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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMURF1
Full Name:
E3 ubiquitin-protein ligase SMURF1
Alias:
E3 ubiquitin ligase SMURF1; EC 6.3.2.-; SMAD specific E3 ubiquitin protein ligase 1; Smad-specific; SMUF1
Type:
Ligase, Ubiquitin conjugating system, Ubiquitin ligase
Mass (Da):
86114
Number AA:
757
UniProt ID:
Q9HCE7
International Prot ID:
IPI00217054
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0070411
GO:0070412
GO:0048185
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0030154
GO:0007398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
N
P
G
T
R
R
N
G
S
S
I
Site 2
S11
P
G
T
R
R
N
G
S
S
I
K
I
R
L
T
Site 3
S12
G
T
R
R
N
G
S
S
I
K
I
R
L
T
V
Site 4
S45
A
K
I
V
V
D
G
S
G
Q
C
H
S
T
D
Site 5
S50
D
G
S
G
Q
C
H
S
T
D
T
V
K
N
T
Site 6
T51
G
S
G
Q
C
H
S
T
D
T
V
K
N
T
L
Site 7
T53
G
Q
C
H
S
T
D
T
V
K
N
T
L
D
P
Site 8
T57
S
T
D
T
V
K
N
T
L
D
P
K
W
N
Q
Site 9
Y66
D
P
K
W
N
Q
H
Y
D
L
Y
V
G
K
T
Site 10
Y69
W
N
Q
H
Y
D
L
Y
V
G
K
T
D
S
I
Site 11
T77
V
G
K
T
D
S
I
T
I
S
V
W
N
H
K
Site 12
S106
R
L
L
S
N
A
I
S
R
L
K
D
T
G
Y
Site 13
T111
A
I
S
R
L
K
D
T
G
Y
Q
R
L
D
L
Site 14
Y113
S
R
L
K
D
T
G
Y
Q
R
L
D
L
C
K
Site 15
T126
C
K
L
N
P
S
D
T
D
A
V
R
G
Q
I
Site 16
S136
V
R
G
Q
I
V
V
S
L
Q
T
R
D
R
I
Site 17
T145
Q
T
R
D
R
I
G
T
G
G
S
V
V
D
C
Site 18
S148
D
R
I
G
T
G
G
S
V
V
D
C
R
G
L
Site 19
T161
G
L
L
E
N
E
G
T
V
Y
E
D
S
G
P
Site 20
Y163
L
E
N
E
G
T
V
Y
E
D
S
G
P
G
R
Site 21
S166
E
G
T
V
Y
E
D
S
G
P
G
R
P
L
S
Site 22
S173
S
G
P
G
R
P
L
S
C
F
M
E
E
P
A
Site 23
Y182
F
M
E
E
P
A
P
Y
T
D
S
T
G
A
A
Site 24
S185
E
P
A
P
Y
T
D
S
T
G
A
A
A
G
G
Site 25
T186
P
A
P
Y
T
D
S
T
G
A
A
A
G
G
G
Site 26
S200
G
N
C
R
F
V
E
S
P
S
Q
D
Q
R
L
Site 27
S202
C
R
F
V
E
S
P
S
Q
D
Q
R
L
Q
A
Site 28
S220
R
N
P
D
V
R
G
S
L
Q
T
P
Q
N
R
Site 29
T223
D
V
R
G
S
L
Q
T
P
Q
N
R
P
H
G
Site 30
S233
N
R
P
H
G
H
Q
S
P
E
L
P
E
G
Y
Site 31
Y240
S
P
E
L
P
E
G
Y
E
Q
R
T
T
V
Q
Site 32
T245
E
G
Y
E
Q
R
T
T
V
Q
G
Q
V
Y
F
Site 33
Y251
T
T
V
Q
G
Q
V
Y
F
L
H
T
Q
T
G
Site 34
T255
G
Q
V
Y
F
L
H
T
Q
T
G
V
S
T
W
Site 35
S260
L
H
T
Q
T
G
V
S
T
W
H
D
P
R
I
Site 36
S269
W
H
D
P
R
I
P
S
P
S
G
T
I
P
G
Site 37
S271
D
P
R
I
P
S
P
S
G
T
I
P
G
G
D
Site 38
T273
R
I
P
S
P
S
G
T
I
P
G
G
D
A
A
Site 39
T291
E
F
L
L
Q
G
H
T
S
E
P
R
D
L
N
Site 40
S292
F
L
L
Q
G
H
T
S
E
P
R
D
L
N
S
Site 41
S299
S
E
P
R
D
L
N
S
V
N
C
D
E
L
G
Site 42
S316
P
P
G
W
E
V
R
S
T
V
S
G
R
I
Y
Site 43
T317
P
G
W
E
V
R
S
T
V
S
G
R
I
Y
F
Site 44
S319
W
E
V
R
S
T
V
S
G
R
I
Y
F
V
D
Site 45
Y323
S
T
V
S
G
R
I
Y
F
V
D
H
N
N
R
Site 46
T332
V
D
H
N
N
R
T
T
Q
F
T
D
P
R
L
Site 47
T335
N
N
R
T
T
Q
F
T
D
P
R
L
H
H
I
Site 48
S353
Q
C
Q
L
K
E
P
S
Q
P
L
P
L
P
S
Site 49
S360
S
Q
P
L
P
L
P
S
E
G
S
L
E
D
E
Site 50
S363
L
P
L
P
S
E
G
S
L
E
D
E
E
L
P
Site 51
Y374
E
E
L
P
A
Q
R
Y
E
R
D
L
V
Q
K
Site 52
S390
K
V
L
R
H
E
L
S
L
Q
Q
P
Q
A
G
Site 53
Y413
E
E
I
F
E
E
S
Y
R
Q
I
M
K
M
R
Site 54
Y440
R
G
E
E
G
L
D
Y
G
G
V
A
R
E
W
Site 55
Y459
C
H
E
M
L
N
P
Y
Y
G
L
F
Q
Y
S
Site 56
Y460
H
E
M
L
N
P
Y
Y
G
L
F
Q
Y
S
T
Site 57
Y465
P
Y
Y
G
L
F
Q
Y
S
T
D
N
I
Y
M
Site 58
Y471
Q
Y
S
T
D
N
I
Y
M
L
Q
I
N
P
D
Site 59
S479
M
L
Q
I
N
P
D
S
S
I
N
P
D
H
L
Site 60
S480
L
Q
I
N
P
D
S
S
I
N
P
D
H
L
S
Site 61
Y488
I
N
P
D
H
L
S
Y
F
H
F
V
G
R
I
Site 62
Y515
G
G
F
T
V
P
F
Y
K
Q
L
L
G
K
P
Site 63
S526
L
G
K
P
I
Q
L
S
D
L
E
S
V
D
P
Site 64
S530
I
Q
L
S
D
L
E
S
V
D
P
E
L
H
K
Site 65
S538
V
D
P
E
L
H
K
S
L
V
W
I
L
E
N
Site 66
T580
N
G
R
N
V
P
V
T
E
E
N
K
K
E
Y
Site 67
Y587
T
E
E
N
K
K
E
Y
V
R
L
Y
V
N
W
Site 68
Y591
K
K
E
Y
V
R
L
Y
V
N
W
R
F
M
R
Site 69
S698
G
F
K
A
L
Q
G
S
T
G
A
A
G
P
R
Site 70
T716
I
H
L
I
D
A
N
T
D
N
L
P
K
A
H
Site 71
Y734
N
R
I
D
I
P
P
Y
E
S
Y
E
K
L
Y
Site 72
S736
I
D
I
P
P
Y
E
S
Y
E
K
L
Y
E
K
Site 73
T746
K
L
Y
E
K
L
L
T
A
V
E
E
T
C
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation