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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TXNRD2
Full Name:
Thioredoxin reductase 2, mitochondrial
Alias:
Selenoprotein Z; SelZ; Thioredoxin reductase 2; Thioredoxin reductase 3; Thioredoxin reductase beta; TR; TR3; TR-beta; TRXR2
Type:
Oxidoreductase; EC 1.8.1.9; Nucleotide Metabolism - pyrimidine
Mass (Da):
56507
Number AA:
524
UniProt ID:
Q9NNW7
International Prot ID:
IPI00220566
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005739
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004791
PhosphoSite+
KinaseNET
Biological Process:
GO:0000302
GO:0000305
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
G
G
R
F
R
W
R
T
Q
A
V
A
G
G
V
Site 2
Y40
A
A
A
G
Q
R
D
Y
D
L
L
V
V
G
G
Site 3
Y70
R
K
V
A
V
V
D
Y
V
E
P
S
P
Q
G
Site 4
S74
V
V
D
Y
V
E
P
S
P
Q
G
T
R
W
G
Site 5
T78
V
E
P
S
P
Q
G
T
R
W
G
L
G
G
T
Site 6
Y113
L
I
Q
D
A
P
N
Y
G
W
E
V
A
Q
P
Site 7
Y154
L
Q
D
R
K
V
K
Y
F
N
I
K
A
S
F
Site 8
S160
K
Y
F
N
I
K
A
S
F
V
D
E
H
T
V
Site 9
Y194
A
T
G
G
R
P
R
Y
P
T
H
I
E
G
A
Site 10
T196
G
G
R
P
R
Y
P
T
H
I
E
G
A
L
E
Site 11
T221
L
K
E
S
P
G
K
T
L
V
V
G
A
S
Y
Site 12
S282
F
L
R
G
C
A
P
S
R
V
R
R
L
P
D
Site 13
T295
P
D
G
Q
L
Q
V
T
W
E
D
S
T
T
G
Site 14
T301
V
T
W
E
D
S
T
T
G
K
E
D
T
G
T
Site 15
T308
T
G
K
E
D
T
G
T
F
D
T
V
L
W
A
Site 16
T311
E
D
T
G
T
F
D
T
V
L
W
A
I
G
R
Site 17
T322
A
I
G
R
V
P
D
T
R
S
L
N
L
E
K
Site 18
S324
G
R
V
P
D
T
R
S
L
N
L
E
K
A
G
Site 19
S335
E
K
A
G
V
D
T
S
P
D
T
Q
K
I
L
Site 20
T338
G
V
D
T
S
P
D
T
Q
K
I
L
V
D
S
Site 21
S345
T
Q
K
I
L
V
D
S
R
E
A
T
S
V
P
Site 22
T349
L
V
D
S
R
E
A
T
S
V
P
H
I
Y
A
Site 23
S386
V
Q
R
L
F
G
G
S
S
D
L
M
D
Y
D
Site 24
Y392
G
S
S
D
L
M
D
Y
D
N
V
P
T
T
V
Site 25
T398
D
Y
D
N
V
P
T
T
V
F
T
P
L
E
Y
Site 26
S411
E
Y
G
C
V
G
L
S
E
E
E
A
V
A
R
Site 27
T437
H
Y
K
P
L
E
F
T
V
A
G
R
D
A
S
Site 28
Y447
G
R
D
A
S
Q
C
Y
V
K
M
V
C
L
R
Site 29
S501
V
G
I
H
P
T
C
S
E
E
V
V
K
L
R
Site 30
S510
E
V
V
K
L
R
I
S
K
R
S
G
L
D
P
Site 31
S513
K
L
R
I
S
K
R
S
G
L
D
P
T
V
T
Site 32
T518
K
R
S
G
L
D
P
T
V
T
G
C
U
G
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation