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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF10L
Full Name:
Rho guanine nucleotide exchange factor 10-like protein
Alias:
FLJ10521; GrinchGEF; KIAA1626; Rho guanine nucleotide exchange factor (GEF) 10-like; RP11-473A10.1
Type:
Cytoskeletal protein; GTPase activating protein, Rac/Rho; Deacetylase; Transcription, coactivator/corepressor
Mass (Da):
140365
Number AA:
1279
UniProt ID:
Q9HCE6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
V
P
G
V
P
G
P
S
S
E
A
E
D
D
P
Site 2
S25
P
G
V
P
G
P
S
S
E
A
E
D
D
P
G
Site 3
S40
E
A
F
E
F
D
D
S
D
D
E
E
D
T
S
Site 4
S47
S
D
D
E
E
D
T
S
A
A
L
G
V
P
S
Site 5
S54
S
A
A
L
G
V
P
S
L
A
P
E
R
D
T
Site 6
T61
S
L
A
P
E
R
D
T
D
P
P
L
I
H
L
Site 7
S70
P
P
L
I
H
L
D
S
I
P
V
T
D
P
D
Site 8
T74
H
L
D
S
I
P
V
T
D
P
D
P
A
A
A
Site 9
S102
D
A
A
D
A
A
F
S
G
A
R
H
S
S
W
Site 10
S107
A
F
S
G
A
R
H
S
S
W
K
R
K
S
S
Site 11
S108
F
S
G
A
R
H
S
S
W
K
R
K
S
S
R
Site 12
S113
H
S
S
W
K
R
K
S
S
R
R
I
D
R
F
Site 13
S114
S
S
W
K
R
K
S
S
R
R
I
D
R
F
T
Site 14
T121
S
R
R
I
D
R
F
T
F
P
A
L
E
E
D
Site 15
Y131
A
L
E
E
D
V
I
Y
D
D
V
P
C
E
S
Site 16
S138
Y
D
D
V
P
C
E
S
P
D
A
H
Q
P
G
Site 17
Y152
G
A
E
R
N
L
L
Y
E
D
A
H
R
A
G
Site 18
S170
Q
A
E
D
L
G
W
S
S
S
E
F
E
S
Y
Site 19
S171
A
E
D
L
G
W
S
S
S
E
F
E
S
Y
S
Site 20
S172
E
D
L
G
W
S
S
S
E
F
E
S
Y
S
E
Site 21
S176
W
S
S
S
E
F
E
S
Y
S
E
D
S
G
E
Site 22
Y177
S
S
S
E
F
E
S
Y
S
E
D
S
G
E
E
Site 23
S178
S
S
E
F
E
S
Y
S
E
D
S
G
E
E
A
Site 24
S199
E
P
A
K
H
R
V
S
F
Q
P
K
L
S
P
Site 25
S205
V
S
F
Q
P
K
L
S
P
D
L
T
R
L
K
Site 26
T209
P
K
L
S
P
D
L
T
R
L
K
E
R
Y
A
Site 27
Y215
L
T
R
L
K
E
R
Y
A
R
T
K
R
D
I
Site 28
T218
L
K
E
R
Y
A
R
T
K
R
D
I
L
A
L
Site 29
Y239
M
Q
E
L
K
H
K
Y
D
C
K
M
T
Q
L
Site 30
S252
Q
L
M
K
A
A
K
S
G
T
K
D
G
L
E
Site 31
T254
M
K
A
A
K
S
G
T
K
D
G
L
E
K
T
Site 32
S270
M
A
V
M
R
K
V
S
F
L
H
R
K
D
V
Site 33
S281
R
K
D
V
L
G
D
S
E
E
E
D
M
G
L
Site 34
S311
G
P
M
P
E
G
L
S
P
Q
Q
V
V
R
R
Site 35
S323
V
R
R
H
I
L
G
S
I
V
Q
S
E
G
S
Site 36
S330
S
I
V
Q
S
E
G
S
Y
V
E
S
L
K
R
Site 37
Y331
I
V
Q
S
E
G
S
Y
V
E
S
L
K
R
I
Site 38
S334
S
E
G
S
Y
V
E
S
L
K
R
I
L
Q
D
Site 39
Y342
L
K
R
I
L
Q
D
Y
R
N
P
L
M
E
M
Site 40
S355
E
M
E
P
K
A
L
S
A
R
K
C
Q
V
V
Site 41
S381
S
M
F
Q
I
A
L
S
S
R
V
A
E
W
D
Site 42
S389
S
R
V
A
E
W
D
S
T
E
K
I
G
D
L
Site 43
T390
R
V
A
E
W
D
S
T
E
K
I
G
D
L
F
Site 44
Y410
K
S
M
V
L
D
V
Y
S
D
Y
V
N
N
F
Site 45
Y413
V
L
D
V
Y
S
D
Y
V
N
N
F
T
S
A
Site 46
T418
S
D
Y
V
N
N
F
T
S
A
M
S
I
I
K
Site 47
S445
L
K
R
R
Q
V
C
S
P
D
R
V
T
L
Y
Site 48
T476
L
Q
D
M
L
K
N
T
P
R
G
H
P
D
R
Site 49
S485
R
G
H
P
D
R
L
S
L
Q
L
A
L
T
E
Site 50
T517
V
A
E
I
Q
Q
L
T
K
S
V
S
D
R
S
Site 51
S519
E
I
Q
Q
L
T
K
S
V
S
D
R
S
S
L
Site 52
S521
Q
Q
L
T
K
S
V
S
D
R
S
S
L
N
K
Site 53
S525
K
S
V
S
D
R
S
S
L
N
K
L
L
T
S
Site 54
T531
S
S
L
N
K
L
L
T
S
G
Q
R
Q
L
L
Site 55
S532
S
L
N
K
L
L
T
S
G
Q
R
Q
L
L
L
Site 56
T546
L
C
E
T
L
T
E
T
V
Y
G
D
R
G
Q
Site 57
Y548
E
T
L
T
E
T
V
Y
G
D
R
G
Q
L
I
Site 58
S557
D
R
G
Q
L
I
K
S
K
E
R
R
V
F
L
Site 59
S588
H
R
G
Q
L
E
I
S
S
L
V
P
L
G
P
Site 60
S589
R
G
Q
L
E
I
S
S
L
V
P
L
G
P
K
Site 61
Y620
V
G
Q
D
G
G
T
Y
D
K
D
N
V
L
I
Site 62
Y646
G
Q
A
Q
N
K
V
Y
L
G
P
P
R
L
F
Site 63
S708
V
K
E
E
E
I
H
S
A
N
K
C
R
L
R
Site 64
S725
L
P
G
K
P
D
K
S
G
R
P
I
S
F
M
Site 65
S742
F
I
T
P
N
P
L
S
K
I
S
W
V
N
R
Site 66
S745
P
N
P
L
S
K
I
S
W
V
N
R
L
H
L
Site 67
S791
A
C
C
I
P
A
F
S
S
R
A
L
S
L
Q
Site 68
Y825
S
T
S
L
P
Q
G
Y
L
W
V
G
G
G
Q
Site 69
S843
G
G
Q
V
E
I
F
S
L
N
R
P
S
P
R
Site 70
S848
I
F
S
L
N
R
P
S
P
R
T
V
K
S
F
Site 71
T851
L
N
R
P
S
P
R
T
V
K
S
F
P
L
A
Site 72
S854
P
S
P
R
T
V
K
S
F
P
L
A
A
P
V
Site 73
S876
E
L
E
E
E
A
E
S
R
D
E
S
P
T
V
Site 74
S880
E
A
E
S
R
D
E
S
P
T
V
A
D
P
S
Site 75
T882
E
S
R
D
E
S
P
T
V
A
D
P
S
A
T
Site 76
S887
S
P
T
V
A
D
P
S
A
T
V
H
P
T
I
Site 77
Y906
Q
D
G
S
I
L
L
Y
S
S
V
D
T
G
T
Site 78
S907
D
G
S
I
L
L
Y
S
S
V
D
T
G
T
Q
Site 79
T913
Y
S
S
V
D
T
G
T
Q
C
L
V
S
C
R
Site 80
S918
T
G
T
Q
C
L
V
S
C
R
S
P
G
L
Q
Site 81
T945
L
A
G
L
Q
D
G
T
L
A
A
Y
P
R
T
Site 82
Y949
Q
D
G
T
L
A
A
Y
P
R
T
S
G
G
V
Site 83
S1005
T
T
L
Q
P
Q
Q
S
F
E
A
H
Q
D
E
Site 84
S1035
M
A
F
S
S
G
T
S
I
R
L
F
H
T
E
Site 85
T1043
I
R
L
F
H
T
E
T
L
E
H
L
Q
E
I
Site 86
S1133
L
A
P
D
I
L
R
S
D
Q
E
E
A
E
G
Site 87
S1159
A
H
E
P
M
P
D
S
H
V
G
R
E
L
T
Site 88
T1166
S
H
V
G
R
E
L
T
R
K
K
G
I
L
L
Site 89
Y1175
K
K
G
I
L
L
Q
Y
R
L
R
S
T
A
H
Site 90
S1179
L
L
Q
Y
R
L
R
S
T
A
H
L
P
G
P
Site 91
T1180
L
Q
Y
R
L
R
S
T
A
H
L
P
G
P
L
Site 92
S1189
H
L
P
G
P
L
L
S
M
R
E
P
A
P
A
Site 93
S1204
D
G
A
A
L
E
H
S
E
E
D
G
S
I
Y
Site 94
S1209
E
H
S
E
E
D
G
S
I
Y
E
M
A
D
D
Site 95
Y1211
S
E
E
D
G
S
I
Y
E
M
A
D
D
P
D
Site 96
Y1247
I
I
S
G
G
Q
G
Y
R
N
F
G
S
A
L
Site 97
S1252
Q
G
Y
R
N
F
G
S
A
L
G
S
S
G
R
Site 98
S1256
N
F
G
S
A
L
G
S
S
G
R
Q
A
P
C
Site 99
S1257
F
G
S
A
L
G
S
S
G
R
Q
A
P
C
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation