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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYO10
Full Name:
Myosin-X
Alias:
KIAA0799; myosin X; myosin-10
Type:
Motor protein
Mass (Da):
237347
Number AA:
2058
UniProt ID:
Q9HD67
International Prot ID:
IPI00289258
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0003774
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
E
N
G
Q
H
F
P
S
T
V
N
S
C
A
E
Site 2
T23
N
G
Q
H
F
P
S
T
V
N
S
C
A
E
G
Site 3
S70
E
G
V
D
D
M
A
S
L
T
E
L
H
G
G
Site 4
Y81
L
H
G
G
S
I
M
Y
N
L
F
Q
R
Y
K
Site 5
Y87
M
Y
N
L
F
Q
R
Y
K
R
N
Q
I
Y
T
Site 6
Y93
R
Y
K
R
N
Q
I
Y
T
Y
I
G
S
I
L
Site 7
T94
Y
K
R
N
Q
I
Y
T
Y
I
G
S
I
L
A
Site 8
Y95
K
R
N
Q
I
Y
T
Y
I
G
S
I
L
A
S
Site 9
Y113
Y
Q
P
I
A
G
L
Y
E
P
A
T
M
E
Q
Site 10
T117
A
G
L
Y
E
P
A
T
M
E
Q
Y
S
R
R
Site 11
Y121
E
P
A
T
M
E
Q
Y
S
R
R
H
L
G
E
Site 12
S122
P
A
T
M
E
Q
Y
S
R
R
H
L
G
E
L
Site 13
S156
D
N
Q
C
I
L
I
S
G
E
S
G
A
G
K
Site 14
S159
C
I
L
I
S
G
E
S
G
A
G
K
T
E
S
Site 15
T164
G
E
S
G
A
G
K
T
E
S
T
K
L
I
L
Site 16
S166
S
G
A
G
K
T
E
S
T
K
L
I
L
K
F
Site 17
S181
L
S
V
I
S
Q
Q
S
L
E
L
S
L
K
E
Site 18
S185
S
Q
Q
S
L
E
L
S
L
K
E
K
T
S
C
Site 19
T212
E
A
F
G
N
A
K
T
V
Y
N
N
N
S
S
Site 20
Y214
F
G
N
A
K
T
V
Y
N
N
N
S
S
R
F
Site 21
S218
K
T
V
Y
N
N
N
S
S
R
F
G
K
F
V
Site 22
Y243
Q
G
G
R
I
V
D
Y
L
L
E
K
N
R
V
Site 23
Y260
Q
N
P
G
E
R
N
Y
H
I
F
Y
A
L
L
Site 24
Y279
H
E
E
R
E
E
F
Y
L
S
T
P
E
N
Y
Site 25
S281
E
R
E
E
F
Y
L
S
T
P
E
N
Y
H
Y
Site 26
T282
R
E
E
F
Y
L
S
T
P
E
N
Y
H
Y
L
Site 27
Y286
Y
L
S
T
P
E
N
Y
H
Y
L
N
Q
S
G
Site 28
Y288
S
T
P
E
N
Y
H
Y
L
N
Q
S
G
C
V
Site 29
T299
S
G
C
V
E
D
K
T
I
S
D
Q
E
S
F
Site 30
S301
C
V
E
D
K
T
I
S
D
Q
E
S
F
R
E
Site 31
S305
K
T
I
S
D
Q
E
S
F
R
E
V
I
T
A
Site 32
S319
A
M
D
V
M
Q
F
S
K
E
E
V
R
E
V
Site 33
S350
T
A
G
G
A
Q
V
S
F
K
T
A
L
G
R
Site 34
T374
T
Q
L
T
D
A
L
T
Q
R
S
M
F
L
R
Site 35
S377
T
D
A
L
T
Q
R
S
M
F
L
R
G
E
E
Site 36
T387
L
R
G
E
E
I
L
T
P
L
N
V
Q
Q
A
Site 37
S397
N
V
Q
Q
A
V
D
S
R
D
S
L
A
M
A
Site 38
S419
W
V
I
K
K
I
N
S
R
I
K
G
N
E
D
Site 39
S429
K
G
N
E
D
F
K
S
I
G
I
L
D
I
F
Site 40
Y461
A
N
E
K
L
Q
E
Y
F
N
K
H
I
F
S
Site 41
S468
Y
F
N
K
H
I
F
S
L
E
Q
L
E
Y
S
Site 42
Y474
F
S
L
E
Q
L
E
Y
S
R
E
G
L
V
W
Site 43
S510
L
A
L
I
N
E
E
S
H
F
P
Q
A
T
D
Site 44
T516
E
S
H
F
P
Q
A
T
D
S
T
L
L
E
K
Site 45
T519
F
P
Q
A
T
D
S
T
L
L
E
K
L
H
S
Site 46
S526
T
L
L
E
K
L
H
S
Q
H
A
N
N
H
F
Site 47
Y534
Q
H
A
N
N
H
F
Y
V
K
P
R
V
A
V
Site 48
Y549
N
N
F
G
V
K
H
Y
A
G
E
V
Q
Y
D
Site 49
Y555
H
Y
A
G
E
V
Q
Y
D
V
R
G
I
L
E
Site 50
T567
I
L
E
K
N
R
D
T
F
R
D
D
L
L
N
Site 51
S579
L
L
N
L
L
R
E
S
R
F
D
F
I
Y
D
Site 52
Y585
E
S
R
F
D
F
I
Y
D
L
F
E
H
V
S
Site 53
S592
Y
D
L
F
E
H
V
S
S
R
N
N
Q
D
T
Site 54
S593
D
L
F
E
H
V
S
S
R
N
N
Q
D
T
L
Site 55
T599
S
S
R
N
N
Q
D
T
L
K
C
G
S
K
H
Site 56
S604
Q
D
T
L
K
C
G
S
K
H
R
R
P
T
V
Site 57
T610
G
S
K
H
R
R
P
T
V
S
S
Q
F
K
D
Site 58
S612
K
H
R
R
P
T
V
S
S
Q
F
K
D
S
L
Site 59
S613
H
R
R
P
T
V
S
S
Q
F
K
D
S
L
H
Site 60
S618
V
S
S
Q
F
K
D
S
L
H
S
L
M
A
T
Site 61
S621
Q
F
K
D
S
L
H
S
L
M
A
T
L
S
S
Site 62
S628
S
L
M
A
T
L
S
S
S
N
P
F
F
V
R
Site 63
Y659
V
V
L
N
Q
L
R
Y
S
G
M
L
E
T
V
Site 64
S660
V
L
N
Q
L
R
Y
S
G
M
L
E
T
V
R
Site 65
T665
R
Y
S
G
M
L
E
T
V
R
I
R
K
A
G
Site 66
Y673
V
R
I
R
K
A
G
Y
A
V
R
R
P
F
Q
Site 67
Y683
R
R
P
F
Q
D
F
Y
K
R
Y
K
V
L
M
Site 68
S705
D
V
R
G
K
C
T
S
L
L
Q
L
Y
D
A
Site 69
Y710
C
T
S
L
L
Q
L
Y
D
A
S
N
S
E
W
Site 70
S729
T
K
V
F
L
R
E
S
L
E
Q
K
L
E
K
Site 71
S743
K
R
R
E
E
E
V
S
H
A
A
M
V
I
R
Site 72
Y762
G
F
L
A
R
K
Q
Y
R
K
V
L
Y
C
V
Site 73
Y808
G
Q
I
A
R
R
V
Y
R
Q
L
L
A
E
K
Site 74
S868
E
L
E
A
L
Q
K
S
Q
K
E
A
E
L
T
Site 75
T875
S
Q
K
E
A
E
L
T
R
E
L
E
K
Q
K
Site 76
S910
M
K
E
Q
Q
E
L
S
L
T
E
A
S
L
Q
Site 77
T912
E
Q
Q
E
L
S
L
T
E
A
S
L
Q
K
L
Site 78
S944
A
A
Q
E
F
L
E
S
L
N
F
D
E
I
D
Site 79
S960
C
V
R
N
I
E
R
S
L
S
V
G
S
E
F
Site 80
S962
R
N
I
E
R
S
L
S
V
G
S
E
F
S
S
Site 81
S965
E
R
S
L
S
V
G
S
E
F
S
S
E
L
A
Site 82
S969
S
V
G
S
E
F
S
S
E
L
A
E
S
A
C
Site 83
S974
F
S
S
E
L
A
E
S
A
C
E
E
K
P
N
Site 84
S985
E
K
P
N
F
N
F
S
Q
P
Y
P
E
E
E
Site 85
Y988
N
F
N
F
S
Q
P
Y
P
E
E
E
V
D
E
Site 86
S1007
D
D
D
A
F
K
D
S
P
N
P
S
E
H
G
Site 87
S1011
F
K
D
S
P
N
P
S
E
H
G
H
S
D
Q
Site 88
S1016
N
P
S
E
H
G
H
S
D
Q
R
T
S
G
I
Site 89
T1020
H
G
H
S
D
Q
R
T
S
G
I
R
T
S
D
Site 90
S1021
G
H
S
D
Q
R
T
S
G
I
R
T
S
D
D
Site 91
T1025
Q
R
T
S
G
I
R
T
S
D
D
S
S
E
E
Site 92
S1026
R
T
S
G
I
R
T
S
D
D
S
S
E
E
D
Site 93
S1029
G
I
R
T
S
D
D
S
S
E
E
D
P
Y
M
Site 94
S1030
I
R
T
S
D
D
S
S
E
E
D
P
Y
M
N
Site 95
Y1035
D
S
S
E
E
D
P
Y
M
N
D
T
V
V
P
Site 96
T1039
E
D
P
Y
M
N
D
T
V
V
P
T
S
P
S
Site 97
S1044
N
D
T
V
V
P
T
S
P
S
A
D
S
T
V
Site 98
S1049
P
T
S
P
S
A
D
S
T
V
L
L
A
P
S
Site 99
S1060
L
A
P
S
V
Q
D
S
G
S
L
H
N
S
S
Site 100
S1062
P
S
V
Q
D
S
G
S
L
H
N
S
S
S
G
Site 101
S1066
D
S
G
S
L
H
N
S
S
S
G
E
S
T
Y
Site 102
S1067
S
G
S
L
H
N
S
S
S
G
E
S
T
Y
C
Site 103
S1068
G
S
L
H
N
S
S
S
G
E
S
T
Y
C
M
Site 104
S1071
H
N
S
S
S
G
E
S
T
Y
C
M
P
Q
N
Site 105
T1072
N
S
S
S
G
E
S
T
Y
C
M
P
Q
N
A
Site 106
Y1073
S
S
S
G
E
S
T
Y
C
M
P
Q
N
A
G
Site 107
S1084
Q
N
A
G
D
L
P
S
P
D
G
D
Y
D
Y
Site 108
Y1089
L
P
S
P
D
G
D
Y
D
Y
D
Q
D
D
Y
Site 109
Y1091
S
P
D
G
D
Y
D
Y
D
Q
D
D
Y
E
D
Site 110
Y1096
Y
D
Y
D
Q
D
D
Y
E
D
G
A
I
T
S
Site 111
S1103
Y
E
D
G
A
I
T
S
G
S
S
V
T
F
S
Site 112
S1105
D
G
A
I
T
S
G
S
S
V
T
F
S
N
S
Site 113
S1106
G
A
I
T
S
G
S
S
V
T
F
S
N
S
Y
Site 114
T1108
I
T
S
G
S
S
V
T
F
S
N
S
Y
G
S
Site 115
S1110
S
G
S
S
V
T
F
S
N
S
Y
G
S
Q
W
Site 116
S1112
S
S
V
T
F
S
N
S
Y
G
S
Q
W
S
P
Site 117
Y1113
S
V
T
F
S
N
S
Y
G
S
Q
W
S
P
D
Site 118
S1115
T
F
S
N
S
Y
G
S
Q
W
S
P
D
Y
R
Site 119
S1118
N
S
Y
G
S
Q
W
S
P
D
Y
R
C
S
V
Site 120
Y1121
G
S
Q
W
S
P
D
Y
R
C
S
V
G
T
Y
Site 121
S1124
W
S
P
D
Y
R
C
S
V
G
T
Y
N
S
S
Site 122
T1127
D
Y
R
C
S
V
G
T
Y
N
S
S
G
A
Y
Site 123
Y1128
Y
R
C
S
V
G
T
Y
N
S
S
G
A
Y
R
Site 124
S1130
C
S
V
G
T
Y
N
S
S
G
A
Y
R
F
S
Site 125
S1131
S
V
G
T
Y
N
S
S
G
A
Y
R
F
S
S
Site 126
Y1134
T
Y
N
S
S
G
A
Y
R
F
S
S
E
G
A
Site 127
S1137
S
S
G
A
Y
R
F
S
S
E
G
A
Q
S
S
Site 128
S1138
S
G
A
Y
R
F
S
S
E
G
A
Q
S
S
F
Site 129
S1143
F
S
S
E
G
A
Q
S
S
F
E
D
S
E
E
Site 130
S1144
S
S
E
G
A
Q
S
S
F
E
D
S
E
E
D
Site 131
S1148
A
Q
S
S
F
E
D
S
E
E
D
F
D
S
R
Site 132
S1154
D
S
E
E
D
F
D
S
R
F
D
T
D
D
E
Site 133
T1158
D
F
D
S
R
F
D
T
D
D
E
L
S
Y
R
Site 134
S1163
F
D
T
D
D
E
L
S
Y
R
R
D
S
V
Y
Site 135
Y1164
D
T
D
D
E
L
S
Y
R
R
D
S
V
Y
S
Site 136
S1168
E
L
S
Y
R
R
D
S
V
Y
S
C
V
T
L
Site 137
Y1170
S
Y
R
R
D
S
V
Y
S
C
V
T
L
P
Y
Site 138
S1171
Y
R
R
D
S
V
Y
S
C
V
T
L
P
Y
F
Site 139
Y1183
P
Y
F
H
S
F
L
Y
M
K
G
G
L
M
N
Site 140
S1226
L
H
K
K
G
G
G
S
S
T
L
S
R
R
N
Site 141
S1227
H
K
K
G
G
G
S
S
T
L
S
R
R
N
W
Site 142
T1228
K
K
G
G
G
S
S
T
L
S
R
R
N
W
K
Site 143
S1230
G
G
G
S
S
T
L
S
R
R
N
W
K
K
R
Site 144
Y1248
L
R
Q
S
K
L
M
Y
F
E
N
D
S
E
E
Site 145
T1260
S
E
E
K
L
K
G
T
V
E
V
R
T
A
K
Site 146
T1273
A
K
E
I
I
D
N
T
T
K
E
N
G
I
D
Site 147
S1294
T
F
H
L
I
A
E
S
P
E
D
A
S
Q
W
Site 148
S1299
A
E
S
P
E
D
A
S
Q
W
F
S
V
L
S
Site 149
S1303
E
D
A
S
Q
W
F
S
V
L
S
Q
V
H
A
Site 150
S1306
S
Q
W
F
S
V
L
S
Q
V
H
A
S
T
D
Site 151
S1344
L
I
D
S
V
C
A
S
D
S
P
D
R
P
N
Site 152
S1346
D
S
V
C
A
S
D
S
P
D
R
P
N
S
F
Site 153
S1352
D
S
P
D
R
P
N
S
F
V
I
I
T
A
N
Site 154
T1377
E
E
M
H
H
W
I
T
L
L
Q
R
S
K
G
Site 155
T1386
L
Q
R
S
K
G
D
T
R
V
E
G
Q
E
F
Site 156
S1406
L
H
K
E
V
K
N
S
P
K
M
S
S
L
K
Site 157
S1410
V
K
N
S
P
K
M
S
S
L
K
L
K
K
R
Site 158
T1422
K
K
R
W
F
V
L
T
H
N
S
L
D
Y
Y
Site 159
S1425
W
F
V
L
T
H
N
S
L
D
Y
Y
K
S
S
Site 160
Y1428
L
T
H
N
S
L
D
Y
Y
K
S
S
E
K
N
Site 161
Y1429
T
H
N
S
L
D
Y
Y
K
S
S
E
K
N
A
Site 162
S1431
N
S
L
D
Y
Y
K
S
S
E
K
N
A
L
K
Site 163
S1432
S
L
D
Y
Y
K
S
S
E
K
N
A
L
K
L
Site 164
Y1463
K
I
F
K
E
T
G
Y
W
N
V
T
V
Y
G
Site 165
Y1469
G
Y
W
N
V
T
V
Y
G
R
K
H
C
Y
R
Site 166
Y1478
R
K
H
C
Y
R
L
Y
T
K
L
L
N
E
A
Site 167
T1479
K
H
C
Y
R
L
Y
T
K
L
L
N
E
A
T
Site 168
T1486
T
K
L
L
N
E
A
T
R
W
S
S
A
I
Q
Site 169
S1489
L
N
E
A
T
R
W
S
S
A
I
Q
N
V
T
Site 170
S1490
N
E
A
T
R
W
S
S
A
I
Q
N
V
T
D
Site 171
T1496
S
S
A
I
Q
N
V
T
D
T
K
A
P
I
D
Site 172
T1498
A
I
Q
N
V
T
D
T
K
A
P
I
D
T
P
Site 173
T1504
D
T
K
A
P
I
D
T
P
T
Q
Q
L
I
Q
Site 174
Y1527
S
D
V
V
E
Q
I
Y
K
R
N
P
I
L
R
Site 175
Y1535
K
R
N
P
I
L
R
Y
T
H
H
P
L
H
S
Site 176
T1536
R
N
P
I
L
R
Y
T
H
H
P
L
H
S
P
Site 177
S1542
Y
T
H
H
P
L
H
S
P
L
L
P
L
P
Y
Site 178
Y1562
N
L
L
K
D
K
G
Y
T
T
L
Q
D
E
A
Site 179
S1575
E
A
I
K
I
F
N
S
L
Q
Q
L
E
S
M
Site 180
S1581
N
S
L
Q
Q
L
E
S
M
S
D
P
I
P
I
Site 181
Y1607
R
P
L
R
D
E
L
Y
C
Q
L
I
K
Q
T
Site 182
T1614
Y
C
Q
L
I
K
Q
T
N
K
V
P
H
P
G
Site 183
S1622
N
K
V
P
H
P
G
S
V
G
N
L
Y
S
W
Site 184
Y1648
P
S
R
G
I
L
K
Y
L
K
F
H
L
K
R
Site 185
S1663
I
R
E
Q
F
P
G
S
E
M
E
K
Y
A
L
Site 186
Y1668
P
G
S
E
M
E
K
Y
A
L
F
T
Y
E
S
Site 187
Y1673
E
K
Y
A
L
F
T
Y
E
S
L
K
K
T
K
Site 188
S1675
Y
A
L
F
T
Y
E
S
L
K
K
T
K
C
R
Site 189
T1679
T
Y
E
S
L
K
K
T
K
C
R
E
F
V
P
Site 190
S1687
K
C
R
E
F
V
P
S
R
D
E
I
E
A
L
Site 191
T1703
H
R
Q
E
M
T
S
T
V
Y
C
H
G
G
G
Site 192
Y1705
Q
E
M
T
S
T
V
Y
C
H
G
G
G
S
C
Site 193
T1715
G
G
G
S
C
K
I
T
I
N
S
H
T
T
A
Site 194
S1738
R
G
L
A
M
E
D
S
R
N
M
F
A
L
F
Site 195
S1757
H
V
D
K
A
I
E
S
R
T
V
V
A
D
V
Site 196
T1774
K
F
E
K
L
A
A
T
S
E
V
G
D
L
P
Site 197
T1794
K
L
Y
C
F
L
D
T
D
N
V
P
K
D
S
Site 198
Y1842
L
Q
Y
L
Q
G
D
Y
T
L
H
A
A
I
P
Site 199
T1843
Q
Y
L
Q
G
D
Y
T
L
H
A
A
I
P
P
Site 200
S1856
P
P
L
E
E
V
Y
S
L
Q
R
L
K
A
R
Site 201
S1865
Q
R
L
K
A
R
I
S
Q
S
T
K
T
F
T
Site 202
S1867
L
K
A
R
I
S
Q
S
T
K
T
F
T
P
C
Site 203
T1868
K
A
R
I
S
Q
S
T
K
T
F
T
P
C
E
Site 204
T1870
R
I
S
Q
S
T
K
T
F
T
P
C
E
R
L
Site 205
T1872
S
Q
S
T
K
T
F
T
P
C
E
R
L
E
K
Site 206
T1882
E
R
L
E
K
R
R
T
S
F
L
E
G
T
L
Site 207
S1883
R
L
E
K
R
R
T
S
F
L
E
G
T
L
R
Site 208
T1888
R
T
S
F
L
E
G
T
L
R
R
S
F
R
T
Site 209
S1892
L
E
G
T
L
R
R
S
F
R
T
G
S
V
V
Site 210
T1895
T
L
R
R
S
F
R
T
G
S
V
V
R
Q
K
Site 211
S1897
R
R
S
F
R
T
G
S
V
V
R
Q
K
V
E
Site 212
S1919
W
I
K
E
E
V
S
S
A
R
A
S
I
I
D
Site 213
S1923
E
V
S
S
A
R
A
S
I
I
D
K
W
R
K
Site 214
S1981
G
V
S
A
D
A
V
S
V
Y
K
R
G
E
G
Site 215
Y1983
S
A
D
A
V
S
V
Y
K
R
G
E
G
R
P
Site 216
Y1996
R
P
L
E
V
F
Q
Y
E
H
I
L
S
F
G
Site 217
S2024
R
E
L
L
F
E
T
S
E
V
V
D
V
A
K
Site 218
Y2036
V
A
K
L
M
K
A
Y
I
S
M
I
V
K
K
Site 219
S2038
K
L
M
K
A
Y
I
S
M
I
V
K
K
R
Y
Site 220
S2046
M
I
V
K
K
R
Y
S
T
T
R
S
A
S
S
Site 221
T2047
I
V
K
K
R
Y
S
T
T
R
S
A
S
S
Q
Site 222
T2048
V
K
K
R
Y
S
T
T
R
S
A
S
S
Q
G
Site 223
S2050
K
R
Y
S
T
T
R
S
A
S
S
Q
G
S
S
Site 224
S2052
Y
S
T
T
R
S
A
S
S
Q
G
S
S
R
_
Site 225
S2053
S
T
T
R
S
A
S
S
Q
G
S
S
R
_
_
Site 226
S2056
R
S
A
S
S
Q
G
S
S
R
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation