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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM16H
Full Name:
Anoctamin-8
Alias:
ANO8; Anoctamin 8; KIAA1623; TM16H; Transmembrane protein 16H
Type:
Unknown function
Mass (Da):
136030
Number AA:
UniProt ID:
Q9HCE9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005254
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
S
G
A
G
G
T
S
L
E
G
E
R
G
K
Site 2
Y49
R
L
L
Q
A
G
R
Y
L
V
S
H
K
A
W
Site 3
T70
E
N
C
D
V
L
M
T
F
P
D
T
T
D
D
Site 4
T79
P
D
T
T
D
D
H
T
L
L
W
L
L
N
H
Site 5
T104
Q
V
R
H
H
R
H
T
R
A
Y
A
F
F
V
Site 6
Y107
H
H
R
H
T
R
A
Y
A
F
F
V
T
A
T
Site 7
S143
G
G
G
T
R
G
F
S
C
E
E
D
F
I
Y
Site 8
Y150
S
C
E
E
D
F
I
Y
E
N
V
E
S
E
L
Site 9
S155
F
I
Y
E
N
V
E
S
E
L
R
F
F
T
S
Site 10
T161
E
S
E
L
R
F
F
T
S
Q
E
R
Q
S
I
Site 11
S162
S
E
L
R
F
F
T
S
Q
E
R
Q
S
I
I
Site 12
T273
G
S
V
L
Y
T
F
T
E
A
D
Q
T
S
R
Site 13
T278
T
F
T
E
A
D
Q
T
S
R
D
V
S
C
V
Site 14
S318
Y
K
W
G
T
L
D
S
P
G
E
A
V
E
E
Site 15
S337
F
R
G
V
R
R
I
S
P
I
T
R
A
E
E
Site 16
T340
V
R
R
I
S
P
I
T
R
A
E
E
F
Y
Y
Site 17
Y346
I
T
R
A
E
E
F
Y
Y
P
P
W
K
R
L
Site 18
Y347
T
R
A
E
E
F
Y
Y
P
P
W
K
R
L
L
Site 19
S431
M
E
N
Y
R
L
E
S
A
Y
E
K
H
L
I
Site 20
Y433
N
Y
R
L
E
S
A
Y
E
K
H
L
I
I
K
Site 21
Y492
E
V
L
Q
P
H
L
Y
R
R
L
G
R
G
E
Site 22
S517
R
A
L
L
G
L
L
S
L
R
R
P
A
P
R
Site 23
S547
G
G
G
R
R
C
L
S
G
G
C
G
A
P
E
Site 24
S618
G
L
R
L
K
K
V
S
F
A
E
R
G
A
G
Site 25
S632
G
R
R
R
P
G
P
S
P
E
A
L
L
E
E
Site 26
S641
E
A
L
L
E
E
G
S
P
T
M
V
E
K
G
Site 27
T643
L
L
E
E
G
S
P
T
M
V
E
K
G
L
E
Site 28
S669
E
A
E
G
A
P
G
S
P
E
R
E
P
P
A
Site 29
S701
G
P
D
P
E
P
G
S
N
S
D
S
T
R
R
Site 30
S703
D
P
E
P
G
S
N
S
D
S
T
R
R
Q
R
Site 31
S705
E
P
G
S
N
S
D
S
T
R
R
Q
R
R
Q
Site 32
T706
P
G
S
N
S
D
S
T
R
R
Q
R
R
Q
N
Site 33
S715
R
Q
R
R
Q
N
R
S
S
W
I
D
P
P
E
Site 34
S716
Q
R
R
Q
N
R
S
S
W
I
D
P
P
E
E
Site 35
S726
D
P
P
E
E
E
H
S
P
Q
L
T
Q
A
E
Site 36
T730
E
E
H
S
P
Q
L
T
Q
A
E
L
E
S
C
Site 37
Y741
L
E
S
C
M
K
K
Y
E
D
T
F
Q
D
Y
Site 38
Y748
Y
E
D
T
F
Q
D
Y
Q
E
M
F
V
Q
F
Site 39
S782
N
N
L
I
E
I
R
S
D
A
F
K
L
C
T
Site 40
S801
P
F
G
Q
R
V
E
S
I
G
Q
W
Q
K
V
Site 41
Y880
E
E
M
A
K
L
E
Y
Q
R
R
E
A
F
K
Site 42
S924
H
A
R
R
E
H
D
S
G
G
R
E
E
A
R
Site 43
T941
G
S
G
L
D
P
A
T
S
S
E
K
A
S
A
Site 44
S942
S
G
L
D
P
A
T
S
S
E
K
A
S
A
K
Site 45
S943
G
L
D
P
A
T
S
S
E
K
A
S
A
K
A
Site 46
S947
A
T
S
S
E
K
A
S
A
K
A
K
G
S
T
Site 47
S953
A
S
A
K
A
K
G
S
T
A
G
G
H
G
P
Site 48
S968
E
R
P
K
R
P
G
S
L
L
A
P
N
N
V
Site 49
S990
P
L
Q
G
K
F
L
S
S
G
A
T
S
S
L
Site 50
T1005
A
A
A
G
A
G
A
T
T
R
P
P
P
A
Q
Site 51
S1013
T
R
P
P
P
A
Q
S
P
T
G
S
D
T
R
Site 52
S1017
P
A
Q
S
P
T
G
S
D
T
R
L
P
A
F
Site 53
T1019
Q
S
P
T
G
S
D
T
R
L
P
A
F
L
S
Site 54
S1032
L
S
F
K
F
L
K
S
P
E
T
R
R
D
S
Site 55
T1035
K
F
L
K
S
P
E
T
R
R
D
S
E
R
S
Site 56
S1039
S
P
E
T
R
R
D
S
E
R
S
H
S
P
P
Site 57
S1042
T
R
R
D
S
E
R
S
H
S
P
P
K
A
F
Site 58
S1044
R
D
S
E
R
S
H
S
P
P
K
A
F
H
A
Site 59
T1060
K
L
F
P
F
G
G
T
R
A
E
P
G
S
N
Site 60
S1066
G
T
R
A
E
P
G
S
N
G
A
G
G
Q
A
Site 61
T1078
G
Q
A
R
P
D
G
T
P
S
S
G
S
S
R
Site 62
S1080
A
R
P
D
G
T
P
S
S
G
S
S
R
V
Q
Site 63
S1081
R
P
D
G
T
P
S
S
G
S
S
R
V
Q
R
Site 64
S1083
D
G
T
P
S
S
G
S
S
R
V
Q
R
S
G
Site 65
S1084
G
T
P
S
S
G
S
S
R
V
Q
R
S
G
P
Site 66
S1110
P
R
P
E
E
E
G
S
G
T
A
L
A
P
V
Site 67
T1112
P
E
E
E
G
S
G
T
A
L
A
P
V
G
A
Site 68
T1124
V
G
A
P
A
L
R
T
R
R
S
R
S
P
A
Site 69
S1127
P
A
L
R
T
R
R
S
R
S
P
A
P
P
P
Site 70
S1129
L
R
T
R
R
S
R
S
P
A
P
P
P
P
M
Site 71
T1143
M
P
L
P
R
P
P
T
P
P
A
G
C
W
Q
Site 72
S1193
Q
P
L
P
G
D
A
S
F
Y
S
L
P
P
P
Site 73
Y1195
L
P
G
D
A
S
F
Y
S
L
P
P
P
P
L
Site 74
S1196
P
G
D
A
S
F
Y
S
L
P
P
P
P
L
P
Site 75
T1205
P
P
P
P
L
P
P
T
S
D
P
L
E
T
P
Site 76
S1206
P
P
P
L
P
P
T
S
D
P
L
E
T
P
A
Site 77
T1211
P
T
S
D
P
L
E
T
P
A
P
S
P
S
P
Site 78
S1215
P
L
E
T
P
A
P
S
P
S
P
S
P
S
P
Site 79
S1217
E
T
P
A
P
S
P
S
P
S
P
S
P
Q
A
Site 80
S1219
P
A
P
S
P
S
P
S
P
S
P
Q
A
V
C
Site 81
S1221
P
S
P
S
P
S
P
S
P
Q
A
V
C
W
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation