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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZFYVE1
Full Name:
Zinc finger FYVE domain-containing protein 1
Alias:
DFCP1; Double FYVE-containing 1; KIAA1589; Phosphoinositide-binding protein SR3; SR3; TAFF1; Tandem FYVE fingers-1; ZFYV1; Zinc finger FYVE domain-containing 1; Zinc finger, FYVE domain containing 1; ZNFN2A1
Type:
Vesicle protein
Mass (Da):
87176
Number AA:
777
UniProt ID:
Q9HBF4
International Prot ID:
IPI00103874
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005795
GO:0005783
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005545
GO:0005547
GO:0043325
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
A
Q
T
S
P
A
E
K
G
L
N
Site 2
S21
P
G
L
M
C
Q
E
S
Y
A
C
S
G
T
D
Site 3
Y22
G
L
M
C
Q
E
S
Y
A
C
S
G
T
D
E
Site 4
S25
C
Q
E
S
Y
A
C
S
G
T
D
E
A
I
F
Site 5
S109
E
C
Q
K
R
T
H
S
G
G
N
K
R
R
H
Site 6
T119
N
K
R
R
H
P
V
T
V
Y
N
V
S
N
L
Site 7
Y121
R
R
H
P
V
T
V
Y
N
V
S
N
L
Q
E
Site 8
S124
P
V
T
V
Y
N
V
S
N
L
Q
E
S
L
E
Site 9
S129
N
V
S
N
L
Q
E
S
L
E
A
E
E
M
D
Site 10
T139
A
E
E
M
D
E
E
T
K
R
K
K
M
T
E
Site 11
T163
E
N
E
E
I
Q
V
T
N
E
E
D
F
I
R
Site 12
S184
D
Q
H
L
K
V
V
S
I
F
G
N
T
G
D
Site 13
S194
G
N
T
G
D
G
K
S
H
T
L
N
H
T
F
Site 14
T196
T
G
D
G
K
S
H
T
L
N
H
T
F
F
Y
Site 15
T200
K
S
H
T
L
N
H
T
F
F
Y
G
R
E
V
Site 16
Y203
T
L
N
H
T
F
F
Y
G
R
E
V
F
K
T
Site 17
T210
Y
G
R
E
V
F
K
T
S
P
T
Q
E
S
C
Site 18
S211
G
R
E
V
F
K
T
S
P
T
Q
E
S
C
T
Site 19
T218
S
P
T
Q
E
S
C
T
V
G
V
W
A
A
Y
Site 20
T243
T
E
G
L
L
G
A
T
V
N
L
S
Q
R
T
Site 21
T267
S
D
L
V
I
Y
R
T
H
A
D
R
L
H
N
Site 22
S284
F
K
F
L
G
D
A
S
E
A
Y
L
K
H
F
Site 23
Y287
L
G
D
A
S
E
A
Y
L
K
H
F
T
K
E
Site 24
T298
F
T
K
E
L
K
A
T
T
A
R
C
G
L
D
Site 25
T324
I
F
H
E
T
V
H
T
Q
L
L
G
S
D
H
Site 26
S329
V
H
T
Q
L
L
G
S
D
H
P
S
E
V
P
Site 27
S333
L
L
G
S
D
H
P
S
E
V
P
E
K
L
I
Site 28
S356
R
F
P
E
A
F
S
S
I
H
Y
K
G
T
R
Site 29
Y359
E
A
F
S
S
I
H
Y
K
G
T
R
T
Y
N
Site 30
T364
I
H
Y
K
G
T
R
T
Y
N
P
P
T
D
F
Site 31
Y365
H
Y
K
G
T
R
T
Y
N
P
P
T
D
F
S
Site 32
T369
T
R
T
Y
N
P
P
T
D
F
S
G
L
R
R
Site 33
T386
E
Q
L
L
E
N
N
T
T
R
S
P
R
H
P
Site 34
T387
Q
L
L
E
N
N
T
T
R
S
P
R
H
P
G
Site 35
S389
L
E
N
N
T
T
R
S
P
R
H
P
G
V
I
Site 36
S404
F
K
A
L
K
A
L
S
D
R
F
S
G
E
I
Site 37
S408
K
A
L
S
D
R
F
S
G
E
I
P
D
D
Q
Site 38
S419
P
D
D
Q
M
A
H
S
S
F
F
P
D
E
Y
Site 39
Y426
S
S
F
F
P
D
E
Y
F
T
C
S
S
L
C
Site 40
S457
G
V
P
H
E
A
K
S
R
C
R
Y
S
H
Q
Site 41
Y461
E
A
K
S
R
C
R
Y
S
H
Q
Y
D
N
R
Site 42
Y465
R
C
R
Y
S
H
Q
Y
D
N
R
V
Y
T
C
Site 43
Y470
H
Q
Y
D
N
R
V
Y
T
C
K
A
C
Y
E
Site 44
Y476
V
Y
T
C
K
A
C
Y
E
R
G
E
E
V
S
Site 45
S483
Y
E
R
G
E
E
V
S
V
V
P
K
T
S
A
Site 46
T488
E
V
S
V
V
P
K
T
S
A
S
T
D
S
P
Site 47
S489
V
S
V
V
P
K
T
S
A
S
T
D
S
P
W
Site 48
S491
V
V
P
K
T
S
A
S
T
D
S
P
W
M
G
Site 49
T492
V
P
K
T
S
A
S
T
D
S
P
W
M
G
L
Site 50
S494
K
T
S
A
S
T
D
S
P
W
M
G
L
A
K
Site 51
Y523
V
V
Y
R
S
R
Q
Y
W
F
G
N
Q
D
P
Site 52
T533
G
N
Q
D
P
V
D
T
V
V
R
T
E
I
V
Site 53
S572
N
F
M
A
Q
S
V
S
E
L
S
L
G
P
T
Site 54
Y594
T
D
Q
I
A
P
A
Y
W
R
P
N
S
Q
I
Site 55
S599
P
A
Y
W
R
P
N
S
Q
I
L
S
C
N
K
Site 56
S603
R
P
N
S
Q
I
L
S
C
N
K
C
A
T
S
Site 57
S610
S
C
N
K
C
A
T
S
F
K
D
N
D
T
K
Site 58
S630
C
G
E
G
F
C
D
S
C
S
S
K
T
R
P
Site 59
S632
E
G
F
C
D
S
C
S
S
K
T
R
P
V
P
Site 60
Y655
V
R
V
C
D
N
C
Y
E
A
R
N
V
Q
L
Site 61
Y711
K
D
A
A
R
P
A
Y
W
V
P
D
H
E
I
Site 62
S757
H
D
R
R
A
V
P
S
R
G
W
D
H
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation