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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OTOF
Full Name:
Otoferlin
Alias:
DFNB6; DFNB9; FER1L2; Fer-1-like protein 2; NSRD9
Type:
Vesicle protein
Mass (Da):
226753
Number AA:
1997
UniProt ID:
Q9HC10
International Prot ID:
IPI00375559
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0031410
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006944
GO:0007605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
I
H
L
K
T
V
S
E
L
R
G
R
G
D
Site 2
T24
G
D
R
I
A
K
V
T
F
R
G
Q
S
F
Y
Site 3
S29
K
V
T
F
R
G
Q
S
F
Y
S
R
V
L
E
Site 4
Y31
T
F
R
G
Q
S
F
Y
S
R
V
L
E
N
C
Site 5
T47
D
V
A
D
F
D
E
T
F
R
W
P
V
A
S
Site 6
S54
T
F
R
W
P
V
A
S
S
I
D
R
N
E
M
Site 7
S55
F
R
W
P
V
A
S
S
I
D
R
N
E
M
L
Site 8
Y69
L
E
I
Q
V
F
N
Y
S
K
V
F
S
N
K
Site 9
S70
E
I
Q
V
F
N
Y
S
K
V
F
S
N
K
L
Site 10
T99
S
H
V
E
V
T
D
T
L
I
D
D
N
N
A
Site 11
T124
R
Y
Q
A
T
D
G
T
V
G
S
W
D
D
G
Site 12
S127
A
T
D
G
T
V
G
S
W
D
D
G
D
F
L
Site 13
S138
G
D
F
L
G
D
E
S
L
Q
E
E
E
K
D
Site 14
S146
L
Q
E
E
E
K
D
S
Q
E
T
D
G
L
L
Site 15
T149
E
E
K
D
S
Q
E
T
D
G
L
L
P
G
S
Site 16
S156
T
D
G
L
L
P
G
S
R
P
S
S
R
P
P
Site 17
S159
L
L
P
G
S
R
P
S
S
R
P
P
G
E
K
Site 18
S160
L
P
G
S
R
P
S
S
R
P
P
G
E
K
S
Site 19
S167
S
R
P
P
G
E
K
S
F
R
R
A
G
R
S
Site 20
S174
S
F
R
R
A
G
R
S
V
F
S
A
M
K
L
Site 21
S177
R
A
G
R
S
V
F
S
A
M
K
L
G
K
N
Site 22
S186
M
K
L
G
K
N
R
S
H
K
E
E
P
Q
R
Site 23
S220
G
D
G
L
D
P
D
S
V
S
L
A
S
V
T
Site 24
T227
S
V
S
L
A
S
V
T
A
L
T
T
N
V
S
Site 25
T230
L
A
S
V
T
A
L
T
T
N
V
S
N
K
R
Site 26
S234
T
A
L
T
T
N
V
S
N
K
R
S
K
P
D
Site 27
S238
T
N
V
S
N
K
R
S
K
P
D
I
K
M
E
Site 28
S247
P
D
I
K
M
E
P
S
A
G
R
P
M
D
Y
Site 29
Y254
S
A
G
R
P
M
D
Y
Q
V
S
I
T
V
I
Site 30
S257
R
P
M
D
Y
Q
V
S
I
T
V
I
E
A
R
Site 31
Y285
E
V
G
D
D
K
K
Y
T
S
M
K
E
S
T
Site 32
T286
V
G
D
D
K
K
Y
T
S
M
K
E
S
T
N
Site 33
S287
G
D
D
K
K
Y
T
S
M
K
E
S
T
N
C
Site 34
Y297
E
S
T
N
C
P
Y
Y
N
E
Y
F
V
F
D
Site 35
S320
F
D
K
I
I
K
I
S
V
I
H
S
K
N
L
Site 36
S324
I
K
I
S
V
I
H
S
K
N
L
L
R
S
G
Site 37
S330
H
S
K
N
L
L
R
S
G
T
L
V
G
S
F
Site 38
T332
K
N
L
L
R
S
G
T
L
V
G
S
F
K
M
Site 39
S336
R
S
G
T
L
V
G
S
F
K
M
D
V
G
T
Site 40
T343
S
F
K
M
D
V
G
T
V
Y
S
Q
P
E
H
Site 41
Y345
K
M
D
V
G
T
V
Y
S
Q
P
E
H
Q
F
Site 42
S360
H
H
K
W
A
I
L
S
D
P
D
D
I
S
S
Site 43
S366
L
S
D
P
D
D
I
S
S
G
L
K
G
Y
V
Site 44
S367
S
D
P
D
D
I
S
S
G
L
K
G
Y
V
K
Site 45
T388
G
K
G
D
N
I
K
T
P
H
K
A
N
E
T
Site 46
Y420
E
R
Q
W
A
R
F
Y
V
K
I
Y
R
A
E
Site 47
Y424
A
R
F
Y
V
K
I
Y
R
A
E
G
L
P
R
Site 48
T434
E
G
L
P
R
M
N
T
S
L
M
A
N
V
K
Site 49
T467
F
A
G
Q
K
G
K
T
S
V
Q
K
S
S
Y
Site 50
S468
A
G
Q
K
G
K
T
S
V
Q
K
S
S
Y
E
Site 51
S472
G
K
T
S
V
Q
K
S
S
Y
E
P
L
W
N
Site 52
S502
M
K
V
Q
I
R
D
S
D
K
V
N
D
V
A
Site 53
S521
F
I
D
L
R
K
I
S
N
D
G
D
K
G
F
Site 54
T531
G
D
K
G
F
L
P
T
L
G
P
A
W
V
N
Site 55
Y540
G
P
A
W
V
N
M
Y
G
S
T
R
N
Y
T
Site 56
Y546
M
Y
G
S
T
R
N
Y
T
L
L
D
E
H
Q
Site 57
T547
Y
G
S
T
R
N
Y
T
L
L
D
E
H
Q
D
Site 58
S581
A
V
E
I
V
D
T
S
N
P
E
L
T
S
S
Site 59
S588
S
N
P
E
L
T
S
S
T
E
V
Q
V
E
Q
Site 60
T597
E
V
Q
V
E
Q
A
T
P
I
S
E
S
C
A
Site 61
S600
V
E
Q
A
T
P
I
S
E
S
C
A
G
K
M
Site 62
S620
F
G
A
F
L
E
A
S
M
I
D
R
R
N
G
Site 63
T632
R
N
G
D
K
P
I
T
F
E
V
T
I
G
N
Site 64
S648
G
N
E
V
D
G
L
S
R
P
Q
R
P
R
P
Site 65
S672
V
D
L
I
Q
N
A
S
D
D
E
A
G
D
A
Site 66
S684
G
D
A
G
D
L
A
S
V
S
S
T
P
P
M
Site 67
S686
A
G
D
L
A
S
V
S
S
T
P
P
M
R
P
Site 68
S687
G
D
L
A
S
V
S
S
T
P
P
M
R
P
Q
Site 69
T688
D
L
A
S
V
S
S
T
P
P
M
R
P
Q
V
Site 70
T696
P
P
M
R
P
Q
V
T
D
R
N
Y
F
H
L
Site 71
Y700
P
Q
V
T
D
R
N
Y
F
H
L
P
Y
L
E
Site 72
Y705
R
N
Y
F
H
L
P
Y
L
E
R
K
P
C
I
Site 73
Y713
L
E
R
K
P
C
I
Y
I
K
S
W
W
P
D
Site 74
Y726
P
D
Q
R
R
R
L
Y
N
A
N
I
M
D
H
Site 75
T751
D
I
Q
E
M
I
K
T
E
K
S
Y
P
E
R
Site 76
S754
E
M
I
K
T
E
K
S
Y
P
E
R
R
L
R
Site 77
Y755
M
I
K
T
E
K
S
Y
P
E
R
R
L
R
G
Site 78
S776
C
G
C
C
R
F
L
S
L
A
D
K
D
Q
G
Site 79
S785
A
D
K
D
Q
G
H
S
S
R
T
R
L
D
R
Site 80
S786
D
K
D
Q
G
H
S
S
R
T
R
L
D
R
E
Site 81
S797
L
D
R
E
R
L
K
S
C
M
R
E
L
E
N
Site 82
T820
R
A
Q
V
K
R
H
T
V
R
D
K
L
R
L
Site 83
Y862
S
N
N
K
R
V
A
Y
A
R
V
P
S
K
D
Site 84
S873
P
S
K
D
L
L
F
S
I
V
E
E
E
T
G
Site 85
S901
P
G
K
R
G
F
G
S
A
G
W
T
V
Q
A
Site 86
S919
L
Y
L
W
L
G
L
S
K
Q
R
K
E
F
L
Site 87
S951
L
H
A
F
P
P
V
S
L
V
Y
T
K
K
Q
Site 88
T955
P
P
V
S
L
V
Y
T
K
K
Q
A
F
Q
L
Site 89
Y967
F
Q
L
R
A
H
M
Y
Q
A
R
S
L
F
A
Site 90
S971
A
H
M
Y
Q
A
R
S
L
F
A
A
D
S
S
Site 91
S977
R
S
L
F
A
A
D
S
S
G
L
S
D
P
F
Site 92
Y1019
V
F
D
N
L
E
L
Y
G
E
A
H
E
L
R
Site 93
T1051
K
A
D
F
M
G
R
T
F
A
K
P
L
V
K
Site 94
Y1064
V
K
M
A
D
E
A
Y
C
P
P
R
F
P
P
Site 95
Y1075
R
F
P
P
Q
L
E
Y
Y
Q
I
Y
R
G
N
Site 96
Y1076
F
P
P
Q
L
E
Y
Y
Q
I
Y
R
G
N
A
Site 97
S1170
A
G
K
G
V
Q
S
S
L
I
H
N
Y
K
K
Site 98
Y1215
D
C
R
A
F
G
R
Y
T
L
V
G
S
H
A
Site 99
S1220
G
R
Y
T
L
V
G
S
H
A
V
S
S
L
R
Site 100
S1225
V
G
S
H
A
V
S
S
L
R
R
F
I
Y
R
Site 101
Y1231
S
S
L
R
R
F
I
Y
R
P
P
D
R
S
A
Site 102
S1237
I
Y
R
P
P
D
R
S
A
P
S
W
N
T
T
Site 103
T1244
S
A
P
S
W
N
T
T
V
R
L
L
R
R
C
Site 104
S1259
R
V
L
C
N
G
G
S
S
S
H
S
T
G
E
Site 105
S1261
L
C
N
G
G
S
S
S
H
S
T
G
E
V
V
Site 106
S1263
N
G
G
S
S
S
H
S
T
G
E
V
V
V
T
Site 107
T1264
G
G
S
S
S
H
S
T
G
E
V
V
V
T
M
Site 108
S1324
E
E
E
E
P
D
E
S
M
L
D
W
W
S
K
Site 109
S1349
Q
L
R
Q
Q
E
P
S
G
I
D
L
E
E
K
Site 110
T1362
E
K
E
E
V
D
N
T
E
G
L
K
G
S
M
Site 111
T1386
K
E
E
K
K
K
K
T
Q
S
S
G
S
G
Q
Site 112
S1388
E
K
K
K
K
T
Q
S
S
G
S
G
Q
G
S
Site 113
S1389
K
K
K
K
T
Q
S
S
G
S
G
Q
G
S
E
Site 114
S1391
K
K
T
Q
S
S
G
S
G
Q
G
S
E
A
P
Site 115
S1395
S
S
G
S
G
Q
G
S
E
A
P
E
K
K
K
Site 116
Y1411
K
I
D
E
L
K
V
Y
P
K
E
L
E
S
E
Site 117
T1428
N
F
E
D
W
L
H
T
F
N
L
L
R
G
K
Site 118
T1436
F
N
L
L
R
G
K
T
G
D
D
E
D
G
S
Site 119
S1443
T
G
D
D
E
D
G
S
T
E
E
E
R
I
V
Site 120
T1444
G
D
D
E
D
G
S
T
E
E
E
R
I
V
G
Site 121
Y1460
F
K
G
S
L
C
V
Y
K
V
P
L
P
E
D
Site 122
S1469
V
P
L
P
E
D
V
S
R
E
A
G
Y
D
S
Site 123
Y1474
D
V
S
R
E
A
G
Y
D
S
T
Y
G
M
F
Site 124
T1477
R
E
A
G
Y
D
S
T
Y
G
M
F
Q
G
I
Site 125
Y1478
E
A
G
Y
D
S
T
Y
G
M
F
Q
G
I
P
Site 126
Y1516
I
N
G
K
A
D
P
Y
I
A
I
R
L
G
K
Site 127
Y1532
D
I
R
D
K
E
N
Y
I
S
K
Q
L
N
P
Site 128
S1550
K
S
F
D
I
E
A
S
F
P
M
E
S
M
L
Site 129
Y1585
I
D
L
E
N
R
F
Y
S
K
H
R
A
T
C
Site 130
S1586
D
L
E
N
R
F
Y
S
K
H
R
A
T
C
G
Site 131
T1617
M
K
P
S
Q
I
L
T
R
L
C
K
D
G
K
Site 132
T1644
K
V
A
N
R
V
F
T
G
P
S
E
I
E
D
Site 133
T1659
E
N
G
Q
R
K
P
T
D
E
H
V
A
L
L
Site 134
T1688
L
V
P
E
H
V
E
T
R
P
L
L
N
P
D
Site 135
T1720
M
D
M
P
A
P
G
T
P
L
D
I
S
P
R
Site 136
S1725
P
G
T
P
L
D
I
S
P
R
K
P
K
K
Y
Site 137
Y1732
S
P
R
K
P
K
K
Y
E
L
R
V
I
I
W
Site 138
T1753
L
E
D
D
D
F
F
T
G
E
K
S
S
D
I
Site 139
S1757
D
F
F
T
G
E
K
S
S
D
I
F
V
R
G
Site 140
S1758
F
F
T
G
E
K
S
S
D
I
F
V
R
G
W
Site 141
T1776
Q
Q
E
D
K
Q
D
T
D
V
H
Y
H
S
L
Site 142
Y1780
K
Q
D
T
D
V
H
Y
H
S
L
T
G
E
G
Site 143
S1782
D
T
D
V
H
Y
H
S
L
T
G
E
G
N
F
Site 144
T1784
D
V
H
Y
H
S
L
T
G
E
G
N
F
N
W
Site 145
Y1793
E
G
N
F
N
W
R
Y
L
F
P
F
D
Y
L
Site 146
Y1799
R
Y
L
F
P
F
D
Y
L
A
A
E
E
K
I
Site 147
S1809
A
E
E
K
I
V
I
S
K
K
E
S
M
F
S
Site 148
S1813
I
V
I
S
K
K
E
S
M
F
S
W
D
E
T
Site 149
S1816
S
K
K
E
S
M
F
S
W
D
E
T
E
Y
K
Site 150
T1820
S
M
F
S
W
D
E
T
E
Y
K
I
P
A
R
Site 151
Y1822
F
S
W
D
E
T
E
Y
K
I
P
A
R
L
T
Site 152
T1829
Y
K
I
P
A
R
L
T
L
Q
I
W
D
A
D
Site 153
T1860
R
F
P
R
G
A
K
T
A
K
Q
C
T
M
E
Site 154
T1904
E
N
D
E
F
E
L
T
G
K
V
E
A
E
L
Site 155
T1942
E
K
P
N
R
P
D
T
S
F
I
W
F
L
N
Site 156
S1943
K
P
N
R
P
D
T
S
F
I
W
F
L
N
P
Site 157
Y1956
N
P
L
K
S
A
R
Y
F
L
W
H
T
Y
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation