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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRPM3
Full Name:
Transient receptor potential cation channel subfamily M member 3
Alias:
GON-2; KIAA1616; Long transient receptor potential channel 3; LTRPC3; Melastatin 2; Melastatin-2; MLSN2; Transient receptor potential cation channel, subfamily M, member 3
Type:
Membrane, Integral membrane protein
Mass (Da):
197543
Number AA:
1732
UniProt ID:
Q9HCF6
International Prot ID:
IPI00328399
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005262
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T42
A
P
R
P
L
N
W
T
I
R
K
L
C
H
A
Site 2
S63
R
L
L
K
A
Q
K
S
W
I
E
R
A
F
Y
Site 3
T81
C
V
H
I
I
P
S
T
K
D
P
H
R
C
C
Site 4
S102
Q
H
V
G
L
T
P
S
I
S
V
L
Q
N
E
Site 5
S104
V
G
L
T
P
S
I
S
V
L
Q
N
E
K
N
Site 6
S116
E
K
N
E
S
R
L
S
R
N
D
I
Q
S
E
Site 7
S122
L
S
R
N
D
I
Q
S
E
K
W
S
I
S
K
Site 8
S126
D
I
Q
S
E
K
W
S
I
S
K
H
T
Q
L
Site 9
S128
Q
S
E
K
W
S
I
S
K
H
T
Q
L
S
P
Site 10
S134
I
S
K
H
T
Q
L
S
P
T
D
A
F
G
T
Site 11
Y155
G
H
S
N
K
A
M
Y
V
R
V
S
F
D
T
Site 12
S159
K
A
M
Y
V
R
V
S
F
D
T
K
P
D
L
Site 13
T162
Y
V
R
V
S
F
D
T
K
P
D
L
L
L
H
Site 14
S240
D
A
L
K
D
H
A
S
K
S
R
G
K
I
C
Site 15
S242
L
K
D
H
A
S
K
S
R
G
K
I
C
T
I
Site 16
T248
K
S
R
G
K
I
C
T
I
G
I
A
P
W
G
Site 17
Y272
G
R
D
V
V
R
P
Y
Q
T
M
S
N
P
M
Site 18
S276
V
R
P
Y
Q
T
M
S
N
P
M
S
K
L
T
Site 19
S280
Q
T
M
S
N
P
M
S
K
L
T
V
L
N
S
Site 20
T283
S
N
P
M
S
K
L
T
V
L
N
S
M
H
S
Site 21
S287
S
K
L
T
V
L
N
S
M
H
S
H
F
I
L
Site 22
S290
T
V
L
N
S
M
H
S
H
F
I
L
A
D
N
Site 23
T299
F
I
L
A
D
N
G
T
T
G
K
Y
G
A
E
Site 24
S318
R
Q
L
E
K
H
I
S
L
Q
K
I
N
T
R
Site 25
Y338
S
L
D
S
R
L
F
Y
S
F
W
G
S
C
Q
Site 26
S394
C
D
G
S
G
R
A
S
D
I
L
A
F
G
H
Site 27
S404
L
A
F
G
H
K
Y
S
E
E
G
G
L
I
N
Site 28
S413
E
G
G
L
I
N
E
S
L
R
D
Q
L
L
V
Site 29
T425
L
L
V
T
I
Q
K
T
F
T
Y
T
R
T
Q
Site 30
Y428
T
I
Q
K
T
F
T
Y
T
R
T
Q
A
Q
H
Site 31
T451
M
K
K
K
E
L
I
T
V
F
R
M
G
S
E
Site 32
S457
I
T
V
F
R
M
G
S
E
G
H
Q
D
I
D
Site 33
S484
A
S
A
P
D
Q
L
S
L
A
L
A
W
N
R
Site 34
S497
N
R
V
D
I
A
R
S
Q
I
F
I
Y
G
Q
Site 35
Y502
A
R
S
Q
I
F
I
Y
G
Q
Q
W
P
V
G
Site 36
S544
M
H
R
F
L
T
I
S
R
L
E
E
L
Y
N
Site 37
Y550
I
S
R
L
E
E
L
Y
N
T
R
H
G
P
S
Site 38
T552
R
L
E
E
L
Y
N
T
R
H
G
P
S
N
T
Site 39
Y561
H
G
P
S
N
T
L
Y
H
L
V
R
D
V
K
Site 40
Y576
K
G
N
L
P
P
D
Y
R
I
S
L
I
D
I
Site 41
Y595
E
Y
L
M
G
G
A
Y
R
C
N
Y
T
R
K
Site 42
Y599
G
G
A
Y
R
C
N
Y
T
R
K
R
F
R
T
Site 43
T606
Y
T
R
K
R
F
R
T
L
Y
H
N
L
F
G
Site 44
Y608
R
K
R
F
R
T
L
Y
H
N
L
F
G
P
K
Site 45
T637
P
L
R
R
G
R
K
T
T
K
K
R
E
E
E
Site 46
T638
L
R
R
G
R
K
T
T
K
K
R
E
E
E
V
Site 47
S715
N
D
M
V
D
D
I
S
Q
E
L
N
H
N
S
Site 48
Y737
V
E
L
L
D
Q
S
Y
K
Q
D
E
Q
L
A
Site 49
T749
Q
L
A
M
K
L
L
T
Y
E
L
K
N
W
S
Site 50
Y750
L
A
M
K
L
L
T
Y
E
L
K
N
W
S
N
Site 51
T776
H
R
D
F
I
A
H
T
C
S
Q
M
L
L
T
Site 52
S796
R
L
R
M
R
K
N
S
G
L
K
V
I
L
G
Site 53
S812
L
L
P
P
S
I
L
S
L
E
F
K
N
K
D
Site 54
Y823
K
N
K
D
D
M
P
Y
M
S
Q
A
Q
E
I
Site 55
S865
L
G
R
N
N
G
E
S
S
R
K
K
D
E
E
Site 56
Y888
I
P
L
G
R
K
I
Y
E
F
Y
N
A
P
I
Site 57
Y891
G
R
K
I
Y
E
F
Y
N
A
P
I
V
K
F
Site 58
T926
K
M
E
R
W
P
S
T
Q
E
W
I
V
I
S
Site 59
S949
K
M
R
E
I
L
M
S
E
P
G
K
L
L
Q
Site 60
S992
L
Q
D
Q
P
F
R
S
D
G
R
V
I
Y
C
Site 61
S1046
I
M
L
V
V
L
M
S
F
G
V
A
R
Q
A
Site 62
T1162
Q
R
Y
Q
L
I
M
T
F
H
E
R
P
V
L
Site 63
S1195
C
R
W
R
K
H
E
S
D
P
D
E
R
D
Y
Site 64
Y1202
S
D
P
D
E
R
D
Y
G
L
K
L
F
I
T
Site 65
T1209
Y
G
L
K
L
F
I
T
D
D
E
L
K
K
V
Site 66
Y1227
E
E
Q
C
I
E
E
Y
F
R
E
K
D
D
R
Site 67
S1237
E
K
D
D
R
F
N
S
S
N
D
E
R
I
R
Site 68
S1238
K
D
D
R
F
N
S
S
N
D
E
R
I
R
V
Site 69
T1246
N
D
E
R
I
R
V
T
S
E
R
V
E
N
M
Site 70
S1247
D
E
R
I
R
V
T
S
E
R
V
E
N
M
S
Site 71
S1254
S
E
R
V
E
N
M
S
M
R
L
E
E
V
N
Site 72
S1266
E
V
N
E
R
E
H
S
M
K
A
S
L
Q
T
Site 73
S1270
R
E
H
S
M
K
A
S
L
Q
T
V
D
I
R
Site 74
T1273
S
M
K
A
S
L
Q
T
V
D
I
R
L
A
Q
Site 75
T1296
A
T
A
L
E
R
L
T
G
L
E
R
A
E
S
Site 76
S1303
T
G
L
E
R
A
E
S
N
K
I
R
S
R
T
Site 77
S1308
A
E
S
N
K
I
R
S
R
T
S
S
D
C
T
Site 78
T1310
S
N
K
I
R
S
R
T
S
S
D
C
T
D
A
Site 79
S1311
N
K
I
R
S
R
T
S
S
D
C
T
D
A
A
Site 80
S1312
K
I
R
S
R
T
S
S
D
C
T
D
A
A
Y
Site 81
T1315
S
R
T
S
S
D
C
T
D
A
A
Y
I
V
R
Site 82
Y1319
S
D
C
T
D
A
A
Y
I
V
R
Q
S
S
F
Site 83
S1324
A
A
Y
I
V
R
Q
S
S
F
N
S
Q
E
G
Site 84
S1325
A
Y
I
V
R
Q
S
S
F
N
S
Q
E
G
N
Site 85
S1328
V
R
Q
S
S
F
N
S
Q
E
G
N
T
F
K
Site 86
T1347
I
D
P
A
G
E
E
T
M
S
P
T
S
P
T
Site 87
S1349
P
A
G
E
E
T
M
S
P
T
S
P
T
L
M
Site 88
T1351
G
E
E
T
M
S
P
T
S
P
T
L
M
P
R
Site 89
S1352
E
E
T
M
S
P
T
S
P
T
L
M
P
R
M
Site 90
T1354
T
M
S
P
T
S
P
T
L
M
P
R
M
R
S
Site 91
S1361
T
L
M
P
R
M
R
S
H
S
F
Y
S
V
N
Site 92
S1363
M
P
R
M
R
S
H
S
F
Y
S
V
N
M
K
Site 93
Y1365
R
M
R
S
H
S
F
Y
S
V
N
M
K
D
K
Site 94
S1366
M
R
S
H
S
F
Y
S
V
N
M
K
D
K
G
Site 95
S1380
G
G
I
E
K
L
E
S
I
F
K
E
R
S
L
Site 96
S1386
E
S
I
F
K
E
R
S
L
S
L
H
R
A
T
Site 97
S1388
I
F
K
E
R
S
L
S
L
H
R
A
T
S
S
Site 98
T1393
S
L
S
L
H
R
A
T
S
S
H
S
V
A
K
Site 99
S1394
L
S
L
H
R
A
T
S
S
H
S
V
A
K
E
Site 100
S1395
S
L
H
R
A
T
S
S
H
S
V
A
K
E
P
Site 101
S1418
T
L
A
I
V
P
D
S
R
R
P
S
S
C
I
Site 102
S1422
V
P
D
S
R
R
P
S
S
C
I
D
I
Y
V
Site 103
S1423
P
D
S
R
R
P
S
S
C
I
D
I
Y
V
S
Site 104
S1457
G
L
G
E
P
S
F
S
T
P
V
P
S
T
A
Site 105
T1458
L
G
E
P
S
F
S
T
P
V
P
S
T
A
P
Site 106
S1462
S
F
S
T
P
V
P
S
T
A
P
S
S
S
A
Site 107
T1463
F
S
T
P
V
P
S
T
A
P
S
S
S
A
Y
Site 108
S1466
P
V
P
S
T
A
P
S
S
S
A
Y
A
T
L
Site 109
S1468
P
S
T
A
P
S
S
S
A
Y
A
T
L
A
P
Site 110
T1472
P
S
S
S
A
Y
A
T
L
A
P
T
D
R
P
Site 111
T1476
A
Y
A
T
L
A
P
T
D
R
P
P
S
R
S
Site 112
S1481
A
P
T
D
R
P
P
S
R
S
I
D
F
E
D
Site 113
S1483
T
D
R
P
P
S
R
S
I
D
F
E
D
I
T
Site 114
T1490
S
I
D
F
E
D
I
T
S
M
D
T
R
S
F
Site 115
S1491
I
D
F
E
D
I
T
S
M
D
T
R
S
F
S
Site 116
T1494
E
D
I
T
S
M
D
T
R
S
F
S
S
D
Y
Site 117
S1496
I
T
S
M
D
T
R
S
F
S
S
D
Y
T
H
Site 118
S1498
S
M
D
T
R
S
F
S
S
D
Y
T
H
L
P
Site 119
Y1501
T
R
S
F
S
S
D
Y
T
H
L
P
E
C
Q
Site 120
T1502
R
S
F
S
S
D
Y
T
H
L
P
E
C
Q
N
Site 121
Y1518
W
D
S
E
P
P
M
Y
H
T
I
E
R
S
K
Site 122
T1520
S
E
P
P
M
Y
H
T
I
E
R
S
K
S
S
Site 123
S1526
H
T
I
E
R
S
K
S
S
R
Y
L
A
T
T
Site 124
Y1529
E
R
S
K
S
S
R
Y
L
A
T
T
P
F
L
Site 125
T1533
S
S
R
Y
L
A
T
T
P
F
L
L
E
E
A
Site 126
S1545
E
E
A
P
I
V
K
S
H
S
F
M
F
S
P
Site 127
S1547
A
P
I
V
K
S
H
S
F
M
F
S
P
S
R
Site 128
S1551
K
S
H
S
F
M
F
S
P
S
R
S
Y
Y
A
Site 129
Y1556
M
F
S
P
S
R
S
Y
Y
A
N
F
G
V
P
Site 130
Y1557
F
S
P
S
R
S
Y
Y
A
N
F
G
V
P
V
Site 131
T1566
N
F
G
V
P
V
K
T
A
E
Y
T
S
I
T
Site 132
T1605
G
D
K
V
E
D
L
T
C
C
H
P
E
R
E
Site 133
S1616
P
E
R
E
A
E
L
S
H
P
S
S
D
S
E
Site 134
S1620
A
E
L
S
H
P
S
S
D
S
E
E
N
E
A
Site 135
S1622
L
S
H
P
S
S
D
S
E
E
N
E
A
K
G
Site 136
T1633
E
A
K
G
R
R
A
T
I
A
I
S
S
Q
E
Site 137
S1638
R
A
T
I
A
I
S
S
Q
E
G
D
N
S
E
Site 138
S1644
S
S
Q
E
G
D
N
S
E
R
T
L
S
N
N
Site 139
T1647
E
G
D
N
S
E
R
T
L
S
N
N
I
T
V
Site 140
S1649
D
N
S
E
R
T
L
S
N
N
I
T
V
P
K
Site 141
T1653
R
T
L
S
N
N
I
T
V
P
K
I
E
R
A
Site 142
S1662
P
K
I
E
R
A
N
S
Y
S
A
E
E
P
S
Site 143
S1664
I
E
R
A
N
S
Y
S
A
E
E
P
S
A
P
Site 144
S1669
S
Y
S
A
E
E
P
S
A
P
Y
A
H
T
R
Site 145
T1675
P
S
A
P
Y
A
H
T
R
K
S
F
S
I
S
Site 146
S1678
P
Y
A
H
T
R
K
S
F
S
I
S
D
K
L
Site 147
S1680
A
H
T
R
K
S
F
S
I
S
D
K
L
D
R
Site 148
S1682
T
R
K
S
F
S
I
S
D
K
L
D
R
Q
R
Site 149
T1691
K
L
D
R
Q
R
N
T
A
S
L
Q
N
P
F
Site 150
S1701
L
Q
N
P
F
Q
R
S
K
S
S
K
P
E
G
Site 151
S1703
N
P
F
Q
R
S
K
S
S
K
P
E
G
R
G
Site 152
S1704
P
F
Q
R
S
K
S
S
K
P
E
G
R
G
D
Site 153
S1712
K
P
E
G
R
G
D
S
L
S
M
R
R
L
S
Site 154
S1714
E
G
R
G
D
S
L
S
M
R
R
L
S
R
T
Site 155
S1719
S
L
S
M
R
R
L
S
R
T
S
A
F
Q
S
Site 156
T1721
S
M
R
R
L
S
R
T
S
A
F
Q
S
F
E
Site 157
S1722
M
R
R
L
S
R
T
S
A
F
Q
S
F
E
S
Site 158
S1726
S
R
T
S
A
F
Q
S
F
E
S
K
H
N
_
Site 159
S1729
S
A
F
Q
S
F
E
S
K
H
N
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation