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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TCF7L1
Full Name:
Transcription factor 7-like 1
Alias:
HMG box transcription factor 3; TCF3; TCF-3; TF7L1; Transcription factor 7-like 1 (T-cell specific, HMG-box)
Type:
Nucleus protein
Mass (Da):
62631
Number AA:
588
UniProt ID:
Q9HCS4
International Prot ID:
IPI00010396
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0006325
GO:0030111
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
G
G
G
G
G
G
G
S
G
G
G
G
G
S
S
Site 2
S21
G
S
G
G
G
G
G
S
S
A
G
A
A
G
G
Site 3
S22
S
G
G
G
G
G
S
S
A
G
A
A
G
G
G
Site 4
S52
G
G
E
E
Q
E
P
S
S
D
S
A
S
A
Q
Site 5
S53
G
E
E
Q
E
P
S
S
D
S
A
S
A
Q
R
Site 6
S55
E
Q
E
P
S
S
D
S
A
S
A
Q
R
D
L
Site 7
S57
E
P
S
S
D
S
A
S
A
Q
R
D
L
D
E
Site 8
S67
R
D
L
D
E
V
K
S
S
L
V
N
E
S
E
Site 9
S68
D
L
D
E
V
K
S
S
L
V
N
E
S
E
N
Site 10
S73
K
S
S
L
V
N
E
S
E
N
Q
S
S
S
S
Site 11
S77
V
N
E
S
E
N
Q
S
S
S
S
D
S
E
A
Site 12
S78
N
E
S
E
N
Q
S
S
S
S
D
S
E
A
E
Site 13
S79
E
S
E
N
Q
S
S
S
S
D
S
E
A
E
R
Site 14
S80
S
E
N
Q
S
S
S
S
D
S
E
A
E
R
R
Site 15
S82
N
Q
S
S
S
S
D
S
E
A
E
R
R
P
Q
Site 16
T94
R
P
Q
P
V
R
D
T
F
Q
K
P
R
D
Y
Site 17
Y101
T
F
Q
K
P
R
D
Y
F
A
E
V
R
R
P
Site 18
S111
E
V
R
R
P
Q
D
S
A
F
F
K
G
P
P
Site 19
Y122
K
G
P
P
Y
P
G
Y
P
F
L
M
I
P
D
Site 20
S132
L
M
I
P
D
L
S
S
P
Y
L
S
N
G
P
Site 21
Y134
I
P
D
L
S
S
P
Y
L
S
N
G
P
L
S
Site 22
S136
D
L
S
S
P
Y
L
S
N
G
P
L
S
P
G
Site 23
S141
Y
L
S
N
G
P
L
S
P
G
G
A
R
T
Y
Site 24
Y148
S
P
G
G
A
R
T
Y
L
Q
M
K
W
P
L
Site 25
S160
W
P
L
L
D
V
P
S
S
A
T
V
K
D
T
Site 26
S161
P
L
L
D
V
P
S
S
A
T
V
K
D
T
R
Site 27
T167
S
S
A
T
V
K
D
T
R
S
P
S
P
A
H
Site 28
S169
A
T
V
K
D
T
R
S
P
S
P
A
H
L
S
Site 29
S171
V
K
D
T
R
S
P
S
P
A
H
L
S
N
K
Site 30
S176
S
P
S
P
A
H
L
S
N
K
V
P
V
V
Q
Site 31
T192
P
H
H
M
H
P
L
T
P
L
I
T
Y
S
N
Site 32
T196
H
P
L
T
P
L
I
T
Y
S
N
D
H
F
S
Site 33
S198
L
T
P
L
I
T
Y
S
N
D
H
F
S
P
G
Site 34
S203
T
Y
S
N
D
H
F
S
P
G
S
P
P
T
H
Site 35
S206
N
D
H
F
S
P
G
S
P
P
T
H
L
S
P
Site 36
T209
F
S
P
G
S
P
P
T
H
L
S
P
E
I
D
Site 37
S212
G
S
P
P
T
H
L
S
P
E
I
D
P
K
T
Site 38
T219
S
P
E
I
D
P
K
T
G
I
P
R
P
P
H
Site 39
S228
I
P
R
P
P
H
P
S
E
L
S
P
Y
Y
P
Site 40
S231
P
P
H
P
S
E
L
S
P
Y
Y
P
L
S
P
Site 41
Y233
H
P
S
E
L
S
P
Y
Y
P
L
S
P
G
A
Site 42
Y234
P
S
E
L
S
P
Y
Y
P
L
S
P
G
A
V
Site 43
Y260
P
Q
Q
G
Q
P
M
Y
S
L
P
P
G
G
F
Site 44
S261
Q
Q
G
Q
P
M
Y
S
L
P
P
G
G
F
R
Site 45
Y271
P
G
G
F
R
H
P
Y
P
A
L
A
M
N
A
Site 46
S285
A
S
M
S
S
L
V
S
S
R
F
S
P
H
M
Site 47
S286
S
M
S
S
L
V
S
S
R
F
S
P
H
M
V
Site 48
S303
A
H
P
G
L
P
T
S
G
I
P
H
P
A
I
Site 49
S323
K
Q
E
P
A
P
P
S
L
S
P
A
V
S
V
Site 50
S325
E
P
A
P
P
S
L
S
P
A
V
S
V
K
S
Site 51
S332
S
P
A
V
S
V
K
S
P
V
T
V
K
K
E
Site 52
T335
V
S
V
K
S
P
V
T
V
K
K
E
E
E
K
Site 53
Y356
P
L
N
A
F
M
L
Y
M
K
E
M
R
A
K
Site 54
S388
G
R
K
W
H
N
L
S
R
E
E
Q
A
K
Y
Site 55
Y395
S
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
Site 56
Y396
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
R
Site 57
S407
R
K
E
R
Q
L
H
S
Q
L
Y
P
T
W
S
Site 58
Y410
R
Q
L
H
S
Q
L
Y
P
T
W
S
A
R
D
Site 59
S414
S
Q
L
Y
P
T
W
S
A
R
D
N
Y
G
K
Site 60
Y419
T
W
S
A
R
D
N
Y
G
K
K
K
K
R
K
Site 61
S432
R
K
R
E
K
Q
L
S
Q
T
Q
S
Q
Q
Q
Site 62
S436
K
Q
L
S
Q
T
Q
S
Q
Q
Q
V
Q
E
A
Site 63
S449
E
A
E
G
A
L
A
S
K
S
K
K
P
C
V
Site 64
S451
E
G
A
L
A
S
K
S
K
K
P
C
V
Q
Y
Site 65
Y458
S
K
K
P
C
V
Q
Y
L
P
P
E
K
P
C
Site 66
S467
P
P
E
K
P
C
D
S
P
A
S
S
H
G
S
Site 67
S470
K
P
C
D
S
P
A
S
S
H
G
S
M
L
D
Site 68
S471
P
C
D
S
P
A
S
S
H
G
S
M
L
D
S
Site 69
S474
S
P
A
S
S
H
G
S
M
L
D
S
P
A
T
Site 70
S478
S
H
G
S
M
L
D
S
P
A
T
P
S
A
A
Site 71
S497
A
A
P
A
A
T
H
S
E
Q
A
Q
P
L
S
Site 72
S504
S
E
Q
A
Q
P
L
S
L
T
T
K
P
E
T
Site 73
T506
Q
A
Q
P
L
S
L
T
T
K
P
E
T
R
A
Site 74
T511
S
L
T
T
K
P
E
T
R
A
Q
L
A
L
H
Site 75
S519
R
A
Q
L
A
L
H
S
A
A
F
L
S
A
K
Site 76
S524
L
H
S
A
A
F
L
S
A
K
A
A
A
S
S
Site 77
S530
L
S
A
K
A
A
A
S
S
S
G
Q
M
G
S
Site 78
S532
A
K
A
A
A
S
S
S
G
Q
M
G
S
Q
P
Site 79
S537
S
S
S
G
Q
M
G
S
Q
P
P
L
L
S
R
Site 80
S543
G
S
Q
P
P
L
L
S
R
P
L
P
L
G
S
Site 81
T565
S
P
P
S
F
P
A
T
L
H
A
H
Q
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation