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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNK12
Full Name:
Potassium channel subfamily K member 12
Alias:
Kcnk12; Kcnkc; Potassium channel, subfamily k, member 12; Thik2; Thik-2
Type:
Channel protein
Mass (Da):
46889
Number AA:
430
UniProt ID:
Q9HB15
International Prot ID:
IPI00004933
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005267
GO:0030955
GO:0005244
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
S
R
S
P
R
P
P
P
R
R
Site 2
S13
P
R
P
P
P
R
R
S
R
R
R
L
P
R
P
Site 3
T36
R
S
H
L
N
E
D
T
G
R
F
V
L
L
A
Site 4
S62
T
V
F
S
A
L
E
S
P
G
E
A
E
A
R
Site 5
T75
A
R
A
R
W
G
A
T
L
R
N
F
S
A
A
Site 6
S80
G
A
T
L
R
N
F
S
A
A
H
G
V
A
E
Site 7
S187
R
E
R
Q
L
R
R
S
G
L
L
P
A
T
F
Site 8
T193
R
S
G
L
L
P
A
T
F
R
R
G
S
A
L
Site 9
S198
P
A
T
F
R
R
G
S
A
L
S
E
A
D
S
Site 10
S201
F
R
R
G
S
A
L
S
E
A
D
S
L
A
G
Site 11
S205
S
A
L
S
E
A
D
S
L
A
G
W
K
P
S
Site 12
Y235
S
C
C
A
S
A
M
Y
T
S
V
E
G
W
D
Site 13
Y243
T
S
V
E
G
W
D
Y
V
D
S
L
Y
F
C
Site 14
S264
I
G
F
G
D
L
V
S
S
Q
H
A
A
Y
R
Site 15
S265
G
F
G
D
L
V
S
S
Q
H
A
A
Y
R
N
Site 16
Y270
V
S
S
Q
H
A
A
Y
R
N
Q
G
L
Y
R
Site 17
Y276
A
Y
R
N
Q
G
L
Y
R
L
G
N
F
L
F
Site 18
T336
L
A
R
R
N
A
I
T
P
G
S
R
L
R
R
Site 19
S339
R
N
A
I
T
P
G
S
R
L
R
R
R
L
A
Site 20
S357
A
D
P
A
A
R
D
S
D
A
E
G
R
R
L
Site 21
S365
D
A
E
G
R
R
L
S
G
E
L
I
S
M
R
Site 22
S370
R
L
S
G
E
L
I
S
M
R
D
L
T
A
S
Site 23
S377
S
M
R
D
L
T
A
S
N
K
V
S
L
A
L
Site 24
S390
A
L
L
Q
K
Q
L
S
E
T
A
N
G
Y
P
Site 25
Y396
L
S
E
T
A
N
G
Y
P
R
S
V
C
V
N
Site 26
S399
T
A
N
G
Y
P
R
S
V
C
V
N
T
R
Q
Site 27
S410
N
T
R
Q
N
G
F
S
G
G
V
G
A
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation