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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLSPN
Full Name:
Claspin
Alias:
Claspin; HClaspin; Hu-Claspin
Type:
Cell cycle regulation; Actin binding protein
Mass (Da):
151094
Number AA:
1339
UniProt ID:
Q9HAW4
International Prot ID:
IPI00186968
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006260
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
I
N
D
P
N
V
I
S
Q
E
E
A
D
S
P
Site 2
S26
I
S
Q
E
E
A
D
S
P
S
D
S
G
Q
G
Site 3
S28
Q
E
E
A
D
S
P
S
D
S
G
Q
G
S
Y
Site 4
S30
E
A
D
S
P
S
D
S
G
Q
G
S
Y
E
T
Site 5
S34
P
S
D
S
G
Q
G
S
Y
E
T
I
G
P
L
Site 6
Y35
S
D
S
G
Q
G
S
Y
E
T
I
G
P
L
S
Site 7
T37
S
G
Q
G
S
Y
E
T
I
G
P
L
S
E
G
Site 8
S42
Y
E
T
I
G
P
L
S
E
G
D
S
D
E
E
Site 9
S46
G
P
L
S
E
G
D
S
D
E
E
I
F
V
S
Site 10
S53
S
D
E
E
I
F
V
S
K
K
L
K
N
R
K
Site 11
S65
N
R
K
V
L
Q
D
S
D
S
E
T
E
D
T
Site 12
S67
K
V
L
Q
D
S
D
S
E
T
E
D
T
N
A
Site 13
T69
L
Q
D
S
D
S
E
T
E
D
T
N
A
S
P
Site 14
T72
S
D
S
E
T
E
D
T
N
A
S
P
E
K
T
Site 15
S75
E
T
E
D
T
N
A
S
P
E
K
T
T
Y
D
Site 16
T79
T
N
A
S
P
E
K
T
T
Y
D
S
A
E
E
Site 17
Y81
A
S
P
E
K
T
T
Y
D
S
A
E
E
E
N
Site 18
S83
P
E
K
T
T
Y
D
S
A
E
E
E
N
K
E
Site 19
Y93
E
E
N
K
E
N
L
Y
A
G
K
N
T
K
I
Site 20
Y104
N
T
K
I
K
R
I
Y
K
T
V
A
D
S
D
Site 21
T106
K
I
K
R
I
Y
K
T
V
A
D
S
D
E
S
Site 22
S110
I
Y
K
T
V
A
D
S
D
E
S
Y
M
E
K
Site 23
S113
T
V
A
D
S
D
E
S
Y
M
E
K
S
L
Y
Site 24
Y114
V
A
D
S
D
E
S
Y
M
E
K
S
L
Y
Q
Site 25
S118
D
E
S
Y
M
E
K
S
L
Y
Q
E
N
L
E
Site 26
Y120
S
Y
M
E
K
S
L
Y
Q
E
N
L
E
A
Q
Site 27
S135
V
K
P
C
L
E
L
S
L
Q
S
G
N
S
T
Site 28
S141
L
S
L
Q
S
G
N
S
T
D
F
T
T
D
R
Site 29
T142
S
L
Q
S
G
N
S
T
D
F
T
T
D
R
K
Site 30
T145
S
G
N
S
T
D
F
T
T
D
R
K
S
S
K
Site 31
T146
G
N
S
T
D
F
T
T
D
R
K
S
S
K
K
Site 32
S150
D
F
T
T
D
R
K
S
S
K
K
H
I
H
D
Site 33
S151
F
T
T
D
R
K
S
S
K
K
H
I
H
D
K
Site 34
S169
A
G
K
A
K
V
K
S
K
R
R
L
E
K
E
Site 35
S225
G
L
E
D
E
N
N
S
P
L
E
D
E
E
S
Site 36
S232
S
P
L
E
D
E
E
S
L
E
S
I
R
A
A
Site 37
S235
E
D
E
E
S
L
E
S
I
R
A
A
V
K
N
Site 38
S253
K
H
K
K
K
E
P
S
L
E
S
G
V
H
S
Site 39
S256
K
K
E
P
S
L
E
S
G
V
H
S
F
E
E
Site 40
S260
S
L
E
S
G
V
H
S
F
E
E
G
S
E
L
Site 41
S282
E
R
K
A
A
R
L
S
K
E
A
L
K
Q
L
Site 42
S291
E
A
L
K
Q
L
H
S
E
T
Q
R
L
I
R
Site 43
T293
L
K
Q
L
H
S
E
T
Q
R
L
I
R
E
S
Site 44
S300
T
Q
R
L
I
R
E
S
A
L
N
L
P
Y
H
Site 45
Y306
E
S
A
L
N
L
P
Y
H
M
P
E
N
K
T
Site 46
T325
F
K
R
K
P
R
P
T
C
H
G
N
A
M
A
Site 47
S336
N
A
M
A
L
L
K
S
S
K
Y
Q
S
S
H
Site 48
S337
A
M
A
L
L
K
S
S
K
Y
Q
S
S
H
H
Site 49
S341
L
K
S
S
K
Y
Q
S
S
H
H
K
E
I
I
Site 50
S342
K
S
S
K
Y
Q
S
S
H
H
K
E
I
I
D
Site 51
S358
A
N
T
T
E
M
N
S
D
H
H
S
K
G
S
Site 52
S362
E
M
N
S
D
H
H
S
K
G
S
E
Q
T
T
Site 53
S365
S
D
H
H
S
K
G
S
E
Q
T
T
G
A
E
Site 54
T369
S
K
G
S
E
Q
T
T
G
A
E
N
E
V
E
Site 55
T391
S
K
E
T
Q
I
I
T
G
S
D
E
S
C
R
Site 56
S393
E
T
Q
I
I
T
G
S
D
E
S
C
R
K
D
Site 57
S396
I
I
T
G
S
D
E
S
C
R
K
D
L
V
K
Site 58
S416
I
Q
E
K
Q
K
Q
S
D
I
R
P
S
P
G
Site 59
S421
K
Q
S
D
I
R
P
S
P
G
D
S
S
V
L
Site 60
S425
I
R
P
S
P
G
D
S
S
V
L
Q
Q
E
S
Site 61
S426
R
P
S
P
G
D
S
S
V
L
Q
Q
E
S
N
Site 62
S440
N
F
L
G
N
N
H
S
E
E
C
Q
V
G
G
Site 63
S481
P
E
Q
Q
N
K
S
S
A
V
G
P
P
E
K
Site 64
T493
P
E
K
V
R
R
F
T
L
D
R
L
K
Q
L
Site 65
S505
K
Q
L
G
V
D
V
S
I
K
P
R
L
G
A
Site 66
S516
R
L
G
A
D
E
D
S
F
V
I
L
E
P
E
Site 67
T562
V
I
V
K
D
M
G
T
D
G
K
E
E
L
K
Site 68
S586
P
K
K
L
D
G
A
S
H
T
K
P
G
E
K
Site 69
T639
E
E
E
E
E
E
M
T
D
E
S
E
E
D
G
Site 70
S642
E
E
E
M
T
D
E
S
E
E
D
G
E
E
K
Site 71
S683
E
T
A
E
F
L
L
S
S
E
E
I
E
T
K
Site 72
S684
T
A
E
F
L
L
S
S
E
E
I
E
T
K
D
Site 73
T689
L
S
S
E
E
I
E
T
K
D
E
K
E
M
D
Site 74
S704
K
E
N
N
D
G
S
S
E
I
G
K
A
V
G
Site 75
S714
G
K
A
V
G
F
L
S
V
P
K
S
L
S
S
Site 76
S718
G
F
L
S
V
P
K
S
L
S
S
D
S
T
L
Site 77
S720
L
S
V
P
K
S
L
S
S
D
S
T
L
L
L
Site 78
S721
S
V
P
K
S
L
S
S
D
S
T
L
L
L
F
Site 79
S723
P
K
S
L
S
S
D
S
T
L
L
L
F
K
D
Site 80
T724
K
S
L
S
S
D
S
T
L
L
L
F
K
D
S
Site 81
S731
T
L
L
L
F
K
D
S
S
S
K
M
G
Y
F
Site 82
S732
L
L
L
F
K
D
S
S
S
K
M
G
Y
F
P
Site 83
S733
L
L
F
K
D
S
S
S
K
M
G
Y
F
P
T
Site 84
Y737
D
S
S
S
K
M
G
Y
F
P
T
E
E
K
S
Site 85
T740
S
K
M
G
Y
F
P
T
E
E
K
S
E
T
D
Site 86
S744
Y
F
P
T
E
E
K
S
E
T
D
E
N
S
G
Site 87
T746
P
T
E
E
K
S
E
T
D
E
N
S
G
K
Q
Site 88
S750
K
S
E
T
D
E
N
S
G
K
Q
P
S
K
L
Site 89
S762
S
K
L
D
E
D
D
S
C
S
L
L
T
K
E
Site 90
S764
L
D
E
D
D
S
C
S
L
L
T
K
E
S
S
Site 91
T767
D
D
S
C
S
L
L
T
K
E
S
S
H
N
S
Site 92
S770
C
S
L
L
T
K
E
S
S
H
N
S
S
F
E
Site 93
S771
S
L
L
T
K
E
S
S
H
N
S
S
F
E
L
Site 94
S774
T
K
E
S
S
H
N
S
S
F
E
L
I
G
S
Site 95
S775
K
E
S
S
H
N
S
S
F
E
L
I
G
S
T
Site 96
S781
S
S
F
E
L
I
G
S
T
I
P
S
Y
Q
P
Site 97
S785
L
I
G
S
T
I
P
S
Y
Q
P
C
N
R
Q
Site 98
Y786
I
G
S
T
I
P
S
Y
Q
P
C
N
R
Q
T
Site 99
T793
Y
Q
P
C
N
R
Q
T
G
R
G
T
S
F
F
Site 100
T797
N
R
Q
T
G
R
G
T
S
F
F
P
T
A
G
Site 101
S798
R
Q
T
G
R
G
T
S
F
F
P
T
A
G
G
Site 102
T802
R
G
T
S
F
F
P
T
A
G
G
F
R
S
P
Site 103
S808
P
T
A
G
G
F
R
S
P
S
P
G
L
F
R
Site 104
S810
A
G
G
F
R
S
P
S
P
G
L
F
R
A
S
Site 105
S817
S
P
G
L
F
R
A
S
L
V
S
S
A
S
K
Site 106
S820
L
F
R
A
S
L
V
S
S
A
S
K
S
S
G
Site 107
S821
F
R
A
S
L
V
S
S
A
S
K
S
S
G
K
Site 108
S823
A
S
L
V
S
S
A
S
K
S
S
G
K
L
S
Site 109
S825
L
V
S
S
A
S
K
S
S
G
K
L
S
E
P
Site 110
S826
V
S
S
A
S
K
S
S
G
K
L
S
E
P
S
Site 111
S830
S
K
S
S
G
K
L
S
E
P
S
L
P
I
E
Site 112
S833
S
G
K
L
S
E
P
S
L
P
I
E
D
S
Q
Site 113
S839
P
S
L
P
I
E
D
S
Q
D
L
Y
N
A
S
Site 114
Y843
I
E
D
S
Q
D
L
Y
N
A
S
P
E
P
K
Site 115
S846
S
Q
D
L
Y
N
A
S
P
E
P
K
T
L
F
Site 116
T851
N
A
S
P
E
P
K
T
L
F
L
G
A
G
D
Site 117
T867
Q
F
C
L
E
D
D
T
Q
S
Q
L
L
D
A
Site 118
Y887
V
R
N
H
R
N
Q
Y
Q
A
L
K
P
R
L
Site 119
S898
K
P
R
L
P
L
A
S
M
D
E
N
A
M
D
Site 120
T916
D
E
L
L
D
L
C
T
G
K
F
T
S
Q
A
Site 121
S921
L
C
T
G
K
F
T
S
Q
A
E
K
H
L
P
Site 122
S931
E
K
H
L
P
R
K
S
D
K
K
E
N
M
E
Site 123
S945
E
E
L
L
N
L
C
S
G
K
F
T
S
Q
D
Site 124
T949
N
L
C
S
G
K
F
T
S
Q
D
A
S
T
P
Site 125
S950
L
C
S
G
K
F
T
S
Q
D
A
S
T
P
A
Site 126
S954
K
F
T
S
Q
D
A
S
T
P
A
S
S
E
L
Site 127
T955
F
T
S
Q
D
A
S
T
P
A
S
S
E
L
N
Site 128
S958
Q
D
A
S
T
P
A
S
S
E
L
N
K
Q
E
Site 129
S969
N
K
Q
E
K
E
S
S
M
G
D
P
M
E
E
Site 130
S982
E
E
A
L
A
L
C
S
G
S
F
P
T
D
K
Site 131
S984
A
L
A
L
C
S
G
S
F
P
T
D
K
E
E
Site 132
T987
L
C
S
G
S
F
P
T
D
K
E
E
E
D
E
Site 133
S1005
F
G
D
F
R
L
V
S
N
D
N
E
F
D
S
Site 134
S1012
S
N
D
N
E
F
D
S
D
E
D
E
H
S
D
Site 135
S1018
D
S
D
E
D
E
H
S
D
S
G
N
D
L
A
Site 136
S1020
D
E
D
E
H
S
D
S
G
N
D
L
A
L
E
Site 137
Y1053
R
Q
M
R
L
R
K
Y
L
E
D
E
A
E
V
Site 138
S1061
L
E
D
E
A
E
V
S
G
S
D
V
G
S
E
Site 139
S1063
D
E
A
E
V
S
G
S
D
V
G
S
E
D
E
Site 140
S1067
V
S
G
S
D
V
G
S
E
D
E
Y
D
G
E
Site 141
Y1071
D
V
G
S
E
D
E
Y
D
G
E
E
I
D
E
Site 142
Y1079
D
G
E
E
I
D
E
Y
E
E
D
V
I
D
E
Site 143
S1090
V
I
D
E
V
L
P
S
D
E
E
L
Q
S
Q
Site 144
S1096
P
S
D
E
E
L
Q
S
Q
I
K
K
I
H
M
Site 145
Y1117
D
K
R
Q
L
R
L
Y
Q
E
R
Y
L
A
D
Site 146
Y1121
L
R
L
Y
Q
E
R
Y
L
A
D
G
D
L
H
Site 147
S1129
L
A
D
G
D
L
H
S
D
G
P
G
R
M
R
Site 148
S1147
W
K
N
I
D
D
A
S
Q
M
D
L
F
H
R
Site 149
S1156
M
D
L
F
H
R
D
S
D
D
D
Q
T
E
E
Site 150
T1161
R
D
S
D
D
D
Q
T
E
E
Q
L
D
E
S
Site 151
S1168
T
E
E
Q
L
D
E
S
E
A
R
W
R
K
E
Site 152
S1204
E
E
E
I
G
E
D
S
Q
F
M
I
L
A
K
Site 153
S1223
K
A
L
Q
K
N
A
S
R
P
M
V
I
Q
E
Site 154
S1233
M
V
I
Q
E
S
K
S
L
L
R
N
P
F
E
Site 155
S1246
F
E
A
I
R
P
G
S
A
Q
Q
V
K
T
G
Site 156
S1270
L
Q
K
L
A
A
L
S
D
H
N
P
S
A
P
Site 157
S1275
A
L
S
D
H
N
P
S
A
P
R
N
S
R
N
Site 158
S1280
N
P
S
A
P
R
N
S
R
N
F
V
F
H
T
Site 159
T1287
S
R
N
F
V
F
H
T
L
S
P
V
K
A
E
Site 160
S1289
N
F
V
F
H
T
L
S
P
V
K
A
E
A
A
Site 161
S1302
A
A
K
E
S
S
K
S
Q
V
K
K
R
G
P
Site 162
S1310
Q
V
K
K
R
G
P
S
F
M
T
S
P
S
P
Site 163
S1314
R
G
P
S
F
M
T
S
P
S
P
K
H
L
K
Site 164
S1316
P
S
F
M
T
S
P
S
P
K
H
L
K
T
D
Site 165
T1322
P
S
P
K
H
L
K
T
D
D
S
T
S
G
L
Site 166
S1325
K
H
L
K
T
D
D
S
T
S
G
L
T
R
S
Site 167
T1326
H
L
K
T
D
D
S
T
S
G
L
T
R
S
I
Site 168
S1327
L
K
T
D
D
S
T
S
G
L
T
R
S
I
F
Site 169
S1332
S
T
S
G
L
T
R
S
I
F
K
Y
L
E
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation