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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SENP2
Full Name:
Sentrin-specific protease 2
Alias:
Axam2; DKFZp762A2316; KIAA1331; Sentrin-specific protease; Smt3ip2; SMT3-specific isopeptidase 2; SUMO1/sentrin/SMT3 specific peptidase 2
Type:
EC 3.4.22.-; Protease
Mass (Da):
67855
Number AA:
589
UniProt ID:
Q9HC62
International Prot ID:
IPI00307683
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005643
Uniprot
OncoNet
Molecular Function:
GO:0016929
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0051028
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
A
L
L
K
R
R
R
S
D
S
T
L
F
S
T
Site 2
S34
L
K
R
R
R
S
D
S
T
L
F
S
T
V
D
Site 3
T35
K
R
R
R
S
D
S
T
L
F
S
T
V
D
T
Site 4
S38
R
S
D
S
T
L
F
S
T
V
D
T
D
E
I
Site 5
T39
S
D
S
T
L
F
S
T
V
D
T
D
E
I
P
Site 6
T42
T
L
F
S
T
V
D
T
D
E
I
P
A
K
R
Site 7
Y64
H
Q
V
K
N
S
L
Y
N
A
A
S
L
F
G
Site 8
S95
G
T
R
N
V
A
P
S
G
E
V
F
S
N
S
Site 9
S100
A
P
S
G
E
V
F
S
N
S
S
S
C
E
L
Site 10
S102
S
G
E
V
F
S
N
S
S
S
C
E
L
T
G
Site 11
S104
E
V
F
S
N
S
S
S
C
E
L
T
G
S
G
Site 12
T108
N
S
S
S
C
E
L
T
G
S
G
S
W
N
N
Site 13
S110
S
S
C
E
L
T
G
S
G
S
W
N
N
M
L
Site 14
S112
C
E
L
T
G
S
G
S
W
N
N
M
L
K
L
Site 15
S123
M
L
K
L
G
N
K
S
P
N
G
I
S
D
Y
Site 16
S128
N
K
S
P
N
G
I
S
D
Y
P
K
I
R
V
Site 17
Y130
S
P
N
G
I
S
D
Y
P
K
I
R
V
T
V
Site 18
T136
D
Y
P
K
I
R
V
T
V
T
R
D
Q
P
R
Site 19
S148
Q
P
R
R
V
L
P
S
F
G
F
T
L
N
S
Site 20
S155
S
F
G
F
T
L
N
S
E
G
C
N
R
R
P
Site 21
S168
R
P
G
G
R
R
H
S
K
G
N
P
E
S
S
Site 22
S174
H
S
K
G
N
P
E
S
S
L
M
W
K
P
Q
Site 23
S175
S
K
G
N
P
E
S
S
L
M
W
K
P
Q
E
Site 24
T186
K
P
Q
E
Q
A
V
T
E
M
I
S
E
E
S
Site 25
T203
G
L
R
R
P
H
C
T
V
E
E
G
V
Q
K
Site 26
Y216
Q
K
E
E
R
E
K
Y
R
K
L
L
E
R
L
Site 27
S231
K
E
S
G
H
G
N
S
V
C
P
V
T
S
N
Site 28
T236
G
N
S
V
C
P
V
T
S
N
Y
H
S
S
Q
Site 29
S237
N
S
V
C
P
V
T
S
N
Y
H
S
S
Q
R
Site 30
Y239
V
C
P
V
T
S
N
Y
H
S
S
Q
R
S
Q
Site 31
S241
P
V
T
S
N
Y
H
S
S
Q
R
S
Q
M
D
Site 32
S242
V
T
S
N
Y
H
S
S
Q
R
S
Q
M
D
T
Site 33
S245
N
Y
H
S
S
Q
R
S
Q
M
D
T
L
K
T
Site 34
T249
S
Q
R
S
Q
M
D
T
L
K
T
K
G
W
G
Site 35
S284
E
T
R
G
P
L
C
S
L
R
S
E
K
R
C
Site 36
S287
G
P
L
C
S
L
R
S
E
K
R
C
S
K
G
Site 37
S292
L
R
S
E
K
R
C
S
K
G
K
I
T
D
T
Site 38
T299
S
K
G
K
I
T
D
T
E
T
M
V
G
I
R
Site 39
T301
G
K
I
T
D
T
E
T
M
V
G
I
R
F
E
Site 40
S311
G
I
R
F
E
N
E
S
R
R
G
Y
Q
L
E
Site 41
Y315
E
N
E
S
R
R
G
Y
Q
L
E
P
D
L
S
Site 42
S322
Y
Q
L
E
P
D
L
S
E
E
V
S
A
R
L
Site 43
S326
P
D
L
S
E
E
V
S
A
R
L
R
L
G
S
Site 44
S333
S
A
R
L
R
L
G
S
G
S
N
G
L
L
R
Site 45
S335
R
L
R
L
G
S
G
S
N
G
L
L
R
R
K
Site 46
S344
G
L
L
R
R
K
V
S
I
I
E
T
K
E
K
Site 47
T348
R
K
V
S
I
I
E
T
K
E
K
N
C
S
G
Site 48
S354
E
T
K
E
K
N
C
S
G
K
E
R
D
R
R
Site 49
T362
G
K
E
R
D
R
R
T
D
D
L
L
E
L
T
Site 50
S377
E
D
M
E
K
E
I
S
N
A
L
G
H
G
P
Site 51
S391
P
Q
D
E
I
L
S
S
A
F
K
L
R
I
T
Site 52
T398
S
A
F
K
L
R
I
T
R
G
D
I
Q
T
L
Site 53
Y432
E
R
N
K
K
Q
G
Y
P
A
L
H
V
F
S
Site 54
Y443
H
V
F
S
T
F
F
Y
P
K
L
K
S
G
G
Site 55
S448
F
F
Y
P
K
L
K
S
G
G
Y
Q
A
V
K
Site 56
Y451
P
K
L
K
S
G
G
Y
Q
A
V
K
R
W
T
Site 57
Y493
L
R
K
K
C
L
K
Y
L
D
S
M
G
Q
K
Site 58
S496
K
C
L
K
Y
L
D
S
M
G
Q
K
G
H
R
Site 59
Y511
I
C
E
I
L
L
Q
Y
L
Q
D
E
S
K
T
Site 60
T518
Y
L
Q
D
E
S
K
T
K
R
N
S
D
L
N
Site 61
S522
E
S
K
T
K
R
N
S
D
L
N
L
L
E
W
Site 62
Y555
C
G
M
F
T
C
K
Y
A
D
Y
I
S
R
D
Site 63
Y558
F
T
C
K
Y
A
D
Y
I
S
R
D
K
P
I
Site 64
T566
I
S
R
D
K
P
I
T
F
T
Q
H
Q
M
P
Site 65
T568
R
D
K
P
I
T
F
T
Q
H
Q
M
P
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation