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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPHS2
Full Name:
Podocin
Alias:
Nephrosis 2, idiopathic, steroid-resistant; NPHS2; PDCN; PODO; SRN1
Type:
Membrane protein, integral
Mass (Da):
42201
Number AA:
383
UniProt ID:
Q9NP85
International Prot ID:
Isoform1 - IPI00014594
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007588
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
R
R
A
R
S
S
S
R
E
S
R
G
Site 2
S8
M
E
R
R
A
R
S
S
S
R
E
S
R
G
R
Site 3
S9
E
R
R
A
R
S
S
S
R
E
S
R
G
R
G
Site 4
S12
A
R
S
S
S
R
E
S
R
G
R
G
G
R
T
Site 5
T19
S
R
G
R
G
G
R
T
P
H
K
E
N
K
R
Site 6
S32
K
R
A
K
A
E
R
S
G
G
G
R
G
R
Q
Site 7
S48
A
G
P
E
P
S
G
S
G
R
A
G
T
P
G
Site 8
T53
S
G
S
G
R
A
G
T
P
G
E
P
R
A
P
Site 9
T63
E
P
R
A
P
A
A
T
V
V
D
V
D
E
V
Site 10
S73
D
V
D
E
V
R
G
S
G
E
E
G
T
E
V
Site 11
S86
E
V
V
A
L
L
E
S
E
R
P
E
E
G
T
Site 12
T93
S
E
R
P
E
E
G
T
K
S
S
G
L
G
A
Site 13
S95
R
P
E
E
G
T
K
S
S
G
L
G
A
C
E
Site 14
T171
K
V
D
L
R
L
Q
T
L
E
I
P
F
H
E
Site 15
Y194
M
E
I
D
A
I
C
Y
Y
R
M
E
N
A
S
Site 16
Y195
E
I
D
A
I
C
Y
Y
R
M
E
N
A
S
L
Site 17
S230
K
R
L
L
A
H
R
S
L
T
E
I
L
L
E
Site 18
T232
L
L
A
H
R
S
L
T
E
I
L
L
E
R
K
Site 19
S240
E
I
L
L
E
R
K
S
I
A
Q
D
A
K
V
Site 20
S302
A
E
A
E
K
A
A
S
E
S
L
R
M
A
A
Site 21
S304
A
E
K
A
A
S
E
S
L
R
M
A
A
E
I
Site 22
S313
R
M
A
A
E
I
L
S
G
T
P
A
A
V
Q
Site 23
T326
V
Q
L
R
Y
L
H
T
L
Q
S
L
S
T
E
Site 24
S329
R
Y
L
H
T
L
Q
S
L
S
T
E
K
P
S
Site 25
S331
L
H
T
L
Q
S
L
S
T
E
K
P
S
T
V
Site 26
T332
H
T
L
Q
S
L
S
T
E
K
P
S
T
V
V
Site 27
S336
S
L
S
T
E
K
P
S
T
V
V
L
P
L
P
Site 28
S351
F
D
L
L
N
C
L
S
S
P
S
N
R
T
Q
Site 29
S352
D
L
L
N
C
L
S
S
P
S
N
R
T
Q
G
Site 30
S354
L
N
C
L
S
S
P
S
N
R
T
Q
G
S
L
Site 31
S360
P
S
N
R
T
Q
G
S
L
P
F
P
S
P
S
Site 32
S365
Q
G
S
L
P
F
P
S
P
S
K
P
V
E
P
Site 33
S367
S
L
P
F
P
S
P
S
K
P
V
E
P
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation