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Updated November 2019
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Protein Info
Short Name:
CHD8
Full Name:
Chromodomain-helicase-DNA-binding protein 8
Alias:
ATP-dependent helicase CHD8; EC 3.6.1.-; Helicase with SNF2 domain 1; HELSNF1; KIAA1564
Type:
Chromatin, Nucleus protein
Mass (Da):
290518
Number AA:
2581
UniProt ID:
Q9HCK8
International Prot ID:
IPI00398992
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
GO:0043234
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003678
PhosphoSite+
KinaseNET
Biological Process:
GO:0043044
GO:0060070
GO:0006333
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
P
N
L
F
G
L
D
S
L
T
D
D
S
F
N
Site 2
T21
L
F
G
L
D
S
L
T
D
D
S
F
N
Q
V
Site 3
S24
L
D
S
L
T
D
D
S
F
N
Q
V
T
Q
D
Site 4
T29
D
D
S
F
N
Q
V
T
Q
D
P
I
E
E
A
Site 5
S41
E
E
A
L
G
L
P
S
S
L
D
S
L
D
Q
Site 6
S42
E
A
L
G
L
P
S
S
L
D
S
L
D
Q
M
Site 7
S45
G
L
P
S
S
L
D
S
L
D
Q
M
N
Q
D
Site 8
S61
G
G
G
D
V
G
N
S
S
A
S
E
L
V
P
Site 9
S64
D
V
G
N
S
S
A
S
E
L
V
P
P
P
E
Site 10
T76
P
P
E
E
T
A
P
T
E
L
S
K
E
S
T
Site 11
S79
E
T
A
P
T
E
L
S
K
E
S
T
A
P
A
Site 12
T83
T
E
L
S
K
E
S
T
A
P
A
P
E
S
I
Site 13
S89
S
T
A
P
A
P
E
S
I
T
L
H
D
Y
T
Site 14
Y95
E
S
I
T
L
H
D
Y
T
T
Q
P
A
S
Q
Site 15
T96
S
I
T
L
H
D
Y
T
T
Q
P
A
S
Q
E
Site 16
T97
I
T
L
H
D
Y
T
T
Q
P
A
S
Q
E
Q
Site 17
S101
D
Y
T
T
Q
P
A
S
Q
E
Q
P
A
Q
P
Site 18
T112
P
A
Q
P
V
L
Q
T
S
T
P
T
S
G
L
Site 19
T114
Q
P
V
L
Q
T
S
T
P
T
S
G
L
L
Q
Site 20
S117
L
Q
T
S
T
P
T
S
G
L
L
Q
V
S
K
Site 21
S123
T
S
G
L
L
Q
V
S
K
S
Q
E
I
L
S
Site 22
S125
G
L
L
Q
V
S
K
S
Q
E
I
L
S
Q
G
Site 23
S130
S
K
S
Q
E
I
L
S
Q
G
N
P
F
M
G
Site 24
S144
G
V
S
A
T
A
V
S
S
S
S
A
G
G
Q
Site 25
S145
V
S
A
T
A
V
S
S
S
S
A
G
G
Q
P
Site 26
S146
S
A
T
A
V
S
S
S
S
A
G
G
Q
P
P
Site 27
T203
N
G
G
K
V
T
F
T
K
V
L
T
G
T
P
Site 28
T207
V
T
F
T
K
V
L
T
G
T
P
L
R
P
G
Site 29
T209
F
T
K
V
L
T
G
T
P
L
R
P
G
V
S
Site 30
S242
V
Q
R
I
V
Q
P
S
R
P
V
K
Q
L
V
Site 31
T274
P
P
L
K
P
A
V
T
L
T
S
T
P
T
Q
Site 32
T276
L
K
P
A
V
T
L
T
S
T
P
T
Q
G
E
Site 33
S277
K
P
A
V
T
L
T
S
T
P
T
Q
G
E
S
Site 34
T278
P
A
V
T
L
T
S
T
P
T
Q
G
E
S
K
Site 35
S284
S
T
P
T
Q
G
E
S
K
R
I
T
L
V
L
Site 36
T288
Q
G
E
S
K
R
I
T
L
V
L
Q
Q
P
Q
Site 37
S296
L
V
L
Q
Q
P
Q
S
G
G
P
Q
G
H
R
Site 38
S359
Q
I
V
P
Q
P
P
S
S
Q
P
Q
P
Q
Q
Site 39
S360
I
V
P
Q
P
P
S
S
Q
P
Q
P
Q
Q
P
Site 40
S369
P
Q
P
Q
Q
P
P
S
T
Q
P
V
T
L
S
Site 41
T370
Q
P
Q
Q
P
P
S
T
Q
P
V
T
L
S
S
Site 42
T374
P
P
S
T
Q
P
V
T
L
S
S
V
Q
Q
A
Site 43
S389
Q
I
M
G
P
G
Q
S
P
G
Q
R
L
S
V
Site 44
S408
V
L
Q
P
Q
A
G
S
S
Q
G
A
S
S
G
Site 45
S409
L
Q
P
Q
A
G
S
S
Q
G
A
S
S
G
L
Site 46
S413
A
G
S
S
Q
G
A
S
S
G
L
S
V
V
K
Site 47
S432
S
E
V
A
A
L
S
S
P
A
S
S
A
P
H
Site 48
S435
A
A
L
S
S
P
A
S
S
A
P
H
S
G
G
Site 49
S436
A
L
S
S
P
A
S
S
A
P
H
S
G
G
K
Site 50
S440
P
A
S
S
A
P
H
S
G
G
K
T
G
M
E
Site 51
T444
A
P
H
S
G
G
K
T
G
M
E
E
N
R
R
Site 52
S491
L
N
E
D
E
L
P
S
V
R
P
E
E
E
G
Site 53
S506
E
K
K
R
R
K
K
S
A
G
E
R
L
K
E
Site 54
S519
K
E
E
K
P
K
K
S
K
T
S
G
A
S
K
Site 55
T521
E
K
P
K
K
S
K
T
S
G
A
S
K
T
K
Site 56
S522
K
P
K
K
S
K
T
S
G
A
S
K
T
K
G
Site 57
T527
K
T
S
G
A
S
K
T
K
G
K
S
K
L
N
Site 58
S531
A
S
K
T
K
G
K
S
K
L
N
T
I
T
P
Site 59
T535
K
G
K
S
K
L
N
T
I
T
P
V
V
G
K
Site 60
T537
K
S
K
L
N
T
I
T
P
V
V
G
K
K
R
Site 61
T548
G
K
K
R
K
R
N
T
S
S
D
N
S
D
V
Site 62
S549
K
K
R
K
R
N
T
S
S
D
N
S
D
V
E
Site 63
S550
K
R
K
R
N
T
S
S
D
N
S
D
V
E
V
Site 64
S553
R
N
T
S
S
D
N
S
D
V
E
V
M
P
A
Site 65
S562
V
E
V
M
P
A
Q
S
P
R
E
D
E
E
S
Site 66
S569
S
P
R
E
D
E
E
S
S
I
Q
K
R
R
S
Site 67
S576
S
S
I
Q
K
R
R
S
N
R
Q
V
K
R
K
Site 68
Y585
R
Q
V
K
R
K
K
Y
T
E
D
L
D
I
K
Site 69
T605
E
E
E
E
V
D
V
T
G
P
I
K
P
E
P
Site 70
T625
V
Q
E
P
D
G
E
T
L
P
S
M
Q
F
F
Site 71
S628
P
D
G
E
T
L
P
S
M
Q
F
F
V
E
N
Site 72
T663
E
L
P
S
G
Q
Y
T
E
A
E
E
F
F
V
Site 73
Y672
A
E
E
F
F
V
K
Y
K
N
Y
S
Y
L
H
Site 74
S686
H
C
E
W
A
T
I
S
Q
L
E
K
D
K
R
Site 75
T703
Q
K
L
K
R
F
K
T
K
M
A
Q
M
R
H
Site 76
Y723
E
E
P
F
N
P
D
Y
V
E
V
D
R
I
L
Site 77
S733
V
D
R
I
L
D
E
S
H
S
I
D
K
D
N
Site 78
S735
R
I
L
D
E
S
H
S
I
D
K
D
N
G
E
Site 79
Y746
D
N
G
E
P
V
I
Y
Y
L
V
K
W
C
S
Site 80
S759
C
S
L
P
Y
E
D
S
T
W
E
L
K
E
D
Site 81
T760
S
L
P
Y
E
D
S
T
W
E
L
K
E
D
V
Site 82
S780
R
E
F
K
R
I
Q
S
R
H
P
E
L
K
R
Site 83
S802
A
W
K
K
L
E
L
S
H
E
Y
K
N
R
N
Site 84
Y814
N
R
N
Q
L
R
E
Y
Q
L
E
G
V
N
W
Site 85
S892
N
T
I
V
Y
H
G
S
L
A
S
R
Q
M
I
Site 86
Y902
S
R
Q
M
I
Q
Q
Y
E
M
Y
C
K
D
S
Site 87
Y905
M
I
Q
Q
Y
E
M
Y
C
K
D
S
R
G
R
Site 88
S932
T
T
F
E
M
I
L
S
D
C
P
E
L
R
E
Site 89
S963
R
N
C
K
L
L
D
S
L
K
H
M
D
L
E
Site 90
T978
H
K
V
L
L
T
G
T
P
L
Q
N
T
V
E
Site 91
T983
T
G
T
P
L
Q
N
T
V
E
E
L
F
S
L
Site 92
S997
L
L
H
F
L
E
P
S
Q
F
P
S
E
S
E
Site 93
S1001
L
E
P
S
Q
F
P
S
E
S
E
F
L
K
N
Site 94
S1003
P
S
Q
F
P
S
E
S
E
F
L
K
N
F
G
Site 95
T1014
K
N
F
G
D
L
K
T
E
E
Q
V
Q
K
L
Site 96
T1054
T
I
I
E
V
E
L
T
N
I
Q
K
K
Y
Y
Site 97
Y1060
L
T
N
I
Q
K
K
Y
Y
R
A
I
L
E
K
Site 98
S1073
E
K
N
F
S
F
L
S
K
G
A
G
H
T
N
Site 99
Y1099
R
K
C
C
N
H
P
Y
L
I
N
G
A
E
E
Site 100
T1110
G
A
E
E
K
I
L
T
E
F
R
E
A
C
H
Site 101
Y1174
D
Y
L
I
Q
R
R
Y
L
Y
E
R
I
D
G
Site 102
Y1176
L
I
Q
R
R
Y
L
Y
E
R
I
D
G
R
V
Site 103
S1196
Q
A
A
I
D
R
F
S
K
P
D
S
D
R
F
Site 104
S1200
D
R
F
S
K
P
D
S
D
R
F
V
F
L
L
Site 105
T1259
V
K
V
Y
R
L
I
T
R
N
S
Y
E
R
E
Site 106
S1262
Y
R
L
I
T
R
N
S
Y
E
R
E
M
F
D
Site 107
Y1263
R
L
I
T
R
N
S
Y
E
R
E
M
F
D
K
Site 108
S1272
R
E
M
F
D
K
A
S
L
K
L
G
L
D
K
Site 109
S1284
L
D
K
A
V
L
Q
S
M
S
G
R
D
G
N
Site 110
S1286
K
A
V
L
Q
S
M
S
G
R
D
G
N
I
T
Site 111
T1293
S
G
R
D
G
N
I
T
G
I
Q
Q
F
S
K
Site 112
T1338
D
Q
I
L
L
R
R
T
T
T
I
T
I
E
S
Site 113
T1339
Q
I
L
L
R
R
T
T
T
I
T
I
E
S
E
Site 114
T1340
I
L
L
R
R
T
T
T
I
T
I
E
S
E
G
Site 115
T1342
L
R
R
T
T
T
I
T
I
E
S
E
G
K
G
Site 116
S1345
T
T
T
I
T
I
E
S
E
G
K
G
S
T
F
Site 117
T1351
E
S
E
G
K
G
S
T
F
A
K
A
S
F
V
Site 118
S1356
G
S
T
F
A
K
A
S
F
V
A
S
E
N
R
Site 119
S1360
A
K
A
S
F
V
A
S
E
N
R
T
D
I
S
Site 120
S1367
S
E
N
R
T
D
I
S
L
D
D
P
N
F
W
Site 121
T1398
K
N
N
L
V
I
D
T
P
R
V
R
K
Q
T
Site 122
T1405
T
P
R
V
R
K
Q
T
R
H
F
S
T
L
K
Site 123
S1409
R
K
Q
T
R
H
F
S
T
L
K
D
D
D
L
Site 124
S1420
D
D
D
L
V
E
F
S
D
L
E
S
E
D
D
Site 125
S1424
V
E
F
S
D
L
E
S
E
D
D
E
R
P
R
Site 126
S1432
E
D
D
E
R
P
R
S
R
R
H
D
R
H
H
Site 127
Y1441
R
H
D
R
H
H
A
Y
G
R
T
D
C
F
R
Site 128
Y1456
V
E
K
H
L
L
V
Y
G
W
G
R
W
R
D
Site 129
S1466
G
R
W
R
D
I
L
S
H
G
R
F
K
R
R
Site 130
T1475
G
R
F
K
R
R
M
T
E
R
D
V
E
T
I
Site 131
S1509
G
F
I
W
D
L
I
S
P
A
E
N
G
K
T
Site 132
T1516
S
P
A
E
N
G
K
T
K
E
L
Q
N
H
S
Site 133
S1526
L
Q
N
H
S
G
L
S
I
P
V
P
R
G
R
Site 134
S1540
R
K
G
K
K
V
K
S
Q
S
T
F
D
I
H
Site 135
S1542
G
K
K
V
K
S
Q
S
T
F
D
I
H
K
A
Site 136
T1543
K
K
V
K
S
Q
S
T
F
D
I
H
K
A
D
Site 137
Y1555
K
A
D
W
I
R
K
Y
N
P
D
T
L
F
Q
Site 138
T1559
I
R
K
Y
N
P
D
T
L
F
Q
D
E
S
Y
Site 139
S1565
D
T
L
F
Q
D
E
S
Y
K
K
H
L
K
H
Site 140
Y1566
T
L
F
Q
D
E
S
Y
K
K
H
L
K
H
Q
Site 141
T1623
D
Q
L
E
V
P
T
T
W
W
D
S
E
A
D
Site 142
S1627
V
P
T
T
W
W
D
S
E
A
D
K
S
L
L
Site 143
S1632
W
D
S
E
A
D
K
S
L
L
I
G
V
F
K
Site 144
Y1642
I
G
V
F
K
H
G
Y
E
K
Y
N
T
M
R
Site 145
Y1645
F
K
H
G
Y
E
K
Y
N
T
M
R
A
D
P
Site 146
T1647
H
G
Y
E
K
Y
N
T
M
R
A
D
P
A
L
Site 147
S1679
H
R
V
L
D
N
F
S
D
I
V
E
G
V
D
Site 148
Y1696
K
D
C
E
D
P
E
Y
K
P
L
Q
G
P
P
Site 149
T1731
D
G
D
E
A
Q
V
T
Q
Q
P
G
H
L
F
Site 150
S1743
H
L
F
W
P
P
G
S
A
L
T
A
R
L
R
Site 151
T1754
A
R
L
R
R
L
V
T
A
Y
Q
R
S
Y
K
Site 152
Y1756
L
R
R
L
V
T
A
Y
Q
R
S
Y
K
R
E
Site 153
S1759
L
V
T
A
Y
Q
R
S
Y
K
R
E
Q
M
K
Site 154
Y1760
V
T
A
Y
Q
R
S
Y
K
R
E
Q
M
K
I
Site 155
T1799
R
E
K
Q
Q
R
W
T
R
R
E
Q
T
D
F
Site 156
T1804
R
W
T
R
R
E
Q
T
D
F
Y
R
V
V
S
Site 157
Y1807
R
R
E
Q
T
D
F
Y
R
V
V
S
T
F
G
Site 158
S1811
T
D
F
Y
R
V
V
S
T
F
G
V
E
Y
D
Site 159
T1812
D
F
Y
R
V
V
S
T
F
G
V
E
Y
D
P
Site 160
Y1817
V
S
T
F
G
V
E
Y
D
P
D
T
M
Q
F
Site 161
T1831
F
H
W
D
R
F
R
T
F
A
R
L
D
K
K
Site 162
T1839
F
A
R
L
D
K
K
T
D
E
S
L
T
K
Y
Site 163
S1842
L
D
K
K
T
D
E
S
L
T
K
Y
F
H
G
Site 164
Y1846
T
D
E
S
L
T
K
Y
F
H
G
F
V
A
M
Site 165
T1879
N
L
F
I
E
P
I
T
E
E
R
A
S
R
T
Site 166
S1884
P
I
T
E
E
R
A
S
R
T
L
Y
R
I
E
Site 167
Y1888
E
R
A
S
R
T
L
Y
R
I
E
L
L
R
R
Site 168
S1943
G
A
A
R
H
G
V
S
Q
T
D
C
N
I
M
Site 169
T1945
A
R
H
G
V
S
Q
T
D
C
N
I
M
Q
D
Site 170
Y1964
F
L
A
A
R
M
N
Y
M
Q
N
H
Q
A
G
Site 171
S1976
Q
A
G
A
P
A
P
S
L
S
R
C
S
T
P
Site 172
S1978
G
A
P
A
P
S
L
S
R
C
S
T
P
L
L
Site 173
S1981
A
P
S
L
S
R
C
S
T
P
L
L
H
Q
Q
Site 174
T1982
P
S
L
S
R
C
S
T
P
L
L
H
Q
Q
Y
Site 175
Y1989
T
P
L
L
H
Q
Q
Y
T
S
R
T
A
S
P
Site 176
T1990
P
L
L
H
Q
Q
Y
T
S
R
T
A
S
P
L
Site 177
S1991
L
L
H
Q
Q
Y
T
S
R
T
A
S
P
L
P
Site 178
T1993
H
Q
Q
Y
T
S
R
T
A
S
P
L
P
L
R
Site 179
S1995
Q
Y
T
S
R
T
A
S
P
L
P
L
R
P
D
Site 180
S2008
P
D
A
P
V
E
K
S
P
E
E
T
A
T
Q
Site 181
T2012
V
E
K
S
P
E
E
T
A
T
Q
V
P
S
L
Site 182
T2014
K
S
P
E
E
T
A
T
Q
V
P
S
L
E
S
Site 183
S2018
E
T
A
T
Q
V
P
S
L
E
S
L
T
L
K
Site 184
S2021
T
Q
V
P
S
L
E
S
L
T
L
K
L
E
H
Site 185
T2037
V
V
A
R
S
R
P
T
P
Q
D
Y
E
M
R
Site 186
Y2041
S
R
P
T
P
Q
D
Y
E
M
R
V
S
P
S
Site 187
S2046
Q
D
Y
E
M
R
V
S
P
S
D
T
T
P
L
Site 188
T2050
M
R
V
S
P
S
D
T
T
P
L
V
S
R
S
Site 189
T2051
R
V
S
P
S
D
T
T
P
L
V
S
R
S
V
Site 190
S2055
S
D
T
T
P
L
V
S
R
S
V
P
P
V
K
Site 191
S2057
T
T
P
L
V
S
R
S
V
P
P
V
K
L
E
Site 192
S2069
K
L
E
D
E
D
D
S
D
S
E
L
D
L
S
Site 193
S2071
E
D
E
D
D
S
D
S
E
L
D
L
S
K
L
Site 194
S2076
S
D
S
E
L
D
L
S
K
L
S
P
S
S
S
Site 195
S2079
E
L
D
L
S
K
L
S
P
S
S
S
S
S
S
Site 196
S2081
D
L
S
K
L
S
P
S
S
S
S
S
S
S
S
Site 197
S2082
L
S
K
L
S
P
S
S
S
S
S
S
S
S
S
Site 198
S2083
S
K
L
S
P
S
S
S
S
S
S
S
S
S
S
Site 199
S2084
K
L
S
P
S
S
S
S
S
S
S
S
S
S
S
Site 200
S2085
L
S
P
S
S
S
S
S
S
S
S
S
S
S
S
Site 201
S2086
S
P
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 202
S2087
P
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 203
S2088
S
S
S
S
S
S
S
S
S
S
S
S
S
S
T
Site 204
S2089
S
S
S
S
S
S
S
S
S
S
S
S
S
T
D
Site 205
S2090
S
S
S
S
S
S
S
S
S
S
S
S
T
D
E
Site 206
S2091
S
S
S
S
S
S
S
S
S
S
S
T
D
E
S
Site 207
S2092
S
S
S
S
S
S
S
S
S
S
T
D
E
S
E
Site 208
S2093
S
S
S
S
S
S
S
S
S
T
D
E
S
E
D
Site 209
S2094
S
S
S
S
S
S
S
S
T
D
E
S
E
D
E
Site 210
T2095
S
S
S
S
S
S
S
T
D
E
S
E
D
E
K
Site 211
S2098
S
S
S
S
T
D
E
S
E
D
E
K
E
E
K
Site 212
T2107
D
E
K
E
E
K
L
T
D
Q
S
R
S
K
L
Site 213
Y2115
D
Q
S
R
S
K
L
Y
D
E
E
S
L
L
S
Site 214
S2119
S
K
L
Y
D
E
E
S
L
L
S
L
T
M
S
Site 215
S2122
Y
D
E
E
S
L
L
S
L
T
M
S
Q
D
G
Site 216
T2124
E
E
S
L
L
S
L
T
M
S
Q
D
G
F
P
Site 217
S2126
S
L
L
S
L
T
M
S
Q
D
G
F
P
N
E
Site 218
T2139
N
E
D
G
E
Q
M
T
P
E
L
L
L
L
Q
Site 219
S2152
L
Q
E
R
Q
R
A
S
E
W
P
K
D
R
V
Site 220
S2178
V
L
S
G
K
W
P
S
S
R
R
S
Q
E
M
Site 221
S2179
L
S
G
K
W
P
S
S
R
R
S
Q
E
M
V
Site 222
S2182
K
W
P
S
S
R
R
S
Q
E
M
V
T
G
G
Site 223
S2200
P
G
N
H
L
L
D
S
P
S
L
T
P
G
E
Site 224
S2202
N
H
L
L
D
S
P
S
L
T
P
G
E
Y
G
Site 225
T2204
L
L
D
S
P
S
L
T
P
G
E
Y
G
D
S
Site 226
S2211
T
P
G
E
Y
G
D
S
P
V
P
T
P
R
S
Site 227
T2215
Y
G
D
S
P
V
P
T
P
R
S
S
S
A
A
Site 228
S2218
S
P
V
P
T
P
R
S
S
S
A
A
S
M
A
Site 229
S2219
P
V
P
T
P
R
S
S
S
A
A
S
M
A
E
Site 230
S2220
V
P
T
P
R
S
S
S
A
A
S
M
A
E
E
Site 231
S2223
P
R
S
S
S
A
A
S
M
A
E
E
E
A
S
Site 232
T2252
G
M
D
E
K
E
F
T
V
Q
I
K
D
E
E
Site 233
T2264
D
E
E
G
L
K
L
T
F
Q
K
H
K
L
M
Site 234
T2313
H
L
D
V
D
L
E
T
R
I
P
V
I
N
K
Site 235
T2386
L
G
M
E
P
V
Q
T
A
N
S
R
N
G
K
Site 236
T2398
N
G
K
K
G
H
H
T
E
T
V
F
N
R
V
Site 237
T2400
K
K
G
H
H
T
E
T
V
F
N
R
V
L
P
Site 238
S2414
P
G
P
I
A
P
E
S
S
K
K
R
A
R
R
Site 239
S2415
G
P
I
A
P
E
S
S
K
K
R
A
R
R
M
Site 240
S2427
R
R
M
R
P
D
L
S
K
M
M
A
L
M
Q
Site 241
T2438
A
L
M
Q
G
G
S
T
G
S
L
S
L
H
N
Site 242
S2440
M
Q
G
G
S
T
G
S
L
S
L
H
N
T
F
Site 243
S2442
G
G
S
T
G
S
L
S
L
H
N
T
F
Q
H
Site 244
T2446
G
S
L
S
L
H
N
T
F
Q
H
S
S
S
G
Site 245
S2450
L
H
N
T
F
Q
H
S
S
S
G
L
Q
S
V
Site 246
S2452
N
T
F
Q
H
S
S
S
G
L
Q
S
V
S
S
Site 247
S2456
H
S
S
S
G
L
Q
S
V
S
S
L
G
H
S
Site 248
S2458
S
S
G
L
Q
S
V
S
S
L
G
H
S
S
A
Site 249
S2459
S
G
L
Q
S
V
S
S
L
G
H
S
S
A
T
Site 250
S2463
S
V
S
S
L
G
H
S
S
A
T
S
A
S
L
Site 251
S2464
V
S
S
L
G
H
S
S
A
T
S
A
S
L
P
Site 252
S2482
F
V
M
G
G
A
P
S
S
P
H
V
D
S
S
Site 253
S2483
V
M
G
G
A
P
S
S
P
H
V
D
S
S
T
Site 254
S2488
P
S
S
P
H
V
D
S
S
T
M
L
H
H
H
Site 255
Y2516
P
G
L
R
A
P
G
Y
P
S
S
P
V
T
T
Site 256
S2518
L
R
A
P
G
Y
P
S
S
P
V
T
T
A
S
Site 257
S2519
R
A
P
G
Y
P
S
S
P
V
T
T
A
S
G
Site 258
T2522
G
Y
P
S
S
P
V
T
T
A
S
G
T
T
L
Site 259
T2523
Y
P
S
S
P
V
T
T
A
S
G
T
T
L
R
Site 260
S2525
S
S
P
V
T
T
A
S
G
T
T
L
R
L
P
Site 261
S2551
E
E
D
D
D
D
L
S
Q
G
Y
D
S
S
E
Site 262
S2556
D
L
S
Q
G
Y
D
S
S
E
R
D
F
S
L
Site 263
S2557
L
S
Q
G
Y
D
S
S
E
R
D
F
S
L
I
Site 264
S2562
D
S
S
E
R
D
F
S
L
I
D
D
P
M
M
Site 265
S2573
D
P
M
M
P
A
N
S
D
S
S
E
D
A
D
Site 266
S2575
M
M
P
A
N
S
D
S
S
E
D
A
D
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation