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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ECT2
Full Name:
Protein ECT2
Alias:
Epithelial cell transforming sequence 2 oncogene; Epithelial cell-transforming sequence 2 oncogene
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
100051
Number AA:
883
UniProt ID:
Q9H8V3
International Prot ID:
IPI00216448
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
E
N
S
V
L
T
S
T
T
G
R
T
S
L
Site 2
T10
E
N
S
V
L
T
S
T
T
G
R
T
S
L
A
Site 3
T11
N
S
V
L
T
S
T
T
G
R
T
S
L
A
D
Site 4
T14
L
T
S
T
T
G
R
T
S
L
A
D
S
S
I
Site 5
S15
T
S
T
T
G
R
T
S
L
A
D
S
S
I
F
Site 6
S19
G
R
T
S
L
A
D
S
S
I
F
D
S
K
V
Site 7
S20
R
T
S
L
A
D
S
S
I
F
D
S
K
V
T
Site 8
S24
A
D
S
S
I
F
D
S
K
V
T
E
I
S
K
Site 9
S30
D
S
K
V
T
E
I
S
K
E
N
L
L
I
G
Site 10
S40
N
L
L
I
G
S
T
S
Y
V
E
E
E
M
P
Site 11
Y41
L
L
I
G
S
T
S
Y
V
E
E
E
M
P
Q
Site 12
S90
E
E
F
E
G
L
D
S
P
E
F
E
N
V
F
Site 13
S105
V
V
T
D
F
Q
D
S
V
F
N
D
L
Y
K
Site 14
Y111
D
S
V
F
N
D
L
Y
K
A
D
C
R
V
I
Site 15
S127
P
P
V
V
L
N
C
S
Q
K
G
E
P
L
P
Site 16
S136
K
G
E
P
L
P
F
S
C
R
P
L
Y
C
T
Site 17
Y213
I
M
K
P
E
W
I
Y
K
A
W
E
R
R
N
Site 18
Y225
R
R
N
E
Q
D
F
Y
A
A
V
D
D
F
R
Site 19
S251
I
L
S
F
L
G
F
S
D
E
E
K
T
N
M
Site 20
Y269
T
E
M
Q
G
G
K
Y
L
P
L
G
D
E
R
Site 21
T278
P
L
G
D
E
R
C
T
H
L
V
V
E
E
N
Site 22
Y299
F
E
P
S
K
K
L
Y
V
V
K
Q
E
W
F
Site 23
Y321
A
R
A
G
E
T
M
Y
L
Y
E
K
A
N
T
Site 24
Y323
A
G
E
T
M
Y
L
Y
E
K
A
N
T
P
E
Site 25
T328
Y
L
Y
E
K
A
N
T
P
E
L
K
K
S
V
Site 26
S334
N
T
P
E
L
K
K
S
V
S
M
L
S
L
N
Site 27
S336
P
E
L
K
K
S
V
S
M
L
S
L
N
T
P
Site 28
S339
K
K
S
V
S
M
L
S
L
N
T
P
N
S
N
Site 29
T342
V
S
M
L
S
L
N
T
P
N
S
N
R
K
R
Site 30
S345
L
S
L
N
T
P
N
S
N
R
K
R
R
R
L
Site 31
T355
K
R
R
R
L
K
E
T
L
A
Q
L
S
R
E
Site 32
S360
K
E
T
L
A
Q
L
S
R
D
T
D
V
S
P
Site 33
T363
L
A
Q
L
S
R
E
T
D
V
S
P
F
P
P
Site 34
S366
L
S
R
E
T
D
V
S
P
F
P
P
R
K
R
Site 35
S375
F
P
P
R
K
R
P
S
A
E
H
S
L
S
I
Site 36
S379
K
R
P
S
A
E
H
S
L
S
I
G
S
L
L
Site 37
S384
E
H
S
L
S
I
G
S
L
L
D
I
S
N
T
Site 38
T391
S
L
L
D
I
S
N
T
P
E
S
S
I
N
Y
Site 39
S394
D
I
S
N
T
P
E
S
S
I
N
Y
G
D
T
Site 40
Y398
T
P
E
S
S
I
N
Y
G
D
T
P
K
S
C
Site 41
T401
S
S
I
N
Y
G
D
T
P
K
S
C
T
K
S
Site 42
S404
N
Y
G
D
T
P
K
S
C
T
K
S
S
K
S
Site 43
T406
G
D
T
P
K
S
C
T
K
S
S
K
S
S
T
Site 44
S408
T
P
K
S
C
T
K
S
S
K
S
S
T
P
V
Site 45
S409
P
K
S
C
T
K
S
S
K
S
S
T
P
V
P
Site 46
S411
S
C
T
K
S
S
K
S
S
T
P
V
P
S
K
Site 47
S412
C
T
K
S
S
K
S
S
T
P
V
P
S
K
Q
Site 48
T413
T
K
S
S
K
S
S
T
P
V
P
S
K
Q
S
Site 49
S417
K
S
S
T
P
V
P
S
K
Q
S
A
R
W
Q
Site 50
S420
T
P
V
P
S
K
Q
S
A
R
W
Q
V
A
K
Site 51
Y430
W
Q
V
A
K
E
L
Y
Q
T
E
S
N
Y
V
Site 52
T432
V
A
K
E
L
Y
Q
T
E
S
N
Y
V
N
I
Site 53
S500
V
N
W
D
E
S
K
S
I
G
D
I
F
L
K
Site 54
T515
Y
S
K
D
L
V
K
T
Y
P
P
F
V
N
F
Site 55
Y516
S
K
D
L
V
K
T
Y
P
P
F
V
N
F
F
Site 56
S557
K
P
E
C
G
R
Q
S
L
V
E
L
L
I
R
Site 57
S591
A
D
E
N
P
D
K
S
T
L
E
K
A
I
G
Site 58
T592
D
E
N
P
D
K
S
T
L
E
K
A
I
G
S
Site 59
T614
I
N
E
D
K
R
K
T
E
A
Q
K
Q
I
F
Site 60
S636
G
C
P
A
N
L
L
S
S
H
R
S
L
V
Q
Site 61
S637
C
P
A
N
L
L
S
S
H
R
S
L
V
Q
R
Site 62
S640
N
L
L
S
S
H
R
S
L
V
Q
R
V
E
T
Site 63
T647
S
L
V
Q
R
V
E
T
I
S
L
G
E
H
P
Site 64
S649
V
Q
R
V
E
T
I
S
L
G
E
H
P
C
D
Site 65
T662
C
D
R
G
E
Q
V
T
L
F
L
F
N
D
C
Site 66
T682
K
R
H
K
V
I
G
T
F
R
S
P
H
G
Q
Site 67
S685
K
V
I
G
T
F
R
S
P
H
G
Q
T
R
P
Site 68
S695
G
Q
T
R
P
P
A
S
L
K
H
I
H
L
M
Site 69
T716
K
V
L
D
I
R
E
T
E
D
C
H
N
A
F
Site 70
S739
E
Q
A
N
V
L
L
S
F
Q
M
T
S
D
E
Site 71
T743
V
L
L
S
F
Q
M
T
S
D
E
L
P
K
E
Site 72
T763
L
C
R
H
V
A
N
T
I
C
K
A
D
A
E
Site 73
Y774
A
D
A
E
N
L
I
Y
T
A
D
P
E
S
F
Site 74
T775
D
A
E
N
L
I
Y
T
A
D
P
E
S
F
E
Site 75
S780
I
Y
T
A
D
P
E
S
F
E
V
N
T
K
D
Site 76
S790
V
N
T
K
D
M
D
S
T
L
S
R
A
S
R
Site 77
T791
N
T
K
D
M
D
S
T
L
S
R
A
S
R
A
Site 78
S793
K
D
M
D
S
T
L
S
R
A
S
R
A
I
K
Site 79
S796
D
S
T
L
S
R
A
S
R
A
I
K
K
T
S
Site 80
T802
A
S
R
A
I
K
K
T
S
K
K
V
T
R
A
Site 81
S803
S
R
A
I
K
K
T
S
K
K
V
T
R
A
F
Site 82
T807
K
K
T
S
K
K
V
T
R
A
F
S
F
S
K
Site 83
S811
K
K
V
T
R
A
F
S
F
S
K
T
P
K
R
Site 84
S813
V
T
R
A
F
S
F
S
K
T
P
K
R
A
L
Site 85
T815
R
A
F
S
F
S
K
T
P
K
R
A
L
R
R
Site 86
T826
A
L
R
R
A
L
M
T
S
H
G
S
V
E
G
Site 87
S827
L
R
R
A
L
M
T
S
H
G
S
V
E
G
R
Site 88
S830
A
L
M
T
S
H
G
S
V
E
G
R
S
P
S
Site 89
S835
H
G
S
V
E
G
R
S
P
S
S
N
D
K
H
Site 90
S837
S
V
E
G
R
S
P
S
S
N
D
K
H
V
M
Site 91
S838
V
E
G
R
S
P
S
S
N
D
K
H
V
M
S
Site 92
S845
S
N
D
K
H
V
M
S
R
L
S
S
T
S
S
Site 93
S848
K
H
V
M
S
R
L
S
S
T
S
S
L
A
G
Site 94
S851
M
S
R
L
S
S
T
S
S
L
A
G
I
P
S
Site 95
S852
S
R
L
S
S
T
S
S
L
A
G
I
P
S
P
Site 96
S858
S
S
L
A
G
I
P
S
P
S
L
V
S
L
P
Site 97
S860
L
A
G
I
P
S
P
S
L
V
S
L
P
S
F
Site 98
S866
P
S
L
V
S
L
P
S
F
F
E
R
R
S
H
Site 99
S872
P
S
F
F
E
R
R
S
H
T
L
S
R
S
T
Site 100
T874
F
F
E
R
R
S
H
T
L
S
R
S
T
T
H
Site 101
S876
E
R
R
S
H
T
L
S
R
S
T
T
H
L
I
Site 102
S878
R
S
H
T
L
S
R
S
T
T
H
L
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation