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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRPV4
Full Name:
Transient receptor potential cation channel subfamily V member 4
Alias:
Osm-9-like TRP channel 4; Osmosensitive transient receptor potential channel 4; OTRPC4; Transient receptor potential cation channel, subfamily V, member 4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmotically activated channel; VRL2; VRL-2; VROAC; VR-OAC
Type:
Channel, cation
Mass (Da):
98281
Number AA:
871
UniProt ID:
Q9HBA0
International Prot ID:
IPI00168624
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005262
GO:0005509
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0006884
GO:0007204
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
D
S
S
E
G
P
R
A
G
P
Site 2
S23
A
E
L
P
G
D
E
S
G
T
P
G
G
E
A
Site 3
T25
L
P
G
D
E
S
G
T
P
G
G
E
A
F
P
Site 4
S46
L
F
E
G
E
D
G
S
L
S
P
S
P
A
D
Site 5
S48
E
G
E
D
G
S
L
S
P
S
P
A
D
A
S
Site 6
S50
E
D
G
S
L
S
P
S
P
A
D
A
S
R
P
Site 7
S55
S
P
S
P
A
D
A
S
R
P
A
G
P
G
D
Site 8
S88
N
P
I
D
L
L
E
S
T
L
Y
E
S
S
V
Site 9
Y91
D
L
L
E
S
T
L
Y
E
S
S
V
V
P
G
Site 10
S94
E
S
T
L
Y
E
S
S
V
V
P
G
P
K
K
Site 11
S106
P
K
K
A
P
M
D
S
L
F
D
Y
G
T
Y
Site 12
Y110
P
M
D
S
L
F
D
Y
G
T
Y
R
H
H
S
Site 13
T112
D
S
L
F
D
Y
G
T
Y
R
H
H
S
S
D
Site 14
Y113
S
L
F
D
Y
G
T
Y
R
H
H
S
S
D
N
Site 15
S118
G
T
Y
R
H
H
S
S
D
N
K
R
W
R
K
Site 16
S134
I
I
E
K
Q
P
Q
S
P
K
A
P
A
P
Q
Site 17
S162
F
D
I
V
S
R
G
S
T
A
D
L
D
G
L
Site 18
T175
G
L
L
P
F
L
L
T
H
K
K
R
L
T
D
Site 19
T181
L
T
H
K
K
R
L
T
D
E
E
F
R
E
P
Site 20
S189
D
E
E
F
R
E
P
S
T
G
K
T
C
L
P
Site 21
T193
R
E
P
S
T
G
K
T
C
L
P
K
A
L
L
Site 22
S203
P
K
A
L
L
N
L
S
N
G
R
N
D
T
I
Site 23
Y235
N
S
P
F
R
D
I
Y
Y
R
G
Q
T
A
L
Site 24
Y236
S
P
F
R
D
I
Y
Y
R
G
Q
T
A
L
H
Site 25
T240
D
I
Y
Y
R
G
Q
T
A
L
H
I
A
I
E
Site 26
Y253
I
E
R
R
C
K
H
Y
V
E
L
L
V
A
Q
Site 27
Y281
Q
P
K
D
E
G
G
Y
F
Y
F
G
E
L
P
Site 28
Y283
K
D
E
G
G
Y
F
Y
F
G
E
L
P
L
S
Site 29
Y303
N
Q
P
H
I
V
N
Y
L
T
E
N
P
H
K
Site 30
T305
P
H
I
V
N
Y
L
T
E
N
P
H
K
K
A
Site 31
S319
A
D
M
R
R
Q
D
S
R
G
N
T
V
L
H
Site 32
T323
R
Q
D
S
R
G
N
T
V
L
H
A
L
V
A
Site 33
T335
L
V
A
I
A
D
N
T
R
E
N
T
K
F
V
Site 34
T339
A
D
N
T
R
E
N
T
K
F
V
T
K
M
Y
Site 35
T395
H
I
I
R
R
E
V
T
D
E
D
T
R
H
L
Site 36
T399
R
E
V
T
D
E
D
T
R
H
L
S
R
K
F
Site 37
S403
D
E
D
T
R
H
L
S
R
K
F
K
D
W
A
Site 38
Y411
R
K
F
K
D
W
A
Y
G
P
V
Y
S
S
L
Site 39
Y415
D
W
A
Y
G
P
V
Y
S
S
L
Y
D
L
S
Site 40
S416
W
A
Y
G
P
V
Y
S
S
L
Y
D
L
S
S
Site 41
Y419
G
P
V
Y
S
S
L
Y
D
L
S
S
L
D
T
Site 42
S422
Y
S
S
L
Y
D
L
S
S
L
D
T
C
G
E
Site 43
S423
S
S
L
Y
D
L
S
S
L
D
T
C
G
E
E
Site 44
T426
Y
D
L
S
S
L
D
T
C
G
E
E
A
S
V
Site 45
Y439
S
V
L
E
I
L
V
Y
N
S
K
I
E
N
R
Site 46
T505
P
P
Y
P
Y
R
T
T
V
D
Y
L
R
L
A
Site 47
Y508
P
Y
R
T
T
V
D
Y
L
R
L
A
G
E
V
Site 48
Y805
D
P
G
K
N
E
T
Y
Q
Y
Y
G
F
S
H
Site 49
S824
L
R
R
D
R
W
S
S
V
V
P
R
V
V
E
Site 50
S847
E
V
V
V
P
L
D
S
M
G
N
P
R
C
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation