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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPON1
Full Name:
Spondin-1
Alias:
F-spondin;Vascular smooth muscle cell growth-promoting factor
Type:
Mass (Da):
90973
Number AA:
807
UniProt ID:
Q9HCB6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
R
L
S
P
A
P
L
K
L
S
Site 2
T33
A
L
A
F
S
D
E
T
L
D
K
V
P
K
S
Site 3
S40
T
L
D
K
V
P
K
S
E
G
Y
C
S
R
I
Site 4
Y43
K
V
P
K
S
E
G
Y
C
S
R
I
L
R
A
Site 5
S45
P
K
S
E
G
Y
C
S
R
I
L
R
A
Q
G
Site 6
T53
R
I
L
R
A
Q
G
T
R
R
E
G
Y
T
E
Site 7
Y58
Q
G
T
R
R
E
G
Y
T
E
F
S
L
R
V
Site 8
T59
G
T
R
R
E
G
Y
T
E
F
S
L
R
V
E
Site 9
S62
R
E
G
Y
T
E
F
S
L
R
V
E
G
D
P
Site 10
Y72
V
E
G
D
P
D
F
Y
K
P
G
T
S
Y
R
Site 11
T76
P
D
F
Y
K
P
G
T
S
Y
R
V
T
L
S
Site 12
S77
D
F
Y
K
P
G
T
S
Y
R
V
T
L
S
A
Site 13
Y78
F
Y
K
P
G
T
S
Y
R
V
T
L
S
A
A
Site 14
T81
P
G
T
S
Y
R
V
T
L
S
A
A
P
P
S
Site 15
S83
T
S
Y
R
V
T
L
S
A
A
P
P
S
Y
F
Site 16
T94
P
S
Y
F
R
G
F
T
L
I
A
L
R
E
N
Site 17
T136
P
V
A
V
T
E
S
T
P
R
R
R
T
R
I
Site 18
T141
E
S
T
P
R
R
R
T
R
I
Q
V
F
W
I
Site 19
Y170
I
V
Q
K
R
I
I
Y
F
Q
D
E
G
S
L
Site 20
S176
I
Y
F
Q
D
E
G
S
L
T
K
K
L
C
E
Site 21
T178
F
Q
D
E
G
S
L
T
K
K
L
C
E
Q
D
Site 22
S186
K
K
L
C
E
Q
D
S
T
F
D
G
V
T
D
Site 23
T187
K
L
C
E
Q
D
S
T
F
D
G
V
T
D
K
Site 24
T192
D
S
T
F
D
G
V
T
D
K
P
I
L
D
C
Site 25
Y207
C
A
C
G
T
A
K
Y
R
L
T
F
Y
G
N
Site 26
T210
G
T
A
K
Y
R
L
T
F
Y
G
N
W
S
E
Site 27
Y212
A
K
Y
R
L
T
F
Y
G
N
W
S
E
K
T
Site 28
Y224
E
K
T
H
P
K
D
Y
P
R
R
A
N
H
W
Site 29
S238
W
S
A
I
I
G
G
S
H
S
K
N
Y
V
L
Site 30
Y243
G
G
S
H
S
K
N
Y
V
L
W
E
Y
G
G
Site 31
Y248
K
N
Y
V
L
W
E
Y
G
G
Y
A
S
E
G
Site 32
Y251
V
L
W
E
Y
G
G
Y
A
S
E
G
V
K
Q
Site 33
S264
K
Q
V
A
E
L
G
S
P
V
K
M
E
E
E
Site 34
S276
E
E
E
I
R
Q
Q
S
D
E
V
L
T
V
I
Site 35
T281
Q
Q
S
D
E
V
L
T
V
I
K
A
K
A
Q
Site 36
S306
A
A
P
S
A
E
F
S
V
D
R
T
R
H
L
Site 37
T310
A
E
F
S
V
D
R
T
R
H
L
M
S
F
L
Site 38
S315
D
R
T
R
H
L
M
S
F
L
T
M
M
G
P
Site 39
T318
R
H
L
M
S
F
L
T
M
M
G
P
S
P
D
Site 40
T337
L
S
A
E
D
L
C
T
K
E
C
G
W
V
Q
Site 41
T357
L
I
P
W
D
A
G
T
D
S
G
V
T
Y
E
Site 42
S359
P
W
D
A
G
T
D
S
G
V
T
Y
E
S
P
Site 43
Y363
G
T
D
S
G
V
T
Y
E
S
P
N
K
P
T
Site 44
S365
D
S
G
V
T
Y
E
S
P
N
K
P
T
I
P
Site 45
T380
Q
E
K
I
R
P
L
T
S
L
D
H
P
Q
S
Site 46
S381
E
K
I
R
P
L
T
S
L
D
H
P
Q
S
P
Site 47
S387
T
S
L
D
H
P
Q
S
P
F
Y
D
P
E
G
Site 48
Y390
D
H
P
Q
S
P
F
Y
D
P
E
G
G
S
I
Site 49
T439
E
E
K
D
E
D
D
T
P
E
T
C
I
Y
S
Site 50
Y445
D
T
P
E
T
C
I
Y
S
N
W
S
P
W
S
Site 51
S456
S
P
W
S
A
C
S
S
S
T
C
D
K
G
K
Site 52
S457
P
W
S
A
C
S
S
S
T
C
D
K
G
K
R
Site 53
S477
L
K
A
Q
L
D
L
S
V
P
C
P
D
T
Q
Site 54
S495
P
C
M
G
P
G
C
S
D
E
D
G
S
T
C
Site 55
S523
S
C
G
M
G
M
R
S
R
E
R
Y
V
K
Q
Site 56
Y527
G
M
R
S
R
E
R
Y
V
K
Q
F
P
E
D
Site 57
S536
K
Q
F
P
E
D
G
S
V
C
T
L
P
T
E
Site 58
T549
T
E
E
T
E
K
C
T
V
N
E
E
C
S
P
Site 59
S555
C
T
V
N
E
E
C
S
P
S
S
C
L
M
T
Site 60
S593
K
M
N
P
A
D
G
S
M
C
K
A
E
T
S
Site 61
S618
H
T
I
P
C
L
L
S
P
W
S
E
W
S
D
Site 62
S643
T
R
Q
R
M
L
K
S
L
A
E
L
G
D
C
Site 63
T709
G
G
A
P
C
P
E
T
V
Q
R
K
K
C
R
Site 64
S725
R
K
C
L
R
N
P
S
I
Q
K
L
R
W
R
Site 65
S737
R
W
R
E
A
R
E
S
R
R
S
E
Q
L
K
Site 66
S740
E
A
R
E
S
R
R
S
E
Q
L
K
E
E
S
Site 67
Y778
G
G
G
I
Q
E
R
Y
M
T
V
K
K
R
F
Site 68
T780
G
I
Q
E
R
Y
M
T
V
K
K
R
F
K
S
Site 69
S787
T
V
K
K
R
F
K
S
S
Q
F
T
S
C
K
Site 70
S788
V
K
K
R
F
K
S
S
Q
F
T
S
C
K
D
Site 71
T791
R
F
K
S
S
Q
F
T
S
C
K
D
K
K
E
Site 72
S792
F
K
S
S
Q
F
T
S
C
K
D
K
K
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation