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Updated November 2019
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Protein Info
Short Name:
MUC5B
Full Name:
Mucin-5B
Alias:
Cervical mucin;High molecular weight salivary mucin MG1;Mucin-5 subtype B, tracheobronchial;Sublingual gland mucin
Type:
Mass (Da):
590499
Number AA:
5703
UniProt ID:
Q9HC84
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
T
Q
G
P
V
E
P
S
W
G
N
A
G
H
T
Site 2
T46
T
M
D
G
G
A
P
T
S
S
P
T
R
R
V
Site 3
S47
M
D
G
G
A
P
T
S
S
P
T
R
R
V
S
Site 4
S48
D
G
G
A
P
T
S
S
P
T
R
R
V
S
F
Site 5
T50
G
A
P
T
S
S
P
T
R
R
V
S
F
V
P
Site 6
S54
S
S
P
T
R
R
V
S
F
V
P
P
V
T
V
Site 7
Y85
S
T
W
G
D
F
H
Y
K
T
F
D
G
D
V
Site 8
Y101
R
F
P
G
L
C
N
Y
V
F
S
E
H
C
R
Site 9
Y111
S
E
H
C
R
A
A
Y
E
D
F
N
V
Q
L
Site 10
S125
L
R
R
G
L
V
G
S
R
P
V
V
T
R
V
Site 11
T130
V
G
S
R
P
V
V
T
R
V
V
I
K
A
Q
Site 12
S144
Q
G
L
V
L
E
A
S
N
G
S
V
L
I
N
Site 13
S147
V
L
E
A
S
N
G
S
V
L
I
N
G
Q
R
Site 14
Y159
G
Q
R
E
E
L
P
Y
S
R
T
G
L
L
V
Site 15
S160
Q
R
E
E
L
P
Y
S
R
T
G
L
L
V
E
Site 16
S169
T
G
L
L
V
E
Q
S
G
D
Y
I
K
V
S
Site 17
Y172
L
V
E
Q
S
G
D
Y
I
K
V
S
I
R
L
Site 18
Y199
L
L
E
L
D
P
K
Y
A
N
Q
T
C
G
L
Site 19
T227
Y
A
H
N
A
R
L
T
P
L
Q
F
G
N
L
Site 20
Y305
P
C
A
T
F
V
E
Y
S
R
Q
C
A
H
A
Site 21
T343
Q
E
C
G
S
P
C
T
D
T
C
S
N
P
Q
Site 22
T345
C
G
S
P
C
T
D
T
C
S
N
P
Q
R
A
Site 23
S347
S
P
C
T
D
T
C
S
N
P
Q
R
A
Q
L
Site 24
T389
P
L
G
Q
C
P
C
T
H
G
G
R
T
Y
S
Site 25
T394
P
C
T
H
G
G
R
T
Y
S
P
G
T
S
F
Site 26
Y395
C
T
H
G
G
R
T
Y
S
P
G
T
S
F
N
Site 27
S396
T
H
G
G
R
T
Y
S
P
G
T
S
F
N
T
Site 28
S400
R
T
Y
S
P
G
T
S
F
N
T
T
C
S
S
Site 29
T403
S
P
G
T
S
F
N
T
T
C
S
S
C
T
C
Site 30
T404
P
G
T
S
F
N
T
T
C
S
S
C
T
C
S
Site 31
S406
T
S
F
N
T
T
C
S
S
C
T
C
S
G
G
Site 32
T425
Q
D
L
P
C
P
G
T
C
S
V
Q
G
G
A
Site 33
S435
V
Q
G
G
A
H
I
S
T
Y
D
E
K
L
Y
Site 34
T436
Q
G
G
A
H
I
S
T
Y
D
E
K
L
Y
D
Site 35
Y437
G
G
A
H
I
S
T
Y
D
E
K
L
Y
D
L
Site 36
Y442
S
T
Y
D
E
K
L
Y
D
L
H
G
D
C
S
Site 37
Y450
D
L
H
G
D
C
S
Y
V
L
S
K
K
C
A
Site 38
S453
G
D
C
S
Y
V
L
S
K
K
C
A
D
S
S
Site 39
S459
L
S
K
K
C
A
D
S
S
F
T
V
L
A
E
Site 40
S460
S
K
K
C
A
D
S
S
F
T
V
L
A
E
L
Site 41
T462
K
C
A
D
S
S
F
T
V
L
A
E
L
R
K
Site 42
T473
E
L
R
K
C
G
L
T
D
N
E
N
C
L
K
Site 43
T491
L
S
L
D
G
G
D
T
A
I
R
V
Q
A
D
Site 44
T575
Q
N
Q
A
D
D
F
T
A
L
S
G
V
V
E
Site 45
S604
A
C
A
N
A
R
N
S
F
E
D
P
C
S
L
Site 46
S610
N
S
F
E
D
P
C
S
L
S
V
E
N
E
N
Site 47
S612
F
E
D
P
C
S
L
S
V
E
N
E
N
Y
A
Site 48
Y618
L
S
V
E
N
E
N
Y
A
R
H
W
C
S
R
Site 49
T627
R
H
W
C
S
R
L
T
D
P
N
S
A
F
S
Site 50
S631
S
R
L
T
D
P
N
S
A
F
S
R
C
H
S
Site 51
S634
T
D
P
N
S
A
F
S
R
C
H
S
I
I
N
Site 52
S638
S
A
F
S
R
C
H
S
I
I
N
P
K
P
F
Site 53
S682
A
A
K
G
V
Q
L
S
D
W
R
D
G
V
C
Site 54
Y692
R
D
G
V
C
T
K
Y
M
Q
N
C
P
K
S
Site 55
Y704
P
K
S
Q
R
Y
A
Y
V
V
D
A
C
Q
P
Site 56
S717
Q
P
T
C
R
G
L
S
E
A
D
V
T
C
S
Site 57
S776
H
D
E
G
A
V
C
S
C
T
G
G
K
L
S
Site 58
S805
P
M
V
Y
L
D
C
S
N
S
S
A
G
T
P
Site 59
S807
V
Y
L
D
C
S
N
S
S
A
G
T
P
G
A
Site 60
T811
C
S
N
S
S
A
G
T
P
G
A
E
C
L
R
Site 61
S819
P
G
A
E
C
L
R
S
C
H
T
L
D
V
G
Site 62
S847
P
G
L
V
S
D
G
S
G
G
C
I
A
E
E
Site 63
T864
P
C
V
H
N
E
A
T
Y
K
P
G
E
T
I
Site 64
Y912
I
T
F
D
G
D
R
Y
S
F
E
G
S
C
E
Site 65
S913
T
F
D
G
D
R
Y
S
F
E
G
S
C
E
Y
Site 66
S917
D
R
Y
S
F
E
G
S
C
E
Y
I
L
A
Q
Site 67
Y920
S
F
E
G
S
C
E
Y
I
L
A
Q
D
Y
C
Site 68
Y926
E
Y
I
L
A
Q
D
Y
C
G
D
N
T
T
H
Site 69
T935
G
D
N
T
T
H
G
T
F
R
I
V
T
E
N
Site 70
T940
H
G
T
F
R
I
V
T
E
N
I
P
C
G
T
Site 71
Y985
G
P
G
G
D
P
P
Y
K
I
R
Y
M
G
I
Site 72
S1004
E
T
H
G
M
A
V
S
W
D
R
K
T
S
V
Site 73
T1009
A
V
S
W
D
R
K
T
S
V
F
I
R
L
H
Site 74
S1010
V
S
W
D
R
K
T
S
V
F
I
R
L
H
Q
Site 75
Y1019
F
I
R
L
H
Q
D
Y
K
G
R
V
C
G
L
Site 76
T1040
N
A
I
N
D
F
A
T
R
S
R
S
V
V
G
Site 77
S1044
D
F
A
T
R
S
R
S
V
V
G
D
A
L
E
Site 78
S1055
D
A
L
E
F
G
N
S
W
K
L
S
P
S
C
Site 79
S1059
F
G
N
S
W
K
L
S
P
S
C
P
D
A
L
Site 80
S1061
N
S
W
K
L
S
P
S
C
P
D
A
L
A
P
Site 81
T1073
L
A
P
K
D
P
C
T
A
N
P
F
R
K
S
Site 82
S1099
P
T
F
A
A
C
R
S
Q
V
D
S
T
K
Y
Site 83
Y1106
S
Q
V
D
S
T
K
Y
Y
E
A
C
V
N
D
Site 84
Y1107
Q
V
D
S
T
K
Y
Y
E
A
C
V
N
D
A
Site 85
S1184
L
K
T
C
R
N
P
S
G
H
C
L
V
D
L
Site 86
Y1198
L
P
G
L
E
G
C
Y
P
K
C
P
P
S
Q
Site 87
Y1228
C
Y
D
K
D
G
N
Y
Y
D
V
G
A
R
V
Site 88
T1237
D
V
G
A
R
V
P
T
A
E
N
C
Q
S
C
Site 89
T1263
S
L
E
A
C
T
C
T
Y
E
D
R
T
Y
S
Site 90
Y1264
L
E
A
C
T
C
T
Y
E
D
R
T
Y
S
Y
Site 91
Y1269
C
T
Y
E
D
R
T
Y
S
Y
Q
D
V
I
Y
Site 92
Y1271
Y
E
D
R
T
Y
S
Y
Q
D
V
I
Y
N
T
Site 93
Y1276
Y
S
Y
Q
D
V
I
Y
N
T
T
D
G
L
G
Site 94
S1322
T
T
A
W
V
P
H
S
T
T
S
P
A
L
P
Site 95
S1325
W
V
P
H
S
T
T
S
P
A
L
P
V
S
T
Site 96
T1361
L
G
G
G
D
F
E
T
F
E
N
L
R
Q
R
Site 97
Y1370
E
N
L
R
Q
R
G
Y
Q
V
C
P
V
L
A
Site 98
S1411
R
G
L
M
C
A
N
S
Q
Q
S
P
P
L
C
Site 99
S1436
E
Y
V
P
C
G
P
S
P
A
P
G
T
S
P
Site 100
T1441
G
P
S
P
A
P
G
T
S
P
Q
P
S
L
S
Site 101
S1442
P
S
P
A
P
G
T
S
P
Q
P
S
L
S
A
Site 102
S1446
P
G
T
S
P
Q
P
S
L
S
A
S
T
E
P
Site 103
S1448
T
S
P
Q
P
S
L
S
A
S
T
E
P
A
V
Site 104
S1450
P
Q
P
S
L
S
A
S
T
E
P
A
V
P
T
Site 105
T1457
S
T
E
P
A
V
P
T
P
T
Q
T
T
A
T
Site 106
T1472
E
K
T
T
L
W
V
T
P
S
I
R
S
T
A
Site 107
T1478
V
T
P
S
I
R
S
T
A
A
L
T
S
Q
T
Site 108
S1483
R
S
T
A
A
L
T
S
Q
T
G
S
S
S
G
Site 109
T1485
T
A
A
L
T
S
Q
T
G
S
S
S
G
P
V
Site 110
S1487
A
L
T
S
Q
T
G
S
S
S
G
P
V
T
V
Site 111
S1489
T
S
Q
T
G
S
S
S
G
P
V
T
V
T
P
Site 112
T1493
G
S
S
S
G
P
V
T
V
T
P
S
A
P
G
Site 113
T1495
S
S
G
P
V
T
V
T
P
S
A
P
G
T
T
Site 114
T1501
V
T
P
S
A
P
G
T
T
T
C
Q
P
R
C
Site 115
Y1518
T
E
W
F
D
E
D
Y
P
K
S
E
Q
L
G
Site 116
S1521
F
D
E
D
Y
P
K
S
E
Q
L
G
G
D
V
Site 117
S1530
Q
L
G
G
D
V
E
S
Y
D
K
I
R
A
A
Site 118
Y1531
L
G
G
D
V
E
S
Y
D
K
I
R
A
A
G
Site 119
T1609
D
H
C
R
G
R
A
T
T
P
P
P
T
T
E
Site 120
T1610
H
C
R
G
R
A
T
T
P
P
P
T
T
E
L
Site 121
T1622
T
E
L
E
T
A
T
T
T
T
T
Q
A
L
F
Site 122
S1630
T
T
T
Q
A
L
F
S
T
P
Q
P
T
S
S
Site 123
T1631
T
T
Q
A
L
F
S
T
P
Q
P
T
S
S
P
Site 124
T1635
L
F
S
T
P
Q
P
T
S
S
P
G
L
T
R
Site 125
S1636
F
S
T
P
Q
P
T
S
S
P
G
L
T
R
A
Site 126
S1637
S
T
P
Q
P
T
S
S
P
G
L
T
R
A
P
Site 127
T1641
P
T
S
S
P
G
L
T
R
A
P
P
A
S
T
Site 128
T1649
R
A
P
P
A
S
T
T
A
V
P
T
L
S
E
Site 129
S1655
T
T
A
V
P
T
L
S
E
G
L
T
S
P
R
Site 130
T1659
P
T
L
S
E
G
L
T
S
P
R
Y
T
S
T
Site 131
S1660
T
L
S
E
G
L
T
S
P
R
Y
T
S
T
L
Site 132
Y1663
E
G
L
T
S
P
R
Y
T
S
T
L
G
T
A
Site 133
T1664
G
L
T
S
P
R
Y
T
S
T
L
G
T
A
T
Site 134
S1665
L
T
S
P
R
Y
T
S
T
L
G
T
A
T
T
Site 135
T1669
R
Y
T
S
T
L
G
T
A
T
T
G
G
P
R
Site 136
S1678
T
T
G
G
P
R
Q
S
A
G
S
T
E
P
T
Site 137
S1681
G
P
R
Q
S
A
G
S
T
E
P
T
V
P
G
Site 138
T1682
P
R
Q
S
A
G
S
T
E
P
T
V
P
G
V
Site 139
T1685
S
A
G
S
T
E
P
T
V
P
G
V
A
T
S
Site 140
S1698
T
S
T
L
P
T
R
S
A
L
P
G
T
T
G
Site 141
T1703
T
R
S
A
L
P
G
T
T
G
S
L
G
T
W
Site 142
S1706
A
L
P
G
T
T
G
S
L
G
T
W
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Site 453
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Site 454
T3659
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Site 456
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Site 458
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Site 459
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Site 460
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Site 461
T3685
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Site 462
T3692
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Site 463
T3813
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Site 464
T3816
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Site 465
T3818
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Site 466
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Site 467
S3821
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Site 468
S3822
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Site 469
T3825
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Site 470
T3828
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Site 471
S3834
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Site 472
T3836
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Site 473
T3838
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Site 474
T3840
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Site 475
S3842
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Site 476
S3844
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Site 477
T3845
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Site 478
T3847
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Site 479
S3849
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Site 480
T3859
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Site 481
T3863
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Site 482
S3872
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Site 483
S3883
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Site 484
T3885
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Site 485
S3888
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Site 486
T3911
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Site 487
T3912
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Site 488
T3924
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Site 489
S4004
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Site 490
T4005
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Site 491
S4009
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Site 492
S4010
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Site 493
T4176
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Site 494
S4177
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Site 495
S4178
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Site 496
T4179
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Site 497
S4183
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Site 498
S4184
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Site 499
T4185
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Site 500
T4188
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Site 501
T4200
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Site 502
S4207
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Site 503
T4208
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Site 504
T4210
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Site 505
S4212
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Site 506
S4213
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Site 507
T4214
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Site 508
T4217
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Site 509
S4226
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Site 510
T4229
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Site 511
T4230
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Site 512
T4232
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Site 513
S4260
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Site 514
S4264
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Site 515
T4266
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Site 516
S4271
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Site 517
T4275
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Site 518
T4278
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Site 519
T4283
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Site 520
T4285
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Site 521
S4291
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Site 522
T4292
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Site 523
T4309
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Site 524
T4313
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Site 525
T4317
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Site 526
S4318
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Site 527
S4319
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Site 528
T4320
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Site 529
S4321
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Site 530
T4322
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Site 531
S4324
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Site 532
S4325
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Site 533
T4326
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Site 534
T4349
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Site 535
T4351
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Site 536
S4353
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Site 537
S4354
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Site 538
T4355
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Site 539
S4377
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Site 540
T4378
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Site 541
T4380
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Site 542
S4382
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Site 543
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Site 544
T4387
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Site 545
T4563
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Site 546
T4565
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Site 547
T4568
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Site 548
T4570
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Site 549
T4572
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Site 550
T4586
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Site 551
T4589
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Site 552
S4662
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Site 553
T4665
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Site 554
S4696
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Site 555
S4697
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Site 556
T4701
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Site 557
T4704
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Site 558
T4711
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Site 559
S4714
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Site 560
S4717
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Site 561
T4718
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Site 562
T4721
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Site 563
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Site 564
T4724
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Site 565
T4727
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Site 566
T4730
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Site 567
T4732
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Site 568
T4735
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Site 569
T4739
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Site 570
T4744
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Site 571
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Site 572
T4749
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Site 573
S4752
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Site 574
T4756
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Site 575
S4775
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Site 576
T4778
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Site 577
T4808
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Site 578
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Site 579
S4810
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Site 580
S4833
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Site 581
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Site 585
T4846
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Site 586
S4858
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Site 587
S4877
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S4878
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S4881
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Site 590
S4894
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N
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S4930
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Site 593
S4935
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Site 594
S4936
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Site 595
S4940
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S4941
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S
P
S
P
A
P
G
C
D
N
Site 598
T4960
P
L
R
Q
V
N
E
T
W
T
L
E
N
C
T
Site 599
S5000
K
H
L
P
I
K
V
S
D
P
S
Q
P
C
D
Site 600
S5003
P
I
K
V
S
D
P
S
Q
P
C
D
F
H
Y
Site 601
Y5024
S
M
W
G
G
S
H
Y
S
T
F
D
G
T
S
Site 602
T5026
W
G
G
S
H
Y
S
T
F
D
G
T
S
Y
T
Site 603
Y5032
S
T
F
D
G
T
S
Y
T
F
R
G
N
C
T
Site 604
Y5040
T
F
R
G
N
C
T
Y
V
L
M
R
E
I
H
Site 605
Y5056
R
F
G
N
L
S
L
Y
L
D
N
H
Y
C
T
Site 606
Y5061
S
L
Y
L
D
N
H
Y
C
T
A
S
A
T
A
Site 607
S5078
A
R
C
P
R
A
L
S
I
H
Y
K
S
M
D
Site 608
S5109
L
F
D
Q
I
P
V
S
S
G
F
S
K
N
G
Site 609
Y5151
V
F
Q
A
R
L
P
Y
S
L
F
H
N
N
T
Site 610
S5152
F
Q
A
R
L
P
Y
S
L
F
H
N
N
T
E
Site 611
T5179
D
C
L
Q
R
D
G
T
T
A
A
S
C
K
D
Site 612
T5205
K
D
G
C
W
A
P
T
G
T
P
P
T
A
S
Site 613
T5207
G
C
W
A
P
T
G
T
P
P
T
A
S
P
A
Site 614
T5210
A
P
T
G
T
P
P
T
A
S
P
A
A
P
V
Site 615
S5212
T
G
T
P
P
T
A
S
P
A
A
P
V
S
S
Site 616
S5218
A
S
P
A
A
P
V
S
S
T
P
T
P
T
P
Site 617
S5219
S
P
A
A
P
V
S
S
T
P
T
P
T
P
C
Site 618
T5220
P
A
A
P
V
S
S
T
P
T
P
T
P
C
P
Site 619
T5222
A
P
V
S
S
T
P
T
P
T
P
C
P
P
Q
Site 620
T5224
V
S
S
T
P
T
P
T
P
C
P
P
Q
P
L
Site 621
Y5275
P
C
Q
S
L
E
A
Y
A
E
L
C
R
A
R
Site 622
T5292
C
S
D
W
R
G
A
T
G
G
L
C
D
L
T
Site 623
Y5306
T
C
P
P
T
K
V
Y
K
P
C
G
P
I
Q
Site 624
T5316
C
G
P
I
Q
P
A
T
C
N
S
R
N
Q
S
Site 625
S5319
I
Q
P
A
T
C
N
S
R
N
Q
S
P
Q
L
Site 626
S5323
T
C
N
S
R
N
Q
S
P
Q
L
E
G
M
A
Site 627
S5382
S
C
V
C
D
E
G
S
V
S
V
Q
C
K
P
Site 628
S5384
V
C
D
E
G
S
V
S
V
Q
C
K
P
L
P
Site 629
T5408
C
N
R
P
G
F
V
T
V
T
R
P
R
A
E
Site 630
S5434
N
T
T
T
C
P
Q
S
L
P
V
C
P
P
G
Site 631
T5447
P
G
Q
E
S
I
C
T
Q
E
E
G
D
C
C
Site 632
Y5466
C
R
P
Q
L
C
S
Y
N
G
T
F
Y
G
V
Site 633
T5493
C
T
C
L
S
G
D
T
Q
D
P
T
V
Q
C
Site 634
T5497
S
G
D
T
Q
D
P
T
V
Q
C
Q
E
D
A
Site 635
Y5516
T
C
P
Q
G
F
E
Y
K
R
V
A
G
Q
C
Site 636
T5534
C
V
Q
T
A
C
L
T
P
D
G
Q
P
V
Q
Site 637
T5545
Q
P
V
Q
L
N
E
T
W
V
N
S
H
V
D
Site 638
Y5557
H
V
D
N
C
T
V
Y
L
C
E
A
E
G
G
Site 639
T5569
E
G
G
V
H
L
L
T
P
Q
P
A
S
C
P
Site 640
S5579
P
A
S
C
P
D
V
S
S
C
R
G
S
L
R
Site 641
S5580
A
S
C
P
D
V
S
S
C
R
G
S
L
R
K
Site 642
S5584
D
V
S
S
C
R
G
S
L
R
K
T
G
C
C
Site 643
Y5592
L
R
K
T
G
C
C
Y
S
C
E
E
D
S
C
Site 644
Y5632
S
C
P
G
A
S
K
Y
S
A
E
A
Q
A
M
Site 645
T5655
E
R
R
V
H
E
E
T
V
P
L
H
C
P
N
Site 646
Y5670
G
S
A
I
L
H
T
Y
T
H
V
D
E
C
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation