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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOD2
Full Name:
Nucleotide-binding oligomerization domain-containing protein 2
Alias:
Caspase recruitment domain-containing protein 15;Inflammatory bowel disease protein 1
Type:
Mass (Da):
115283
Number AA:
1040
UniProt ID:
Q9HC29
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
G
E
E
G
G
S
A
S
H
D
E
E
E
Site 2
S17
H
D
E
E
E
R
A
S
V
L
L
G
H
S
P
Site 3
S30
S
P
G
C
E
M
C
S
Q
E
A
F
Q
A
Q
Site 4
S67
L
L
S
W
E
V
L
S
W
E
D
Y
E
G
F
Site 5
Y71
E
V
L
S
W
E
D
Y
E
G
F
H
L
L
G
Site 6
T91
L
A
R
R
L
L
D
T
V
W
N
K
G
T
W
Site 7
S114
A
Q
E
A
Q
A
D
S
Q
S
P
K
L
H
G
Site 8
S116
E
A
Q
A
D
S
Q
S
P
K
L
H
G
C
W
Site 9
S136
H
P
A
R
D
L
Q
S
H
R
P
A
I
V
R
Site 10
S147
A
I
V
R
R
L
H
S
H
V
E
N
M
L
D
Site 11
Y165
E
R
G
F
V
S
Q
Y
E
C
D
E
I
R
L
Site 12
T176
E
I
R
L
P
I
F
T
P
S
Q
R
A
R
R
Site 13
S178
R
L
P
I
F
T
P
S
Q
R
A
R
R
L
L
Site 14
Y222
E
A
A
T
C
K
K
Y
M
A
K
L
R
T
T
Site 15
T229
Y
M
A
K
L
R
T
T
V
S
A
Q
S
R
F
Site 16
S231
A
K
L
R
T
T
V
S
A
Q
S
R
F
L
S
Site 17
S234
R
T
T
V
S
A
Q
S
R
F
L
S
T
Y
D
Site 18
S238
S
A
Q
S
R
F
L
S
T
Y
D
G
A
E
T
Site 19
T239
A
Q
S
R
F
L
S
T
Y
D
G
A
E
T
L
Site 20
Y240
Q
S
R
F
L
S
T
Y
D
G
A
E
T
L
C
Site 21
T245
S
T
Y
D
G
A
E
T
L
C
L
E
D
I
Y
Site 22
S272
M
A
G
P
P
Q
K
S
P
A
T
L
G
L
E
Site 23
S283
L
G
L
E
E
L
F
S
T
P
G
H
L
N
D
Site 24
T284
G
L
E
E
L
F
S
T
P
G
H
L
N
D
D
Site 25
T307
E
A
G
S
G
K
S
T
L
L
Q
R
L
H
L
Site 26
T377
H
P
D
R
V
L
L
T
F
D
G
F
D
E
F
Site 27
S396
T
D
R
E
R
H
C
S
P
T
D
P
T
S
V
Site 28
T398
R
E
R
H
C
S
P
T
D
P
T
S
V
Q
T
Site 29
T401
H
C
S
P
T
D
P
T
S
V
Q
T
L
L
F
Site 30
S402
C
S
P
T
D
P
T
S
V
Q
T
L
L
F
N
Site 31
T424
K
N
A
R
K
V
V
T
S
R
P
A
A
V
S
Site 32
S425
N
A
R
K
V
V
T
S
R
P
A
A
V
S
A
Site 33
Y437
V
S
A
F
L
R
K
Y
I
R
T
E
F
N
L
Site 34
T440
F
L
R
K
Y
I
R
T
E
F
N
L
K
G
F
Site 35
S448
E
F
N
L
K
G
F
S
E
Q
G
I
E
L
Y
Site 36
Y455
S
E
Q
G
I
E
L
Y
L
R
K
R
H
H
E
Site 37
S477
I
R
L
L
Q
E
T
S
A
L
H
G
L
C
H
Site 38
S493
P
V
F
S
W
M
V
S
K
C
H
Q
E
L
L
Site 39
S506
L
L
L
Q
E
G
G
S
P
K
T
T
T
D
M
Site 40
T509
Q
E
G
G
S
P
K
T
T
T
D
M
Y
L
L
Site 41
T510
E
G
G
S
P
K
T
T
T
D
M
Y
L
L
I
Site 42
T526
Q
H
F
L
L
H
A
T
P
P
D
S
A
S
Q
Site 43
S530
L
H
A
T
P
P
D
S
A
S
Q
G
L
G
P
Site 44
S532
A
T
P
P
D
S
A
S
Q
G
L
G
P
S
L
Site 45
S538
A
S
Q
G
L
G
P
S
L
L
R
G
R
L
P
Site 46
S576
Q
L
Q
A
A
Q
V
S
P
D
D
I
S
L
G
Site 47
S638
N
C
G
R
P
G
N
S
P
M
A
R
L
L
P
Site 48
S657
Q
A
S
E
G
K
D
S
S
V
A
A
L
L
Q
Site 49
S658
A
S
E
G
K
D
S
S
V
A
A
L
L
Q
K
Site 50
S696
L
L
A
E
C
Q
T
S
E
K
A
L
L
R
R
Site 51
S721
S
L
R
K
H
F
H
S
I
P
P
A
A
P
G
Site 52
S732
A
A
P
G
E
A
K
S
V
H
A
M
P
G
F
Site 53
Y747
I
W
L
I
R
S
L
Y
E
M
Q
E
E
R
L
Site 54
S828
Y
L
R
D
N
N
I
S
D
R
G
I
C
K
L
Site 55
T899
A
E
G
L
R
G
N
T
S
L
Q
F
L
G
F
Site 56
S900
E
G
L
R
G
N
T
S
L
Q
F
L
G
F
W
Site 57
S928
E
A
L
G
D
H
Q
S
L
R
W
L
S
L
V
Site 58
S933
H
Q
S
L
R
W
L
S
L
V
G
N
N
I
G
Site 59
S974
L
Q
D
E
G
V
C
S
L
A
E
G
L
K
K
Site 60
S984
E
G
L
K
K
N
S
S
L
K
I
L
K
L
S
Site 61
T1012
Q
A
L
E
R
N
D
T
I
L
E
V
W
L
R
Site 62
T1022
E
V
W
L
R
G
N
T
F
S
L
E
E
V
D
Site 63
S1024
W
L
R
G
N
T
F
S
L
E
E
V
D
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation