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Updated November 2019
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Protein Info
Short Name:
MARCH-VII
Full Name:
E3 ubiquitin-protein ligase MARCH7
Alias:
AXO; AXOT; axotrophin; MARCH-VII; MARH7; membrane-associated ring finger (C3HC4) 7; membrane-associated RING-CH protein VII; RNF177
Type:
Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-
Mass (Da):
78051
Number AA:
704
UniProt ID:
Q9H992
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
S
K
P
S
R
I
P
R
R
I
S
Site 2
S13
S
R
I
P
R
R
I
S
V
Q
P
S
S
S
L
Site 3
S17
R
R
I
S
V
Q
P
S
S
S
L
S
A
R
M
Site 4
S18
R
I
S
V
Q
P
S
S
S
L
S
A
R
M
M
Site 5
S19
I
S
V
Q
P
S
S
S
L
S
A
R
M
M
S
Site 6
S21
V
Q
P
S
S
S
L
S
A
R
M
M
S
G
S
Site 7
S26
S
L
S
A
R
M
M
S
G
S
R
G
S
S
L
Site 8
S28
S
A
R
M
M
S
G
S
R
G
S
S
L
N
D
Site 9
S31
M
M
S
G
S
R
G
S
S
L
N
D
T
Y
H
Site 10
S32
M
S
G
S
R
G
S
S
L
N
D
T
Y
H
S
Site 11
T36
R
G
S
S
L
N
D
T
Y
H
S
R
D
S
S
Site 12
Y37
G
S
S
L
N
D
T
Y
H
S
R
D
S
S
F
Site 13
S39
S
L
N
D
T
Y
H
S
R
D
S
S
F
R
L
Site 14
S42
D
T
Y
H
S
R
D
S
S
F
R
L
D
S
E
Site 15
S43
T
Y
H
S
R
D
S
S
F
R
L
D
S
E
Y
Site 16
S48
D
S
S
F
R
L
D
S
E
Y
Q
S
T
S
A
Site 17
Y50
S
F
R
L
D
S
E
Y
Q
S
T
S
A
S
A
Site 18
S52
R
L
D
S
E
Y
Q
S
T
S
A
S
A
S
A
Site 19
T53
L
D
S
E
Y
Q
S
T
S
A
S
A
S
A
S
Site 20
S54
D
S
E
Y
Q
S
T
S
A
S
A
S
A
S
P
Site 21
S56
E
Y
Q
S
T
S
A
S
A
S
A
S
P
F
Q
Site 22
S58
Q
S
T
S
A
S
A
S
A
S
P
F
Q
S
A
Site 23
S60
T
S
A
S
A
S
A
S
P
F
Q
S
A
W
Y
Site 24
S64
A
S
A
S
P
F
Q
S
A
W
Y
S
E
S
E
Site 25
S68
P
F
Q
S
A
W
Y
S
E
S
E
I
T
Q
G
Site 26
S70
Q
S
A
W
Y
S
E
S
E
I
T
Q
G
A
R
Site 27
T73
W
Y
S
E
S
E
I
T
Q
G
A
R
S
R
S
Site 28
S80
T
Q
G
A
R
S
R
S
Q
N
Q
Q
R
D
H
Site 29
S89
N
Q
Q
R
D
H
D
S
K
R
P
K
L
S
C
Site 30
S95
D
S
K
R
P
K
L
S
C
T
N
C
T
T
S
Site 31
T97
K
R
P
K
L
S
C
T
N
C
T
T
S
A
G
Site 32
T113
N
V
G
N
G
L
N
T
L
S
D
S
S
W
R
Site 33
S115
G
N
G
L
N
T
L
S
D
S
S
W
R
H
S
Site 34
S117
G
L
N
T
L
S
D
S
S
W
R
H
S
Q
V
Site 35
S118
L
N
T
L
S
D
S
S
W
R
H
S
Q
V
P
Site 36
S122
S
D
S
S
W
R
H
S
Q
V
P
R
S
S
S
Site 37
S127
R
H
S
Q
V
P
R
S
S
S
M
V
L
G
S
Site 38
S128
H
S
Q
V
P
R
S
S
S
M
V
L
G
S
F
Site 39
S129
S
Q
V
P
R
S
S
S
M
V
L
G
S
F
G
Site 40
T150
R
R
D
L
E
R
R
T
D
S
S
I
S
N
L
Site 41
S152
D
L
E
R
R
T
D
S
S
I
S
N
L
M
D
Site 42
S153
L
E
R
R
T
D
S
S
I
S
N
L
M
D
Y
Site 43
Y160
S
I
S
N
L
M
D
Y
S
H
R
S
G
D
F
Site 44
S161
I
S
N
L
M
D
Y
S
H
R
S
G
D
F
T
Site 45
S164
L
M
D
Y
S
H
R
S
G
D
F
T
T
S
S
Site 46
T168
S
H
R
S
G
D
F
T
T
S
S
Y
V
Q
D
Site 47
S170
R
S
G
D
F
T
T
S
S
Y
V
Q
D
R
V
Site 48
S171
S
G
D
F
T
T
S
S
Y
V
Q
D
R
V
P
Site 49
Y172
G
D
F
T
T
S
S
Y
V
Q
D
R
V
P
S
Site 50
S179
Y
V
Q
D
R
V
P
S
Y
S
Q
G
A
R
P
Site 51
S181
Q
D
R
V
P
S
Y
S
Q
G
A
R
P
K
E
Site 52
S190
G
A
R
P
K
E
N
S
M
S
T
L
Q
L
N
Site 53
S192
R
P
K
E
N
S
M
S
T
L
Q
L
N
T
S
Site 54
S199
S
T
L
Q
L
N
T
S
S
T
N
H
Q
L
P
Site 55
T201
L
Q
L
N
T
S
S
T
N
H
Q
L
P
S
E
Site 56
T211
Q
L
P
S
E
H
Q
T
I
L
S
S
R
D
S
Site 57
S214
S
E
H
Q
T
I
L
S
S
R
D
S
R
N
S
Site 58
S215
E
H
Q
T
I
L
S
S
R
D
S
R
N
S
L
Site 59
S218
T
I
L
S
S
R
D
S
R
N
S
L
R
S
N
Site 60
S221
S
S
R
D
S
R
N
S
L
R
S
N
F
S
S
Site 61
S224
D
S
R
N
S
L
R
S
N
F
S
S
R
E
S
Site 62
S227
N
S
L
R
S
N
F
S
S
R
E
S
E
S
S
Site 63
S228
S
L
R
S
N
F
S
S
R
E
S
E
S
S
R
Site 64
S231
S
N
F
S
S
R
E
S
E
S
S
R
S
N
T
Site 65
S233
F
S
S
R
E
S
E
S
S
R
S
N
T
Q
P
Site 66
S234
S
S
R
E
S
E
S
S
R
S
N
T
Q
P
G
Site 67
S236
R
E
S
E
S
S
R
S
N
T
Q
P
G
F
S
Site 68
T238
S
E
S
S
R
S
N
T
Q
P
G
F
S
Y
S
Site 69
S243
S
N
T
Q
P
G
F
S
Y
S
S
S
R
D
E
Site 70
S245
T
Q
P
G
F
S
Y
S
S
S
R
D
E
A
P
Site 71
S246
Q
P
G
F
S
Y
S
S
S
R
D
E
A
P
I
Site 72
S247
P
G
F
S
Y
S
S
S
R
D
E
A
P
I
I
Site 73
S257
E
A
P
I
I
S
N
S
E
R
V
V
S
S
Q
Site 74
S262
S
N
S
E
R
V
V
S
S
Q
R
P
F
Q
E
Site 75
S263
N
S
E
R
V
V
S
S
Q
R
P
F
Q
E
S
Site 76
S270
S
Q
R
P
F
Q
E
S
S
D
N
E
G
R
R
Site 77
S271
Q
R
P
F
Q
E
S
S
D
N
E
G
R
R
T
Site 78
T278
S
D
N
E
G
R
R
T
T
R
R
L
L
S
R
Site 79
T279
D
N
E
G
R
R
T
T
R
R
L
L
S
R
I
Site 80
S284
R
T
T
R
R
L
L
S
R
I
A
S
S
M
S
Site 81
S291
S
R
I
A
S
S
M
S
S
T
F
F
S
R
R
Site 82
S292
R
I
A
S
S
M
S
S
T
F
F
S
R
R
S
Site 83
T293
I
A
S
S
M
S
S
T
F
F
S
R
R
S
S
Site 84
S296
S
M
S
S
T
F
F
S
R
R
S
S
Q
D
S
Site 85
S299
S
T
F
F
S
R
R
S
S
Q
D
S
L
N
T
Site 86
S300
T
F
F
S
R
R
S
S
Q
D
S
L
N
T
R
Site 87
S303
S
R
R
S
S
Q
D
S
L
N
T
R
S
L
N
Site 88
S308
Q
D
S
L
N
T
R
S
L
N
S
E
N
S
Y
Site 89
S311
L
N
T
R
S
L
N
S
E
N
S
Y
V
S
P
Site 90
S314
R
S
L
N
S
E
N
S
Y
V
S
P
R
I
L
Site 91
Y315
S
L
N
S
E
N
S
Y
V
S
P
R
I
L
T
Site 92
S317
N
S
E
N
S
Y
V
S
P
R
I
L
T
A
S
Site 93
T322
Y
V
S
P
R
I
L
T
A
S
Q
S
R
S
N
Site 94
S324
S
P
R
I
L
T
A
S
Q
S
R
S
N
V
P
Site 95
S326
R
I
L
T
A
S
Q
S
R
S
N
V
P
S
A
Site 96
S328
L
T
A
S
Q
S
R
S
N
V
P
S
A
S
E
Site 97
S332
Q
S
R
S
N
V
P
S
A
S
E
V
P
D
N
Site 98
S334
R
S
N
V
P
S
A
S
E
V
P
D
N
R
A
Site 99
S342
E
V
P
D
N
R
A
S
E
A
S
Q
G
F
R
Site 100
S345
D
N
R
A
S
E
A
S
Q
G
F
R
F
L
R
Site 101
S358
L
R
R
R
W
G
L
S
S
L
S
H
N
H
S
Site 102
S359
R
R
R
W
G
L
S
S
L
S
H
N
H
S
S
Site 103
S361
R
W
G
L
S
S
L
S
H
N
H
S
S
E
S
Site 104
S365
S
S
L
S
H
N
H
S
S
E
S
D
S
E
N
Site 105
S366
S
L
S
H
N
H
S
S
E
S
D
S
E
N
F
Site 106
S368
S
H
N
H
S
S
E
S
D
S
E
N
F
N
Q
Site 107
S370
N
H
S
S
E
S
D
S
E
N
F
N
Q
E
S
Site 108
T382
Q
E
S
E
G
R
N
T
G
P
W
L
S
S
S
Site 109
S387
R
N
T
G
P
W
L
S
S
S
L
R
N
R
C
Site 110
S389
T
G
P
W
L
S
S
S
L
R
N
R
C
T
P
Site 111
T395
S
S
L
R
N
R
C
T
P
L
F
S
R
R
R
Site 112
S399
N
R
C
T
P
L
F
S
R
R
R
R
E
G
R
Site 113
S409
R
R
E
G
R
D
E
S
S
R
I
P
T
S
D
Site 114
S410
R
E
G
R
D
E
S
S
R
I
P
T
S
D
T
Site 115
T414
D
E
S
S
R
I
P
T
S
D
T
S
S
R
S
Site 116
S415
E
S
S
R
I
P
T
S
D
T
S
S
R
S
H
Site 117
T417
S
R
I
P
T
S
D
T
S
S
R
S
H
I
F
Site 118
S418
R
I
P
T
S
D
T
S
S
R
S
H
I
F
R
Site 119
S419
I
P
T
S
D
T
S
S
R
S
H
I
F
R
R
Site 120
S428
S
H
I
F
R
R
E
S
N
E
V
V
H
L
E
Site 121
S451
A
A
N
R
P
Q
A
S
A
A
S
S
S
A
T
Site 122
S454
R
P
Q
A
S
A
A
S
S
S
A
T
T
G
G
Site 123
S455
P
Q
A
S
A
A
S
S
S
A
T
T
G
G
S
Site 124
S456
Q
A
S
A
A
S
S
S
A
T
T
G
G
S
T
Site 125
T458
S
A
A
S
S
S
A
T
T
G
G
S
T
S
D
Site 126
T459
A
A
S
S
S
A
T
T
G
G
S
T
S
D
S
Site 127
S462
S
S
A
T
T
G
G
S
T
S
D
S
A
Q
G
Site 128
S464
A
T
T
G
G
S
T
S
D
S
A
Q
G
G
R
Site 129
S466
T
G
G
S
T
S
D
S
A
Q
G
G
R
N
T
Site 130
T473
S
A
Q
G
G
R
N
T
G
I
S
G
I
L
P
Site 131
S513
I
I
P
S
G
W
N
S
A
D
G
K
S
D
K
Site 132
S518
W
N
S
A
D
G
K
S
D
K
T
K
S
A
P
Site 133
T521
A
D
G
K
S
D
K
T
K
S
A
P
S
R
D
Site 134
S523
G
K
S
D
K
T
K
S
A
P
S
R
D
P
E
Site 135
S526
D
K
T
K
S
A
P
S
R
D
P
E
R
L
Q
Site 136
S544
E
S
L
L
L
E
D
S
E
E
E
E
G
D
L
Site 137
Y578
K
C
T
G
S
L
Q
Y
V
H
Q
D
C
M
K
Site 138
T603
S
S
L
E
A
V
T
T
C
E
L
C
K
E
K
Site 139
Y634
H
A
N
E
Q
A
E
Y
E
F
I
S
S
G
L
Site 140
T661
F
S
D
M
M
G
N
T
N
E
P
S
T
R
V
Site 141
T666
G
N
T
N
E
P
S
T
R
V
R
F
I
N
L
Site 142
T686
A
H
M
E
D
L
E
T
S
E
D
D
S
E
E
Site 143
S687
H
M
E
D
L
E
T
S
E
D
D
S
E
E
D
Site 144
S691
L
E
T
S
E
D
D
S
E
E
D
G
D
H
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation