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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UPF2
Full Name:
Regulator of nonsense transcripts 2
Alias:
DKFZP434D222; KIAA1408; Nonsense mRNA reducing factor 2; RENT2; Smg-3; UPF2 regulator of nonsense transcripts
Type:
RNA binding protein
Mass (Da):
147810
Number AA:
1272
UniProt ID:
Q9HAU5
International Prot ID:
IPI00300504
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0000184
GO:0000956
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
E
R
K
K
P
A
S
M
E
E
K
D
S
L
Site 2
S16
A
S
M
E
E
K
D
S
L
P
N
N
K
E
K
Site 3
S26
N
N
K
E
K
D
C
S
E
R
R
T
V
S
S
Site 4
T30
K
D
C
S
E
R
R
T
V
S
S
K
E
R
P
Site 5
S32
C
S
E
R
R
T
V
S
S
K
E
R
P
K
D
Site 6
S33
S
E
R
R
T
V
S
S
K
E
R
P
K
D
D
Site 7
T44
P
K
D
D
I
K
L
T
A
K
K
E
V
S
K
Site 8
S127
Q
M
K
E
K
E
E
S
I
Q
L
H
Q
E
A
Site 9
S146
H
L
R
K
E
L
R
S
K
N
Q
N
A
P
D
Site 10
S154
K
N
Q
N
A
P
D
S
R
P
E
E
N
F
F
Site 11
S162
R
P
E
E
N
F
F
S
R
L
D
S
S
L
K
Site 12
S166
N
F
F
S
R
L
D
S
S
L
K
K
N
T
A
Site 13
S167
F
F
S
R
L
D
S
S
L
K
K
N
T
A
F
Site 14
T180
A
F
V
K
K
L
K
T
I
T
E
Q
Q
R
D
Site 15
S188
I
T
E
Q
Q
R
D
S
L
S
H
D
F
N
G
Site 16
S190
E
Q
Q
R
D
S
L
S
H
D
F
N
G
L
N
Site 17
Y233
C
S
L
F
H
Q
R
Y
A
D
F
A
P
S
L
Site 18
S239
R
Y
A
D
F
A
P
S
L
L
Q
V
W
K
K
Site 19
T256
E
A
R
K
E
E
K
T
P
N
I
T
K
L
R
Site 20
S301
I
I
N
A
D
R
E
S
H
T
H
V
S
V
V
Site 21
S306
R
E
S
H
T
H
V
S
V
V
I
S
F
C
R
Site 22
S329
L
V
P
R
K
V
K
S
A
A
E
K
F
N
L
Site 23
S341
F
N
L
S
F
P
P
S
E
I
I
S
P
E
K
Site 24
S345
F
P
P
S
E
I
I
S
P
E
K
Q
Q
P
F
Site 25
Y359
F
Q
N
L
L
K
E
Y
F
T
S
L
T
K
H
Site 26
S362
L
L
K
E
Y
F
T
S
L
T
K
H
L
K
R
Site 27
T377
D
H
R
E
L
Q
N
T
E
R
Q
N
R
R
I
Site 28
S387
Q
N
R
R
I
L
H
S
K
G
E
L
S
E
D
Site 29
S392
L
H
S
K
G
E
L
S
E
D
R
H
K
Q
Y
Site 30
Y399
S
E
D
R
H
K
Q
Y
E
E
F
A
M
S
Y
Site 31
S405
Q
Y
E
E
F
A
M
S
Y
Q
K
L
L
A
N
Site 32
S415
K
L
L
A
N
S
Q
S
L
A
D
L
L
D
E
Site 33
T433
D
L
P
Q
D
K
P
T
P
E
E
H
G
P
G
Site 34
T445
G
P
G
I
D
I
F
T
P
G
K
P
G
E
Y
Site 35
Y452
T
P
G
K
P
G
E
Y
D
L
E
G
G
I
W
Site 36
Y468
D
E
D
A
R
N
F
Y
E
N
L
I
D
L
K
Site 37
S489
L
F
K
D
N
E
K
S
C
Q
N
K
E
S
N
Site 38
T500
K
E
S
N
K
D
D
T
K
E
A
K
E
S
K
Site 39
S506
D
T
K
E
A
K
E
S
K
E
N
K
E
V
S
Site 40
S514
K
E
N
K
E
V
S
S
P
D
D
L
E
L
E
Site 41
T531
N
L
E
I
N
D
D
T
L
E
L
E
G
G
D
Site 42
T560
Q
E
D
E
E
A
S
T
G
S
H
L
K
L
I
Site 43
T597
D
F
C
M
N
M
N
T
K
A
N
R
K
K
L
Site 44
S642
D
V
A
E
D
L
C
S
M
L
R
G
D
F
R
Site 45
T666
N
I
E
T
K
N
K
T
V
R
F
I
G
E
L
Site 46
S717
C
G
R
F
L
F
R
S
P
E
S
H
L
R
T
Site 47
S720
F
L
F
R
S
P
E
S
H
L
R
T
S
V
L
Site 48
T724
S
P
E
S
H
L
R
T
S
V
L
L
E
Q
M
Site 49
S725
P
E
S
H
L
R
T
S
V
L
L
E
Q
M
M
Site 50
Y744
A
M
H
L
D
A
R
Y
V
T
M
V
E
N
A
Site 51
T746
H
L
D
A
R
Y
V
T
M
V
E
N
A
Y
Y
Site 52
Y752
V
T
M
V
E
N
A
Y
Y
Y
C
N
P
P
P
Site 53
Y753
T
M
V
E
N
A
Y
Y
Y
C
N
P
P
P
A
Site 54
Y754
M
V
E
N
A
Y
Y
Y
C
N
P
P
P
A
E
Site 55
T763
N
P
P
P
A
E
K
T
V
K
K
K
R
P
P
Site 56
Y774
K
R
P
P
L
Q
E
Y
V
R
K
L
L
Y
K
Site 57
Y780
E
Y
V
R
K
L
L
Y
K
D
L
S
K
V
T
Site 58
S784
K
L
L
Y
K
D
L
S
K
V
T
T
E
K
V
Site 59
T788
K
D
L
S
K
V
T
T
E
K
V
L
R
Q
M
Site 60
Y808
Q
D
Q
E
V
K
D
Y
V
I
C
C
M
I
N
Site 61
S870
K
F
N
Q
R
R
I
S
S
A
K
F
L
G
E
Site 62
S871
F
N
Q
R
R
I
S
S
A
K
F
L
G
E
L
Site 63
Y879
A
K
F
L
G
E
L
Y
N
Y
R
M
V
E
S
Site 64
S898
R
T
L
Y
S
F
T
S
F
G
V
N
P
D
G
Site 65
S906
F
G
V
N
P
D
G
S
P
S
S
L
D
P
P
Site 66
S908
V
N
P
D
G
S
P
S
S
L
D
P
P
E
H
Site 67
S909
N
P
D
G
S
P
S
S
L
D
P
P
E
H
L
Site 68
Y932
I
L
D
T
C
G
Q
Y
F
D
R
G
S
S
K
Site 69
S937
G
Q
Y
F
D
R
G
S
S
K
R
K
L
D
C
Site 70
S938
Q
Y
F
D
R
G
S
S
K
R
K
L
D
C
F
Site 71
Y952
F
L
V
Y
F
Q
R
Y
V
W
W
K
K
S
L
Site 72
Y974
P
F
P
I
D
I
D
Y
M
I
S
D
T
L
E
Site 73
T979
I
D
Y
M
I
S
D
T
L
E
L
L
R
P
K
Site 74
S992
P
K
I
K
L
C
N
S
L
E
E
S
I
R
Q
Site 75
S996
L
C
N
S
L
E
E
S
I
R
Q
V
Q
D
L
Site 76
S1019
G
L
V
N
D
K
D
S
K
D
S
M
T
E
G
Site 77
S1022
N
D
K
D
S
K
D
S
M
T
E
G
E
N
L
Site 78
S1046
G
A
E
T
E
E
Q
S
G
N
E
S
E
V
N
Site 79
S1050
E
E
Q
S
G
N
E
S
E
V
N
E
P
E
E
Site 80
S1061
E
P
E
E
E
E
G
S
D
N
D
D
D
E
G
Site 81
T1076
E
E
E
E
E
E
N
T
D
Y
L
T
D
S
N
Site 82
Y1078
E
E
E
E
N
T
D
Y
L
T
D
S
N
K
E
Site 83
T1080
E
E
N
T
D
Y
L
T
D
S
N
K
E
N
E
Site 84
S1082
N
T
D
Y
L
T
D
S
N
K
E
N
E
T
D
Site 85
T1088
D
S
N
K
E
N
E
T
D
E
E
N
T
E
V
Site 86
S1148
A
I
P
L
H
L
K
S
Q
L
R
K
G
P
P
Site 87
S1165
G
G
E
G
E
A
E
S
A
D
T
M
P
F
V
Site 88
S1191
K
I
L
N
V
P
M
S
S
Q
L
A
A
N
H
Site 89
T1216
R
M
R
M
K
K
L
T
L
D
I
N
E
R
Q
Site 90
Y1228
E
R
Q
E
Q
E
D
Y
Q
E
M
L
Q
S
L
Site 91
S1234
D
Y
Q
E
M
L
Q
S
L
A
Q
R
P
A
P
Site 92
Y1252
N
R
E
R
R
P
R
Y
Q
H
P
K
G
A
P
Site 93
T1267
N
A
D
L
I
F
K
T
G
G
R
R
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation