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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZFYVE28
Full Name:
Lateral signaling target protein 2 homolog
Alias:
Zinc finger FYVE domain-containing protein 28
Type:
Mass (Da):
96490
Number AA:
887
UniProt ID:
Q9HCC9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
N
R
F
R
K
W
L
Y
K
P
K
R
S
D
P
Site 2
Y24
P
Q
L
L
A
R
F
Y
Y
A
D
E
E
L
N
Site 3
Y25
Q
L
L
A
R
F
Y
Y
A
D
E
E
L
N
Q
Site 4
S39
Q
V
A
A
E
L
D
S
L
D
G
R
K
D
P
Site 5
T50
R
K
D
P
Q
R
C
T
L
L
V
S
Q
F
R
Site 6
S54
Q
R
C
T
L
L
V
S
Q
F
R
S
C
Q
D
Site 7
S58
L
L
V
S
Q
F
R
S
C
Q
D
N
V
L
N
Site 8
S134
L
A
K
E
L
T
R
S
L
E
D
V
R
G
A
Site 9
T152
Q
A
L
R
D
L
N
T
Y
T
E
K
M
R
E
Site 10
Y153
A
L
R
D
L
N
T
Y
T
E
K
M
R
E
A
Site 11
S184
S
A
M
V
P
V
K
S
P
R
E
Y
Y
V
Q
Site 12
Y188
P
V
K
S
P
R
E
Y
Y
V
Q
Q
E
V
I
Site 13
Y189
V
K
S
P
R
E
Y
Y
V
Q
Q
E
V
I
V
Site 14
Y210
E
R
A
L
D
F
G
Y
L
T
Q
D
M
I
D
Site 15
T212
A
L
D
F
G
Y
L
T
Q
D
M
I
D
D
Y
Site 16
Y219
T
Q
D
M
I
D
D
Y
E
P
A
L
M
F
S
Site 17
S254
D
R
K
V
E
D
M
S
E
L
F
R
P
F
H
Site 18
T273
K
I
R
D
L
L
Q
T
L
T
E
E
E
L
H
Site 19
T275
R
D
L
L
Q
T
L
T
E
E
E
L
H
T
L
Site 20
T281
L
T
E
E
E
L
H
T
L
E
R
N
L
C
I
Site 21
S321
L
P
P
E
G
P
L
S
A
K
A
K
D
P
D
Site 22
S334
P
D
A
E
L
A
C
S
M
Q
Y
D
D
Q
E
Site 23
S357
H
R
A
G
D
E
M
S
S
L
L
S
P
P
I
Site 24
S358
R
A
G
D
E
M
S
S
L
L
S
P
P
I
A
Site 25
S361
D
E
M
S
S
L
L
S
P
P
I
A
C
Q
S
Site 26
S368
S
P
P
I
A
C
Q
S
P
A
H
R
P
G
A
Site 27
S378
H
R
P
G
A
E
G
S
P
G
G
E
A
S
P
Site 28
S384
G
S
P
G
G
E
A
S
P
G
R
P
R
L
R
Site 29
S392
P
G
R
P
R
L
R
S
G
S
D
E
E
E
R
Site 30
S394
R
P
R
L
R
S
G
S
D
E
E
E
R
V
F
Site 31
S418
E
A
L
A
R
P
E
S
P
A
G
P
F
G
W
Site 32
S428
G
P
F
G
W
A
G
S
T
W
A
D
P
Q
E
Site 33
S448
P
G
G
A
A
G
I
S
L
P
A
S
E
K
E
Site 34
S452
A
G
I
S
L
P
A
S
E
K
E
E
D
L
S
Site 35
S459
S
E
K
E
E
D
L
S
N
N
N
L
E
A
E
Site 36
T468
N
N
L
E
A
E
G
T
D
G
A
S
L
A
G
Site 37
S472
A
E
G
T
D
G
A
S
L
A
G
T
S
S
C
Site 38
S478
A
S
L
A
G
T
S
S
C
S
C
L
D
S
R
Site 39
S480
L
A
G
T
S
S
C
S
C
L
D
S
R
L
H
Site 40
S484
S
S
C
S
C
L
D
S
R
L
H
L
D
G
W
Site 41
T500
V
G
A
D
D
A
E
T
A
E
M
I
A
H
R
Site 42
S523
T
V
I
F
N
P
K
S
P
T
S
L
D
S
A
Site 43
S526
F
N
P
K
S
P
T
S
L
D
S
A
V
A
T
Site 44
S529
K
S
P
T
S
L
D
S
A
V
A
T
Q
E
A
Site 45
T533
S
L
D
S
A
V
A
T
Q
E
A
A
S
E
P
Site 46
S553
D
G
G
P
H
K
L
S
T
G
A
T
N
C
L
Site 47
T557
H
K
L
S
T
G
A
T
N
C
L
L
H
S
C
Site 48
S573
C
C
G
S
C
G
D
S
R
E
D
V
V
E
R
Site 49
S586
E
R
L
R
E
K
C
S
P
G
G
V
I
G
A
Site 50
S603
A
A
G
L
A
K
A
S
D
R
A
P
E
R
Q
Site 51
S617
Q
E
E
A
P
P
P
S
E
D
A
S
N
G
R
Site 52
S621
P
P
P
S
E
D
A
S
N
G
R
E
P
K
A
Site 53
S631
R
E
P
K
A
P
T
S
D
K
C
L
P
H
T
Site 54
S641
C
L
P
H
T
S
G
S
Q
V
D
T
A
S
G
Site 55
T645
T
S
G
S
Q
V
D
T
A
S
G
L
Q
G
E
Site 56
S647
G
S
Q
V
D
T
A
S
G
L
Q
G
E
A
G
Site 57
S670
A
R
E
L
H
A
G
S
P
S
A
H
E
A
P
Site 58
S672
E
L
H
A
G
S
P
S
A
H
E
A
P
Q
A
Site 59
S681
H
E
A
P
Q
A
L
S
G
S
S
S
S
T
A
Site 60
S683
A
P
Q
A
L
S
G
S
S
S
S
T
A
G
S
Site 61
S685
Q
A
L
S
G
S
S
S
S
T
A
G
S
C
S
Site 62
S686
A
L
S
G
S
S
S
S
T
A
G
S
C
S
S
Site 63
T687
L
S
G
S
S
S
S
T
A
G
S
C
S
S
D
Site 64
S690
S
S
S
S
T
A
G
S
C
S
S
D
K
M
G
Site 65
S692
S
S
T
A
G
S
C
S
S
D
K
M
G
P
E
Site 66
S693
S
T
A
G
S
C
S
S
D
K
M
G
P
E
A
Site 67
S718
A
T
R
E
K
I
R
S
R
F
H
G
S
H
D
Site 68
Y745
A
D
Q
L
Q
T
N
Y
A
S
D
L
R
S
I
Site 69
S747
Q
L
Q
T
N
Y
A
S
D
L
R
S
I
L
K
Site 70
S751
N
Y
A
S
D
L
R
S
I
L
K
T
L
F
E
Site 71
T776
K
E
K
L
R
K
V
T
Q
T
L
R
S
A
A
Site 72
T778
K
L
R
K
V
T
Q
T
L
R
S
A
A
L
E
Site 73
T793
D
C
A
L
C
Q
E
T
L
S
S
S
E
L
A
Site 74
S795
A
L
C
Q
E
T
L
S
S
S
E
L
A
A
K
Site 75
T831
T
A
C
K
A
P
F
T
V
I
R
R
K
H
H
Site 76
S848
S
C
G
K
I
F
C
S
R
C
S
S
H
S
A
Site 77
S851
K
I
F
C
S
R
C
S
S
H
S
A
P
L
P
Site 78
S852
I
F
C
S
R
C
S
S
H
S
A
P
L
P
R
Site 79
S854
C
S
R
C
S
S
H
S
A
P
L
P
R
Y
G
Site 80
Y860
H
S
A
P
L
P
R
Y
G
Q
V
K
P
V
R
Site 81
T870
V
K
P
V
R
V
C
T
H
C
Y
M
F
H
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation