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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ROBO2
Full Name:
Roundabout homolog 2
Alias:
KIAA1568; roundabout homolog 2; roundabout, axon guidance receptor, 2; roundabout, axon guidance receptor, homolog 2
Type:
Motility/polarity/chemotaxis; Cell development/differentiation; Adhesion
Mass (Da):
151200
Number AA:
1378
UniProt ID:
Q9HCK4
International Prot ID:
IPI00792163
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0008046
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0007420
GO:0006935
GO:0007156
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y65
P
T
P
T
I
E
W
Y
K
D
G
E
R
V
E
Site 2
Y270
A
D
L
P
R
G
R
Y
D
I
K
D
D
Y
T
Site 3
Y276
R
Y
D
I
K
D
D
Y
T
L
R
I
K
K
T
Site 4
Y291
M
S
T
D
E
G
T
Y
M
C
I
A
E
N
R
Site 5
T577
T
V
A
N
H
V
K
T
T
L
Y
T
V
R
G
Site 6
T578
V
A
N
H
V
K
T
T
L
Y
T
V
R
G
L
Site 7
Y580
N
H
V
K
T
T
L
Y
T
V
R
G
L
R
P
Site 8
T581
H
V
K
T
T
L
Y
T
V
R
G
L
R
P
N
Site 9
S696
A
K
V
P
T
E
R
S
A
V
L
V
N
L
K
Site 10
Y881
M
G
F
S
I
W
L
Y
W
R
R
K
K
R
K
Site 11
S891
R
K
K
R
K
G
L
S
N
Y
A
V
T
F
Q
Site 12
Y893
K
R
K
G
L
S
N
Y
A
V
T
F
Q
R
G
Site 13
T896
G
L
S
N
Y
A
V
T
F
Q
R
G
D
G
G
Site 14
S906
R
G
D
G
G
L
M
S
N
G
S
R
P
G
L
Site 15
S909
G
G
L
M
S
N
G
S
R
P
G
L
L
N
A
Site 16
S920
L
L
N
A
G
D
P
S
Y
P
W
L
A
D
S
Site 17
Y921
L
N
A
G
D
P
S
Y
P
W
L
A
D
S
W
Site 18
S927
S
Y
P
W
L
A
D
S
W
P
A
T
S
L
P
Site 19
T931
L
A
D
S
W
P
A
T
S
L
P
V
N
N
S
Site 20
S932
A
D
S
W
P
A
T
S
L
P
V
N
N
S
N
Site 21
S938
T
S
L
P
V
N
N
S
N
S
G
P
N
E
I
Site 22
S940
L
P
V
N
N
S
N
S
G
P
N
E
I
G
N
Site 23
T964
V
P
G
Q
G
D
K
T
A
T
M
L
S
D
G
Site 24
S969
D
K
T
A
T
M
L
S
D
G
A
I
Y
S
S
Site 25
S975
L
S
D
G
A
I
Y
S
S
I
D
F
T
T
K
Site 26
S976
S
D
G
A
I
Y
S
S
I
D
F
T
T
K
T
Site 27
T980
I
Y
S
S
I
D
F
T
T
K
T
S
Y
N
S
Site 28
T981
Y
S
S
I
D
F
T
T
K
T
S
Y
N
S
S
Site 29
T983
S
I
D
F
T
T
K
T
S
Y
N
S
S
S
Q
Site 30
S984
I
D
F
T
T
K
T
S
Y
N
S
S
S
Q
I
Site 31
Y985
D
F
T
T
K
T
S
Y
N
S
S
S
Q
I
T
Site 32
S988
T
K
T
S
Y
N
S
S
S
Q
I
T
Q
A
T
Site 33
S989
K
T
S
Y
N
S
S
S
Q
I
T
Q
A
T
P
Site 34
T995
S
S
Q
I
T
Q
A
T
P
Y
A
T
T
Q
I
Site 35
Y997
Q
I
T
Q
A
T
P
Y
A
T
T
Q
I
L
H
Site 36
T999
T
Q
A
T
P
Y
A
T
T
Q
I
L
H
S
N
Site 37
S1005
A
T
T
Q
I
L
H
S
N
S
I
H
E
L
A
Site 38
S1007
T
Q
I
L
H
S
N
S
I
H
E
L
A
V
D
Site 39
T1028
K
S
S
I
Q
Q
K
T
D
L
M
G
F
G
Y
Site 40
Y1035
T
D
L
M
G
F
G
Y
S
L
P
D
Q
N
K
Site 41
S1036
D
L
M
G
F
G
Y
S
L
P
D
Q
N
K
G
Site 42
S1059
K
K
K
N
K
N
S
S
K
P
Q
K
N
N
G
Site 43
Y1090
P
G
T
E
L
E
H
Y
A
V
E
Q
Q
E
N
Site 44
Y1099
V
E
Q
Q
E
N
G
Y
D
S
D
S
W
C
P
Site 45
S1101
Q
Q
E
N
G
Y
D
S
D
S
W
C
P
P
L
Site 46
S1103
E
N
G
Y
D
S
D
S
W
C
P
P
L
P
V
Site 47
Y1113
P
P
L
P
V
Q
T
Y
L
H
Q
G
L
E
D
Site 48
T1131
E
D
D
D
R
V
P
T
P
P
V
R
G
V
A
Site 49
S1149
A
I
S
F
G
Q
Q
S
T
A
T
L
T
P
S
Site 50
T1152
F
G
Q
Q
S
T
A
T
L
T
P
S
P
R
E
Site 51
T1154
Q
Q
S
T
A
T
L
T
P
S
P
R
E
E
M
Site 52
S1156
S
T
A
T
L
T
P
S
P
R
E
E
M
Q
P
Site 53
Y1176
L
D
E
L
T
R
A
Y
Q
F
D
I
A
K
Q
Site 54
T1214
A
L
I
S
D
L
E
T
D
V
A
D
D
D
A
Site 55
T1240
P
L
R
A
L
D
Q
T
P
G
S
S
M
D
N
Site 56
S1243
A
L
D
Q
T
P
G
S
S
M
D
N
L
D
S
Site 57
S1244
L
D
Q
T
P
G
S
S
M
D
N
L
D
S
S
Site 58
S1250
S
S
M
D
N
L
D
S
S
V
T
G
K
A
F
Site 59
S1251
S
M
D
N
L
D
S
S
V
T
G
K
A
F
T
Site 60
S1260
T
G
K
A
F
T
S
S
Q
R
P
R
P
T
S
Site 61
T1266
S
S
Q
R
P
R
P
T
S
P
F
S
T
D
S
Site 62
S1267
S
Q
R
P
R
P
T
S
P
F
S
T
D
S
N
Site 63
S1270
P
R
P
T
S
P
F
S
T
D
S
N
T
S
A
Site 64
T1271
R
P
T
S
P
F
S
T
D
S
N
T
S
A
A
Site 65
S1273
T
S
P
F
S
T
D
S
N
T
S
A
A
L
S
Site 66
T1275
P
F
S
T
D
S
N
T
S
A
A
L
S
Q
S
Site 67
S1276
F
S
T
D
S
N
T
S
A
A
L
S
Q
S
Q
Site 68
S1280
S
N
T
S
A
A
L
S
Q
S
Q
R
P
R
P
Site 69
S1282
T
S
A
A
L
S
Q
S
Q
R
P
R
P
T
K
Site 70
T1288
Q
S
Q
R
P
R
P
T
K
K
H
K
G
G
R
Site 71
T1310
P
H
R
R
E
G
M
T
D
E
E
A
L
V
P
Site 72
Y1318
D
E
E
A
L
V
P
Y
S
K
P
S
F
P
S
Site 73
S1319
E
E
A
L
V
P
Y
S
K
P
S
F
P
S
P
Site 74
S1322
L
V
P
Y
S
K
P
S
F
P
S
P
G
G
H
Site 75
S1325
Y
S
K
P
S
F
P
S
P
G
G
H
S
S
S
Site 76
S1330
F
P
S
P
G
G
H
S
S
S
G
T
A
S
S
Site 77
S1331
P
S
P
G
G
H
S
S
S
G
T
A
S
S
K
Site 78
S1332
S
P
G
G
H
S
S
S
G
T
A
S
S
K
G
Site 79
T1334
G
G
H
S
S
S
G
T
A
S
S
K
G
S
T
Site 80
S1336
H
S
S
S
G
T
A
S
S
K
G
S
T
G
P
Site 81
S1337
S
S
S
G
T
A
S
S
K
G
S
T
G
P
R
Site 82
S1340
G
T
A
S
S
K
G
S
T
G
P
R
K
T
E
Site 83
T1341
T
A
S
S
K
G
S
T
G
P
R
K
T
E
V
Site 84
T1346
G
S
T
G
P
R
K
T
E
V
L
R
A
G
H
Site 85
S1358
A
G
H
Q
R
N
A
S
D
L
L
D
I
G
Y
Site 86
Y1365
S
D
L
L
D
I
G
Y
M
G
S
N
S
Q
G
Site 87
S1368
L
D
I
G
Y
M
G
S
N
S
Q
G
Q
F
T
Site 88
S1370
I
G
Y
M
G
S
N
S
Q
G
Q
F
T
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation