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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RC3H2
Full Name:
RING finger and CCCH-type zinc finger domain-containing protein 2
Alias:
Membrane-associated nucleic acid-binding; Membrane-associated nucleic acid-binding protein; RING finger 164; RNF164
Type:
Membrane, Membrane fraction, Endomembrane system, Cytoplasm, Cell surface protein
Mass (Da):
131669
Number AA:
1191
UniProt ID:
Q9HBD1
International Prot ID:
IPI00177819
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0012505
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
E
N
V
H
K
P
I
S
L
G
C
S
H
T
V
Site 2
S83
A
Q
V
P
D
H
Q
S
I
K
L
S
N
L
G
Site 3
S87
D
H
Q
S
I
K
L
S
N
L
G
E
N
K
H
Site 4
Y95
N
L
G
E
N
K
H
Y
E
V
A
K
K
C
V
Site 5
S120
S
G
G
K
G
V
A
S
L
N
Q
S
A
L
S
Site 6
S124
G
V
A
S
L
N
Q
S
A
L
S
R
P
M
Q
Site 7
T164
S
L
G
E
R
T
V
T
E
L
I
L
Q
H
Q
Site 8
S235
E
P
R
F
P
Q
A
S
K
T
S
I
G
H
V
Site 9
T237
R
F
P
Q
A
S
K
T
S
I
G
H
V
V
Q
Site 10
S250
V
Q
L
L
Y
R
A
S
C
F
K
V
T
K
R
Site 11
S261
V
T
K
R
D
E
D
S
S
L
M
Q
L
K
E
Site 12
S262
T
K
R
D
E
D
S
S
L
M
Q
L
K
E
E
Site 13
Y273
L
K
E
E
F
R
S
Y
E
A
L
R
R
E
H
Site 14
S296
M
E
A
G
L
R
I
S
P
E
Q
W
S
S
L
Site 15
S302
I
S
P
E
Q
W
S
S
L
L
Y
G
D
L
A
Site 16
Y305
E
Q
W
S
S
L
L
Y
G
D
L
A
H
K
S
Site 17
S316
A
H
K
S
H
M
Q
S
I
I
D
K
L
Q
S
Site 18
S323
S
I
I
D
K
L
Q
S
P
E
S
F
A
K
S
Site 19
S326
D
K
L
Q
S
P
E
S
F
A
K
S
V
Q
E
Site 20
S330
S
P
E
S
F
A
K
S
V
Q
E
L
T
I
V
Site 21
S368
D
P
N
P
D
A
V
S
P
T
W
E
Q
L
E
Site 22
Y395
L
V
D
F
I
Q
N
Y
S
R
K
G
H
E
T
Site 23
T402
Y
S
R
K
G
H
E
T
P
Q
P
Q
P
N
S
Site 24
S409
T
P
Q
P
Q
P
N
S
K
Y
K
T
S
M
C
Site 25
T413
Q
P
N
S
K
Y
K
T
S
M
C
R
D
L
R
Site 26
S414
P
N
S
K
Y
K
T
S
M
C
R
D
L
R
Q
Site 27
S436
T
N
C
T
F
A
H
S
Q
E
E
L
E
K
Y
Site 28
Y443
S
Q
E
E
L
E
K
Y
R
L
R
N
K
K
I
Site 29
T453
R
N
K
K
I
N
A
T
V
R
T
F
P
L
L
Site 30
T493
T
G
K
I
V
P
S
T
N
G
I
S
N
A
E
Site 31
S502
G
I
S
N
A
E
N
S
V
S
Q
L
I
S
R
Site 32
S504
S
N
A
E
N
S
V
S
Q
L
I
S
R
S
T
Site 33
S508
N
S
V
S
Q
L
I
S
R
S
T
D
S
T
L
Site 34
S510
V
S
Q
L
I
S
R
S
T
D
S
T
L
R
A
Site 35
T511
S
Q
L
I
S
R
S
T
D
S
T
L
R
A
L
Site 36
S513
L
I
S
R
S
T
D
S
T
L
R
A
L
E
T
Site 37
T514
I
S
R
S
T
D
S
T
L
R
A
L
E
T
V
Site 38
T520
S
T
L
R
A
L
E
T
V
K
K
V
G
K
V
Site 39
S541
A
A
G
P
S
A
D
S
V
T
E
N
K
I
G
Site 40
T543
G
P
S
A
D
S
V
T
E
N
K
I
G
S
P
Site 41
S549
V
T
E
N
K
I
G
S
P
P
K
T
P
V
S
Site 42
T553
K
I
G
S
P
P
K
T
P
V
S
N
V
A
A
Site 43
S556
S
P
P
K
T
P
V
S
N
V
A
A
T
S
A
Site 44
S566
A
A
T
S
A
G
P
S
N
V
G
T
E
L
N
Site 45
T570
A
G
P
S
N
V
G
T
E
L
N
S
V
P
Q
Site 46
S574
N
V
G
T
E
L
N
S
V
P
Q
K
S
S
P
Site 47
S579
L
N
S
V
P
Q
K
S
S
P
F
L
T
R
V
Site 48
S580
N
S
V
P
Q
K
S
S
P
F
L
T
R
V
P
Site 49
T584
Q
K
S
S
P
F
L
T
R
V
P
V
Y
P
P
Site 50
Y589
F
L
T
R
V
P
V
Y
P
P
H
S
E
N
I
Site 51
Y598
P
H
S
E
N
I
Q
Y
F
Q
D
P
R
T
Q
Site 52
T604
Q
Y
F
Q
D
P
R
T
Q
I
P
F
E
V
P
Site 53
Y613
I
P
F
E
V
P
Q
Y
P
Q
T
G
Y
Y
P
Site 54
T616
E
V
P
Q
Y
P
Q
T
G
Y
Y
P
P
P
P
Site 55
Y618
P
Q
Y
P
Q
T
G
Y
Y
P
P
P
P
T
V
Site 56
Y619
Q
Y
P
Q
T
G
Y
Y
P
P
P
P
T
V
P
Site 57
T624
G
Y
Y
P
P
P
P
T
V
P
A
G
V
A
P
Site 58
S639
C
V
P
R
F
V
R
S
N
N
V
P
E
S
S
Site 59
S645
R
S
N
N
V
P
E
S
S
L
P
P
A
S
M
Site 60
S646
S
N
N
V
P
E
S
S
L
P
P
A
S
M
P
Site 61
S651
E
S
S
L
P
P
A
S
M
P
Y
A
D
H
Y
Site 62
Y658
S
M
P
Y
A
D
H
Y
S
T
F
S
P
R
D
Site 63
S659
M
P
Y
A
D
H
Y
S
T
F
S
P
R
D
R
Site 64
T660
P
Y
A
D
H
Y
S
T
F
S
P
R
D
R
M
Site 65
S662
A
D
H
Y
S
T
F
S
P
R
D
R
M
N
S
Site 66
S669
S
P
R
D
R
M
N
S
S
P
Y
Q
P
P
P
Site 67
S670
P
R
D
R
M
N
S
S
P
Y
Q
P
P
P
P
Site 68
Y672
D
R
M
N
S
S
P
Y
Q
P
P
P
P
Q
P
Site 69
Y680
Q
P
P
P
P
Q
P
Y
G
P
V
P
P
V
P
Site 70
Y691
P
P
V
P
S
G
M
Y
A
P
V
Y
D
S
R
Site 71
Y695
S
G
M
Y
A
P
V
Y
D
S
R
R
I
W
R
Site 72
Y706
R
I
W
R
P
P
M
Y
Q
R
D
D
I
I
R
Site 73
S714
Q
R
D
D
I
I
R
S
N
S
L
P
P
M
D
Site 74
S716
D
D
I
I
R
S
N
S
L
P
P
M
D
V
M
Site 75
S726
P
M
D
V
M
H
S
S
V
Y
Q
T
S
L
R
Site 76
S731
H
S
S
V
Y
Q
T
S
L
R
E
R
Y
N
S
Site 77
Y736
Q
T
S
L
R
E
R
Y
N
S
L
D
G
Y
Y
Site 78
S738
S
L
R
E
R
Y
N
S
L
D
G
Y
Y
S
V
Site 79
Y742
R
Y
N
S
L
D
G
Y
Y
S
V
A
C
Q
P
Site 80
Y743
Y
N
S
L
D
G
Y
Y
S
V
A
C
Q
P
P
Site 81
S744
N
S
L
D
G
Y
Y
S
V
A
C
Q
P
P
S
Site 82
S751
S
V
A
C
Q
P
P
S
E
P
R
T
T
V
P
Site 83
T755
Q
P
P
S
E
P
R
T
T
V
P
L
P
R
E
Site 84
T756
P
P
S
E
P
R
T
T
V
P
L
P
R
E
P
Site 85
T769
E
P
C
G
H
L
K
T
S
C
E
E
Q
I
R
Site 86
S770
P
C
G
H
L
K
T
S
C
E
E
Q
I
R
R
Site 87
T801
S
S
T
L
P
V
A
T
Q
S
P
T
P
P
S
Site 88
S803
T
L
P
V
A
T
Q
S
P
T
P
P
S
P
L
Site 89
T805
P
V
A
T
Q
S
P
T
P
P
S
P
L
F
S
Site 90
S808
T
Q
S
P
T
P
P
S
P
L
F
S
V
D
F
Site 91
S812
T
P
P
S
P
L
F
S
V
D
F
R
A
D
F
Site 92
S820
V
D
F
R
A
D
F
S
E
S
V
S
G
T
K
Site 93
S822
F
R
A
D
F
S
E
S
V
S
G
T
K
F
E
Site 94
S824
A
D
F
S
E
S
V
S
G
T
K
F
E
E
D
Site 95
T826
F
S
E
S
V
S
G
T
K
F
E
E
D
H
L
Site 96
Y836
E
E
D
H
L
S
H
Y
S
P
W
S
C
G
T
Site 97
S871
A
V
L
M
D
L
D
S
G
D
V
K
R
R
V
Site 98
T883
R
R
V
H
L
F
E
T
Q
R
R
T
K
E
E
Site 99
T887
L
F
E
T
Q
R
R
T
K
E
E
D
P
I
I
Site 100
S897
E
D
P
I
I
P
F
S
D
G
P
I
I
S
K
Site 101
S903
F
S
D
G
P
I
I
S
K
W
G
A
I
S
R
Site 102
S909
I
S
K
W
G
A
I
S
R
S
S
R
T
G
Y
Site 103
S911
K
W
G
A
I
S
R
S
S
R
T
G
Y
H
T
Site 104
S912
W
G
A
I
S
R
S
S
R
T
G
Y
H
T
T
Site 105
Y916
S
R
S
S
R
T
G
Y
H
T
T
D
P
V
Q
Site 106
T918
S
S
R
T
G
Y
H
T
T
D
P
V
Q
A
T
Site 107
S927
D
P
V
Q
A
T
A
S
Q
G
S
A
T
K
P
Site 108
T932
T
A
S
Q
G
S
A
T
K
P
I
S
V
S
D
Site 109
S936
G
S
A
T
K
P
I
S
V
S
D
Y
V
P
Y
Site 110
Y943
S
V
S
D
Y
V
P
Y
V
N
A
V
D
S
R
Site 111
S949
P
Y
V
N
A
V
D
S
R
W
S
S
Y
G
N
Site 112
S952
N
A
V
D
S
R
W
S
S
Y
G
N
E
A
T
Site 113
S953
A
V
D
S
R
W
S
S
Y
G
N
E
A
T
S
Site 114
S961
Y
G
N
E
A
T
S
S
A
H
Y
V
E
R
D
Site 115
Y964
E
A
T
S
S
A
H
Y
V
E
R
D
R
F
I
Site 116
S976
R
F
I
V
T
D
L
S
G
H
R
K
H
S
S
Site 117
S982
L
S
G
H
R
K
H
S
S
T
G
D
L
L
S
Site 118
S983
S
G
H
R
K
H
S
S
T
G
D
L
L
S
L
Site 119
T984
G
H
R
K
H
S
S
T
G
D
L
L
S
L
E
Site 120
S989
S
S
T
G
D
L
L
S
L
E
L
Q
Q
A
K
Site 121
S997
L
E
L
Q
Q
A
K
S
N
S
L
L
L
Q
R
Site 122
S999
L
Q
Q
A
K
S
N
S
L
L
L
Q
R
E
A
Site 123
S1017
A
M
Q
Q
K
W
N
S
L
D
E
G
R
H
L
Site 124
T1025
L
D
E
G
R
H
L
T
L
N
L
L
S
K
E
Site 125
Y1044
N
G
E
L
Q
S
D
Y
T
E
D
A
T
D
T
Site 126
T1045
G
E
L
Q
S
D
Y
T
E
D
A
T
D
T
K
Site 127
T1049
S
D
Y
T
E
D
A
T
D
T
K
P
D
R
D
Site 128
S1062
R
D
I
E
L
E
L
S
A
L
D
T
D
E
P
Site 129
T1066
L
E
L
S
A
L
D
T
D
E
P
D
G
Q
S
Site 130
S1088
D
I
Q
L
G
I
S
S
Q
N
D
Q
L
L
N
Site 131
S1119
P
P
K
Q
K
K
Q
S
L
G
E
D
H
V
I
Site 132
T1169
A
G
N
L
I
L
K
T
H
V
M
S
E
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation