KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PDE11A
Full Name:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Alias:
cAMP and cGMP phosphodiesterase 11A; dual ''''cyclic-AMP and -GMP phosphodiesterase 11A; FLJ23693; MGC133355; MGC133356; PDE11; phosphodiesterase 11A; PPNAD2
Type:
Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.35; EC 3.1.4.17
Mass (Da):
104792
Number AA:
934
UniProt ID:
Q9HCR9
International Prot ID:
IPI00073708
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0047555
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
H
P
E
L
F
E
D
Y
L
M
R
K
G
K
Q
Site 2
S43
E
K
W
L
Q
R
H
S
Q
G
Q
G
A
L
G
Site 3
T58
P
R
P
S
L
A
G
T
S
S
L
A
H
S
T
Site 4
S60
P
S
L
A
G
T
S
S
L
A
H
S
T
C
R
Site 5
S64
G
T
S
S
L
A
H
S
T
C
R
G
G
S
S
Site 6
T65
T
S
S
L
A
H
S
T
C
R
G
G
S
S
V
Site 7
S70
H
S
T
C
R
G
G
S
S
V
G
G
G
T
G
Site 8
S71
S
T
C
R
G
G
S
S
V
G
G
G
T
G
P
Site 9
S81
G
G
T
G
P
N
G
S
A
H
S
Q
P
L
P
Site 10
S84
G
P
N
G
S
A
H
S
Q
P
L
P
G
G
G
Site 11
S99
D
C
G
G
V
P
L
S
P
S
W
A
G
G
S
Site 12
S101
G
G
V
P
L
S
P
S
W
A
G
G
S
R
G
Site 13
S117
G
N
L
Q
R
R
A
S
Q
K
E
L
R
K
S
Site 14
S124
S
Q
K
E
L
R
K
S
F
A
R
S
K
A
I
Site 15
S128
L
R
K
S
F
A
R
S
K
A
I
H
V
N
R
Site 16
Y137
A
I
H
V
N
R
T
Y
D
E
Q
V
T
S
R
Site 17
S143
T
Y
D
E
Q
V
T
S
R
A
Q
E
P
L
S
Site 18
S150
S
R
A
Q
E
P
L
S
S
V
R
R
R
A
L
Site 19
S151
R
A
Q
E
P
L
S
S
V
R
R
R
A
L
L
Site 20
S162
R
A
L
L
R
K
A
S
S
L
P
P
T
T
A
Site 21
S163
A
L
L
R
K
A
S
S
L
P
P
T
T
A
H
Site 22
Y185
S
R
V
N
L
P
Q
Y
P
P
T
A
I
D
Y
Site 23
Y192
Y
P
P
T
A
I
D
Y
K
C
H
L
K
K
H
Site 24
S213
L
E
L
V
K
D
I
S
N
D
L
D
L
T
S
Site 25
S239
M
V
D
A
D
R
C
S
L
F
L
V
E
G
A
Site 26
T252
G
A
A
A
G
K
K
T
L
V
S
K
F
F
D
Site 27
S255
A
G
K
K
T
L
V
S
K
F
F
D
V
H
A
Site 28
S270
G
T
P
L
L
P
C
S
S
T
E
N
S
N
E
Site 29
S271
T
P
L
L
P
C
S
S
T
E
N
S
N
E
V
Site 30
T272
P
L
L
P
C
S
S
T
E
N
S
N
E
V
Q
Site 31
S275
P
C
S
S
T
E
N
S
N
E
V
Q
V
P
W
Site 32
Y289
W
G
K
G
I
I
G
Y
V
G
E
H
G
E
T
Site 33
T296
Y
V
G
E
H
G
E
T
V
N
I
P
D
A
Y
Site 34
Y303
T
V
N
I
P
D
A
Y
Q
D
R
R
F
N
D
Site 35
T316
N
D
E
I
D
K
L
T
G
Y
K
T
K
S
L
Site 36
Y318
E
I
D
K
L
T
G
Y
K
T
K
S
L
L
C
Site 37
T320
D
K
L
T
G
Y
K
T
K
S
L
L
C
M
P
Site 38
Y383
F
A
A
S
R
K
E
Y
E
R
S
R
A
L
L
Site 39
S386
S
R
K
E
Y
E
R
S
R
A
L
L
E
V
V
Site 40
T416
K
I
M
H
R
A
Q
T
L
L
K
C
E
R
C
Site 41
T439
E
S
P
V
V
K
F
T
K
S
F
E
L
M
S
Site 42
S441
P
V
V
K
F
T
K
S
F
E
L
M
S
P
K
Site 43
S446
T
K
S
F
E
L
M
S
P
K
C
S
A
D
A
Site 44
S450
E
L
M
S
P
K
C
S
A
D
A
E
N
S
F
Site 45
S456
C
S
A
D
A
E
N
S
F
K
E
S
M
E
K
Site 46
S460
A
E
N
S
F
K
E
S
M
E
K
S
S
Y
S
Site 47
S464
F
K
E
S
M
E
K
S
S
Y
S
D
W
L
I
Site 48
S465
K
E
S
M
E
K
S
S
Y
S
D
W
L
I
N
Site 49
Y466
E
S
M
E
K
S
S
Y
S
D
W
L
I
N
N
Site 50
S489
T
G
L
P
V
N
I
S
D
A
Y
Q
D
P
R
Site 51
Y492
P
V
N
I
S
D
A
Y
Q
D
P
R
F
D
A
Site 52
Y564
G
I
N
N
T
I
M
Y
D
Q
V
K
K
S
W
Site 53
Y583
V
A
L
D
V
L
S
Y
H
A
T
C
S
K
A
Site 54
T586
D
V
L
S
Y
H
A
T
C
S
K
A
E
V
D
Site 55
Y644
V
Q
K
F
K
I
D
Y
E
T
L
C
R
W
L
Site 56
T653
T
L
C
R
W
L
L
T
V
R
K
N
Y
R
M
Site 57
Y658
L
L
T
V
R
K
N
Y
R
M
V
L
Y
H
N
Site 58
T711
H
D
L
D
H
R
G
T
N
N
A
F
Q
A
K
Site 59
S758
N
I
F
A
N
L
S
S
K
E
Y
S
D
L
M
Site 60
S762
N
L
S
S
K
E
Y
S
D
L
M
Q
L
L
K
Site 61
S771
L
M
Q
L
L
K
Q
S
I
L
A
T
D
L
T
Site 62
T778
S
I
L
A
T
D
L
T
L
Y
F
E
R
R
T
Site 63
Y780
L
A
T
D
L
T
L
Y
F
E
R
R
T
E
F
Site 64
T785
T
L
Y
F
E
R
R
T
E
F
F
E
L
V
S
Site 65
Y796
E
L
V
S
K
G
E
Y
D
W
N
I
K
N
H
Site 66
S836
Q
V
A
E
L
V
T
S
E
F
F
E
Q
G
D
Site 67
T852
E
R
L
E
L
K
L
T
P
S
A
I
F
D
R
Site 68
S854
L
E
L
K
L
T
P
S
A
I
F
D
R
N
R
Site 69
S897
K
L
K
P
M
L
D
S
V
A
T
N
R
S
K
Site 70
T900
P
M
L
D
S
V
A
T
N
R
S
K
W
E
E
Site 71
S903
D
S
V
A
T
N
R
S
K
W
E
E
L
H
Q
Site 72
S916
H
Q
K
R
L
L
A
S
T
A
S
S
S
S
P
Site 73
T917
Q
K
R
L
L
A
S
T
A
S
S
S
S
P
A
Site 74
S925
A
S
S
S
S
P
A
S
V
M
V
A
K
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation