KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SYTL2
Full Name:
Synaptotagmin-like protein 2
Alias:
Breast cancer-associated antigen SGA-72M; CHR11SYT; Chromosome 11 synaptotagmin; Exophilin-4; FLJ20163; FLJ21219; KIAA1597; MGC102768; SGA72M; SLP2; Synaptotagmin-like 2
Type:
Vesicle protein
Mass (Da):
104930
Number AA:
934
UniProt ID:
Q9HCH5
International Prot ID:
IPI00059975
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070382
GO:0019897
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0017137
GO:0042043
GO:0005546
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0006904
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S75
G
A
D
I
I
R
A
S
M
R
K
K
R
P
Q
Site 2
S88
P
Q
I
A
A
E
Q
S
K
D
R
E
N
G
A
Site 3
S98
R
E
N
G
A
K
E
S
W
V
N
N
V
N
K
Site 4
S128
E
E
D
A
A
P
A
S
P
S
S
S
V
V
N
Site 5
S130
D
A
A
P
A
S
P
S
S
S
V
V
N
P
A
Site 6
S131
A
A
P
A
S
P
S
S
S
V
V
N
P
A
S
Site 7
S132
A
P
A
S
P
S
S
S
V
V
N
P
A
S
S
Site 8
S139
S
V
V
N
P
A
S
S
V
I
D
M
S
Q
E
Site 9
S144
A
S
S
V
I
D
M
S
Q
E
N
T
R
K
P
Site 10
T148
I
D
M
S
Q
E
N
T
R
K
P
N
V
S
P
Site 11
S154
N
T
R
K
P
N
V
S
P
E
K
R
K
N
P
Site 12
S165
R
K
N
P
F
N
S
S
K
L
P
E
G
H
S
Site 13
S172
S
K
L
P
E
G
H
S
S
Q
Q
T
K
N
E
Site 14
S173
K
L
P
E
G
H
S
S
Q
Q
T
K
N
E
Q
Site 15
T176
E
G
H
S
S
Q
Q
T
K
N
E
Q
S
K
N
Site 16
S198
T
S
K
E
D
E
L
S
E
S
K
E
K
S
T
Site 17
S200
K
E
D
E
L
S
E
S
K
E
K
S
T
V
A
Site 18
S204
L
S
E
S
K
E
K
S
T
V
A
D
T
S
I
Site 19
T205
S
E
S
K
E
K
S
T
V
A
D
T
S
I
Q
Site 20
S210
K
S
T
V
A
D
T
S
I
Q
K
L
E
K
S
Site 21
S217
S
I
Q
K
L
E
K
S
K
Q
T
L
P
G
L
Site 22
S225
K
Q
T
L
P
G
L
S
N
G
S
Q
I
K
A
Site 23
S228
L
P
G
L
S
N
G
S
Q
I
K
A
P
I
P
Site 24
Y242
P
K
A
R
K
M
I
Y
K
S
T
D
L
N
K
Site 25
S244
A
R
K
M
I
Y
K
S
T
D
L
N
K
D
D
Site 26
S254
L
N
K
D
D
N
Q
S
F
P
R
Q
R
T
D
Site 27
T260
Q
S
F
P
R
Q
R
T
D
S
L
K
A
R
G
Site 28
S262
R
G
I
L
K
R
N
S
S
S
S
S
T
D
S
Site 29
S277
R
G
I
L
K
R
N
S
S
S
S
S
T
D
S
Site 30
S278
G
I
L
K
R
N
S
S
S
S
S
T
D
S
E
Site 31
S279
I
L
K
R
N
S
S
S
S
S
T
D
S
E
T
Site 32
S280
L
K
R
N
S
S
S
S
S
T
D
S
E
T
L
Site 33
S281
K
R
N
S
S
S
S
S
T
D
S
E
T
L
R
Site 34
T282
R
N
S
S
S
S
S
T
D
S
E
T
L
R
Y
Site 35
S284
S
S
S
S
S
T
D
S
E
T
L
R
Y
N
H
Site 36
T286
S
S
S
T
D
S
E
T
L
R
Y
N
H
N
F
Site 37
Y289
T
D
S
E
T
L
R
Y
N
H
N
F
E
P
K
Site 38
S297
N
H
N
F
E
P
K
S
K
I
V
S
P
G
L
Site 39
S301
R
I
S
E
K
E
H
S
L
E
D
N
S
S
P
Site 40
T305
K
I
V
S
P
G
L
T
I
H
E
R
I
S
E
Site 41
S311
L
T
I
H
E
R
I
S
E
K
E
H
S
L
E
Site 42
S316
R
I
S
E
K
E
H
S
L
E
D
N
S
S
P
Site 43
S321
E
H
S
L
E
D
N
S
S
P
N
S
L
E
P
Site 44
S322
H
S
L
E
D
N
S
S
P
N
S
L
E
P
L
Site 45
S325
E
D
N
S
S
P
N
S
L
E
P
L
K
H
V
Site 46
S335
P
L
K
H
V
R
F
S
A
V
K
D
E
L
P
Site 47
S344
V
K
D
E
L
P
Q
S
P
G
L
I
H
G
R
Site 48
S357
G
R
E
V
G
E
F
S
V
L
E
S
D
R
L
Site 49
S361
G
E
F
S
V
L
E
S
D
R
L
K
N
G
M
Site 50
T374
G
M
E
D
A
G
D
T
E
E
F
Q
S
D
P
Site 51
S379
G
D
T
E
E
F
Q
S
D
P
K
P
S
Q
Y
Site 52
S384
F
Q
S
D
P
K
P
S
Q
Y
R
K
P
S
L
Site 53
Y386
S
D
P
K
P
S
Q
Y
R
K
P
S
L
F
H
Site 54
S390
P
S
Q
Y
R
K
P
S
L
F
H
Q
S
T
S
Site 55
S395
K
P
S
L
F
H
Q
S
T
S
S
P
Y
V
S
Site 56
T396
P
S
L
F
H
Q
S
T
S
S
P
Y
V
S
K
Site 57
S397
S
L
F
H
Q
S
T
S
S
P
Y
V
S
K
S
Site 58
S398
L
F
H
Q
S
T
S
S
P
Y
V
S
K
S
E
Site 59
Y400
H
Q
S
T
S
S
P
Y
V
S
K
S
E
T
H
Site 60
S402
S
T
S
S
P
Y
V
S
K
S
E
T
H
Q
P
Site 61
S404
S
S
P
Y
V
S
K
S
E
T
H
Q
P
M
T
Site 62
T406
P
Y
V
S
K
S
E
T
H
Q
P
M
T
S
G
Site 63
T411
S
E
T
H
Q
P
M
T
S
G
S
F
P
I
N
Site 64
S412
E
T
H
Q
P
M
T
S
G
S
F
P
I
N
G
Site 65
S414
H
Q
P
M
T
S
G
S
F
P
I
N
G
L
H
Site 66
S424
I
N
G
L
H
S
H
S
E
V
L
T
A
R
P
Site 67
T428
H
S
H
S
E
V
L
T
A
R
P
Q
S
M
E
Site 68
S433
V
L
T
A
R
P
Q
S
M
E
N
S
P
T
I
Site 69
S437
R
P
Q
S
M
E
N
S
P
T
I
N
E
P
K
Site 70
T439
Q
S
M
E
N
S
P
T
I
N
E
P
K
D
K
Site 71
S447
I
N
E
P
K
D
K
S
S
E
L
T
R
L
E
Site 72
T451
K
D
K
S
S
E
L
T
R
L
E
S
V
L
P
Site 73
S455
S
E
L
T
R
L
E
S
V
L
P
R
S
P
A
Site 74
S460
L
E
S
V
L
P
R
S
P
A
D
E
L
S
H
Site 75
S466
R
S
P
A
D
E
L
S
H
C
V
E
P
E
P
Site 76
S474
H
C
V
E
P
E
P
S
Q
V
P
G
G
S
S
Site 77
S480
P
S
Q
V
P
G
G
S
S
R
D
R
Q
Q
G
Site 78
S481
S
Q
V
P
G
G
S
S
R
D
R
Q
Q
G
S
Site 79
S488
S
R
D
R
Q
Q
G
S
E
E
E
P
S
P
V
Site 80
S493
Q
G
S
E
E
E
P
S
P
V
L
K
T
L
E
Site 81
T498
E
P
S
P
V
L
K
T
L
E
R
S
A
A
R
Site 82
S502
V
L
K
T
L
E
R
S
A
A
R
K
M
P
S
Site 83
S509
S
A
A
R
K
M
P
S
K
S
L
E
D
I
S
Site 84
S511
A
R
K
M
P
S
K
S
L
E
D
I
S
S
D
Site 85
S516
S
K
S
L
E
D
I
S
S
D
S
S
N
Q
A
Site 86
S517
K
S
L
E
D
I
S
S
D
S
S
N
Q
A
K
Site 87
S520
Q
P
E
E
L
V
R
S
A
E
D
D
E
K
P
Site 88
S535
Q
P
E
E
L
V
R
S
A
E
D
V
S
T
V
Site 89
S540
V
R
S
A
E
D
V
S
T
V
P
T
Q
P
D
Site 90
T541
R
S
A
E
D
V
S
T
V
P
T
Q
P
D
N
Site 91
T544
E
D
V
S
T
V
P
T
Q
P
D
N
P
F
S
Site 92
S551
T
Q
P
D
N
P
F
S
H
P
D
K
L
K
R
Site 93
S560
P
D
K
L
K
R
M
S
K
S
V
P
A
F
L
Site 94
S562
K
L
K
R
M
S
K
S
V
P
A
F
L
Q
D
Site 95
S571
P
A
F
L
Q
D
E
S
D
D
R
E
T
D
T
Site 96
T576
D
E
S
D
D
R
E
T
D
T
A
S
E
S
S
Site 97
T578
S
D
D
R
E
T
D
T
A
S
E
S
S
Y
Q
Site 98
S580
D
R
E
T
D
T
A
S
E
S
S
Y
Q
L
S
Site 99
S582
E
T
D
T
A
S
E
S
S
Y
Q
L
S
R
H
Site 100
S583
T
D
T
A
S
E
S
S
Y
Q
L
S
R
H
K
Site 101
Y584
D
T
A
S
E
S
S
Y
Q
L
S
R
H
K
K
Site 102
S587
S
E
S
S
Y
Q
L
S
R
H
K
K
S
P
S
Site 103
S592
Q
L
S
R
H
K
K
S
P
S
S
L
T
N
L
Site 104
S594
S
R
H
K
K
S
P
S
S
L
T
N
L
S
S
Site 105
S595
R
H
K
K
S
P
S
S
L
T
N
L
S
S
S
Site 106
T597
K
K
S
P
S
S
L
T
N
L
S
S
S
S
G
Site 107
S600
P
S
S
L
T
N
L
S
S
S
S
G
M
T
S
Site 108
S601
S
S
L
T
N
L
S
S
S
S
G
M
T
S
L
Site 109
S602
S
L
T
N
L
S
S
S
S
G
M
T
S
L
S
Site 110
S603
L
T
N
L
S
S
S
S
G
M
T
S
L
S
S
Site 111
T606
L
S
S
S
S
G
M
T
S
L
S
S
V
S
G
Site 112
S607
S
S
S
S
G
M
T
S
L
S
S
V
S
G
S
Site 113
Y668
K
K
Q
R
S
D
P
Y
V
K
A
Y
L
L
P
Site 114
Y672
S
D
P
Y
V
K
A
Y
L
L
P
D
K
G
K
Site 115
T685
G
K
M
G
K
K
K
T
L
V
V
K
K
T
L
Site 116
T691
K
T
L
V
V
K
K
T
L
N
P
V
Y
N
E
Site 117
Y696
K
K
T
L
N
P
V
Y
N
E
I
L
R
Y
K
Site 118
Y702
V
Y
N
E
I
L
R
Y
K
I
E
K
Q
I
L
Site 119
T711
I
E
K
Q
I
L
K
T
Q
K
L
N
L
S
I
Site 120
T723
L
S
I
W
H
R
D
T
F
K
R
N
S
F
L
Site 121
S728
R
D
T
F
K
R
N
S
F
L
G
E
V
E
L
Site 122
Y753
Q
N
K
Q
L
R
W
Y
P
L
K
R
K
T
A
Site 123
T759
W
Y
P
L
K
R
K
T
A
P
V
A
L
E
A
Site 124
Y778
E
M
K
L
A
L
Q
Y
V
P
E
P
V
P
G
Site 125
T791
P
G
K
K
L
P
T
T
G
E
V
H
I
W
V
Site 126
S810
D
L
P
L
L
R
G
S
H
L
N
S
F
V
K
Site 127
T819
L
N
S
F
V
K
C
T
I
L
P
D
T
S
R
Site 128
T824
K
C
T
I
L
P
D
T
S
R
K
S
R
Q
K
Site 129
S828
L
P
D
T
S
R
K
S
R
Q
K
T
R
A
V
Site 130
T832
S
R
K
S
R
Q
K
T
R
A
V
G
K
T
T
Site 131
T838
K
T
R
A
V
G
K
T
T
N
P
I
F
N
H
Site 132
Y849
I
F
N
H
T
M
V
Y
D
G
F
R
P
E
D
Site 133
Y870
E
L
T
V
W
D
H
Y
K
L
T
N
Q
F
L
Site 134
T886
G
L
R
I
G
F
G
T
G
K
S
Y
G
T
E
Site 135
S889
I
G
F
G
T
G
K
S
Y
G
T
E
V
D
W
Site 136
S899
T
E
V
D
W
M
D
S
T
S
E
E
V
A
L
Site 137
T900
E
V
D
W
M
D
S
T
S
E
E
V
A
L
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation