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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HES4
Full Name:
Transcription factor HES-4
Alias:
Class B basic helix-loop-helix protein 42;Hairy and enhancer of split 4;bHLH factor Hes4
Type:
Mass (Da):
23523
Number AA:
221
UniProt ID:
Q9HCC6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
A
A
D
T
P
G
K
P
S
A
S
Site 2
S10
A
D
T
P
G
K
P
S
A
S
P
M
A
G
A
Site 3
S12
T
P
G
K
P
S
A
S
P
M
A
G
A
P
A
Site 4
S20
P
M
A
G
A
P
A
S
A
S
R
T
P
D
K
Site 5
S22
A
G
A
P
A
S
A
S
R
T
P
D
K
P
R
Site 6
T24
A
P
A
S
A
S
R
T
P
D
K
P
R
S
A
Site 7
S30
R
T
P
D
K
P
R
S
A
A
E
H
R
K
S
Site 8
S37
S
A
A
E
H
R
K
S
S
K
P
V
M
E
K
Site 9
S38
A
A
E
H
R
K
S
S
K
P
V
M
E
K
R
Site 10
S53
R
R
A
R
I
N
E
S
L
A
Q
L
K
T
L
Site 11
S69
L
D
A
L
R
K
E
S
S
R
H
S
K
L
E
Site 12
S70
D
A
L
R
K
E
S
S
R
H
S
K
L
E
K
Site 13
S73
R
K
E
S
S
R
H
S
K
L
E
K
A
D
I
Site 14
T84
K
A
D
I
L
E
M
T
V
R
H
L
R
S
L
Site 15
S90
M
T
V
R
H
L
R
S
L
R
R
V
Q
V
T
Site 16
T97
S
L
R
R
V
Q
V
T
A
A
L
S
A
D
P
Site 17
S101
V
Q
V
T
A
A
L
S
A
D
P
A
V
L
G
Site 18
Y110
D
P
A
V
L
G
K
Y
R
A
G
F
H
E
C
Site 19
S153
C
L
R
Q
L
G
P
S
R
R
P
A
S
L
S
Site 20
S158
G
P
S
R
R
P
A
S
L
S
P
A
A
P
A
Site 21
S160
S
R
R
P
A
S
L
S
P
A
A
P
A
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation