KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LPHN3
Full Name:
Latrophilin-3
Alias:
Calcium-independent alpha-latrotoxin receptor 3; KIAA0768; LEC3; Lectomedin-3
Type:
Plasma membrane, Integral membrane protein
Mass (Da):
161812
Number AA:
1447
UniProt ID:
Q9HAR2
International Prot ID:
IPI00410310
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0005529
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
W
P
S
Q
L
L
I
F
M
M
Site 2
S21
A
P
I
I
H
A
F
S
R
A
P
I
P
M
A
Site 3
S35
A
V
V
R
R
E
L
S
C
E
S
Y
P
I
E
Site 4
S38
R
R
E
L
S
C
E
S
Y
P
I
E
L
R
C
Site 5
Y39
R
E
L
S
C
E
S
Y
P
I
E
L
R
C
P
Site 6
Y58
I
M
I
E
S
A
N
Y
G
R
T
D
D
K
I
Site 7
S68
T
D
D
K
I
C
D
S
D
P
A
Q
M
E
N
Site 8
Y79
Q
M
E
N
I
R
C
Y
L
P
D
A
Y
K
I
Site 9
Y84
R
C
Y
L
P
D
A
Y
K
I
M
S
Q
R
C
Site 10
T95
S
Q
R
C
N
N
R
T
Q
C
A
V
V
A
G
Site 11
Y116
P
C
P
G
T
Y
K
Y
L
E
V
Q
Y
E
C
Site 12
Y121
Y
K
Y
L
E
V
Q
Y
E
C
V
P
Y
K
V
Site 13
Y126
V
Q
Y
E
C
V
P
Y
K
V
E
Q
K
V
F
Site 14
Y143
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
Site 15
S145
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
Site 16
S151
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
Site 17
Y170
L
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
Site 18
Y171
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
Site 19
T181
W
T
P
Y
R
T
D
T
L
T
E
Y
S
S
K
Site 20
T183
P
Y
R
T
D
T
L
T
E
Y
S
S
K
D
D
Site 21
Y185
R
T
D
T
L
T
E
Y
S
S
K
D
D
F
I
Site 22
S187
D
T
L
T
E
Y
S
S
K
D
D
F
I
A
G
Site 23
T197
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
Site 24
T198
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
Site 25
Y200
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
Site 26
T209
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
Site 27
T235
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
Site 28
S239
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
Site 29
Y249
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
Site 30
Y255
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
Site 31
S261
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
Site 32
S288
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
Site 33
Y293
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
Site 34
T294
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
Site 35
T303
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
Site 36
Y305
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
Site 37
S311
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
Site 38
S325
G
I
L
Y
V
V
K
S
V
Y
E
D
D
D
N
Site 39
Y341
A
T
G
N
K
I
D
Y
I
Y
N
T
D
Q
S
Site 40
Y343
G
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
Site 41
T345
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
Site 42
S351
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
Site 43
Y363
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
Site 44
Y369
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Site 45
Y377
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
Site 46
Y387
N
N
Y
H
V
V
K
Y
S
L
D
F
G
P
L
Site 47
S388
N
Y
H
V
V
K
Y
S
L
D
F
G
P
L
D
Site 48
S396
L
D
F
G
P
L
D
S
R
S
G
Q
A
H
H
Site 49
S398
F
G
P
L
D
S
R
S
G
Q
A
H
H
G
Q
Site 50
S407
Q
A
H
H
G
Q
V
S
Y
I
S
P
P
I
H
Site 51
Y408
A
H
H
G
Q
V
S
Y
I
S
P
P
I
H
L
Site 52
S410
H
G
Q
V
S
Y
I
S
P
P
I
H
L
D
S
Site 53
S417
S
P
P
I
H
L
D
S
E
L
E
R
P
S
V
Site 54
S423
D
S
E
L
E
R
P
S
V
K
D
I
S
T
T
Site 55
S428
R
P
S
V
K
D
I
S
T
T
G
P
L
G
M
Site 56
T429
P
S
V
K
D
I
S
T
T
G
P
L
G
M
G
Site 57
S437
T
G
P
L
G
M
G
S
T
T
T
S
T
T
L
Site 58
T438
G
P
L
G
M
G
S
T
T
T
S
T
T
L
R
Site 59
S441
G
M
G
S
T
T
T
S
T
T
L
R
T
T
T
Site 60
T443
G
S
T
T
T
S
T
T
L
R
T
T
T
L
S
Site 61
T446
T
T
S
T
T
L
R
T
T
T
L
S
P
G
R
Site 62
T447
T
S
T
T
L
R
T
T
T
L
S
P
G
R
S
Site 63
T448
S
T
T
L
R
T
T
T
L
S
P
G
R
S
T
Site 64
S450
T
L
R
T
T
T
L
S
P
G
R
S
T
T
P
Site 65
S454
T
T
L
S
P
G
R
S
T
T
P
S
V
S
G
Site 66
T455
T
L
S
P
G
R
S
T
T
P
S
V
S
G
R
Site 67
T456
L
S
P
G
R
S
T
T
P
S
V
S
G
R
R
Site 68
S458
P
G
R
S
T
T
P
S
V
S
G
R
R
N
R
Site 69
S460
R
S
T
T
P
S
V
S
G
R
R
N
R
S
T
Site 70
S466
V
S
G
R
R
N
R
S
T
S
T
P
S
P
A
Site 71
T467
S
G
R
R
N
R
S
T
S
T
P
S
P
A
V
Site 72
S468
G
R
R
N
R
S
T
S
T
P
S
P
A
V
E
Site 73
T469
R
R
N
R
S
T
S
T
P
S
P
A
V
E
V
Site 74
S471
N
R
S
T
S
T
P
S
P
A
V
E
V
L
D
Site 75
T481
V
E
V
L
D
D
M
T
T
H
L
P
S
A
S
Site 76
T482
E
V
L
D
D
M
T
T
H
L
P
S
A
S
S
Site 77
S486
D
M
T
T
H
L
P
S
A
S
S
Q
I
P
A
Site 78
S489
T
H
L
P
S
A
S
S
Q
I
P
A
L
E
E
Site 79
S497
Q
I
P
A
L
E
E
S
C
E
A
V
E
A
R
Site 80
S548
D
P
Q
G
P
D
L
S
N
C
S
S
P
W
V
Site 81
S552
P
D
L
S
N
C
S
S
P
W
V
N
H
I
T
Site 82
T559
S
P
W
V
N
H
I
T
Q
K
L
K
S
G
E
Site 83
S564
H
I
T
Q
K
L
K
S
G
E
T
A
A
N
I
Site 84
T589
H
L
N
A
G
D
I
T
Y
S
V
R
A
M
D
Site 85
Y590
L
N
A
G
D
I
T
Y
S
V
R
A
M
D
Q
Site 86
S591
N
A
G
D
I
T
Y
S
V
R
A
M
D
Q
L
Site 87
T610
D
V
Q
L
R
N
L
T
P
G
G
K
D
S
A
Site 88
S616
L
T
P
G
G
K
D
S
A
A
R
S
L
N
K
Site 89
S620
G
K
D
S
A
A
R
S
L
N
K
A
M
V
E
Site 90
T645
L
N
A
W
R
D
L
T
T
S
D
Q
L
R
A
Site 91
S647
A
W
R
D
L
T
T
S
D
Q
L
R
A
A
T
Site 92
T654
S
D
Q
L
R
A
A
T
M
L
L
H
T
V
E
Site 93
T674
L
A
D
N
L
L
K
T
D
I
V
R
E
N
T
Site 94
T681
T
D
I
V
R
E
N
T
D
N
I
K
L
E
V
Site 95
S692
K
L
E
V
A
R
L
S
T
E
G
N
L
E
D
Site 96
T693
L
E
V
A
R
L
S
T
E
G
N
L
E
D
L
Site 97
S710
P
E
N
M
G
H
G
S
T
I
Q
L
S
A
N
Site 98
Y741
L
Y
N
N
L
G
P
Y
L
S
T
E
N
A
S
Site 99
S743
N
N
L
G
P
Y
L
S
T
E
N
A
S
M
K
Site 100
T814
F
W
S
Y
S
K
R
T
M
T
G
Y
W
S
T
Site 101
T816
S
Y
S
K
R
T
M
T
G
Y
W
S
T
Q
G
Site 102
Y818
S
K
R
T
M
T
G
Y
W
S
T
Q
G
C
R
Site 103
T821
T
M
T
G
Y
W
S
T
Q
G
C
R
L
L
T
Site 104
T828
T
Q
G
C
R
L
L
T
T
N
K
T
H
T
T
Site 105
T832
R
L
L
T
T
N
K
T
H
T
T
C
S
C
N
Site 106
T834
L
T
T
N
K
T
H
T
T
C
S
C
N
H
L
Site 107
S856
A
H
V
E
V
K
H
S
D
A
V
H
D
L
L
Site 108
T898
G
L
Q
S
D
R
N
T
I
H
K
N
L
C
I
Site 109
S962
M
L
V
E
V
F
E
S
E
H
S
R
R
K
Y
Site 110
S965
E
V
F
E
S
E
H
S
R
R
K
Y
F
Y
L
Site 111
Y969
S
E
H
S
R
R
K
Y
F
Y
L
V
G
Y
G
Site 112
Y971
H
S
R
R
K
Y
F
Y
L
V
G
Y
G
M
P
Site 113
Y990
A
V
S
A
A
V
D
Y
R
S
Y
G
T
D
K
Site 114
S992
S
A
A
V
D
Y
R
S
Y
G
T
D
K
V
C
Site 115
Y993
A
A
V
D
Y
R
S
Y
G
T
D
K
V
C
W
Site 116
S1044
T
A
I
L
K
P
E
S
G
C
L
D
N
I
K
Site 117
Y1112
Q
K
K
V
R
K
E
Y
G
K
C
L
R
T
H
Site 118
T1118
E
Y
G
K
C
L
R
T
H
C
C
S
G
K
S
Site 119
S1122
C
L
R
T
H
C
C
S
G
K
S
T
E
S
S
Site 120
S1125
T
H
C
C
S
G
K
S
T
E
S
S
I
G
S
Site 121
T1126
H
C
C
S
G
K
S
T
E
S
S
I
G
S
G
Site 122
S1128
C
S
G
K
S
T
E
S
S
I
G
S
G
K
T
Site 123
S1129
S
G
K
S
T
E
S
S
I
G
S
G
K
T
S
Site 124
S1132
S
T
E
S
S
I
G
S
G
K
T
S
G
S
R
Site 125
S1136
S
I
G
S
G
K
T
S
G
S
R
T
P
G
R
Site 126
S1138
G
S
G
K
T
S
G
S
R
T
P
G
R
Y
S
Site 127
T1140
G
K
T
S
G
S
R
T
P
G
R
Y
S
T
G
Site 128
Y1144
G
S
R
T
P
G
R
Y
S
T
G
S
Q
S
R
Site 129
S1145
S
R
T
P
G
R
Y
S
T
G
S
Q
S
R
I
Site 130
T1146
R
T
P
G
R
Y
S
T
G
S
Q
S
R
I
R
Site 131
S1148
P
G
R
Y
S
T
G
S
Q
S
R
I
R
R
M
Site 132
S1150
R
Y
S
T
G
S
Q
S
R
I
R
R
M
W
N
Site 133
T1159
I
R
R
M
W
N
D
T
V
R
K
Q
S
E
S
Site 134
S1164
N
D
T
V
R
K
Q
S
E
S
S
F
I
T
G
Site 135
S1166
T
V
R
K
Q
S
E
S
S
F
I
T
G
D
I
Site 136
S1167
V
R
K
Q
S
E
S
S
F
I
T
G
D
I
N
Site 137
T1170
Q
S
E
S
S
F
I
T
G
D
I
N
S
S
A
Site 138
S1175
F
I
T
G
D
I
N
S
S
A
S
L
N
R
E
Site 139
S1176
I
T
G
D
I
N
S
S
A
S
L
N
R
E
G
Site 140
S1178
G
D
I
N
S
S
A
S
L
N
R
E
G
L
L
Site 141
T1191
L
L
N
N
A
R
D
T
S
V
M
D
T
L
P
Site 142
S1192
L
N
N
A
R
D
T
S
V
M
D
T
L
P
L
Site 143
T1196
R
D
T
S
V
M
D
T
L
P
L
N
G
N
H
Site 144
Y1207
N
G
N
H
G
N
S
Y
S
I
A
S
G
E
Y
Site 145
S1208
G
N
H
G
N
S
Y
S
I
A
S
G
E
Y
L
Site 146
S1211
G
N
S
Y
S
I
A
S
G
E
Y
L
S
N
C
Site 147
Y1226
V
Q
I
I
D
R
G
Y
N
H
N
E
T
A
L
Site 148
T1242
K
K
I
L
K
E
L
T
S
N
Y
I
P
S
Y
Site 149
S1243
K
I
L
K
E
L
T
S
N
Y
I
P
S
Y
L
Site 150
Y1245
L
K
E
L
T
S
N
Y
I
P
S
Y
L
N
N
Site 151
Y1249
T
S
N
Y
I
P
S
Y
L
N
N
H
E
R
S
Site 152
S1257
L
N
N
H
E
R
S
S
E
Q
N
R
N
L
M
Site 153
S1273
K
L
V
N
N
L
G
S
G
R
E
D
D
A
I
Site 154
T1286
A
I
V
L
D
D
A
T
S
F
N
H
E
E
S
Site 155
S1287
I
V
L
D
D
A
T
S
F
N
H
E
E
S
L
Site 156
S1293
T
S
F
N
H
E
E
S
L
G
L
E
L
I
H
Site 157
S1303
L
E
L
I
H
E
E
S
D
A
P
L
L
P
P
Site 158
Y1313
P
L
L
P
P
R
V
Y
S
T
E
N
H
Q
P
Site 159
S1314
L
L
P
P
R
V
Y
S
T
E
N
H
Q
P
H
Site 160
T1315
L
P
P
R
V
Y
S
T
E
N
H
Q
P
H
H
Site 161
Y1323
E
N
H
Q
P
H
H
Y
T
R
R
R
I
P
Q
Site 162
S1333
R
R
I
P
Q
D
H
S
E
S
F
F
P
L
L
Site 163
S1335
I
P
Q
D
H
S
E
S
F
F
P
L
L
T
N
Site 164
T1345
P
L
L
T
N
E
H
T
E
D
L
Q
S
P
H
Site 165
S1350
E
H
T
E
D
L
Q
S
P
H
R
D
S
L
Y
Site 166
S1355
L
Q
S
P
H
R
D
S
L
Y
T
S
M
P
T
Site 167
Y1357
S
P
H
R
D
S
L
Y
T
S
M
P
T
L
A
Site 168
T1358
P
H
R
D
S
L
Y
T
S
M
P
T
L
A
G
Site 169
S1359
H
R
D
S
L
Y
T
S
M
P
T
L
A
G
V
Site 170
S1371
A
G
V
A
A
T
E
S
V
T
T
S
T
Q
T
Site 171
S1375
A
T
E
S
V
T
T
S
T
Q
T
E
P
P
P
Site 172
Y1392
C
G
D
A
E
D
V
Y
Y
K
S
M
P
N
L
Site 173
Y1393
G
D
A
E
D
V
Y
Y
K
S
M
P
N
L
G
Site 174
S1395
A
E
D
V
Y
Y
K
S
M
P
N
L
G
S
R
Site 175
Y1411
H
V
H
Q
L
H
T
Y
Y
Q
L
G
R
G
S
Site 176
Y1412
V
H
Q
L
H
T
Y
Y
Q
L
G
R
G
S
S
Site 177
S1418
Y
Y
Q
L
G
R
G
S
S
D
G
F
I
V
P
Site 178
S1419
Y
Q
L
G
R
G
S
S
D
G
F
I
V
P
P
Site 179
T1431
V
P
P
N
K
D
G
T
P
P
E
G
S
S
K
Site 180
S1436
D
G
T
P
P
E
G
S
S
K
G
P
A
H
L
Site 181
T1445
K
G
P
A
H
L
V
T
S
L
Site 182
S1446
G
P
A
H
L
V
T
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation