KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ChREBP
Full Name:
Williams-Beuren syndrome chromosomal region 14 protein
Alias:
BHLHd14; Carbohydrate response element binding protein; CHREBP; MIO; MLX interacting protein-like; Mlx interactor; MLX-interacting protein-like; MLXIPL; MONDOB; WBS14; WBSCR14; Williams-Beuren syndrome chromosome region 14 protein; WS basic-helix- loop-helix leucine zipper protein; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH
Type:
Transcription factor
Mass (Da):
93073
Number AA:
852
UniProt ID:
Q9NP71
International Prot ID:
IPI00016812
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0046982
GO:0016563
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0042593
GO:0045723
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
Q
V
P
R
V
A
P
S
P
D
S
D
S
D
T
Site 2
S23
R
V
A
P
S
P
D
S
D
S
D
T
D
S
E
Site 3
S25
A
P
S
P
D
S
D
S
D
T
D
S
E
D
P
Site 4
T27
S
P
D
S
D
S
D
T
D
S
E
D
P
S
L
Site 5
S29
D
S
D
S
D
T
D
S
E
D
P
S
L
R
R
Site 6
S33
D
T
D
S
E
D
P
S
L
R
R
S
A
G
G
Site 7
S37
E
D
P
S
L
R
R
S
A
G
G
L
L
R
S
Site 8
S44
S
A
G
G
L
L
R
S
Q
V
I
H
S
G
H
Site 9
S49
L
R
S
Q
V
I
H
S
G
H
F
M
V
S
S
Site 10
S55
H
S
G
H
F
M
V
S
S
P
H
S
D
S
L
Site 11
S56
S
G
H
F
M
V
S
S
P
H
S
D
S
L
P
Site 12
S59
F
M
V
S
S
P
H
S
D
S
L
P
R
R
R
Site 13
S61
V
S
S
P
H
S
D
S
L
P
R
R
R
D
Q
Site 14
S71
R
R
R
D
Q
E
G
S
V
G
P
S
D
F
G
Site 15
S75
Q
E
G
S
V
G
P
S
D
F
G
P
R
S
I
Site 16
S81
P
S
D
F
G
P
R
S
I
D
P
T
L
T
R
Site 17
T85
G
P
R
S
I
D
P
T
L
T
R
L
F
E
C
Site 18
S98
E
C
L
S
L
A
Y
S
G
K
L
V
S
P
K
Site 19
S103
A
Y
S
G
K
L
V
S
P
K
W
K
N
F
K
Site 20
Y134
W
R
A
W
Y
I
Q
Y
V
K
R
R
K
S
P
Site 21
S140
Q
Y
V
K
R
R
K
S
P
V
C
G
F
V
T
Site 22
T147
S
P
V
C
G
F
V
T
P
L
Q
G
P
E
A
Site 23
Y187
E
Y
H
K
W
R
I
Y
Y
K
K
R
L
R
K
Site 24
Y188
Y
H
K
W
R
I
Y
Y
K
K
R
L
R
K
P
Site 25
S196
K
K
R
L
R
K
P
S
R
E
D
D
L
L
A
Site 26
T258
D
I
S
D
T
L
F
T
M
T
Q
S
G
P
S
Site 27
T260
S
D
T
L
F
T
M
T
Q
S
G
P
S
P
L
Site 28
S262
T
L
F
T
M
T
Q
S
G
P
S
P
L
Q
L
Site 29
S265
T
M
T
Q
S
G
P
S
P
L
Q
L
P
P
E
Site 30
Y275
Q
L
P
P
E
D
A
Y
V
G
N
A
D
M
I
Site 31
T287
D
M
I
Q
P
D
L
T
P
L
Q
P
S
L
D
Site 32
S292
D
L
T
P
L
Q
P
S
L
D
D
F
M
D
I
Site 33
T304
M
D
I
S
D
F
F
T
N
S
R
L
P
Q
P
Site 34
S306
I
S
D
F
F
T
N
S
R
L
P
Q
P
P
M
Site 35
S315
L
P
Q
P
P
M
P
S
N
F
P
E
P
P
S
Site 36
S322
S
N
F
P
E
P
P
S
F
S
P
V
V
D
S
Site 37
T335
D
S
L
F
S
S
G
T
L
G
P
E
V
P
P
Site 38
S344
G
P
E
V
P
P
A
S
S
A
M
T
H
L
S
Site 39
S345
P
E
V
P
P
A
S
S
A
M
T
H
L
S
G
Site 40
T348
P
P
A
S
S
A
M
T
H
L
S
G
H
S
R
Site 41
S351
S
S
A
M
T
H
L
S
G
H
S
R
L
Q
A
Site 42
S361
S
R
L
Q
A
R
N
S
C
P
G
P
L
D
S
Site 43
S368
S
C
P
G
P
L
D
S
S
A
F
L
S
S
D
Site 44
S369
C
P
G
P
L
D
S
S
A
F
L
S
S
D
F
Site 45
S374
D
S
S
A
F
L
S
S
D
F
L
L
P
E
D
Site 46
Y398
V
P
P
P
L
L
H
Y
P
P
P
A
K
V
P
Site 47
S432
L
Q
E
E
P
L
F
S
P
R
F
P
F
P
T
Site 48
T439
S
P
R
F
P
F
P
T
V
P
P
A
P
G
V
Site 49
T458
A
P
A
A
F
P
P
T
P
Q
S
V
P
S
P
Site 50
S461
A
F
P
P
T
P
Q
S
V
P
S
P
A
P
T
Site 51
S464
P
T
P
Q
S
V
P
S
P
A
P
T
P
F
P
Site 52
S489
P
A
F
G
P
C
F
S
M
P
R
G
K
P
P
Site 53
S499
R
G
K
P
P
A
P
S
P
R
G
Q
K
A
S
Site 54
S506
S
P
R
G
Q
K
A
S
P
P
T
L
A
P
A
Site 55
T509
G
Q
K
A
S
P
P
T
L
A
P
A
T
A
S
Site 56
T514
P
P
T
L
A
P
A
T
A
S
P
P
T
T
A
Site 57
S516
T
L
A
P
A
T
A
S
P
P
T
T
A
G
S
Site 58
T519
P
A
T
A
S
P
P
T
T
A
G
S
N
N
P
Site 59
T520
A
T
A
S
P
P
T
T
A
G
S
N
N
P
C
Site 60
S523
S
P
P
T
T
A
G
S
N
N
P
C
L
T
Q
Site 61
T533
P
C
L
T
Q
L
L
T
A
A
K
P
E
Q
A
Site 62
T549
E
P
P
L
V
S
S
T
L
L
R
S
P
G
S
Site 63
S553
V
S
S
T
L
L
R
S
P
G
S
P
Q
E
T
Site 64
S556
T
L
L
R
S
P
G
S
P
Q
E
T
V
P
E
Site 65
T560
S
P
G
S
P
Q
E
T
V
P
E
F
P
C
T
Site 66
T572
P
C
T
F
L
P
P
T
P
A
P
T
P
P
R
Site 67
T576
L
P
P
T
P
A
P
T
P
P
R
P
P
P
G
Site 68
T586
R
P
P
P
G
P
A
T
L
A
P
S
R
P
L
Site 69
S602
V
P
K
A
E
R
L
S
P
P
A
P
S
G
S
Site 70
S607
R
L
S
P
P
A
P
S
G
S
E
R
R
L
S
Site 71
S609
S
P
P
A
P
S
G
S
E
R
R
L
S
G
D
Site 72
S614
S
G
S
E
R
R
L
S
G
D
L
S
S
M
P
Site 73
S618
R
R
L
S
G
D
L
S
S
M
P
G
P
G
T
Site 74
S619
R
L
S
G
D
L
S
S
M
P
G
P
G
T
L
Site 75
T625
S
S
M
P
G
P
G
T
L
S
V
R
V
S
P
Site 76
S627
M
P
G
P
G
T
L
S
V
R
V
S
P
P
Q
Site 77
S631
G
T
L
S
V
R
V
S
P
P
Q
P
I
L
S
Site 78
S638
S
P
P
Q
P
I
L
S
R
G
R
P
D
S
N
Site 79
S644
L
S
R
G
R
P
D
S
N
K
T
E
N
R
R
Site 80
T647
G
R
P
D
S
N
K
T
E
N
R
R
I
T
H
Site 81
T653
K
T
E
N
R
R
I
T
H
I
S
A
E
Q
K
Site 82
S656
N
R
R
I
T
H
I
S
A
E
Q
K
R
R
F
Site 83
S677
D
T
L
H
G
L
V
S
T
L
S
A
Q
P
S
Site 84
S684
S
T
L
S
A
Q
P
S
L
K
V
S
K
A
T
Site 85
S688
A
Q
P
S
L
K
V
S
K
A
T
T
L
Q
K
Site 86
T692
L
K
V
S
K
A
T
T
L
Q
K
T
A
E
Y
Site 87
T738
C
Q
Q
Q
L
P
A
T
G
V
P
I
T
H
Q
Site 88
T743
P
A
T
G
V
P
I
T
H
Q
R
F
D
Q
M
Site 89
Y757
M
R
D
M
F
D
D
Y
V
R
T
R
T
L
H
Site 90
T797
S
V
H
T
L
R
Q
T
S
L
A
W
L
D
Q
Site 91
S798
V
H
T
L
R
Q
T
S
L
A
W
L
D
Q
Y
Site 92
S807
A
W
L
D
Q
Y
C
S
L
P
A
L
R
P
T
Site 93
T814
S
L
P
A
L
R
P
T
V
L
N
S
L
R
Q
Site 94
S818
L
R
P
T
V
L
N
S
L
R
Q
L
G
T
S
Site 95
T824
N
S
L
R
Q
L
G
T
S
T
S
I
L
T
D
Site 96
S825
S
L
R
Q
L
G
T
S
T
S
I
L
T
D
P
Site 97
S827
R
Q
L
G
T
S
T
S
I
L
T
D
P
G
R
Site 98
T844
E
Q
A
T
R
A
V
T
E
G
T
L
G
K
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation