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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LGR6
Full Name:
Leucine-rich repeat-containing G-protein coupled receptor 6
Alias:
Gonadotropin receptor; VTS20631
Type:
Receptor, GPCR
Mass (Da):
104298
Number AA:
967
UniProt ID:
Q9HBX8
International Prot ID:
IPI00151908
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0016500
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
P
Q
P
G
P
G
P
T
A
C
P
A
P
C
H
Site 2
S49
Q
E
D
G
I
M
L
S
A
D
C
S
E
L
G
Site 3
S58
D
C
S
E
L
G
L
S
A
V
P
G
D
L
D
Site 4
Y70
D
L
D
P
L
T
A
Y
L
D
L
S
M
N
N
Site 5
S98
F
L
E
E
L
R
L
S
G
N
H
L
S
H
I
Site 6
S103
R
L
S
G
N
H
L
S
H
I
P
G
Q
A
F
Site 7
S139
E
A
L
W
E
L
P
S
L
Q
S
L
R
L
D
Site 8
S142
W
E
L
P
S
L
Q
S
L
R
L
D
A
N
L
Site 9
S151
R
L
D
A
N
L
I
S
L
V
P
E
R
S
F
Site 10
S162
E
R
S
F
E
G
L
S
S
L
R
H
L
W
L
Site 11
S163
R
S
F
E
G
L
S
S
L
R
H
L
W
L
D
Site 12
Y204
R
I
S
H
I
P
D
Y
A
F
Q
N
L
T
S
Site 13
T227
N
R
I
Q
H
L
G
T
H
S
F
E
G
L
H
Site 14
S229
I
Q
H
L
G
T
H
S
F
E
G
L
H
N
L
Site 15
T238
E
G
L
H
N
L
E
T
L
D
L
N
Y
N
K
Site 16
Y243
L
E
T
L
D
L
N
Y
N
K
L
Q
E
F
P
Site 17
T255
E
F
P
V
A
I
R
T
L
G
R
L
Q
E
L
Site 18
Y303
V
G
R
S
A
F
Q
Y
L
P
K
L
H
T
L
Site 19
T309
Q
Y
L
P
K
L
H
T
L
S
L
N
G
A
M
Site 20
S360
R
L
R
V
L
E
L
S
H
N
Q
I
E
E
L
Site 21
S369
N
Q
I
E
E
L
P
S
L
H
R
C
Q
K
L
Site 22
S395
E
I
G
A
D
T
F
S
Q
L
S
S
L
Q
A
Site 23
S399
D
T
F
S
Q
L
S
S
L
Q
A
L
D
L
S
Site 24
S412
L
S
W
N
A
I
R
S
I
H
P
E
A
F
S
Site 25
S419
S
I
H
P
E
A
F
S
T
L
H
S
L
V
K
Site 26
S457
L
K
G
N
L
A
L
S
Q
A
F
S
K
D
S
Site 27
S461
L
A
L
S
Q
A
F
S
K
D
S
F
P
K
L
Site 28
S464
S
Q
A
F
S
K
D
S
F
P
K
L
R
I
L
Site 29
S507
L
H
L
D
D
E
E
S
S
K
R
P
L
G
L
Site 30
S508
H
L
D
D
E
E
S
S
K
R
P
L
G
L
L
Site 31
S537
L
Q
L
E
M
E
D
S
K
P
H
P
S
V
Q
Site 32
S542
E
D
S
K
P
H
P
S
V
Q
C
S
P
T
P
Site 33
S546
P
H
P
S
V
Q
C
S
P
T
P
G
P
F
K
Site 34
T548
P
S
V
Q
C
S
P
T
P
G
P
F
K
P
C
Site 35
Y557
G
P
F
K
P
C
E
Y
L
F
E
S
W
G
I
Site 36
Y632
T
F
G
Q
F
S
E
Y
G
A
R
W
E
T
G
Site 37
T638
E
Y
G
A
R
W
E
T
G
L
G
C
R
A
T
Site 38
T661
E
A
S
V
L
L
L
T
L
A
A
V
Q
C
S
Site 39
S670
A
A
V
Q
C
S
V
S
V
S
C
V
R
A
Y
Site 40
Y677
S
V
S
C
V
R
A
Y
G
K
S
P
S
L
G
Site 41
S680
C
V
R
A
Y
G
K
S
P
S
L
G
S
V
R
Site 42
S682
R
A
Y
G
K
S
P
S
L
G
S
V
R
A
G
Site 43
Y720
A
S
P
L
C
L
P
Y
A
P
P
E
G
Q
P
Site 44
Y755
A
G
A
Y
I
K
L
Y
C
D
L
P
R
G
D
Site 45
S810
V
T
P
E
A
V
K
S
V
L
L
V
V
L
P
Site 46
Y827
A
C
L
N
P
L
L
Y
L
L
F
N
P
H
F
Site 47
S848
L
R
P
R
A
G
D
S
G
P
L
A
Y
A
A
Site 48
S862
A
A
G
E
L
E
K
S
S
C
D
S
T
Q
A
Site 49
T867
E
K
S
S
C
D
S
T
Q
A
L
V
A
F
S
Site 50
S883
V
D
L
I
L
E
A
S
E
A
G
R
P
P
G
Site 51
Y894
R
P
P
G
L
E
T
Y
G
F
P
S
V
T
L
Site 52
S915
G
A
P
R
L
E
G
S
H
C
V
E
P
E
G
Site 53
S931
H
F
G
N
P
Q
P
S
M
D
G
E
L
L
L
Site 54
T944
L
L
R
A
E
G
S
T
P
A
G
G
G
L
S
Site 55
S951
T
P
A
G
G
G
L
S
G
G
G
G
F
Q
P
Site 56
S959
G
G
G
G
F
Q
P
S
G
L
A
F
A
S
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation