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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTGES2
Full Name:
Prostaglandin E synthase 2
Alias:
EC 5.3.99.3; Microsomal prostaglandin E synthase 2; MPGES-2; PGES2
Type:
Enzyme - Isomerase. Catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form.
Mass (Da):
41943
Number AA:
377
UniProt ID:
Q9H7Z7
International Prot ID:
IPI00303568
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016021
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0009055
GO:0050220
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0045454
GO:0001516
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T32
R
P
Q
P
L
L
P
T
Q
S
R
A
G
F
A
Site 2
S34
Q
P
L
L
P
T
Q
S
R
A
G
F
A
G
A
Site 3
T75
G
A
L
G
L
Y
H
T
A
R
W
H
L
R
A
Site 4
S90
Q
D
L
H
A
E
R
S
A
A
Q
L
S
L
S
Site 5
S95
E
R
S
A
A
Q
L
S
L
S
S
R
L
Q
L
Site 6
T103
L
S
S
R
L
Q
L
T
L
Y
Q
Y
K
T
C
Site 7
Y105
S
R
L
Q
L
T
L
Y
Q
Y
K
T
C
P
F
Site 8
Y107
L
Q
L
T
L
Y
Q
Y
K
T
C
P
F
C
S
Site 9
T109
L
T
L
Y
Q
Y
K
T
C
P
F
C
S
K
V
Site 10
S143
R
R
A
E
I
K
F
S
S
Y
R
K
V
P
I
Site 11
S144
R
A
E
I
K
F
S
S
Y
R
K
V
P
I
L
Site 12
S159
V
A
Q
E
G
E
S
S
Q
Q
L
N
D
S
S
Site 13
S166
S
Q
Q
L
N
D
S
S
V
I
I
S
A
L
K
Site 14
T187
Q
P
L
E
E
I
I
T
Y
Y
P
A
M
K
A
Site 15
Y209
V
T
E
F
G
N
K
Y
W
L
M
L
N
E
K
Site 16
Y222
E
K
E
A
Q
Q
V
Y
G
G
K
E
A
R
T
Site 17
S247
D
W
L
V
H
L
I
S
P
N
V
Y
R
T
P
Site 18
Y251
H
L
I
S
P
N
V
Y
R
T
P
T
E
A
L
Site 19
T253
I
S
P
N
V
Y
R
T
P
T
E
A
L
A
S
Site 20
T255
P
N
V
Y
R
T
P
T
E
A
L
A
S
F
D
Site 21
S260
T
P
T
E
A
L
A
S
F
D
Y
I
V
R
E
Site 22
Y263
E
A
L
A
S
F
D
Y
I
V
R
E
G
K
F
Site 23
Y280
V
E
G
A
V
A
K
Y
M
G
A
A
A
M
Y
Site 24
S290
A
A
A
M
Y
L
I
S
K
R
L
K
S
R
H
Site 25
S295
L
I
S
K
R
L
K
S
R
H
R
L
Q
D
N
Site 26
Y308
D
N
V
R
E
D
L
Y
E
A
A
D
K
W
V
Site 27
Y363
H
T
H
I
Q
P
W
Y
L
R
V
E
R
A
I
Site 28
T371
L
R
V
E
R
A
I
T
E
A
S
P
A
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation