q
Site 84
T742
D
E
E
G
V
S
F
T
D
F
Q
P
Q
D
V
Site 85
T750
D
F
Q
P
Q
D
V
T
Q
H
Q
G
F
P
D
Site 86
S763
P
D
E
L
A
F
R
S
C
S
E
I
R
S
A
Site 87
S765
E
L
A
F
R
S
C
S
E
I
R
S
A
W
Q
Site 88
S769
R
S
C
S
E
I
R
S
A
W
Q
A
L
E
Q
Site 89
S794
P
L
L
I
L
E
D
S
D
L
G
G
D
S
G
Site 90
S800
D
S
D
L
G
G
D
S
G
S
G
K
A
G
A
Site 91
S802
D
L
G
G
D
S
G
S
G
K
A
G
A
P
S
Site 92
S809
S
G
K
A
G
A
P
S
S
E
R
T
A
S
R
Site 93
S810
G
K
A
G
A
P
S
S
E
R
T
A
S
R
V
Site 94
T813
G
A
P
S
S
E
R
T
A
S
R
V
R
E
L
Site 95
S815
P
S
S
E
R
T
A
S
R
V
R
E
L
A
R
Site 96
Y824
V
R
E
L
A
R
L
Y
S
E
R
I
Q
Q
M
Site 97
S825
R
E
L
A
R
L
Y
S
E
R
I
Q
Q
M
Q
Site 98
T836
Q
Q
M
Q
R
A
E
T
R
A
S
A
N
A
P
Site 99
S839
Q
R
A
E
T
R
A
S
A
N
A
P
R
R
R
Site 100
S856
V
L
A
Q
P
Q
P
S
P
C
L
P
Q
E
Q
Site 101
S906
V
Q
A
A
I
P
L
S
K
Q
G
G
S
P
D
Site 102
S911
P
L
S
K
Q
G
G
S
P
D
G
Q
G
L
H
Site 103
S920
D
G
Q
G
L
H
V
S
N
L
P
K
Q
D
L
Site 104
T953
H
V
Q
A
P
A
A
T
P
L
P
K
Q
E
G
Site 105
T971
L
Q
V
P
A
L
T
T
F
S
D
Q
G
H
P
Site 106
S973
V
P
A
L
T
T
F
S
D
Q
G
H
P
E
I
Site 107
T985
P
E
I
Q
V
P
A
T
T
P
L
P
E
H
K
Site 108
T986
E
I
Q
V
P
A
T
T
P
L
P
E
H
K
S
Site 109
S993
T
P
L
P
E
H
K
S
H
M
V
I
P
A
P
Site 110
T1019
A
D
I
H
V
P
T
T
P
A
L
P
K
E
I
Site 111
T1036
D
F
T
V
S
V
T
T
P
V
P
K
Q
E
G
Site 112
S1047
K
Q
E
G
H
L
D
S
E
S
P
T
N
I
P
Site 113
S1049
E
G
H
L
D
S
E
S
P
T
N
I
P
L
T
Site 114
T1051
H
L
D
S
E
S
P
T
N
I
P
L
T
K
Q
Site 115
T1056
S
P
T
N
I
P
L
T
K
Q
G
G
S
R
D
Site 116
S1061
P
L
T
K
Q
G
G
S
R
D
V
Q
G
P
D
Site 117
S1072
Q
G
P
D
P
V
C
S
Q
P
I
Q
P
L
S
Site 118
S1079
S
Q
P
I
Q
P
L
S
W
H
G
S
S
L
D
Site 119
S1083
Q
P
L
S
W
H
G
S
S
L
D
P
Q
G
P
Site 120
S1084
P
L
S
W
H
G
S
S
L
D
P
Q
G
P
G
Site 121
T1093
D
P
Q
G
P
G
D
T
L
P
P
L
P
C
H
Site 122
T1109
P
D
L
Q
I
P
G
T
S
P
L
P
A
H
G
Site 123
S1110
D
L
Q
I
P
G
T
S
P
L
P
A
H
G
S
Site 124
S1117
S
P
L
P
A
H
G
S
H
L
D
H
R
I
P
Site 125
S1130
I
P
A
N
A
P
L
S
L
S
Q
E
L
P
D
Site 126
S1132
A
N
A
P
L
S
L
S
Q
E
L
P
D
T
Q
Site 127
T1138
L
S
Q
E
L
P
D
T
Q
V
P
A
T
T
P
Site 128
T1144
D
T
Q
V
P
A
T
T
P
L
P
L
P
Q
V
Site 129
S1163
W
V
Q
A
L
P
T
S
P
K
Q
G
S
L
P
Site 130
S1168
P
T
S
P
K
Q
G
S
L
P
D
I
Q
G
P
Site 131
T1187
P
L
P
E
P
S
L
T
D
T
Q
V
Q
K
L
Site 132
T1189
P
E
P
S
L
T
D
T
Q
V
Q
K
L
T
P
Site 133
T1195
D
T
Q
V
Q
K
L
T
P
S
L
E
Q
K
S
Site 134
S1197
Q
V
Q
K
L
T
P
S
L
E
Q
K
S
L
I
Site 135
S1202
T
P
S
L
E
Q
K
S
L
I
D
A
H
V
P
Site 136
T1212
D
A
H
V
P
A
A
T
P
L
P
E
R
G
G
Site 137
S1220
P
L
P
E
R
G
G
S
L
D
I
Q
G
L
S
Site 138
S1227
S
L
D
I
Q
G
L
S
P
T
P
V
Q
T
T
Site 139
S1246
K
P
G
G
S
L
A
S
H
V
A
R
L
E
S
Site 140
S1253
S
H
V
A
R
L
E
S
S
D
L
T
P
P
H
Site 141
S1254
H
V
A
R
L
E
S
S
D
L
T
P
P
H
S
Site 142
T1257
R
L
E
S
S
D
L
T
P
P
H
S
P
P
P
Site 143
S1261
S
D
L
T
P
P
H
S
P
P
P
S
S
R
Q
Site 144
S1265
P
P
H
S
P
P
P
S
S
R
Q
L
L
G
P
Site 145
S1266
P
H
S
P
P
P
S
S
R
Q
L
L
G
P
N
Site 146
S1278
G
P
N
A
A
A
L
S
R
Y
L
A
A
S
Y
Site 147
Y1285
S
R
Y
L
A
A
S
Y
I
S
Q
S
L
A
R
Site 148
S1289
A
A
S
Y
I
S
Q
S
L
A
R
R
Q
G
P
Site 149
S1304
G
G
G
A
P
A
A
S
R
G
S
W
S
S
A
Site 150
S1307
A
P
A
A
S
R
G
S
W
S
S
A
P
T
S
Site 151
S1309
A
A
S
R
G
S
W
S
S
A
P
T
S
R
A
Site 152
S1310
A
S
R
G
S
W
S
S
A
P
T
S
R
A
S
Site 153
T1313
G
S
W
S
S
A
P
T
S
R
A
S
S
P
P
Site 154
S1314
S
W
S
S
A
P
T
S
R
A
S
S
P
P
P
Site 155
S1317
S
A
P
T
S
R
A
S
S
P
P
P
Q
P
Q
Site 156
S1318
A
P
T
S
R
A
S
S
P
P
P
Q
P
Q
P
Site 157
S1334
P
P
A
A
R
R
L
S
Y
A
T
T
V
N
I
Site 158
Y1335
P
A
A
R
R
L
S
Y
A
T
T
V
N
I
H
Site 159
T1337
A
R
R
L
S
Y
A
T
T
V
N
I
H
V
G
Site 160
T1338
R
R
L
S
Y
A
T
T
V
N
I
H
V
G
G
Site 161
S1370
L
L
A
S
T
Q
E
S
M
G
L
H
R
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation