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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCM
Full Name:
Pre-mRNA-splicing factor CWC22 homolog
Alias:
CWC22 spliceosome-associated protein; EIF4GL; FSAPb; Functional spliceosome-associated protein b; KIAA1604; Nucampholin; Nucampholin homolog
Type:
RNA processing
Mass (Da):
105535
Number AA:
908
UniProt ID:
Q9HCG8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
GO:0048024
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
K
S
S
V
A
Q
I
K
P
Site 2
S12
V
A
Q
I
K
P
S
S
G
H
D
R
R
E
N
Site 3
S22
D
R
R
E
N
L
N
S
Y
Q
R
N
S
S
P
Site 4
Y23
R
R
E
N
L
N
S
Y
Q
R
N
S
S
P
E
Site 5
S27
L
N
S
Y
Q
R
N
S
S
P
E
D
R
Y
E
Site 6
S28
N
S
Y
Q
R
N
S
S
P
E
D
R
Y
E
E
Site 7
Y33
N
S
S
P
E
D
R
Y
E
E
Q
E
R
S
P
Site 8
S39
R
Y
E
E
Q
E
R
S
P
R
D
R
D
Y
F
Site 9
Y45
R
S
P
R
D
R
D
Y
F
D
Y
S
R
S
D
Site 10
Y48
R
D
R
D
Y
F
D
Y
S
R
S
D
Y
E
H
Site 11
S49
D
R
D
Y
F
D
Y
S
R
S
D
Y
E
H
S
Site 12
S51
D
Y
F
D
Y
S
R
S
D
Y
E
H
S
R
R
Site 13
Y53
F
D
Y
S
R
S
D
Y
E
H
S
R
R
G
R
Site 14
S56
S
R
S
D
Y
E
H
S
R
R
G
R
S
Y
D
Site 15
S61
E
H
S
R
R
G
R
S
Y
D
S
S
M
E
S
Site 16
Y62
H
S
R
R
G
R
S
Y
D
S
S
M
E
S
R
Site 17
S64
R
R
G
R
S
Y
D
S
S
M
E
S
R
N
R
Site 18
S65
R
G
R
S
Y
D
S
S
M
E
S
R
N
R
D
Site 19
S68
S
Y
D
S
S
M
E
S
R
N
R
D
R
E
K
Site 20
T83
R
R
E
R
E
R
D
T
D
R
K
R
S
R
K
Site 21
S88
R
D
T
D
R
K
R
S
R
K
S
P
S
P
G
Site 22
S91
D
R
K
R
S
R
K
S
P
S
P
G
R
R
N
Site 23
S93
K
R
S
R
K
S
P
S
P
G
R
R
N
P
E
Site 24
T101
P
G
R
R
N
P
E
T
S
V
T
Q
S
S
S
Site 25
S102
G
R
R
N
P
E
T
S
V
T
Q
S
S
S
A
Site 26
T104
R
N
P
E
T
S
V
T
Q
S
S
S
A
Q
D
Site 27
S106
P
E
T
S
V
T
Q
S
S
S
A
Q
D
E
P
Site 28
S107
E
T
S
V
T
Q
S
S
S
A
Q
D
E
P
A
Site 29
S108
T
S
V
T
Q
S
S
S
A
Q
D
E
P
A
T
Site 30
Y133
L
T
R
T
G
G
A
Y
I
P
P
A
K
L
R
Site 31
T147
R
M
M
Q
E
Q
I
T
D
K
N
S
L
A
Y
Site 32
S151
E
Q
I
T
D
K
N
S
L
A
Y
Q
R
M
S
Site 33
Y154
T
D
K
N
S
L
A
Y
Q
R
M
S
W
E
A
Site 34
S158
S
L
A
Y
Q
R
M
S
W
E
A
L
K
K
S
Site 35
S165
S
W
E
A
L
K
K
S
I
N
G
L
I
N
K
Site 36
S198
V
R
G
R
G
L
L
S
R
S
V
L
Q
A
Q
Site 37
S200
G
R
G
L
L
S
R
S
V
L
Q
A
Q
S
A
Site 38
S206
R
S
V
L
Q
A
Q
S
A
S
P
I
F
T
H
Site 39
Y245
I
L
N
F
R
K
G
Y
R
R
N
D
K
Q
L
Site 40
T255
N
D
K
Q
L
C
L
T
A
S
K
F
V
A
H
Site 41
T286
T
L
L
L
E
R
P
T
D
D
S
V
E
V
A
Site 42
S289
L
E
R
P
T
D
D
S
V
E
V
A
I
G
F
Site 43
Y376
M
L
P
L
E
D
D
Y
N
P
E
D
V
L
N
Site 44
T411
E
I
L
D
E
G
D
T
D
S
N
T
D
Q
D
Site 45
S413
L
D
E
G
D
T
D
S
N
T
D
Q
D
A
G
Site 46
T415
E
G
D
T
D
S
N
T
D
Q
D
A
G
S
S
Site 47
T448
K
V
T
I
H
D
K
T
E
I
N
L
V
S
F
Site 48
S454
K
T
E
I
N
L
V
S
F
R
R
T
I
Y
L
Site 49
S484
L
K
M
E
F
P
E
S
Q
T
K
E
L
C
N
Site 50
Y503
C
C
A
Q
Q
R
T
Y
E
K
F
F
G
L
L
Site 51
Y521
F
C
M
L
K
K
E
Y
M
E
S
F
E
G
I
Site 52
S524
L
K
K
E
Y
M
E
S
F
E
G
I
F
K
E
Site 53
Y533
E
G
I
F
K
E
Q
Y
D
T
I
H
R
L
E
Site 54
T535
I
F
K
E
Q
Y
D
T
I
H
R
L
E
T
N
Site 55
T541
D
T
I
H
R
L
E
T
N
K
L
R
N
V
A
Site 56
Y556
K
M
F
A
H
L
L
Y
T
D
S
L
P
W
S
Site 57
S571
V
L
E
C
I
K
L
S
E
E
T
T
T
S
S
Site 58
T575
I
K
L
S
E
E
T
T
T
S
S
S
R
I
F
Site 59
T576
K
L
S
E
E
T
T
T
S
S
S
R
I
F
V
Site 60
S577
L
S
E
E
T
T
T
S
S
S
R
I
F
V
K
Site 61
S578
S
E
E
T
T
T
S
S
S
R
I
F
V
K
I
Site 62
S579
E
E
T
T
T
S
S
S
R
I
F
V
K
I
F
Site 63
Y593
F
F
Q
E
L
C
E
Y
M
G
L
P
K
L
N
Site 64
T607
N
A
R
L
K
D
E
T
L
Q
P
F
F
E
G
Site 65
T640
S
I
G
L
G
G
L
T
D
E
L
R
E
H
L
Site 66
T650
L
R
E
H
L
K
N
T
P
K
V
I
V
A
Q
Site 67
S666
P
D
V
E
Q
N
K
S
S
P
S
S
S
S
S
Site 68
S667
D
V
E
Q
N
K
S
S
P
S
S
S
S
S
A
Site 69
S669
E
Q
N
K
S
S
P
S
S
S
S
S
A
S
S
Site 70
S670
Q
N
K
S
S
P
S
S
S
S
S
A
S
S
S
Site 71
S671
N
K
S
S
P
S
S
S
S
S
A
S
S
S
S
Site 72
S672
K
S
S
P
S
S
S
S
S
A
S
S
S
S
E
Site 73
S673
S
S
P
S
S
S
S
S
A
S
S
S
S
E
S
Site 74
S675
P
S
S
S
S
S
A
S
S
S
S
E
S
D
S
Site 75
S676
S
S
S
S
S
A
S
S
S
S
E
S
D
S
S
Site 76
S677
S
S
S
S
A
S
S
S
S
E
S
D
S
S
D
Site 77
S678
S
S
S
A
S
S
S
S
E
S
D
S
S
D
S
Site 78
S680
S
A
S
S
S
S
E
S
D
S
S
D
S
D
S
Site 79
S682
S
S
S
S
E
S
D
S
S
D
S
D
S
D
S
Site 80
S683
S
S
S
E
S
D
S
S
D
S
D
S
D
S
S
Site 81
S685
S
E
S
D
S
S
D
S
D
S
D
S
S
D
S
Site 82
S687
S
D
S
S
D
S
D
S
D
S
S
D
S
S
S
Site 83
S689
S
S
D
S
D
S
D
S
S
D
S
S
S
E
S
Site 84
S690
S
D
S
D
S
D
S
S
D
S
S
S
E
S
S
Site 85
S692
S
D
S
D
S
S
D
S
S
S
E
S
S
S
E
Site 86
S693
D
S
D
S
S
D
S
S
S
E
S
S
S
E
E
Site 87
S694
S
D
S
S
D
S
S
S
E
S
S
S
E
E
S
Site 88
S696
S
S
D
S
S
S
E
S
S
S
E
E
S
D
S
Site 89
S697
S
D
S
S
S
E
S
S
S
E
E
S
D
S
S
Site 90
S698
D
S
S
S
E
S
S
S
E
E
S
D
S
S
S
Site 91
S701
S
E
S
S
S
E
E
S
D
S
S
S
I
S
S
Site 92
S703
S
S
S
E
E
S
D
S
S
S
I
S
S
H
S
Site 93
S704
S
S
E
E
S
D
S
S
S
I
S
S
H
S
S
Site 94
S705
S
E
E
S
D
S
S
S
I
S
S
H
S
S
A
Site 95
S707
E
S
D
S
S
S
I
S
S
H
S
S
A
S
A
Site 96
S708
S
D
S
S
S
I
S
S
H
S
S
A
S
A
N
Site 97
S710
S
S
S
I
S
S
H
S
S
A
S
A
N
D
V
Site 98
S711
S
S
I
S
S
H
S
S
A
S
A
N
D
V
R
Site 99
S727
K
G
H
G
K
T
R
S
K
E
V
D
K
L
I
Site 100
T758
H
G
H
Q
E
T
R
T
E
R
E
R
R
S
E
Site 101
S764
R
T
E
R
E
R
R
S
E
K
H
R
D
Q
N
Site 102
S772
E
K
H
R
D
Q
N
S
R
G
S
N
W
R
D
Site 103
S775
R
D
Q
N
S
R
G
S
N
W
R
D
P
I
T
Site 104
T782
S
N
W
R
D
P
I
T
K
Y
T
S
D
K
D
Site 105
Y784
W
R
D
P
I
T
K
Y
T
S
D
K
D
V
P
Site 106
S786
D
P
I
T
K
Y
T
S
D
K
D
V
P
S
E
Site 107
S792
T
S
D
K
D
V
P
S
E
R
N
N
Y
S
R
Site 108
Y797
V
P
S
E
R
N
N
Y
S
R
V
A
N
D
R
Site 109
S829
K
R
G
E
R
R
N
S
F
S
E
N
E
K
H
Site 110
S831
G
E
R
R
N
S
F
S
E
N
E
K
H
T
H
Site 111
S843
H
T
H
R
I
K
D
S
E
N
F
R
R
K
D
Site 112
S852
N
F
R
R
K
D
R
S
K
S
K
E
M
N
R
Site 113
S854
R
R
K
D
R
S
K
S
K
E
M
N
R
K
H
Site 114
S862
K
E
M
N
R
K
H
S
G
S
R
S
D
E
D
Site 115
S864
M
N
R
K
H
S
G
S
R
S
D
E
D
R
Y
Site 116
S866
R
K
H
S
G
S
R
S
D
E
D
R
Y
Q
N
Site 117
Y871
S
R
S
D
E
D
R
Y
Q
N
G
A
E
R
R
Site 118
S882
A
E
R
R
W
E
K
S
S
R
Y
S
E
Q
S
Site 119
S883
E
R
R
W
E
K
S
S
R
Y
S
E
Q
S
R
Site 120
S886
W
E
K
S
S
R
Y
S
E
Q
S
R
E
S
K
Site 121
S889
S
S
R
Y
S
E
Q
S
R
E
S
K
K
N
Q
Site 122
S892
Y
S
E
Q
S
R
E
S
K
K
N
Q
D
R
R
Site 123
S903
Q
D
R
R
R
E
K
S
P
A
K
Q
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation