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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIAE
Full Name:
Sialate O-acetylesterase
Alias:
H-Lse;Sialic acid-specific 9-O-acetylesterase
Type:
Mass (Da):
58315
Number AA:
523
UniProt ID:
Q9HAT2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T58
G
T
P
G
A
T
V
T
V
T
L
R
Q
G
Q
Site 2
T60
P
G
A
T
V
T
V
T
L
R
Q
G
Q
E
T
Site 3
T67
T
L
R
Q
G
Q
E
T
I
M
K
K
V
T
S
Site 4
S74
T
I
M
K
K
V
T
S
V
K
A
H
S
D
T
Site 5
S79
V
T
S
V
K
A
H
S
D
T
W
M
V
V
L
Site 6
T81
S
V
K
A
H
S
D
T
W
M
V
V
L
D
P
Site 7
T102
F
E
V
M
A
Q
Q
T
L
E
K
I
N
F
T
Site 8
S144
F
N
A
T
R
E
L
S
N
T
A
A
Y
Q
S
Site 9
T146
A
T
R
E
L
S
N
T
A
A
Y
Q
S
V
R
Site 10
Y149
E
L
S
N
T
A
A
Y
Q
S
V
R
I
L
S
Site 11
S151
S
N
T
A
A
Y
Q
S
V
R
I
L
S
V
S
Site 12
S156
Y
Q
S
V
R
I
L
S
V
S
P
I
Q
A
E
Site 13
S158
S
V
R
I
L
S
V
S
P
I
Q
A
E
Q
E
Site 14
S177
V
A
V
D
L
Q
W
S
K
P
T
S
E
N
L
Site 15
S181
L
Q
W
S
K
P
T
S
E
N
L
G
H
G
Y
Site 16
Y188
S
E
N
L
G
H
G
Y
F
K
Y
M
S
A
V
Site 17
Y204
W
L
F
G
R
H
L
Y
D
T
L
Q
Y
P
I
Site 18
T206
F
G
R
H
L
Y
D
T
L
Q
Y
P
I
G
L
Site 19
T221
I
A
S
S
W
G
G
T
P
I
E
A
W
S
S
Site 20
S227
G
T
P
I
E
A
W
S
S
G
R
S
L
K
A
Site 21
S228
T
P
I
E
A
W
S
S
G
R
S
L
K
A
C
Site 22
S231
E
A
W
S
S
G
R
S
L
K
A
C
G
V
P
Site 23
S242
C
G
V
P
K
Q
G
S
I
P
Y
D
S
V
T
Site 24
Y245
P
K
Q
G
S
I
P
Y
D
S
V
T
G
P
S
Site 25
S247
Q
G
S
I
P
Y
D
S
V
T
G
P
S
K
H
Site 26
T249
S
I
P
Y
D
S
V
T
G
P
S
K
H
S
V
Site 27
S252
Y
D
S
V
T
G
P
S
K
H
S
V
L
W
N
Site 28
Y284
Q
G
E
S
N
I
N
Y
N
T
D
L
Y
N
C
Site 29
Y289
I
N
Y
N
T
D
L
Y
N
C
T
F
P
A
L
Site 30
T292
N
T
D
L
Y
N
C
T
F
P
A
L
I
E
D
Site 31
T303
L
I
E
D
W
R
E
T
F
H
R
G
S
Q
G
Site 32
S308
R
E
T
F
H
R
G
S
Q
G
Q
T
E
R
F
Site 33
T312
H
R
G
S
Q
G
Q
T
E
R
F
F
P
F
G
Site 34
S324
P
F
G
L
V
Q
L
S
S
D
L
S
K
K
S
Site 35
S325
F
G
L
V
Q
L
S
S
D
L
S
K
K
S
S
Site 36
S328
V
Q
L
S
S
D
L
S
K
K
S
S
D
D
G
Site 37
S331
S
S
D
L
S
K
K
S
S
D
D
G
F
P
Q
Site 38
S332
S
D
L
S
K
K
S
S
D
D
G
F
P
Q
I
Site 39
Y349
H
Q
T
A
D
F
G
Y
V
P
N
P
K
M
P
Site 40
S371
M
D
L
C
D
R
D
S
P
F
G
S
I
H
P
Site 41
S375
D
R
D
S
P
F
G
S
I
H
P
R
D
K
Q
Site 42
T383
I
H
P
R
D
K
Q
T
V
A
Y
R
L
H
L
Site 43
T403
A
Y
G
E
K
N
L
T
F
E
G
P
L
P
E
Site 44
Y425
K
G
L
L
N
L
T
Y
Y
Q
Q
I
Q
V
Q
Site 45
Y426
G
L
L
N
L
T
Y
Y
Q
Q
I
Q
V
Q
K
Site 46
T458
W
L
P
A
S
M
N
T
V
S
T
Q
S
L
T
Site 47
Y495
E
Y
K
Q
C
P
L
Y
H
P
S
S
A
L
P
Site 48
T511
P
P
F
I
A
F
I
T
D
Q
G
P
G
H
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation