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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPAP
Full Name:
Centromere protein J
Alias:
BM032; CENPJ; Centrosomal P4.1-associated protein; LAG-3- associated protein; LAP; LIP1; LYST-interacting protein 1; MCPH6
Type:
Transcription, coactivator/corepressor; Cell cycle regulation; Microtubule binding protein
Mass (Da):
153000
Number AA:
1338
UniProt ID:
Q9HC77
International Prot ID:
IPI00043201
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005814
GO:0005829
GO:0008275
Uniprot
OncoNet
Molecular Function:
GO:0019904
GO:0015631
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007099
GO:0007020
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
F
L
M
P
T
S
S
E
L
N
S
G
Q
Site 2
S8
M
F
L
M
P
T
S
S
E
L
N
S
G
Q
N
Site 3
S12
P
T
S
S
E
L
N
S
G
Q
N
F
L
T
Q
Site 4
S53
A
A
V
D
I
S
T
S
F
P
I
K
G
T
H
Site 5
S62
P
I
K
G
T
H
F
S
D
S
F
S
F
I
N
Site 6
S64
K
G
T
H
F
S
D
S
F
S
F
I
N
E
E
Site 7
S66
T
H
F
S
D
S
F
S
F
I
N
E
E
D
S
Site 8
S73
S
F
I
N
E
E
D
S
L
L
E
E
Q
K
L
Site 9
Y86
K
L
E
S
N
N
P
Y
K
P
Q
S
D
K
S
Site 10
S90
N
N
P
Y
K
P
Q
S
D
K
S
E
T
H
T
Site 11
S93
Y
K
P
Q
S
D
K
S
E
T
H
T
A
F
P
Site 12
T95
P
Q
S
D
K
S
E
T
H
T
A
F
P
C
I
Site 13
T97
S
D
K
S
E
T
H
T
A
F
P
C
I
K
K
Site 14
S113
P
Q
V
A
A
C
H
S
A
P
G
H
Q
E
E
Site 15
S131
D
F
I
P
D
L
A
S
E
F
K
E
G
A
Y
Site 16
Y138
S
E
F
K
E
G
A
Y
K
D
P
L
F
K
K
Site 17
T180
E
E
Q
E
K
L
L
T
M
V
S
G
Q
C
T
Site 18
S192
Q
C
T
L
P
G
L
S
L
L
P
D
D
Q
S
Site 19
S199
S
L
L
P
D
D
Q
S
Q
K
H
R
S
P
G
Site 20
S204
D
Q
S
Q
K
H
R
S
P
G
N
T
T
T
G
Site 21
T208
K
H
R
S
P
G
N
T
T
T
G
E
R
A
T
Site 22
T210
R
S
P
G
N
T
T
T
G
E
R
A
T
C
C
Site 23
T215
T
T
T
G
E
R
A
T
C
C
F
P
S
Y
V
Site 24
Y221
A
T
C
C
F
P
S
Y
V
Y
P
D
P
T
Q
Site 25
Y223
C
C
F
P
S
Y
V
Y
P
D
P
T
Q
E
E
Site 26
T227
S
Y
V
Y
P
D
P
T
Q
E
E
T
Y
P
S
Site 27
Y232
D
P
T
Q
E
E
T
Y
P
S
N
I
L
S
H
Site 28
S234
T
Q
E
E
T
Y
P
S
N
I
L
S
H
E
Q
Site 29
T255
A
H
G
D
F
V
L
T
S
K
R
A
S
P
N
Site 30
S256
H
G
D
F
V
L
T
S
K
R
A
S
P
N
L
Site 31
S260
V
L
T
S
K
R
A
S
P
N
L
F
S
E
A
Site 32
Y269
N
L
F
S
E
A
Q
Y
Q
E
A
P
V
E
K
Site 33
S316
N
L
Q
K
H
D
D
S
S
E
V
A
N
I
E
Site 34
S317
L
Q
K
H
D
D
S
S
E
V
A
N
I
E
E
Site 35
T337
A
I
G
E
R
K
Q
T
F
E
D
Y
L
E
E
Site 36
Y341
R
K
Q
T
F
E
D
Y
L
E
E
Q
I
Q
L
Site 37
T386
G
E
G
L
A
R
F
T
N
A
K
S
K
F
Q
Site 38
S390
A
R
F
T
N
A
K
S
K
F
Q
K
G
K
E
Site 39
T402
G
K
E
S
K
L
V
T
N
Q
S
T
S
E
D
Site 40
S405
S
K
L
V
T
N
Q
S
T
S
E
D
Q
P
L
Site 41
S407
L
V
T
N
Q
S
T
S
E
D
Q
P
L
F
K
Site 42
T424
R
Q
Q
L
Q
R
K
T
A
L
K
N
K
E
L
Site 43
S442
N
P
I
L
K
K
D
S
K
A
R
T
K
S
G
Site 44
T446
K
K
D
S
K
A
R
T
K
S
G
S
V
T
L
Site 45
S448
D
S
K
A
R
T
K
S
G
S
V
T
L
S
Q
Site 46
S450
K
A
R
T
K
S
G
S
V
T
L
S
Q
K
P
Site 47
T452
R
T
K
S
G
S
V
T
L
S
Q
K
P
K
M
Site 48
S454
K
S
G
S
V
T
L
S
Q
K
P
K
M
L
K
Site 49
S463
K
P
K
M
L
K
C
S
N
R
K
S
L
S
P
Site 50
S467
L
K
C
S
N
R
K
S
L
S
P
S
G
L
K
Site 51
S469
C
S
N
R
K
S
L
S
P
S
G
L
K
I
Q
Site 52
S471
N
R
K
S
L
S
P
S
G
L
K
I
Q
T
G
Site 53
T496
I
K
F
E
N
K
V
T
S
N
N
K
E
N
V
Site 54
T504
S
N
N
K
E
N
V
T
E
C
P
K
P
C
D
Site 55
S529
G
K
D
R
L
P
L
S
T
G
P
A
S
R
L
Site 56
T530
K
D
R
L
P
L
S
T
G
P
A
S
R
L
A
Site 57
S534
P
L
S
T
G
P
A
S
R
L
A
A
K
S
P
Site 58
S540
A
S
R
L
A
A
K
S
P
I
R
E
T
M
K
Site 59
T545
A
K
S
P
I
R
E
T
M
K
E
S
E
S
S
Site 60
S549
I
R
E
T
M
K
E
S
E
S
S
L
D
V
S
Site 61
S551
E
T
M
K
E
S
E
S
S
L
D
V
S
L
Q
Site 62
S552
T
M
K
E
S
E
S
S
L
D
V
S
L
Q
K
Site 63
S556
S
E
S
S
L
D
V
S
L
Q
K
K
L
E
T
Site 64
S589
E
Q
A
A
D
E
I
S
F
S
S
N
S
S
F
Site 65
S592
A
D
E
I
S
F
S
S
N
S
S
F
V
L
K
Site 66
S595
I
S
F
S
S
N
S
S
F
V
L
K
I
L
E
Site 67
S614
I
C
K
G
H
R
M
S
S
T
P
V
K
A
V
Site 68
S615
C
K
G
H
R
M
S
S
T
P
V
K
A
V
P
Site 69
T616
K
G
H
R
M
S
S
T
P
V
K
A
V
P
Q
Site 70
T625
V
K
A
V
P
Q
K
T
N
P
A
D
P
I
S
Site 71
S632
T
N
P
A
D
P
I
S
H
C
N
R
S
E
D
Site 72
T643
R
S
E
D
L
D
H
T
A
R
E
K
E
S
E
Site 73
S660
V
A
P
K
Q
L
H
S
L
S
S
A
D
E
L
Site 74
S662
P
K
Q
L
H
S
L
S
S
A
D
E
L
R
E
Site 75
S663
K
Q
L
H
S
L
S
S
A
D
E
L
R
E
Q
Site 76
S681
I
R
K
A
V
Q
K
S
T
S
E
N
Q
T
E
Site 77
T682
R
K
A
V
Q
K
S
T
S
E
N
Q
T
E
W
Site 78
S683
K
A
V
Q
K
S
T
S
E
N
Q
T
E
W
N
Site 79
T687
K
S
T
S
E
N
Q
T
E
W
N
A
R
D
D
Site 80
S700
D
D
E
G
V
P
N
S
D
S
S
T
D
S
E
Site 81
S702
E
G
V
P
N
S
D
S
S
T
D
S
E
E
Q
Site 82
S703
G
V
P
N
S
D
S
S
T
D
S
E
E
Q
L
Site 83
T704
V
P
N
S
D
S
S
T
D
S
E
E
Q
L
D
Site 84
S706
N
S
D
S
S
T
D
S
E
E
Q
L
D
V
T
Site 85
T713
S
E
E
Q
L
D
V
T
I
K
P
S
T
E
D
Site 86
S717
L
D
V
T
I
K
P
S
T
E
D
R
E
R
G
Site 87
T718
D
V
T
I
K
P
S
T
E
D
R
E
R
G
I
Site 88
S726
E
D
R
E
R
G
I
S
S
R
E
D
S
P
Q
Site 89
S727
D
R
E
R
G
I
S
S
R
E
D
S
P
Q
V
Site 90
S731
G
I
S
S
R
E
D
S
P
Q
V
C
D
D
K
Site 91
T746
G
P
F
K
D
T
R
T
Q
E
D
K
R
R
D
Site 92
S759
R
D
V
D
L
D
L
S
D
K
D
Y
S
S
D
Site 93
Y763
L
D
L
S
D
K
D
Y
S
S
D
E
S
I
M
Site 94
S764
D
L
S
D
K
D
Y
S
S
D
E
S
I
M
E
Site 95
S765
L
S
D
K
D
Y
S
S
D
E
S
I
M
E
S
Site 96
S768
K
D
Y
S
S
D
E
S
I
M
E
S
I
K
H
Site 97
S772
S
D
E
S
I
M
E
S
I
K
H
K
V
S
E
Site 98
S778
E
S
I
K
H
K
V
S
E
P
S
R
S
S
S
Site 99
S781
K
H
K
V
S
E
P
S
R
S
S
S
L
S
L
Site 100
S783
K
V
S
E
P
S
R
S
S
S
L
S
L
S
K
Site 101
S784
V
S
E
P
S
R
S
S
S
L
S
L
S
K
M
Site 102
S785
S
E
P
S
R
S
S
S
L
S
L
S
K
M
D
Site 103
S787
P
S
R
S
S
S
L
S
L
S
K
M
D
F
D
Site 104
S789
R
S
S
S
L
S
L
S
K
M
D
F
D
D
E
Site 105
T798
M
D
F
D
D
E
R
T
W
T
D
L
E
E
N
Site 106
T800
F
D
D
E
R
T
W
T
D
L
E
E
N
L
C
Site 107
S817
D
V
V
L
G
N
E
S
T
Y
G
T
P
Q
T
Site 108
Y819
V
L
G
N
E
S
T
Y
G
T
P
Q
T
C
Y
Site 109
T821
G
N
E
S
T
Y
G
T
P
Q
T
C
Y
P
N
Site 110
Y826
Y
G
T
P
Q
T
C
Y
P
N
N
E
I
G
I
Site 111
T837
E
I
G
I
L
D
K
T
I
K
R
K
I
A
P
Site 112
S852
V
K
R
G
E
D
L
S
K
S
R
R
S
R
S
Site 113
S854
R
G
E
D
L
S
K
S
R
R
S
R
S
P
P
Site 114
S857
D
L
S
K
S
R
R
S
R
S
P
P
T
S
E
Site 115
S859
S
K
S
R
R
S
R
S
P
P
T
S
E
L
M
Site 116
T862
R
R
S
R
S
P
P
T
S
E
L
M
M
K
F
Site 117
S863
R
S
R
S
P
P
T
S
E
L
M
M
K
F
F
Site 118
S872
L
M
M
K
F
F
P
S
L
K
P
K
P
K
S
Site 119
S879
S
L
K
P
K
P
K
S
D
S
H
L
G
N
E
Site 120
S892
N
E
L
K
L
N
I
S
Q
D
Q
P
P
G
D
Site 121
S903
P
P
G
D
N
A
R
S
Q
V
L
R
E
K
I
Site 122
S926
K
F
K
A
E
N
A
S
L
A
K
L
R
I
E
Site 123
S936
K
L
R
I
E
R
E
S
A
L
E
K
L
R
K
Site 124
T982
K
V
F
E
K
Y
T
T
A
A
R
T
F
P
D
Site 125
T986
K
Y
T
T
A
A
R
T
F
P
D
K
K
E
R
Site 126
T998
K
E
R
E
E
I
Q
T
L
K
Q
Q
I
A
D
Site 127
T1015
E
D
L
K
R
K
E
T
K
W
S
S
T
H
S
Site 128
S1018
K
R
K
E
T
K
W
S
S
T
H
S
R
L
R
Site 129
S1019
R
K
E
T
K
W
S
S
T
H
S
R
L
R
S
Site 130
S1022
T
K
W
S
S
T
H
S
R
L
R
S
Q
I
Q
Site 131
S1026
S
T
H
S
R
L
R
S
Q
I
Q
M
L
V
R
Site 132
T1036
Q
M
L
V
R
E
N
T
D
L
R
E
E
I
K
Site 133
S1061
K
R
A
E
A
I
E
S
S
L
E
V
E
K
K
Site 134
S1062
R
A
E
A
I
E
S
S
L
E
V
E
K
K
D
Site 135
T1074
K
K
D
K
L
A
N
T
S
V
R
F
Q
N
S
Site 136
S1075
K
D
K
L
A
N
T
S
V
R
F
Q
N
S
Q
Site 137
S1081
T
S
V
R
F
Q
N
S
Q
I
S
S
G
T
Q
Site 138
S1085
F
Q
N
S
Q
I
S
S
G
T
Q
V
E
K
Y
Site 139
Y1092
S
G
T
Q
V
E
K
Y
K
K
N
Y
L
P
M
Site 140
Y1096
V
E
K
Y
K
K
N
Y
L
P
M
Q
G
N
P
Site 141
S1107
Q
G
N
P
P
R
R
S
K
S
A
P
P
R
D
Site 142
S1109
N
P
P
R
R
S
K
S
A
P
P
R
D
L
G
Site 143
S1125
L
D
K
G
Q
A
A
S
P
R
E
P
L
E
P
Site 144
Y1140
L
N
F
P
D
P
E
Y
K
E
E
E
E
D
Q
Site 145
Y1164
D
G
K
V
E
K
V
Y
K
N
G
C
R
V
I
Site 146
S1182
N
G
T
R
K
E
V
S
A
D
G
K
T
I
T
Site 147
T1189
S
A
D
G
K
T
I
T
V
T
F
F
N
G
D
Site 148
T1191
D
G
K
T
I
T
V
T
F
F
N
G
D
V
K
Site 149
Y1208
M
P
D
Q
R
V
I
Y
Y
Y
A
A
A
Q
T
Site 150
Y1210
D
Q
R
V
I
Y
Y
Y
A
A
A
Q
T
T
H
Site 151
T1218
A
A
A
Q
T
T
H
T
T
Y
P
E
G
L
E
Site 152
Y1220
A
Q
T
T
H
T
T
Y
P
E
G
L
E
V
L
Site 153
S1231
L
E
V
L
H
F
S
S
G
Q
I
E
K
H
Y
Site 154
Y1238
S
G
Q
I
E
K
H
Y
P
D
G
R
K
E
I
Site 155
T1246
P
D
G
R
K
E
I
T
F
P
D
Q
T
V
K
Site 156
T1251
E
I
T
F
P
D
Q
T
V
K
N
L
F
P
D
Site 157
S1263
F
P
D
G
Q
E
E
S
I
F
P
D
G
T
I
Site 158
T1269
E
S
I
F
P
D
G
T
I
V
R
V
Q
R
D
Site 159
Y1300
A
Q
F
K
R
R
E
Y
P
D
G
T
V
K
T
Site 160
T1304
R
R
E
Y
P
D
G
T
V
K
T
V
Y
A
N
Site 161
T1307
Y
P
D
G
T
V
K
T
V
Y
A
N
G
H
Q
Site 162
Y1309
D
G
T
V
K
T
V
Y
A
N
G
H
Q
E
T
Site 163
Y1318
N
G
H
Q
E
T
K
Y
R
S
G
R
I
R
V
Site 164
S1320
H
Q
E
T
K
Y
R
S
G
R
I
R
V
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation