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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAGE-E1
Full Name:
Melanoma-associated antigen E1
Alias:
Hepatocellular carcinoma-associated protein 1; MAGEE1; MGE1
Type:
Dystrophin-associated glycoprotein complex, Cytoplasm, Plasma membrane, Nucleus, Postsynaptic membrane, Dendrite, Cytoskeleton, Perinuclear region of cytoplasm protein
Mass (Da):
103254
Number AA:
957
UniProt ID:
Q9HCI5
International Prot ID:
IPI00015306
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030425
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
L
V
S
Q
N
S
R
R
R
R
R
R
V
Site 2
T19
R
R
R
V
A
K
A
T
A
H
N
S
S
W
G
Site 3
S23
A
K
A
T
A
H
N
S
S
W
G
E
M
Q
A
Site 4
S43
L
P
A
D
V
P
G
S
D
V
P
Q
G
P
S
Site 5
S50
S
D
V
P
Q
G
P
S
D
S
Q
I
L
Q
G
Site 6
S52
V
P
Q
G
P
S
D
S
Q
I
L
Q
G
L
C
Site 7
T66
C
A
S
E
G
P
S
T
S
V
L
P
T
S
A
Site 8
S67
A
S
E
G
P
S
T
S
V
L
P
T
S
A
E
Site 9
T71
P
S
T
S
V
L
P
T
S
A
E
G
P
S
T
Site 10
S72
S
T
S
V
L
P
T
S
A
E
G
P
S
T
F
Site 11
S77
P
T
S
A
E
G
P
S
T
F
V
P
P
T
I
Site 12
T78
T
S
A
E
G
P
S
T
F
V
P
P
T
I
S
Site 13
T83
P
S
T
F
V
P
P
T
I
S
E
A
S
S
A
Site 14
S85
T
F
V
P
P
T
I
S
E
A
S
S
A
S
G
Site 15
S89
P
T
I
S
E
A
S
S
A
S
G
Q
P
T
I
Site 16
S91
I
S
E
A
S
S
A
S
G
Q
P
T
I
S
E
Site 17
T95
S
S
A
S
G
Q
P
T
I
S
E
G
P
G
T
Site 18
S97
A
S
G
Q
P
T
I
S
E
G
P
G
T
S
V
Site 19
T102
T
I
S
E
G
P
G
T
S
V
L
P
T
P
S
Site 20
S103
I
S
E
G
P
G
T
S
V
L
P
T
P
S
E
Site 21
T107
P
G
T
S
V
L
P
T
P
S
E
G
L
S
T
Site 22
S109
T
S
V
L
P
T
P
S
E
G
L
S
T
S
G
Site 23
S113
P
T
P
S
E
G
L
S
T
S
G
P
P
T
I
Site 24
T114
T
P
S
E
G
L
S
T
S
G
P
P
T
I
S
Site 25
S115
P
S
E
G
L
S
T
S
G
P
P
T
I
S
K
Site 26
T119
L
S
T
S
G
P
P
T
I
S
K
G
L
C
T
Site 27
S121
T
S
G
P
P
T
I
S
K
G
L
C
T
S
V
Site 28
S133
T
S
V
T
L
A
A
S
E
G
R
N
T
S
R
Site 29
T138
A
A
S
E
G
R
N
T
S
R
P
P
T
S
S
Site 30
S139
A
S
E
G
R
N
T
S
R
P
P
T
S
S
E
Site 31
T143
R
N
T
S
R
P
P
T
S
S
E
E
P
S
T
Site 32
S144
N
T
S
R
P
P
T
S
S
E
E
P
S
T
S
Site 33
S145
T
S
R
P
P
T
S
S
E
E
P
S
T
S
V
Site 34
S149
P
T
S
S
E
E
P
S
T
S
V
P
P
T
A
Site 35
T150
T
S
S
E
E
P
S
T
S
V
P
P
T
A
S
Site 36
S151
S
S
E
E
P
S
T
S
V
P
P
T
A
S
E
Site 37
T155
P
S
T
S
V
P
P
T
A
S
E
V
P
S
T
Site 38
S157
T
S
V
P
P
T
A
S
E
V
P
S
T
S
L
Site 39
S161
P
T
A
S
E
V
P
S
T
S
L
P
P
T
P
Site 40
T162
T
A
S
E
V
P
S
T
S
L
P
P
T
P
G
Site 41
S163
A
S
E
V
P
S
T
S
L
P
P
T
P
G
E
Site 42
T167
P
S
T
S
L
P
P
T
P
G
E
G
T
S
T
Site 43
S173
P
T
P
G
E
G
T
S
T
S
V
P
P
T
A
Site 44
T174
T
P
G
E
G
T
S
T
S
V
P
P
T
A
Y
Site 45
S175
P
G
E
G
T
S
T
S
V
P
P
T
A
Y
E
Site 46
T179
T
S
T
S
V
P
P
T
A
Y
E
G
P
S
T
Site 47
Y181
T
S
V
P
P
T
A
Y
E
G
P
S
T
S
V
Site 48
S185
P
T
A
Y
E
G
P
S
T
S
V
V
P
T
P
Site 49
T186
T
A
Y
E
G
P
S
T
S
V
V
P
T
P
D
Site 50
S187
A
Y
E
G
P
S
T
S
V
V
P
T
P
D
E
Site 51
T191
P
S
T
S
V
V
P
T
P
D
E
G
P
S
T
Site 52
S197
P
T
P
D
E
G
P
S
T
S
V
L
P
T
P
Site 53
T198
T
P
D
E
G
P
S
T
S
V
L
P
T
P
G
Site 54
S199
P
D
E
G
P
S
T
S
V
L
P
T
P
G
E
Site 55
T203
P
S
T
S
V
L
P
T
P
G
E
G
P
G
T
Site 56
T210
T
P
G
E
G
P
G
T
S
V
P
L
A
A
T
Site 57
S211
P
G
E
G
P
G
T
S
V
P
L
A
A
T
E
Site 58
S221
L
A
A
T
E
G
L
S
T
S
V
Q
A
T
P
Site 59
T222
A
A
T
E
G
L
S
T
S
V
Q
A
T
P
D
Site 60
S223
A
T
E
G
L
S
T
S
V
Q
A
T
P
D
E
Site 61
T227
L
S
T
S
V
Q
A
T
P
D
E
G
P
S
T
Site 62
S233
A
T
P
D
E
G
P
S
T
S
V
P
P
T
A
Site 63
T234
T
P
D
E
G
P
S
T
S
V
P
P
T
A
T
Site 64
S235
P
D
E
G
P
S
T
S
V
P
P
T
A
T
E
Site 65
T239
P
S
T
S
V
P
P
T
A
T
E
G
L
S
T
Site 66
S245
P
T
A
T
E
G
L
S
T
P
V
P
P
T
R
Site 67
T246
T
A
T
E
G
L
S
T
P
V
P
P
T
R
D
Site 68
T251
L
S
T
P
V
P
P
T
R
D
E
G
P
S
T
Site 69
S257
P
T
R
D
E
G
P
S
T
S
V
P
A
T
P
Site 70
T258
T
R
D
E
G
P
S
T
S
V
P
A
T
P
G
Site 71
S259
R
D
E
G
P
S
T
S
V
P
A
T
P
G
E
Site 72
T263
P
S
T
S
V
P
A
T
P
G
E
G
P
S
T
Site 73
S269
A
T
P
G
E
G
P
S
T
S
V
L
P
A
A
Site 74
T270
T
P
G
E
G
P
S
T
S
V
L
P
A
A
S
Site 75
S271
P
G
E
G
P
S
T
S
V
L
P
A
A
S
D
Site 76
S281
P
A
A
S
D
G
Q
S
I
S
L
V
P
T
R
Site 77
S283
A
S
D
G
Q
S
I
S
L
V
P
T
R
G
K
Site 78
T287
Q
S
I
S
L
V
P
T
R
G
K
G
S
S
T
Site 79
S293
P
T
R
G
K
G
S
S
T
S
V
P
P
T
A
Site 80
T294
T
R
G
K
G
S
S
T
S
V
P
P
T
A
T
Site 81
S295
R
G
K
G
S
S
T
S
V
P
P
T
A
T
E
Site 82
T299
S
S
T
S
V
P
P
T
A
T
E
G
L
S
T
Site 83
T301
T
S
V
P
P
T
A
T
E
G
L
S
T
S
V
Site 84
S305
P
T
A
T
E
G
L
S
T
S
V
Q
P
T
A
Site 85
T306
T
A
T
E
G
L
S
T
S
V
Q
P
T
A
G
Site 86
S307
A
T
E
G
L
S
T
S
V
Q
P
T
A
G
E
Site 87
T311
L
S
T
S
V
Q
P
T
A
G
E
G
S
S
T
Site 88
S317
P
T
A
G
E
G
S
S
T
S
V
P
P
T
P
Site 89
T318
T
A
G
E
G
S
S
T
S
V
P
P
T
P
G
Site 90
S319
A
G
E
G
S
S
T
S
V
P
P
T
P
G
G
Site 91
T323
S
S
T
S
V
P
P
T
P
G
G
G
L
S
T
Site 92
S329
P
T
P
G
G
G
L
S
T
S
V
P
P
T
A
Site 93
S331
P
G
G
G
L
S
T
S
V
P
P
T
A
T
E
Site 94
T335
L
S
T
S
V
P
P
T
A
T
E
E
L
S
T
Site 95
T337
T
S
V
P
P
T
A
T
E
E
L
S
T
S
V
Site 96
S341
P
T
A
T
E
E
L
S
T
S
V
P
P
T
P
Site 97
T342
T
A
T
E
E
L
S
T
S
V
P
P
T
P
G
Site 98
S343
A
T
E
E
L
S
T
S
V
P
P
T
P
G
E
Site 99
T347
L
S
T
S
V
P
P
T
P
G
E
G
P
S
T
Site 100
S353
P
T
P
G
E
G
P
S
T
S
V
L
P
I
P
Site 101
T354
T
P
G
E
G
P
S
T
S
V
L
P
I
P
G
Site 102
S355
P
G
E
G
P
S
T
S
V
L
P
I
P
G
E
Site 103
S365
P
I
P
G
E
G
L
S
T
S
V
P
P
T
A
Site 104
T366
I
P
G
E
G
L
S
T
S
V
P
P
T
A
S
Site 105
S367
P
G
E
G
L
S
T
S
V
P
P
T
A
S
D
Site 106
T371
L
S
T
S
V
P
P
T
A
S
D
G
S
D
T
Site 107
S373
T
S
V
P
P
T
A
S
D
G
S
D
T
S
V
Site 108
S376
P
P
T
A
S
D
G
S
D
T
S
V
P
P
T
Site 109
T378
T
A
S
D
G
S
D
T
S
V
P
P
T
P
G
Site 110
S379
A
S
D
G
S
D
T
S
V
P
P
T
P
G
E
Site 111
T383
S
D
T
S
V
P
P
T
P
G
E
G
A
S
T
Site 112
S389
P
T
P
G
E
G
A
S
T
L
V
Q
P
T
A
Site 113
T390
T
P
G
E
G
A
S
T
L
V
Q
P
T
A
P
Site 114
S402
T
A
P
D
G
P
G
S
S
V
L
P
N
P
G
Site 115
S403
A
P
D
G
P
G
S
S
V
L
P
N
P
G
E
Site 116
S413
P
N
P
G
E
G
P
S
T
L
F
S
S
S
A
Site 117
T414
N
P
G
E
G
P
S
T
L
F
S
S
S
A
S
Site 118
S417
E
G
P
S
T
L
F
S
S
S
A
S
V
D
R
Site 119
S418
G
P
S
T
L
F
S
S
S
A
S
V
D
R
N
Site 120
S419
P
S
T
L
F
S
S
S
A
S
V
D
R
N
P
Site 121
S421
T
L
F
S
S
S
A
S
V
D
R
N
P
S
K
Site 122
S427
A
S
V
D
R
N
P
S
K
C
S
L
V
L
P
Site 123
S430
D
R
N
P
S
K
C
S
L
V
L
P
S
P
R
Site 124
S435
K
C
S
L
V
L
P
S
P
R
V
T
K
A
S
Site 125
T439
V
L
P
S
P
R
V
T
K
A
S
V
D
S
D
Site 126
S442
S
P
R
V
T
K
A
S
V
D
S
D
S
E
G
Site 127
S445
V
T
K
A
S
V
D
S
D
S
E
G
P
K
G
Site 128
S447
K
A
S
V
D
S
D
S
E
G
P
K
G
A
E
Site 129
S467
E
V
L
R
D
C
E
S
P
N
S
I
S
I
M
Site 130
S470
R
D
C
E
S
P
N
S
I
S
I
M
G
L
N
Site 131
S508
F
L
L
V
K
D
Q
S
K
Y
P
I
R
E
S
Site 132
Y510
L
V
K
D
Q
S
K
Y
P
I
R
E
S
E
M
Site 133
S515
S
K
Y
P
I
R
E
S
E
M
R
E
Y
I
V
Site 134
Y520
R
E
S
E
M
R
E
Y
I
V
K
E
Y
R
N
Site 135
Y525
R
E
Y
I
V
K
E
Y
R
N
Q
F
P
E
I
Site 136
Y558
L
D
P
E
A
H
T
Y
I
L
L
N
K
L
G
Site 137
S575
P
F
E
G
L
E
E
S
P
N
G
P
K
M
G
Site 138
S619
V
Q
R
E
R
R
L
S
I
F
G
N
P
K
R
Site 139
S629
G
N
P
K
R
L
L
S
V
E
F
V
W
Q
R
Site 140
Y637
V
E
F
V
W
Q
R
Y
L
D
Y
R
P
V
T
Site 141
Y640
V
W
Q
R
Y
L
D
Y
R
P
V
T
D
C
K
Site 142
T644
Y
L
D
Y
R
P
V
T
D
C
K
P
V
E
Y
Site 143
Y651
T
D
C
K
P
V
E
Y
E
F
F
W
G
P
R
Site 144
T663
G
P
R
S
H
L
E
T
T
K
M
K
I
L
K
Site 145
Y687
P
M
D
W
P
E
K
Y
N
E
A
L
E
E
D
Site 146
S723
E
A
A
A
E
V
P
S
P
D
S
E
V
S
S
Site 147
S726
A
E
V
P
S
P
D
S
E
V
S
S
Y
S
S
Site 148
S729
P
S
P
D
S
E
V
S
S
Y
S
S
K
Y
A
Site 149
S730
S
P
D
S
E
V
S
S
Y
S
S
K
Y
A
P
Site 150
Y731
P
D
S
E
V
S
S
Y
S
S
K
Y
A
P
H
Site 151
S732
D
S
E
V
S
S
Y
S
S
K
Y
A
P
H
S
Site 152
S733
S
E
V
S
S
Y
S
S
K
Y
A
P
H
S
W
Site 153
Y735
V
S
S
Y
S
S
K
Y
A
P
H
S
W
P
E
Site 154
S739
S
S
K
Y
A
P
H
S
W
P
E
S
R
L
E
Site 155
S743
A
P
H
S
W
P
E
S
R
L
E
S
K
A
R
Site 156
S747
W
P
E
S
R
L
E
S
K
A
R
K
L
V
Q
Site 157
Y773
I
P
K
K
G
I
L
Y
Y
I
G
R
E
C
S
Site 158
Y774
P
K
K
G
I
L
Y
Y
I
G
R
E
C
S
K
Site 159
S780
Y
Y
I
G
R
E
C
S
K
V
F
P
D
L
L
Site 160
S811
V
L
D
P
R
N
H
S
Y
T
L
Y
N
R
R
Site 161
T813
D
P
R
N
H
S
Y
T
L
Y
N
R
R
E
M
Site 162
Y815
R
N
H
S
Y
T
L
Y
N
R
R
E
M
E
E
Site 163
T823
N
R
R
E
M
E
E
T
E
E
I
V
D
S
P
Site 164
S829
E
T
E
E
I
V
D
S
P
N
R
P
G
N
N
Site 165
T875
A
G
R
K
H
V
I
T
C
R
Y
L
S
Q
R
Site 166
Y878
K
H
V
I
T
C
R
Y
L
S
Q
R
Y
I
D
Site 167
Y883
C
R
Y
L
S
Q
R
Y
I
D
S
L
R
V
P
Site 168
S886
L
S
Q
R
Y
I
D
S
L
R
V
P
D
S
D
Site 169
S892
D
S
L
R
V
P
D
S
D
P
V
Q
Y
E
F
Site 170
Y897
P
D
S
D
P
V
Q
Y
E
F
V
W
G
P
R
Site 171
T909
G
P
R
A
R
L
E
T
S
K
M
K
A
L
R
Site 172
Y917
C
R
Y
L
S
Q
R
Y
I
D
S
L
R
V
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation