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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EML4
Full Name:
Echinoderm microtubule-associated protein-like 4
Alias:
C2ORF2; Echinoderm microtubule associated protein like 4; Echinoderm microtubule-associated protein-like 4; ELP120; EMAL4; EMAP-4; EMAPL4; Restrictedly overexpressed proliferation-associated protein; Ropp 120; ROPP120
Type:
Cytoskeletal protein
Mass (Da):
108903
Number AA:
981
UniProt ID:
Q9HC35
International Prot ID:
IPI00001466
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007017
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Echinoderm microtubule-associated protein-like 4 Y226 phosphosite-specific antibody AB-PN510#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN510#Echinoderm microtubule-associated protein-like 4 (E223-M229, human) pY226 phosphopeptide - Powder PE-04AHG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHG99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
G
F
A
G
S
L
D
D
S
I
S
A
Site 2
S11
F
A
G
S
L
D
D
S
I
S
A
A
S
T
S
Site 3
S13
G
S
L
D
D
S
I
S
A
A
S
T
S
D
V
Site 4
S16
D
D
S
I
S
A
A
S
T
S
D
V
Q
D
R
Site 5
T17
D
S
I
S
A
A
S
T
S
D
V
Q
D
R
L
Site 6
S25
S
D
V
Q
D
R
L
S
A
L
E
S
R
V
Q
Site 7
S29
D
R
L
S
A
L
E
S
R
V
Q
Q
Q
E
D
Site 8
T39
Q
Q
Q
E
D
E
I
T
V
L
K
A
A
L
A
Site 9
S61
I
S
E
D
H
V
A
S
V
K
K
S
V
S
S
Site 10
S65
H
V
A
S
V
K
K
S
V
S
S
K
G
Q
P
Site 11
S67
A
S
V
K
K
S
V
S
S
K
G
Q
P
S
P
Site 12
S68
S
V
K
K
S
V
S
S
K
G
Q
P
S
P
R
Site 13
S73
V
S
S
K
G
Q
P
S
P
R
A
V
I
P
M
Site 14
S87
M
S
C
I
T
N
G
S
G
A
N
R
K
P
S
Site 15
S94
S
G
A
N
R
K
P
S
H
T
S
A
V
S
I
Site 16
T96
A
N
R
K
P
S
H
T
S
A
V
S
I
A
G
Site 17
S100
P
S
H
T
S
A
V
S
I
A
G
K
E
T
L
Site 18
S108
I
A
G
K
E
T
L
S
S
A
A
K
S
G
T
Site 19
S109
A
G
K
E
T
L
S
S
A
A
K
S
G
T
E
Site 20
S113
T
L
S
S
A
A
K
S
G
T
E
K
K
K
E
Site 21
S132
Q
R
E
K
K
E
E
S
H
S
N
D
Q
S
P
Site 22
S134
E
K
K
E
E
S
H
S
N
D
Q
S
P
Q
I
Site 23
S138
E
S
H
S
N
D
Q
S
P
Q
I
R
A
S
P
Site 24
S144
Q
S
P
Q
I
R
A
S
P
S
P
Q
P
S
S
Site 25
S146
P
Q
I
R
A
S
P
S
P
Q
P
S
S
Q
P
Site 26
S150
A
S
P
S
P
Q
P
S
S
Q
P
L
Q
I
H
Site 27
S151
S
P
S
P
Q
P
S
S
Q
P
L
Q
I
H
R
Site 28
T160
P
L
Q
I
H
R
Q
T
P
E
S
K
N
A
T
Site 29
S163
I
H
R
Q
T
P
E
S
K
N
A
T
P
T
K
Site 30
T167
T
P
E
S
K
N
A
T
P
T
K
S
I
K
R
Site 31
S171
K
N
A
T
P
T
K
S
I
K
R
P
S
P
A
Site 32
S176
T
K
S
I
K
R
P
S
P
A
E
K
S
H
N
Site 33
S181
R
P
S
P
A
E
K
S
H
N
S
W
E
N
S
Site 34
S184
P
A
E
K
S
H
N
S
W
E
N
S
D
D
S
Site 35
S188
S
H
N
S
W
E
N
S
D
D
S
R
N
K
L
Site 36
S191
S
W
E
N
S
D
D
S
R
N
K
L
S
K
I
Site 37
S196
D
D
S
R
N
K
L
S
K
I
P
S
T
P
K
Site 38
S200
N
K
L
S
K
I
P
S
T
P
K
L
I
P
K
Site 39
T201
K
L
S
K
I
P
S
T
P
K
L
I
P
K
V
Site 40
T209
P
K
L
I
P
K
V
T
K
T
A
D
K
H
K
Site 41
T211
L
I
P
K
V
T
K
T
A
D
K
H
K
D
V
Site 42
Y226
I
I
N
Q
E
G
E
Y
I
K
M
F
M
R
G
Echinoderm microtubule-associated protein-like 4 Y226 phosphosite-specific antibody AB-PN510#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN510#Echinoderm microtubule-associated protein-like 4 (E223-M229, human) pY226 phosphopeptide - Powder PE-04AHG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHG99
Site 43
Y247
I
P
S
D
V
D
N
Y
D
D
I
R
T
E
L
Site 44
T252
D
N
Y
D
D
I
R
T
E
L
P
P
E
K
L
Site 45
Y265
K
L
K
L
E
W
A
Y
G
Y
R
G
K
D
C
Site 46
Y277
K
D
C
R
A
N
V
Y
L
L
P
T
G
E
I
Site 47
Y297
S
V
V
V
L
F
N
Y
E
E
R
T
Q
R
H
Site 48
Y305
E
E
R
T
Q
R
H
Y
L
G
H
T
D
C
V
Site 49
T326
P
D
K
I
R
I
A
T
G
Q
I
A
G
V
D
Site 50
S348
P
H
V
R
V
W
D
S
V
T
L
S
T
L
Q
Site 51
T424
F
H
P
T
D
A
N
T
I
I
T
C
G
K
S
Site 52
Y453
K
Q
G
I
F
G
K
Y
E
K
P
K
F
V
Q
Site 53
T486
M
L
I
W
S
K
T
T
V
E
P
T
P
G
K
Site 54
T490
S
K
T
T
V
E
P
T
P
G
K
G
P
K
G
Site 55
Y499
G
K
G
P
K
G
V
Y
Q
I
S
K
Q
I
K
Site 56
S502
P
K
G
V
Y
Q
I
S
K
Q
I
K
A
H
D
Site 57
Y552
E
I
E
V
P
D
Q
Y
G
T
I
R
A
V
A
Site 58
T579
R
N
F
I
L
R
G
T
F
N
D
G
F
Q
I
Site 59
S679
T
D
G
N
E
Q
L
S
V
M
R
Y
S
I
D
Site 60
Y683
E
Q
L
S
V
M
R
Y
S
I
D
G
T
F
L
Site 61
Y700
G
S
H
D
N
F
I
Y
L
Y
V
V
S
E
N
Site 62
Y702
H
D
N
F
I
Y
L
Y
V
V
S
E
N
G
R
Site 63
Y711
V
S
E
N
G
R
K
Y
S
R
Y
G
R
C
T
Site 64
S712
S
E
N
G
R
K
Y
S
R
Y
G
R
C
T
G
Site 65
Y714
N
G
R
K
Y
S
R
Y
G
R
C
T
G
H
S
Site 66
T718
Y
S
R
Y
G
R
C
T
G
H
S
S
Y
I
T
Site 67
Y723
R
C
T
G
H
S
S
Y
I
T
H
L
D
W
S
Site 68
T725
T
G
H
S
S
Y
I
T
H
L
D
W
S
P
D
Site 69
Y735
D
W
S
P
D
N
K
Y
I
M
S
N
S
G
D
Site 70
Y743
I
M
S
N
S
G
D
Y
E
I
L
Y
W
D
I
Site 71
Y747
S
G
D
Y
E
I
L
Y
W
D
I
P
N
G
C
Site 72
Y771
K
D
I
D
W
T
T
Y
T
C
V
L
G
F
Q
Site 73
S787
F
G
V
W
P
E
G
S
D
G
T
D
I
N
A
Site 74
S798
D
I
N
A
L
V
R
S
H
N
R
K
V
I
A
Site 75
Y818
C
K
V
H
L
F
Q
Y
P
C
S
K
A
K
A
Site 76
S821
H
L
F
Q
Y
P
C
S
K
A
K
A
P
S
H
Site 77
S827
C
S
K
A
K
A
P
S
H
K
Y
S
A
H
S
Site 78
Y830
A
K
A
P
S
H
K
Y
S
A
H
S
S
H
V
Site 79
S831
K
A
P
S
H
K
Y
S
A
H
S
S
H
V
T
Site 80
S835
H
K
Y
S
A
H
S
S
H
V
T
N
V
S
F
Site 81
T838
S
A
H
S
S
H
V
T
N
V
S
F
T
H
N
Site 82
S841
S
S
H
V
T
N
V
S
F
T
H
N
D
S
H
Site 83
T843
H
V
T
N
V
S
F
T
H
N
D
S
H
L
I
Site 84
S847
V
S
F
T
H
N
D
S
H
L
I
S
T
G
G
Site 85
S851
H
N
D
S
H
L
I
S
T
G
G
K
D
M
S
Site 86
S858
S
T
G
G
K
D
M
S
I
I
Q
W
K
L
V
Site 87
S869
W
K
L
V
E
K
L
S
L
P
Q
N
E
T
V
Site 88
T875
L
S
L
P
Q
N
E
T
V
A
D
T
T
L
T
Site 89
T880
N
E
T
V
A
D
T
T
L
T
K
A
P
V
S
Site 90
T882
T
V
A
D
T
T
L
T
K
A
P
V
S
S
T
Site 91
S887
T
L
T
K
A
P
V
S
S
T
E
S
V
I
Q
Site 92
T889
T
K
A
P
V
S
S
T
E
S
V
I
Q
S
N
Site 93
S891
A
P
V
S
S
T
E
S
V
I
Q
S
N
T
P
Site 94
S895
S
T
E
S
V
I
Q
S
N
T
P
T
P
P
P
Site 95
T897
E
S
V
I
Q
S
N
T
P
T
P
P
P
S
Q
Site 96
T899
V
I
Q
S
N
T
P
T
P
P
P
S
Q
P
L
Site 97
S903
N
T
P
T
P
P
P
S
Q
P
L
N
E
T
A
Site 98
T909
P
S
Q
P
L
N
E
T
A
E
E
E
S
R
I
Site 99
S917
A
E
E
E
S
R
I
S
S
S
P
T
L
L
E
Site 100
S918
E
E
E
S
R
I
S
S
S
P
T
L
L
E
N
Site 101
S919
E
E
S
R
I
S
S
S
P
T
L
L
E
N
S
Site 102
T921
S
R
I
S
S
S
P
T
L
L
E
N
S
L
E
Site 103
S926
S
P
T
L
L
E
N
S
L
E
Q
T
V
E
P
Site 104
T930
L
E
N
S
L
E
Q
T
V
E
P
S
E
D
H
Site 105
S934
L
E
Q
T
V
E
P
S
E
D
H
S
E
E
E
Site 106
S938
V
E
P
S
E
D
H
S
E
E
E
S
E
E
G
Site 107
S942
E
D
H
S
E
E
E
S
E
E
G
S
G
D
L
Site 108
S946
E
E
E
S
E
E
G
S
G
D
L
G
E
P
L
Site 109
Y954
G
D
L
G
E
P
L
Y
E
E
P
C
N
E
I
Site 110
S978
L
E
D
Q
Q
D
P
S
P
S
S
_
_
_
_
Site 111
S980
D
Q
Q
D
P
S
P
S
S
_
_
_
_
_
_
Site 112
S981
Q
Q
D
P
S
P
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation