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Updated November 2019
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Protein Info
Short Name:
USP42
Full Name:
Ubiquitin carboxyl-terminal hydrolase 42
Alias:
Deubiquitinating enzyme 42; FLJ12697; UB42; Ubiquitin specific peptidase 42; Ubiquitin thiolesterase 42; Ubiquitin-specific processing protease 42; UBP42
Type:
EC 3.1.2.15; Protease
Mass (Da):
145548
Number AA:
1325
UniProt ID:
Q9H9J4
International Prot ID:
IPI00375124
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
T
I
V
D
K
A
S
E
S
S
D
P
S
A
Site 2
S10
I
V
D
K
A
S
E
S
S
D
P
S
A
Y
Q
Site 3
S14
A
S
E
S
S
D
P
S
A
Y
Q
N
Q
P
G
Site 4
Y16
E
S
S
D
P
S
A
Y
Q
N
Q
P
G
S
S
Site 5
S22
A
Y
Q
N
Q
P
G
S
S
E
A
V
S
P
G
Site 6
S23
Y
Q
N
Q
P
G
S
S
E
A
V
S
P
G
D
Site 7
S27
P
G
S
S
E
A
V
S
P
G
D
M
D
A
G
Site 8
S35
P
G
D
M
D
A
G
S
A
S
W
G
A
V
S
Site 9
S37
D
M
D
A
G
S
A
S
W
G
A
V
S
S
L
Site 10
S43
A
S
W
G
A
V
S
S
L
N
D
V
S
N
H
Site 11
S48
V
S
S
L
N
D
V
S
N
H
T
L
S
L
G
Site 12
T51
L
N
D
V
S
N
H
T
L
S
L
G
P
V
P
Site 13
S53
D
V
S
N
H
T
L
S
L
G
P
V
P
G
A
Site 14
S64
V
P
G
A
V
V
Y
S
S
S
S
V
P
D
K
Site 15
S65
P
G
A
V
V
Y
S
S
S
S
V
P
D
K
S
Site 16
S66
G
A
V
V
Y
S
S
S
S
V
P
D
K
S
K
Site 17
S67
A
V
V
Y
S
S
S
S
V
P
D
K
S
K
P
Site 18
S72
S
S
S
V
P
D
K
S
K
P
S
P
Q
K
D
Site 19
S75
V
P
D
K
S
K
P
S
P
Q
K
D
Q
A
L
Site 20
T106
I
C
L
K
W
Q
Q
T
H
R
V
G
A
G
L
Site 21
Y138
Y
T
P
P
L
A
N
Y
M
L
S
H
E
H
S
Site 22
S141
P
L
A
N
Y
M
L
S
H
E
H
S
K
T
C
Site 23
T147
L
S
H
E
H
S
K
T
C
H
A
E
G
F
C
Site 24
T164
C
T
M
Q
A
H
I
T
Q
A
L
S
N
P
G
Site 25
S168
A
H
I
T
Q
A
L
S
N
P
G
D
V
I
K
Site 26
Y204
D
A
H
E
F
L
Q
Y
T
V
D
A
M
Q
K
Site 27
T205
A
H
E
F
L
Q
Y
T
V
D
A
M
Q
K
A
Site 28
S217
Q
K
A
C
L
N
G
S
N
K
L
D
R
H
T
Site 29
T224
S
N
K
L
D
R
H
T
Q
A
T
T
L
V
C
Site 30
Y237
V
C
Q
I
F
G
G
Y
L
R
S
R
V
K
C
Site 31
T253
N
C
K
G
V
S
D
T
F
D
P
Y
L
D
I
Site 32
S288
E
Q
L
D
G
E
N
S
Y
K
C
S
K
C
K
Site 33
Y289
Q
L
D
G
E
N
S
Y
K
C
S
K
C
K
K
Site 34
T305
V
P
A
S
K
R
F
T
I
H
R
S
S
N
V
Site 35
S309
K
R
F
T
I
H
R
S
S
N
V
L
T
L
S
Site 36
T314
H
R
S
S
N
V
L
T
L
S
L
K
R
F
A
Site 37
T324
L
K
R
F
A
N
F
T
G
G
K
I
A
K
D
Site 38
Y334
K
I
A
K
D
V
K
Y
P
E
Y
L
D
I
R
Site 39
Y337
K
D
V
K
Y
P
E
Y
L
D
I
R
P
Y
M
Site 40
Y343
E
Y
L
D
I
R
P
Y
M
S
Q
P
N
G
E
Site 41
S345
L
D
I
R
P
Y
M
S
Q
P
N
G
E
P
I
Site 42
Y375
H
A
G
H
Y
F
C
Y
I
K
A
S
N
G
L
Site 43
Y384
K
A
S
N
G
L
W
Y
Q
M
N
D
S
I
V
Site 44
S392
Q
M
N
D
S
I
V
S
T
S
D
I
R
S
V
Site 45
S394
N
D
S
I
V
S
T
S
D
I
R
S
V
L
S
Site 46
S398
V
S
T
S
D
I
R
S
V
L
S
Q
Q
A
Y
Site 47
Y409
Q
Q
A
Y
V
L
F
Y
I
R
S
H
D
V
K
Site 48
T422
V
K
N
G
G
E
L
T
H
P
T
H
S
P
G
Site 49
T425
G
G
E
L
T
H
P
T
H
S
P
G
Q
S
S
Site 50
S427
E
L
T
H
P
T
H
S
P
G
Q
S
S
P
R
Site 51
S431
P
T
H
S
P
G
Q
S
S
P
R
P
V
I
S
Site 52
S432
T
H
S
P
G
Q
S
S
P
R
P
V
I
S
Q
Site 53
S438
S
S
P
R
P
V
I
S
Q
R
V
V
T
N
K
Site 54
T443
V
I
S
Q
R
V
V
T
N
K
Q
A
A
P
G
Site 55
T476
G
T
G
P
L
K
D
T
P
S
S
S
M
S
S
Site 56
S478
G
P
L
K
D
T
P
S
S
S
M
S
S
P
N
Site 57
S479
P
L
K
D
T
P
S
S
S
M
S
S
P
N
G
Site 58
S480
L
K
D
T
P
S
S
S
M
S
S
P
N
G
N
Site 59
S482
D
T
P
S
S
S
M
S
S
P
N
G
N
S
S
Site 60
S483
T
P
S
S
S
M
S
S
P
N
G
N
S
S
V
Site 61
S489
S
S
P
N
G
N
S
S
V
N
R
A
S
P
V
Site 62
S494
N
S
S
V
N
R
A
S
P
V
N
A
S
A
S
Site 63
S499
R
A
S
P
V
N
A
S
A
S
V
Q
N
W
S
Site 64
S501
S
P
V
N
A
S
A
S
V
Q
N
W
S
V
N
Site 65
S506
S
A
S
V
Q
N
W
S
V
N
R
S
S
V
I
Site 66
S510
Q
N
W
S
V
N
R
S
S
V
I
P
E
H
P
Site 67
S511
N
W
S
V
N
R
S
S
V
I
P
E
H
P
K
Site 68
S525
K
K
Q
K
I
T
I
S
I
H
N
K
L
P
V
Site 69
S537
L
P
V
R
Q
C
Q
S
Q
P
N
L
H
S
N
Site 70
S543
Q
S
Q
P
N
L
H
S
N
S
L
E
N
P
T
Site 71
S545
Q
P
N
L
H
S
N
S
L
E
N
P
T
K
P
Site 72
S556
P
T
K
P
V
P
S
S
T
I
T
N
S
A
V
Site 73
T557
T
K
P
V
P
S
S
T
I
T
N
S
A
V
Q
Site 74
T559
P
V
P
S
S
T
I
T
N
S
A
V
Q
S
T
Site 75
S561
P
S
S
T
I
T
N
S
A
V
Q
S
T
S
N
Site 76
S565
I
T
N
S
A
V
Q
S
T
S
N
A
S
T
M
Site 77
S567
N
S
A
V
Q
S
T
S
N
A
S
T
M
S
V
Site 78
S570
V
Q
S
T
S
N
A
S
T
M
S
V
S
S
K
Site 79
T571
Q
S
T
S
N
A
S
T
M
S
V
S
S
K
V
Site 80
S573
T
S
N
A
S
T
M
S
V
S
S
K
V
T
K
Site 81
S576
A
S
T
M
S
V
S
S
K
V
T
K
P
I
P
Site 82
S585
V
T
K
P
I
P
R
S
E
S
C
S
Q
P
V
Site 83
S587
K
P
I
P
R
S
E
S
C
S
Q
P
V
M
N
Site 84
S589
I
P
R
S
E
S
C
S
Q
P
V
M
N
G
K
Site 85
S597
Q
P
V
M
N
G
K
S
K
L
N
S
S
V
L
Site 86
S601
N
G
K
S
K
L
N
S
S
V
L
V
P
Y
G
Site 87
S602
G
K
S
K
L
N
S
S
V
L
V
P
Y
G
A
Site 88
Y607
N
S
S
V
L
V
P
Y
G
A
E
S
S
E
D
Site 89
S611
L
V
P
Y
G
A
E
S
S
E
D
S
D
E
E
Site 90
S612
V
P
Y
G
A
E
S
S
E
D
S
D
E
E
S
Site 91
S615
G
A
E
S
S
E
D
S
D
E
E
S
K
G
L
Site 92
S619
S
E
D
S
D
E
E
S
K
G
L
G
K
E
N
Site 93
T630
G
K
E
N
G
I
G
T
I
V
S
S
H
S
P
Site 94
S633
N
G
I
G
T
I
V
S
S
H
S
P
G
Q
D
Site 95
S634
G
I
G
T
I
V
S
S
H
S
P
G
Q
D
A
Site 96
S636
G
T
I
V
S
S
H
S
P
G
Q
D
A
E
D
Site 97
T647
D
A
E
D
E
E
A
T
P
H
E
L
Q
E
P
Site 98
T656
H
E
L
Q
E
P
M
T
L
N
G
A
N
S
A
Site 99
S662
M
T
L
N
G
A
N
S
A
D
S
D
S
D
P
Site 100
S665
N
G
A
N
S
A
D
S
D
S
D
P
K
E
N
Site 101
S667
A
N
S
A
D
S
D
S
D
P
K
E
N
G
L
Site 102
S680
G
L
A
P
D
G
A
S
C
Q
G
Q
P
A
L
Site 103
S689
Q
G
Q
P
A
L
H
S
E
N
P
F
A
K
A
Site 104
T719
P
E
D
K
I
L
E
T
F
R
L
S
N
K
L
Site 105
S723
I
L
E
T
F
R
L
S
N
K
L
K
G
S
T
Site 106
T730
S
N
K
L
K
G
S
T
D
E
M
S
A
P
G
Site 107
S734
K
G
S
T
D
E
M
S
A
P
G
A
E
R
G
Site 108
S754
D
A
E
P
Q
P
G
S
P
A
A
E
S
L
E
Site 109
S759
P
G
S
P
A
A
E
S
L
E
E
P
D
A
A
Site 110
S770
P
D
A
A
A
G
L
S
S
T
K
K
A
P
P
Site 111
T783
P
P
P
R
D
P
G
T
P
A
T
K
E
G
A
Site 112
S804
A
P
E
E
P
P
P
S
A
G
E
D
I
V
G
Site 113
T813
G
E
D
I
V
G
D
T
A
P
P
D
L
C
D
Site 114
S823
P
D
L
C
D
P
G
S
L
T
G
D
A
S
P
Site 115
T825
L
C
D
P
G
S
L
T
G
D
A
S
P
L
S
Site 116
S829
G
S
L
T
G
D
A
S
P
L
S
Q
D
A
K
Site 117
S832
T
G
D
A
S
P
L
S
Q
D
A
K
G
M
I
Site 118
S846
I
A
E
G
P
R
D
S
A
L
A
E
A
P
E
Site 119
S856
A
E
A
P
E
G
L
S
P
A
P
P
A
R
S
Site 120
S863
S
P
A
P
P
A
R
S
E
E
P
C
E
Q
P
Site 121
S876
Q
P
L
L
V
H
P
S
G
D
H
A
R
D
A
Site 122
S887
A
R
D
A
Q
D
P
S
Q
S
L
G
A
P
E
Site 123
S919
P
E
G
D
A
E
P
S
P
G
E
R
V
E
D
Site 124
S936
A
P
K
A
P
G
P
S
P
A
K
E
K
I
G
Site 125
S944
P
A
K
E
K
I
G
S
L
R
K
V
D
R
G
Site 126
Y953
R
K
V
D
R
G
H
Y
R
S
R
R
E
R
S
Site 127
S955
V
D
R
G
H
Y
R
S
R
R
E
R
S
S
S
Site 128
S960
Y
R
S
R
R
E
R
S
S
S
G
E
P
A
R
Site 129
S961
R
S
R
R
E
R
S
S
S
G
E
P
A
R
E
Site 130
S962
S
R
R
E
R
S
S
S
G
E
P
A
R
E
S
Site 131
S969
S
G
E
P
A
R
E
S
R
S
K
T
E
G
H
Site 132
S971
E
P
A
R
E
S
R
S
K
T
E
G
H
R
H
Site 133
T973
A
R
E
S
R
S
K
T
E
G
H
R
H
R
R
Site 134
T983
H
R
H
R
R
R
R
T
C
P
R
E
R
D
R
Site 135
S1007
P
G
H
G
D
R
L
S
P
G
E
R
R
S
L
Site 136
S1013
L
S
P
G
E
R
R
S
L
G
R
C
S
H
H
Site 137
S1018
R
R
S
L
G
R
C
S
H
H
H
S
R
H
R
Site 138
S1022
G
R
C
S
H
H
H
S
R
H
R
S
G
V
E
Site 139
S1026
H
H
H
S
R
H
R
S
G
V
E
L
D
W
V
Site 140
Y1037
L
D
W
V
R
H
H
Y
T
E
G
E
R
G
W
Site 141
Y1050
G
W
G
R
E
K
F
Y
P
D
R
P
R
W
D
Site 142
Y1061
P
R
W
D
R
C
R
Y
Y
H
D
R
Y
A
L
Site 143
Y1066
C
R
Y
Y
H
D
R
Y
A
L
Y
A
A
R
D
Site 144
Y1069
Y
H
D
R
Y
A
L
Y
A
A
R
D
W
K
P
Site 145
S1115
E
R
E
R
H
R
P
S
S
P
R
A
G
A
P
Site 146
S1116
R
E
R
H
R
P
S
S
P
R
A
G
A
P
H
Site 147
S1133
A
P
H
P
D
R
F
S
H
D
R
T
A
L
V
Site 148
T1137
D
R
F
S
H
D
R
T
A
L
V
A
G
D
N
Site 149
S1159
H
E
H
E
N
G
K
S
R
K
R
R
H
D
S
Site 150
S1166
S
R
K
R
R
H
D
S
V
E
N
S
D
S
H
Site 151
S1170
R
H
D
S
V
E
N
S
D
S
H
V
E
K
K
Site 152
S1172
D
S
V
E
N
S
D
S
H
V
E
K
K
A
R
Site 153
S1181
V
E
K
K
A
R
R
S
E
Q
K
D
P
L
E
Site 154
S1198
K
A
K
K
H
K
K
S
K
K
K
K
K
S
K
Site 155
S1204
K
S
K
K
K
K
K
S
K
D
K
H
R
D
R
Site 156
S1213
D
K
H
R
D
R
D
S
R
R
H
Q
Q
D
S
Site 157
S1220
S
R
R
H
Q
Q
D
S
D
L
S
A
A
C
S
Site 158
S1223
H
Q
Q
D
S
D
L
S
A
A
C
S
D
A
D
Site 159
S1227
S
D
L
S
A
A
C
S
D
A
D
L
H
R
H
Site 160
S1245
K
K
K
K
K
R
H
S
R
K
S
E
D
F
V
Site 161
S1248
K
K
R
H
S
R
K
S
E
D
F
V
K
D
S
Site 162
S1255
S
E
D
F
V
K
D
S
E
L
H
L
P
R
V
Site 163
T1263
E
L
H
L
P
R
V
T
S
L
E
T
V
A
Q
Site 164
T1267
P
R
V
T
S
L
E
T
V
A
Q
F
R
R
A
Site 165
S1281
A
Q
G
G
F
P
L
S
G
G
P
P
L
E
G
Site 166
T1296
V
G
P
F
R
E
K
T
K
H
L
R
M
E
S
Site 167
S1303
T
K
H
L
R
M
E
S
R
D
D
R
C
R
L
Site 168
Y1313
D
R
C
R
L
F
E
Y
G
Q
G
K
R
R
Y
Site 169
Y1320
Y
G
Q
G
K
R
R
Y
L
E
L
G
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation